Siegfried Hekimi
@siegfriedhekimi.bsky.social
Biologist seeking to formulate and test new conjectures about aging.
McGill U.
Worms, yeast, mice, patient cells.
Aging, mitochondria, CoQ.
Former professional cyclist.
hekimilab.mcgill.ca
https://scholar.google.com/citations?hl=en&user=2WIdFlcAAAAJ
McGill U.
Worms, yeast, mice, patient cells.
Aging, mitochondria, CoQ.
Former professional cyclist.
hekimilab.mcgill.ca
https://scholar.google.com/citations?hl=en&user=2WIdFlcAAAAJ
Pinned
Hi everyone! Blue Sky seems alright!
Check out our massive new review on Coenzyme Q that earned the cover 😉.
Check out our massive new review on Coenzyme Q that earned the cover 😉.
Lavater finally vindicated 🤪
A new paper suggests a photo can tell a recruiter much about an applicant’s personality
Should facial analysis help determine whom companies hire?
A new paper suggests a photo can tell a recruiter much about an applicant’s personality
econ.st
November 6, 2025 at 10:51 PM
Lavater finally vindicated 🤪
Reposted by Siegfried Hekimi
The prostate cancer PSA screening story over 23 years of follow-up for >166,000 participants: more detection, small reduction of mortality www.nejm.org/doi/full/10....
October 29, 2025 at 9:41 PM
The prostate cancer PSA screening story over 23 years of follow-up for >166,000 participants: more detection, small reduction of mortality www.nejm.org/doi/full/10....
Maybe enhanced DNA repair can only be beneficial for them because they are otherwise protected from the environment thanks to size (whales) and stable habitat (mole rats).
What do the naked mole rat and bowhead whale (lives to ~200 years) have in common to explain their remarkable longevity?
Enhanced DNA repair
www.nature.com/articles/s41...
erictopol.substack.com/p/a-long-awa...
Enhanced DNA repair
www.nature.com/articles/s41...
erictopol.substack.com/p/a-long-awa...
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein. &nbs...
www.nature.com
October 29, 2025 at 4:30 PM
Maybe enhanced DNA repair can only be beneficial for them because they are otherwise protected from the environment thanks to size (whales) and stable habitat (mole rats).
Bill Gates underestimates the perils of the climate crisis, but I agree with him: we shouldn’t sacrifice those alive now for future people who might never exist.
It’s like buying a lifetime supply of petri dishes at a discount and then switch to a field that doesn’t need any.
It’s like buying a lifetime supply of petri dishes at a discount and then switch to a field that doesn’t need any.
October 29, 2025 at 3:44 PM
Bill Gates underestimates the perils of the climate crisis, but I agree with him: we shouldn’t sacrifice those alive now for future people who might never exist.
It’s like buying a lifetime supply of petri dishes at a discount and then switch to a field that doesn’t need any.
It’s like buying a lifetime supply of petri dishes at a discount and then switch to a field that doesn’t need any.
Reposted by Siegfried Hekimi
Not all leaves are alike. And despite the fear and regret that the world is falling apart, I delight to be able to name them!
October 28, 2025 at 3:46 PM
Not all leaves are alike. And despite the fear and regret that the world is falling apart, I delight to be able to name them!
Not all leaves are alike. And despite the fear and regret that the world is falling apart, I delight to be able to name them!
October 28, 2025 at 3:46 PM
Not all leaves are alike. And despite the fear and regret that the world is falling apart, I delight to be able to name them!
Reposted by Siegfried Hekimi
Guess what? COVID mRNA vaccines don't just protect against COVID.
COVID mRNA vaccines also cause cancers to become sensitive to immune checkpoint inhibitors (ICIs). buff.ly/GEfJ5Zl
Let's fund more mRNA research!
#medsky #oncsky 🛟😷🧪
COVID mRNA vaccines also cause cancers to become sensitive to immune checkpoint inhibitors (ICIs). buff.ly/GEfJ5Zl
Let's fund more mRNA research!
#medsky #oncsky 🛟😷🧪
October 24, 2025 at 4:13 PM
Guess what? COVID mRNA vaccines don't just protect against COVID.
COVID mRNA vaccines also cause cancers to become sensitive to immune checkpoint inhibitors (ICIs). buff.ly/GEfJ5Zl
Let's fund more mRNA research!
#medsky #oncsky 🛟😷🧪
COVID mRNA vaccines also cause cancers to become sensitive to immune checkpoint inhibitors (ICIs). buff.ly/GEfJ5Zl
Let's fund more mRNA research!
#medsky #oncsky 🛟😷🧪
Reposted by Siegfried Hekimi
The dude who singlehandedly controls the government is demanding it pay him a quarter of a billion dollars of our tax money as restitution for having been caught committing crimes.
He’s discovered forms of looting no one ever even thought possible.
He’s discovered forms of looting no one ever even thought possible.
October 25, 2025 at 4:59 AM
The dude who singlehandedly controls the government is demanding it pay him a quarter of a billion dollars of our tax money as restitution for having been caught committing crimes.
