Siegfried Hekimi
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siegfriedhekimi.bsky.social
Siegfried Hekimi
@siegfriedhekimi.bsky.social
820 followers 800 following 450 posts

Biologist seeking to formulate and test new conjectures about aging.
McGill U.
Worms, yeast, mice, patient cells.
Aging, mitochondria, CoQ.
Former professional cyclist.

hekimilab.mcgill.ca
https://scholar.google.com/citations?hl=en&user=2WIdFlcAAAAJ .. more

Videos
Biology 76%
Neuroscience 9%
Posts Replies Media Videos
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siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · Nov 29
Hi everyone! Blue Sky seems alright!
Check out our massive new review on Coenzyme Q that earned the cover 😉.

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · 4d
Lavater finally vindicated 🤪

Reposted by Timnit Gebru, Rosemary A. Joyce, Malcolm MacLean , and 13 more

economist.com
The Economist @economist.com · 4d
A new paper suggests a photo can tell a recruiter much about an applicant’s personality
Should facial analysis help determine whom companies hire?
A new paper suggests a photo can tell a recruiter much about an applicant’s personality
econ.st

Reposted by Paul Glasziou, Ruairidh Milne, Siegfried Hekimi

erictopol.bsky.social
Eric Topol @erictopol.bsky.social · 12d
The prostate cancer PSA screening story over 23 years of follow-up for >166,000 participants: more detection, small reduction of mortality www.nejm.org/doi/full/10....

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · 12d
Maybe enhanced DNA repair can only be beneficial for them because they are otherwise protected from the environment thanks to size (whales) and stable habitat (mole rats).

Reposted by Siegfried Hekimi

erictopol.bsky.social
Eric Topol @erictopol.bsky.social · 12d
What do the naked mole rat and bowhead whale (lives to ~200 years) have in common to explain their remarkable longevity?
Enhanced DNA repair
www.nature.com/articles/s41...
erictopol.substack.com/p/a-long-awa...
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.  &nbs...
www.nature.com

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · 12d
Bill Gates underestimates the perils of the climate crisis, but I agree with him: we shouldn’t sacrifice those alive now for future people who might never exist.
It’s like buying a lifetime supply of petri dishes at a discount and then switch to a field that doesn’t need any.

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · 13d
Not all leaves are alike. And despite the fear and regret that the world is falling apart, I delight to be able to name them!

Reposted by Siegfried Hekimi

inuyasha1953.bsky.social
Master Elrond [he/him] @inuyasha1953.bsky.social · 17d
The dude who singlehandedly controls the government is demanding it pay him a quarter of a billion dollars of our tax money as restitution for having been caught committing crimes.

He’s discovered forms of looting no one ever even thought possible.

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · 17d
Great color!!!

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · 17d
Eating Beaver Tails is MAHA diet 🤔😉

Reposted by Hugo Mercier, Siegfried Hekimi

wajali.bsky.social
Wajahat Ali @wajali.bsky.social · 17d
That’s no ballroom…

Reposted by Siegfried Hekimi

drruth.bsky.social
Ruth Ann Crystal @drruth.bsky.social · 17d
Guess what? COVID mRNA vaccines don't just protect against COVID.

COVID mRNA vaccines also cause cancers to become sensitive to immune checkpoint inhibitors (ICIs). buff.ly/GEfJ5Zl

Let's fund more mRNA research!

#medsky #oncsky 🛟😷🧪
complicated diagram with red cancer cells, green T cells, and other immune cells in purple (dendritic cells). Shows mRNA vaccine priming immunity for checkpoint inhibitors.

