Sarah Ross
@sarahhross.bsky.social
Associate editor Science Magazine
Immunology | Haematology | Host-pathogen interactions
Immunology | Haematology | Host-pathogen interactions
The human immune system evolved over millennia - and can adapt within a single lifetime. This review examines how the immune responses change over the life course. By Jessica Metcalf, Andrea Graham, Andrew Yates and Derek Cummings @science.org
buff.ly/GJpPUO7
buff.ly/GJpPUO7
August 16, 2025 at 6:44 PM
The human immune system evolved over millennia - and can adapt within a single lifetime. This review examines how the immune responses change over the life course. By Jessica Metcalf, Andrea Graham, Andrew Yates and Derek Cummings @science.org
buff.ly/GJpPUO7
buff.ly/GJpPUO7
Tissue immunity meets biological sex differences - context is important in the immune system. Another of my reading recommendations during a trip to @iuis-online.bsky.social Congress. From Sonia Sharma, Alicia Gibbons and Erica Ollmann Saphire in @science.org
buff.ly/XPN0Tpb
buff.ly/XPN0Tpb
August 16, 2025 at 4:57 PM
Tissue immunity meets biological sex differences - context is important in the immune system. Another of my reading recommendations during a trip to @iuis-online.bsky.social Congress. From Sonia Sharma, Alicia Gibbons and Erica Ollmann Saphire in @science.org
buff.ly/XPN0Tpb
buff.ly/XPN0Tpb
If you are looking for a great read during your journey to @iuis-online.bsky.social Congress, take a peek at this review from from Matthias Nahrendorf, Florent Ginhoux and @filswirski.bsky.social in @science.org that explores the role of immune cells beyond host defence.
buff.ly/S5RkqTf
buff.ly/S5RkqTf
August 16, 2025 at 3:31 PM
If you are looking for a great read during your journey to @iuis-online.bsky.social Congress, take a peek at this review from from Matthias Nahrendorf, Florent Ginhoux and @filswirski.bsky.social in @science.org that explores the role of immune cells beyond host defence.
buff.ly/S5RkqTf
buff.ly/S5RkqTf
Anyone traveling to @iuis-online.bsky.social Congress and looking for something to read? Don't miss the reviews from our @science.org Evolving Immunity Special Issue!
Here, Kassiotis and Stoye consider endogenous retroviruses and antiviral defences.
buff.ly/IU4nbSE
Here, Kassiotis and Stoye consider endogenous retroviruses and antiviral defences.
buff.ly/IU4nbSE
August 16, 2025 at 1:05 PM
Anyone traveling to @iuis-online.bsky.social Congress and looking for something to read? Don't miss the reviews from our @science.org Evolving Immunity Special Issue!
Here, Kassiotis and Stoye consider endogenous retroviruses and antiviral defences.
buff.ly/IU4nbSE
Here, Kassiotis and Stoye consider endogenous retroviruses and antiviral defences.
buff.ly/IU4nbSE
Such a beautiful and intricate image! I was fascinated by the creative process for the cover, and loved getting a behind-the-scenes look at the work of artist Rioka Hayama and the Science Visuals team. Have you guessed all the features yet?
Can you can identify these 10 components featured on our Evolving Immunity special issue cover? 🔎
Drop your guesses in the comments. We’ll reveal the answers next week, so stay tuned!
Discover more about the special issue here: https://scim.ag/3JdpWYj
Drop your guesses in the comments. We’ll reveal the answers next week, so stay tuned!
Discover more about the special issue here: https://scim.ag/3JdpWYj
August 16, 2025 at 12:42 PM
Such a beautiful and intricate image! I was fascinated by the creative process for the cover, and loved getting a behind-the-scenes look at the work of artist Rioka Hayama and the Science Visuals team. Have you guessed all the features yet?
Not long to go - I'm looking forward to some fantastic immunology!
Heads up: @science.org 's immunology editor @sarahhross.bsky.social and I will both be attending the @iuis-online.bsky.social 19th International Congress next week in the ever enchanting city of #Vienna! We hope to see many of you there!
Home - IUIS 2025
IUIS 2025 ACCREDITED WITH 26 CME CREDITSThe 19th International Congress of Immunology (IUIS 2025), Vienna, Austria 17/08/2025 – 22/08/2025, has been accredited by the European Accreditation Council fo...
iuis2025.org
August 16, 2025 at 12:01 PM
Not long to go - I'm looking forward to some fantastic immunology!
This week @science.org examines the wonders of the immune system! From molecular defences that co-evolved with pathogens to specialised cells that are intricately linked with physiology, the immune system is attuned to biological sex and different stages of life.
A new special issue of Science explores the immune system at the molecular and cellular level and how it has evolved to govern multiple facets of human health.
Learn more: scim.ag/3IYhnk7
Learn more: scim.ag/3IYhnk7
August 7, 2025 at 6:17 PM
This week @science.org examines the wonders of the immune system! From molecular defences that co-evolved with pathogens to specialised cells that are intricately linked with physiology, the immune system is attuned to biological sex and different stages of life.
