Peter Hill
@peterwshill.bsky.social
Group Leader at KCL working on relapsing invasive non-typhoidal Salmonella infections. Wellcome CDA Fellow. 🇨🇦🇬🇧
Reposted by Peter Hill
September 26, 2025 at 5:13 AM
Reposted by Peter Hill
New preprint reveals bacteria can't just collect all resistance genes like Pokemon cards.
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
Genomic constraints shape the evolution of alternative routes to drug resistance in prokaryotes
Background Variation within the prokaryotic pangenome is not random, and natural selection that favours particular combinations of genes appears to dominate over random drift. What is less clear is wh...
www.biorxiv.org
August 29, 2025 at 2:05 PM
New preprint reveals bacteria can't just collect all resistance genes like Pokemon cards.
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
We found mutually exclusive evolutionary pathways to multidrug resistance in E. coli & P. aeruginosa - some resistance mechanisms actively prevent others from coexisting www.biorxiv.org/content/10.1...
Reposted by Peter Hill
Epigenetics Update - Regulation of inflammatory responses by pH-dependent transcriptional condensates bit.ly/4kJ2Ju0
Ruslan Medzhitov and Xu Zhou reporting in Cell
#Epigenetics #Condensates #Chromatin
---
Perfect for cancer, immunology, and aging research; epigenometech.com
Ruslan Medzhitov and Xu Zhou reporting in Cell
#Epigenetics #Condensates #Chromatin
---
Perfect for cancer, immunology, and aging research; epigenometech.com
July 25, 2025 at 7:59 AM
Epigenetics Update - Regulation of inflammatory responses by pH-dependent transcriptional condensates bit.ly/4kJ2Ju0
Ruslan Medzhitov and Xu Zhou reporting in Cell
#Epigenetics #Condensates #Chromatin
---
Perfect for cancer, immunology, and aging research; epigenometech.com
Ruslan Medzhitov and Xu Zhou reporting in Cell
#Epigenetics #Condensates #Chromatin
---
Perfect for cancer, immunology, and aging research; epigenometech.com
Reposted by Peter Hill
🧫🦠🔬🧬🖥 A much needed review on #plasmids from @eprocha.bsky.social lab!
Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...
July 23, 2025 at 2:19 PM
🧫🦠🔬🧬🖥 A much needed review on #plasmids from @eprocha.bsky.social lab!
Reposted by Peter Hill
We have a new preprint on Salmonella effector SteE! Here we describe how kinase reprogramming drives transcriptional remodelling of the infected macrophage www.biorxiv.org/cgi/content/... - work led by @ines-ddo.bsky.social and fantastic collaboration with @peterwshill.bsky.social
Salmonella Effector SteE Reprogrammes the Macrophage Regulatory Network to Drive Specific Hyperactivation of STAT3 Target Genes
The ability of Salmonella Typhimurium to exploit macrophages as a niche for survival, replication and dissemination is central to its pathogenesis. The effector SteE, which polarises macrophages into ...
www.biorxiv.org
July 16, 2025 at 4:03 PM
We have a new preprint on Salmonella effector SteE! Here we describe how kinase reprogramming drives transcriptional remodelling of the infected macrophage www.biorxiv.org/cgi/content/... - work led by @ines-ddo.bsky.social and fantastic collaboration with @peterwshill.bsky.social
Reposted by Peter Hill
🌟 paper tweetorial! 🌟 check out my first first-author paper from my Ph.D! We wrote a small (=easy-to-read) Perspective piece trying to bridge the gap between #evolutionarybiology and the expanding world of #genomic assays, specifically #chromatin conformation capture (3C and related approaches) 🧵1/7
As 3D genome tools become more accessible, studying three-dimensional genome architecture in non-model organisms offers powerful ways to integrate evolution and gene regulation. Read more in this new Perspective by @a-mack-s.bsky.social & Wray.
🔗 doi.org/10.1093/gbe/evaf113
#genome #evolution
🔗 doi.org/10.1093/gbe/evaf113
#genome #evolution
July 1, 2025 at 6:31 PM
🌟 paper tweetorial! 🌟 check out my first first-author paper from my Ph.D! We wrote a small (=easy-to-read) Perspective piece trying to bridge the gap between #evolutionarybiology and the expanding world of #genomic assays, specifically #chromatin conformation capture (3C and related approaches) 🧵1/7
Reposted by Peter Hill
🧬🖥️ scAtlas of CD34+ cells from 148 people reveals how circulating hematopoietic stem/progenitor cells (cHSPCs) shift with age, sex & disease. Reference model enables myelodysplastic syndrome (MDS) diagnosis. From great Liran Shlush & Amos Tanay @natmed.nature.com: doi.org/10.1038/s415... 🧪
A reference model of circulating hematopoietic stem cells across the lifespan with applications to diagnostics
Nature Medicine - A large single-cell transcriptomic-based reference model for hematopoietic stem and progenitor cells from 148 age- and sex-diverse individuals identifies physiological and...