Reposted by Siegfried Hekimi

wbderry.bsky.social
W. Brent Derry @wbderry.bsky.social · 17d
Meanwhile in Canada... www.youtube.com/watch?v=S1yY...
When the ICE agent is Canadian… | This Hour Has 22 Minutes
YouTube video by 22 Minutes
www.youtube.com

Reposted by Siegfried Hekimi

wbderry.bsky.social
W. Brent Derry @wbderry.bsky.social · 18d
#TodaysJam

Reposted by Joe R. Feagin, Steve Peers, Joseph Schafer , and 4 more

markjacob.bsky.social
Mark Jacob @markjacob.bsky.social · 20d
Both the U.S. marshal and the immigrant were shot by federal officers. You’d never know that from this headline.
U.S. marshal and undocumented immigrant shot during ICE stop in Los Angeles, officials say

Reposted by Anna O. Law, Steven Heydemann, Archon Fung , and 6 more

jakemgrumbach.bsky.social
Jake Grumbach @jakemgrumbach.bsky.social · 25d
AOC has just officially become the top House fundraiser, beating out Hakeem Jeffries. Now lemme take a big sip of coffee as I look at the age distribution of donors to AOC vs Jeffries
Alexandria Ocasio Cortez 80000 60000 40000 20000 0 Bernie Sanders 200000 Number of Donations 150000 100000 50000 Elizabeth Warren 60000 40000 20000 01 25 50 Donor Age 75 Hakeem Jeffries 40000 30000 20000 10000 Nancy Pelosi 100000 Number of Donations 75000 50000 25000 Suzan DelBene 2000 1500 1000 500 25 50 75 Donor Age

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · 25d
Thanks for keeping them there!

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · 25d
In the fall, even the weeds look good.

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · 25d
Where were the wasps all summer? And why now?

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · 28d
🤣🤣🤣
muellershewrote.com Mueller, She Wrote @muellershewrote.com · 29d
THESE are the promises I want to hear.
grahamformaine.bsky.social Graham Platner for Senate @grahamformaine.bsky.social · 29d
We have armed secret police kidnapping people off the street based on the color of their skin.

When we win: we will haul them before a Senate committee. The masks will come off. There will be consequences.

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · 28d
Will we have to close the border to prevent US-imported measles, covid, soon polio? Or should we allow our economic overlords to kill children in Canada for their self-aggrandizement ?
—Apparently, I feel a bit angry today.

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · 28d
The naked mole rat lives in a hyper-sheltered environment. Thus, it might benefit from costly physiological/cell biological adjustments that organisms in more variable niches might not be able to afford.

Reposted by W. Andy Knight, Anne Norton, Siegfried Hekimi , and 1 more

muellershewrote.com
Mueller, She Wrote @muellershewrote.com · 29d
THESE are the promises I want to hear.
grahamformaine.bsky.social Graham Platner for Senate @grahamformaine.bsky.social · 29d
We have armed secret police kidnapping people off the street based on the color of their skin.

When we win: we will haul them before a Senate committee. The masks will come off. There will be consequences.

Reposted by Siegfried Hekimi

erictopol.bsky.social
Eric Topol @erictopol.bsky.social · 29d
New @nejm.org
One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing
www.nejm.org/doi/full/10.1056/NEJMoa2400521
DB-OTO Gene Therapy for Inherited Deafness | NEJM
Genetic deficiency of otoferlin, a protein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafness. Medicines to treat the condition are lacking; children...
www.nejm.org

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · Oct 9
Giacometti in the woods.
Sort of.

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · Oct 8
Who wouldn’t?

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · Oct 8
My first language was German. Now my command of French and English might be better than that of German. But I still feel strongly that the real name of things is the German name. Weirdly, sometimes I feel the real word is the Italian word (maybe too much Latin in school).

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · Oct 8
In any case, the Hauberk papers were more exciting (for me professionally).

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · Oct 8
No, John Gurdon, who just died (left), didn’t clone a sheep! Rather, he was dramatically ahead of his time.

siegfriedhekimi.bsky.social
Siegfried Hekimi @siegfriedhekimi.bsky.social · Oct 5
In the playing style of Claudio Colombo there is something that makes music music that is missing. But it is also fascinating and weirdly addictive.