He’s discovered forms of looting no one ever even thought possible.
He’s discovered forms of looting no one ever even thought possible.
Reposted by Siegfried Hekimi
Great color!!!
October 24, 2025 at 9:18 PM
Great color!!!
Eating Beaver Tails is MAHA diet 🤔😉
October 24, 2025 at 9:15 PM
Eating Beaver Tails is MAHA diet 🤔😉
Reposted by Siegfried Hekimi
Both the U.S. marshal and the immigrant were shot by federal officers. You’d never know that from this headline.
October 22, 2025 at 12:55 AM
Both the U.S. marshal and the immigrant were shot by federal officers. You’d never know that from this headline.
Reposted by Siegfried Hekimi
AOC has just officially become the top House fundraiser, beating out Hakeem Jeffries. Now lemme take a big sip of coffee as I look at the age distribution of donors to AOC vs Jeffries
October 16, 2025 at 8:51 PM
AOC has just officially become the top House fundraiser, beating out Hakeem Jeffries. Now lemme take a big sip of coffee as I look at the age distribution of donors to AOC vs Jeffries
In the fall, even the weeds look good.
October 16, 2025 at 4:22 PM
In the fall, even the weeds look good.
Where were the wasps all summer? And why now?
October 16, 2025 at 4:21 PM
Where were the wasps all summer? And why now?
🤣🤣🤣
THESE are the promises I want to hear.
We have armed secret police kidnapping people off the street based on the color of their skin.
When we win: we will haul them before a Senate committee. The masks will come off. There will be consequences.
When we win: we will haul them before a Senate committee. The masks will come off. There will be consequences.
October 13, 2025 at 3:37 PM
🤣🤣🤣
Will we have to close the border to prevent US-imported measles, covid, soon polio? Or should we allow our economic overlords to kill children in Canada for their self-aggrandizement ?
—Apparently, I feel a bit angry today.
—Apparently, I feel a bit angry today.
October 13, 2025 at 3:34 PM
Will we have to close the border to prevent US-imported measles, covid, soon polio? Or should we allow our economic overlords to kill children in Canada for their self-aggrandizement ?
—Apparently, I feel a bit angry today.
—Apparently, I feel a bit angry today.
The naked mole rat lives in a hyper-sheltered environment. Thus, it might benefit from costly physiological/cell biological adjustments that organisms in more variable niches might not be able to afford.
October 13, 2025 at 3:15 PM
The naked mole rat lives in a hyper-sheltered environment. Thus, it might benefit from costly physiological/cell biological adjustments that organisms in more variable niches might not be able to afford.
Reposted by Siegfried Hekimi
New @nejm.org
One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing
www.nejm.org/doi/full/10.1056/NEJMoa2400521
One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing
www.nejm.org/doi/full/10.1056/NEJMoa2400521
DB-OTO Gene Therapy for Inherited Deafness | NEJM
Genetic deficiency of otoferlin, a protein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafness. Medicines to treat the condition are lacking; children...
www.nejm.org
October 12, 2025 at 2:19 PM
New @nejm.org
One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing
www.nejm.org/doi/full/10.1056/NEJMoa2400521
One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing
www.nejm.org/doi/full/10.1056/NEJMoa2400521
Giacometti in the woods.
Sort of.
Sort of.
October 9, 2025 at 5:03 PM
Giacometti in the woods.
Sort of.
Sort of.
My first language was German. Now my command of French and English might be better than that of German. But I still feel strongly that the real name of things is the German name. Weirdly, sometimes I feel the real word is the Italian word (maybe too much Latin in school).
October 8, 2025 at 3:34 PM
My first language was German. Now my command of French and English might be better than that of German. But I still feel strongly that the real name of things is the German name. Weirdly, sometimes I feel the real word is the Italian word (maybe too much Latin in school).
Reposted by Siegfried Hekimi
Right, we should have fewer Dirac and more lecturers who are chosen for their ability to make you feel good.
"That was not a question, it was a statement" said the famous physicist Paul Dirac after a long silence, in a lecture, when a student said to him, "I don't understand that equation".
That was a hundred years ago and not enough has changed since then in our 'welcoming' culture in science..
That was a hundred years ago and not enough has changed since then in our 'welcoming' culture in science..
September 27, 2025 at 2:14 PM
Right, we should have fewer Dirac and more lecturers who are chosen for their ability to make you feel good.
Reposted by Siegfried Hekimi
Reposted by Siegfried Hekimi
In the playing style of Claudio Colombo there is something that makes music music that is missing. But it is also fascinating and weirdly addictive.
October 5, 2025 at 3:38 PM
In the playing style of Claudio Colombo there is something that makes music music that is missing. But it is also fascinating and weirdly addictive.
Reposted by Siegfried Hekimi
No, John Gurdon, who just died (left), didn’t clone a sheep! Rather, he was dramatically ahead of his time.
October 8, 2025 at 11:23 AM
No, John Gurdon, who just died (left), didn’t clone a sheep! Rather, he was dramatically ahead of his time.