doi.org
June 30, 2025 at 2:24 PM
🧬🖥️ scAtlas of CD34+ cells from 148 people reveals how circulating hematopoietic stem/progenitor cells (cHSPCs) shift with age, sex & disease. Reference model enables myelodysplastic syndrome (MDS) diagnosis. From great Liran Shlush & Amos Tanay @natmed.nature.com: doi.org/10.1038/s415... 🧪
Reposted by Peter Hill
#Medsky🧪 #IDsky #immunosky Macrophages are versatile innate immune cells that act as sentinels, warriors & healers in virtually every tissue. This review on current insights into their developmental origins and the organ-specific cues that imprint diverse tissue-resident & monocyte derived programs
Check out the latest review article from #TeamKhanna superstars Eduardo Bernier and recent alumni Dr. Eric Bartnicki.
Macrophages: sentinels, warriors, and healers
Free Link:
academic.oup.com/hmg/advance-...
@khannakm.bsky.social
Macrophages: sentinels, warriors, and healers
Free Link:
academic.oup.com/hmg/advance-...
@khannakm.bsky.social
June 7, 2025 at 6:38 PM
#Medsky🧪 #IDsky #immunosky Macrophages are versatile innate immune cells that act as sentinels, warriors & healers in virtually every tissue. This review on current insights into their developmental origins and the organ-specific cues that imprint diverse tissue-resident & monocyte derived programs
Reposted by Peter Hill
In this episode of the Epigenetics Podcast, Petra Hajkova from the @mrc-lms.bsky.social discusses her research on mammalian development, focusing on DNA methylation, histone modifications and TET enzymes. #podcast #epigenetics
🎧 Listen here: activemotif.com/podcasts-pet...
🎧 Listen here: activemotif.com/podcasts-pet...
June 6, 2025 at 7:01 AM
In this episode of the Epigenetics Podcast, Petra Hajkova from the @mrc-lms.bsky.social discusses her research on mammalian development, focusing on DNA methylation, histone modifications and TET enzymes. #podcast #epigenetics
🎧 Listen here: activemotif.com/podcasts-pet...
🎧 Listen here: activemotif.com/podcasts-pet...
Reposted by Peter Hill
NEW Highlight of @nature.com paper by @davidjlynn.bsky.social and colleagues @sahmri.bsky.social reporting a prospective observational study of human immune responses to #vaccination after early-life #antibiotic exposure.
#immunology #immunosky #medsky #IDsky #pedsky #publichealth
#immunology #immunosky #medsky #IDsky #pedsky #publichealth
Neonatal antibiotics impair infant vaccine responses - Nature Reviews Immunology
A prospective observational study of human immune responses to vaccination after early-life antibiotic exposure shows that neonatal exposure reduces the immune response to several vaccine antigens and...
www.nature.com
April 23, 2025 at 1:20 PM
NEW Highlight of @nature.com paper by @davidjlynn.bsky.social and colleagues @sahmri.bsky.social reporting a prospective observational study of human immune responses to #vaccination after early-life #antibiotic exposure.
#immunology #immunosky #medsky #IDsky #pedsky #publichealth
#immunology #immunosky #medsky #IDsky #pedsky #publichealth
Reposted by Peter Hill
Reporting in Nature, Eitan Yaffe and colleagues demonstrate that resistance to an antibiotic can rapidly emerge in commensal gut bacteria in vivo, and that such resistant lineages can persist for a long period following cessation of the antibiotic. 👇 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Brief antibiotic use drives human gut bacteria towards low-cost resistance - Nature
Brief ciprofloxacin exposure in humans drives antibiotic resistance evolution in gut bacteria through selective sweeps, particularly involving DNA gyrase mutations, which persist long after exposure a...
www.nature.com
April 25, 2025 at 4:31 PM
Reporting in Nature, Eitan Yaffe and colleagues demonstrate that resistance to an antibiotic can rapidly emerge in commensal gut bacteria in vivo, and that such resistant lineages can persist for a long period following cessation of the antibiotic. 👇 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Peter Hill
🚨 Exciting news for #UKCellMicro2025!