#Immunology out now @science.org
After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.
buff.ly/49bKcTG
By Jobin, Seetharama, Rüttger et al.
After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.
buff.ly/49bKcTG
By Jobin, Seetharama, Rüttger et al.
April 11, 2025 at 4:17 PM
#Immunology out now @science.org
After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.
buff.ly/49bKcTG
By Jobin, Seetharama, Rüttger et al.
After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.
buff.ly/49bKcTG
By Jobin, Seetharama, Rüttger et al.
#Immunology out now @science.org
Regulatory T cells inhibit pain sensing in female, but not male, mice.
buff.ly/SKtHnfK
By Élora Midavaine, Sakeen Kashem et al.
Regulatory T cells inhibit pain sensing in female, but not male, mice.
buff.ly/SKtHnfK
By Élora Midavaine, Sakeen Kashem et al.
April 4, 2025 at 3:26 PM
#Immunology out now @science.org
Regulatory T cells inhibit pain sensing in female, but not male, mice.
buff.ly/SKtHnfK
By Élora Midavaine, Sakeen Kashem et al.
Regulatory T cells inhibit pain sensing in female, but not male, mice.
buff.ly/SKtHnfK
By Élora Midavaine, Sakeen Kashem et al.
ICYMI by First release - now in print @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
March 14, 2025 at 3:25 PM
ICYMI by First release - now in print @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.
buff.ly/3DjNQ1e
By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
#Immunology by First Release @science.org
In mice, during immune responses accompanied by elevated self-antigens, autoreactive CD4 T cells must be restrained by regulatory CD4 T cells with the same antigen specificity to prevent autoimmunity.
buff.ly/3EXaXQa
In mice, during immune responses accompanied by elevated self-antigens, autoreactive CD4 T cells must be restrained by regulatory CD4 T cells with the same antigen specificity to prevent autoimmunity.
buff.ly/3EXaXQa
February 27, 2025 at 7:20 PM
#Immunology by First Release @science.org
In mice, during immune responses accompanied by elevated self-antigens, autoreactive CD4 T cells must be restrained by regulatory CD4 T cells with the same antigen specificity to prevent autoimmunity.
buff.ly/3EXaXQa
In mice, during immune responses accompanied by elevated self-antigens, autoreactive CD4 T cells must be restrained by regulatory CD4 T cells with the same antigen specificity to prevent autoimmunity.
buff.ly/3EXaXQa
#Immunology out now @science.org
Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases.
https://buff.ly/3QvxSVf
By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.
Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases.
https://buff.ly/3QvxSVf
By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.
February 20, 2025 at 7:35 PM
#Immunology out now @science.org
Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases.
https://buff.ly/3QvxSVf
By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.
Machine learning, using the sequences of an individual's B and T cell receptors, has the potential to diagnose immune-related diseases.
https://buff.ly/3QvxSVf
By Maxim Zaslavsky, Erin Craig, @anshulkundaje.bsky.social , @scottboydlab.bsky.social et al.
#Immunology out now @science.org
In mice, the transcription factor KLF2 keeps activated CD8 T cells on track to differentiate into functional effector T cells.
https://buff.ly/4hBmL8W
By Eric Fagerberg, Nikhil Joshi @nikjoshilabyale.bsky.social et al
In mice, the transcription factor KLF2 keeps activated CD8 T cells on track to differentiate into functional effector T cells.
https://buff.ly/4hBmL8W
By Eric Fagerberg, Nikhil Joshi @nikjoshilabyale.bsky.social et al
February 13, 2025 at 7:40 PM
#Immunology out now @science.org
In mice, the transcription factor KLF2 keeps activated CD8 T cells on track to differentiate into functional effector T cells.
https://buff.ly/4hBmL8W
By Eric Fagerberg, Nikhil Joshi @nikjoshilabyale.bsky.social et al
In mice, the transcription factor KLF2 keeps activated CD8 T cells on track to differentiate into functional effector T cells.
https://buff.ly/4hBmL8W
By Eric Fagerberg, Nikhil Joshi @nikjoshilabyale.bsky.social et al
ICYMI by First Release - now officially in print @science.org
Specific combinations of nutrients and metabolic enzymes determine T cell differentiation via loci-specific histone acetylations.
https://buff.ly/4gvqKTz
From Shixin Ma, Sue Kaech @tcellogic.bsky.social et al.
#immunometabolism
Specific combinations of nutrients and metabolic enzymes determine T cell differentiation via loci-specific histone acetylations.
https://buff.ly/4gvqKTz
From Shixin Ma, Sue Kaech @tcellogic.bsky.social et al.
#immunometabolism
February 7, 2025 at 5:25 PM
ICYMI by First Release - now officially in print @science.org
Specific combinations of nutrients and metabolic enzymes determine T cell differentiation via loci-specific histone acetylations.
https://buff.ly/4gvqKTz
From Shixin Ma, Sue Kaech @tcellogic.bsky.social et al.
#immunometabolism
Specific combinations of nutrients and metabolic enzymes determine T cell differentiation via loci-specific histone acetylations.
https://buff.ly/4gvqKTz
From Shixin Ma, Sue Kaech @tcellogic.bsky.social et al.