The meeting is now supported by the EMBO Young Investigator Programme
We’re thrilled to have their backing for this year’s meeting. 🌟
🔗 Full details & programme: www.ukcellmicro.org
#CellMicro #ECR #EMBO
The meeting is now supported by the EMBO Young Investigator Programme
We’re thrilled to have their backing for this year’s meeting. 🌟
🔗 Full details & programme: www.ukcellmicro.org
#CellMicro #ECR #EMBO
April 14, 2025 at 3:32 PM
🚨 Exciting news for #UKCellMicro2025!
The meeting is now supported by the EMBO Young Investigator Programme
We’re thrilled to have their backing for this year’s meeting. 🌟
🔗 Full details & programme: www.ukcellmicro.org
#CellMicro #ECR #EMBO
The meeting is now supported by the EMBO Young Investigator Programme
We’re thrilled to have their backing for this year’s meeting. 🌟
🔗 Full details & programme: www.ukcellmicro.org
#CellMicro #ECR #EMBO
Reposted by Peter Hill
Adapting systems biology to address the complexity of human disease in the single-cell era go.nature.com/3XBo6Vh #Review by @davidsebfischer.bsky.social, Martin A. Villanueva, Peter S. Winter & Alex K. Shalek @broadinstitute.org @mitofficial.bsky.social @ragoninstitute.bsky.social
Adapting systems biology to address the complexity of human disease in the single-cell era - Nature Reviews Genetics
Differences between humans and experimental models create a translational gap that makes it difficult to extrapolate research findings. The authors review systems-focused approaches to identify and co...
go.nature.com
March 11, 2025 at 9:05 AM
Adapting systems biology to address the complexity of human disease in the single-cell era go.nature.com/3XBo6Vh #Review by @davidsebfischer.bsky.social, Martin A. Villanueva, Peter S. Winter & Alex K. Shalek @broadinstitute.org @mitofficial.bsky.social @ragoninstitute.bsky.social
Reposted by Peter Hill
🚨 New paper on ArXiv:
“Uncertainty quantification and posterior sampling for network reconstruction”
TL;DR; We present an efficient method to sample the entire ensemble of possible network reconstructions that are compatible with an indirect observation, e.g. a dynamics.
Short thread: 1/N
“Uncertainty quantification and posterior sampling for network reconstruction”
TL;DR; We present an efficient method to sample the entire ensemble of possible network reconstructions that are compatible with an indirect observation, e.g. a dynamics.
Short thread: 1/N
March 12, 2025 at 11:57 AM
🚨 New paper on ArXiv:
“Uncertainty quantification and posterior sampling for network reconstruction”
TL;DR; We present an efficient method to sample the entire ensemble of possible network reconstructions that are compatible with an indirect observation, e.g. a dynamics.
Short thread: 1/N
“Uncertainty quantification and posterior sampling for network reconstruction”
TL;DR; We present an efficient method to sample the entire ensemble of possible network reconstructions that are compatible with an indirect observation, e.g. a dynamics.
Short thread: 1/N
Reposted by Peter Hill
Given hyperbole about this paper www.nature.com/articles/s41... in the news today (eg www.bbc.co.uk/news/article...) it is a good day to post this classic from >20 years ago: www.microbiologyresearch.org/content/jour...
Arming the enemy: the evolution of resistance to self-proteins
A remarkable range of novel antibiotics is attracting increasing interest as a major new weapon in the campaign against bacterial infection. They are based on the toxic peptides that provide the innat...
www.microbiologyresearch.org
March 6, 2025 at 6:57 AM
Given hyperbole about this paper www.nature.com/articles/s41... in the news today (eg www.bbc.co.uk/news/article...) it is a good day to post this classic from >20 years ago: www.microbiologyresearch.org/content/jour...
Reposted by Peter Hill
#Immunology out now @science.org
Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases.
https://buff.ly/3QvxSVf
By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.
Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases.
https://buff.ly/3QvxSVf
By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.
February 20, 2025 at 7:35 PM
#Immunology out now @science.org
Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases.
https://buff.ly/3QvxSVf
By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.
Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases.
https://buff.ly/3QvxSVf
By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.
Reposted by Peter Hill
Are you interested in bacterial pathogen physiology 🧫 and their interactions with our tissues during infections?
Alex and I wrote about how organoids + microbiology offer a powerful, tractable way to decode these interactions. Check it out! 👇
🔗 doi.org/10.1038/s443...
@embojournal.org #MicroSky
Alex and I wrote about how organoids + microbiology offer a powerful, tractable way to decode these interactions. Check it out! 👇
🔗 doi.org/10.1038/s443...
@embojournal.org #MicroSky
February 21, 2025 at 9:18 PM
Are you interested in bacterial pathogen physiology 🧫 and their interactions with our tissues during infections?
Alex and I wrote about how organoids + microbiology offer a powerful, tractable way to decode these interactions. Check it out! 👇
🔗 doi.org/10.1038/s443...
@embojournal.org #MicroSky
Alex and I wrote about how organoids + microbiology offer a powerful, tractable way to decode these interactions. Check it out! 👇
🔗 doi.org/10.1038/s443...
@embojournal.org #MicroSky
Reposted by Peter Hill
Legitmately thrilled to share our latest work, in which @fernpizza.bsky.social solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!
February 21, 2025 at 8:42 PM
Legitmately thrilled to share our latest work, in which @fernpizza.bsky.social solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!
Reposted by Peter Hill
Nature whispering
(from Crow & Casanova,
Human life within a narrow range: The lethal ups and downs of type I interferons)
#Immunology
www.science.org/doi/abs/10.1...
(from Crow & Casanova,
Human life within a narrow range: The lethal ups and downs of type I interferons)
#Immunology
www.science.org/doi/abs/10.1...
February 18, 2025 at 1:12 PM
Nature whispering
(from Crow & Casanova,
Human life within a narrow range: The lethal ups and downs of type I interferons)
#Immunology
www.science.org/doi/abs/10.1...
(from Crow & Casanova,
Human life within a narrow range: The lethal ups and downs of type I interferons)
#Immunology
www.science.org/doi/abs/10.1...
Reposted by Peter Hill
Identifying perturbation targets through causal differential networks #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2410.03380
https://arxiv.org/abs/2410.03380
February 11, 2025 at 7:50 AM
Identifying perturbation targets through causal differential networks #SingleCell 🧪🧬🖥️
https://arxiv.org/abs/2410.03380
https://arxiv.org/abs/2410.03380
Reposted by Peter Hill
The overview of AMR that you always wanted (someone else to write) - amazing!
Truly brilliant paper with great figures! @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Truly brilliant paper with great figures! @lancetmicrobe.bsky.social
www.thelancet.com/journals/lan...
Antimicrobial resistance: a concise update
Antimicrobial resistance (AMR) is a serious threat to global public health, with approximately
5 million deaths associated with bacterial AMR in 2019. Tackling AMR requires a multifaceted
and cohesive...
www.thelancet.com
February 5, 2025 at 11:29 AM
Reposted by Peter Hill
Fun to share our experience using tissue micro arrays to lower cost and increase throughput in spatial transcriptomic studies.
How was Dr. Nick Banovich able to achieve an eight-fold reduction in per-sample costs for Xenium and increase throughput for #singlecellspatial studies? Find out in this new Q&A blog!
How TGen drastically reduced Xenium per-sample costs for large cohorts with tumor microarrays - 10x Genomics
TGen’s Dr. Nick Banovich leveraged a custom tissue microarray approach to achieve a nearly eight-fold reduction in per-sample costs for large Xenium In Situ studies.
www.10xgenomics.com
January 29, 2025 at 4:10 PM
Fun to share our experience using tissue micro arrays to lower cost and increase throughput in spatial transcriptomic studies.
Reposted by Peter Hill
Reposted by Peter Hill
How cool! Amit Singh lab shows M. tuberculosis exploits macrophage metabolism to dodge drugs. Flipping macrophages from OXPHOS to glycolysis with FDA-approved meclizine subverts redox heterogeneity & cuts drug tolerance 🚀 #TBResearch #DrugResistance #MicroSky
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 27, 2025 at 9:49 AM
How cool! Amit Singh lab shows M. tuberculosis exploits macrophage metabolism to dodge drugs. Flipping macrophages from OXPHOS to glycolysis with FDA-approved meclizine subverts redox heterogeneity & cuts drug tolerance 🚀 #TBResearch #DrugResistance #MicroSky
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Peter Hill
Is it anything Hfq-like (RNA chaperone)? Or similar to CsrA (global translation modulator)? We don't know yet. But as it stands, Bacteroidota RRM proteins appear as excellent candidates to map post-transcriptional networks in a substantial fraction of the microbiota. www.nature.com/articles/s41...
January 9, 2025 at 9:33 AM
Is it anything Hfq-like (RNA chaperone)? Or similar to CsrA (global translation modulator)? We don't know yet. But as it stands, Bacteroidota RRM proteins appear as excellent candidates to map post-transcriptional networks in a substantial fraction of the microbiota. www.nature.com/articles/s41...