#immunometabolism
Not long to go now! Don’t miss out on applying for the NOSTER & @science.org Microbiome Prize!
Enter: buff.ly/4gS29ZH
More details: ⤵️
Enter: buff.ly/4gS29ZH
More details: ⤵️
If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 years don’t miss out on applying for the NOSTER & @science.org Microbiome Prize!
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
February 5, 2025 at 2:43 PM
Not long to go now! Don’t miss out on applying for the NOSTER & @science.org Microbiome Prize!
Enter: buff.ly/4gS29ZH
More details: ⤵️
Enter: buff.ly/4gS29ZH
More details: ⤵️
This Perspective from Aaron Ver Heul puts the work of Andrew Liu, @danhkaplan.bsky.social et al into context.
https://buff.ly/40Bp1G1
#Immunology @science.org
https://buff.ly/40Bp1G1
#Immunology @science.org
January 31, 2025 at 1:12 PM
This Perspective from Aaron Ver Heul puts the work of Andrew Liu, @danhkaplan.bsky.social et al into context.
https://buff.ly/40Bp1G1
#Immunology @science.org
https://buff.ly/40Bp1G1
#Immunology @science.org
#Immunology out now @science.org
Scratching in mice promotes pain-sensing neurons to release a neuropeptide that stimulated antigen-activated mast cells to degranulate and produce inflammatory mediators.
https://buff.ly/4hDAgF2
From Andrew Liu, @danhkaplan.bsky.social et al
Scratching in mice promotes pain-sensing neurons to release a neuropeptide that stimulated antigen-activated mast cells to degranulate and produce inflammatory mediators.
https://buff.ly/4hDAgF2
From Andrew Liu, @danhkaplan.bsky.social et al
January 31, 2025 at 1:05 PM
#Immunology out now @science.org
Scratching in mice promotes pain-sensing neurons to release a neuropeptide that stimulated antigen-activated mast cells to degranulate and produce inflammatory mediators.
https://buff.ly/4hDAgF2
From Andrew Liu, @danhkaplan.bsky.social et al
Scratching in mice promotes pain-sensing neurons to release a neuropeptide that stimulated antigen-activated mast cells to degranulate and produce inflammatory mediators.
https://buff.ly/4hDAgF2
From Andrew Liu, @danhkaplan.bsky.social et al
ICYMI by First Release - now officially in print @science.org
Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation.
https://buff.ly/3BzpLmL
By Andrew MacLean, Michel Nussenzweig et al.
#Immunology
Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation.
https://buff.ly/3BzpLmL
By Andrew MacLean, Michel Nussenzweig et al.
#Immunology
January 24, 2025 at 3:23 PM
ICYMI by First Release - now officially in print @science.org
Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation.
https://buff.ly/3BzpLmL
By Andrew MacLean, Michel Nussenzweig et al.
#Immunology
Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation.
https://buff.ly/3BzpLmL
By Andrew MacLean, Michel Nussenzweig et al.
#Immunology
#Immunology out now @science.org
ILC2s contribute to glucose homeostasis. Neurons that innervate the gut from areas of the brain associated with glucose sensing can stimulate ILC2s in the gut to relocate to the pancreas upon fasting.
https://buff.ly/42iBst0
ILC2s contribute to glucose homeostasis. Neurons that innervate the gut from areas of the brain associated with glucose sensing can stimulate ILC2s in the gut to relocate to the pancreas upon fasting.
https://buff.ly/42iBst0
January 16, 2025 at 7:20 PM
#Immunology out now @science.org
ILC2s contribute to glucose homeostasis. Neurons that innervate the gut from areas of the brain associated with glucose sensing can stimulate ILC2s in the gut to relocate to the pancreas upon fasting.
https://buff.ly/42iBst0
ILC2s contribute to glucose homeostasis. Neurons that innervate the gut from areas of the brain associated with glucose sensing can stimulate ILC2s in the gut to relocate to the pancreas upon fasting.
https://buff.ly/42iBst0
If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 years don’t miss out on applying for the NOSTER & @science.org Microbiome Prize!
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
January 14, 2025 at 5:26 PM
If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 years don’t miss out on applying for the NOSTER & @science.org Microbiome Prize!
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
#Immunology by first release now @science.org
Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation.
https://buff.ly/3BzpLmL
By Andrew MacLean, Michel Nussenzweig et al.
Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation.
https://buff.ly/3BzpLmL
By Andrew MacLean, Michel Nussenzweig et al.
December 19, 2024 at 8:13 PM
#Immunology by first release now @science.org
Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation.
https://buff.ly/3BzpLmL
By Andrew MacLean, Michel Nussenzweig et al.
Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation.
https://buff.ly/3BzpLmL
By Andrew MacLean, Michel Nussenzweig et al.
#Immunology by First release now @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
December 19, 2024 at 8:08 PM
#Immunology by First release now @science.org
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection
https://buff.ly/3DjNQ1e
By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
#Immunology out now @science.org
An unstructured region within MAVS interacts with cellular, rather than viral, RNA. This alters how MAVS interacts with other proteins and influences antiviral responses.
https://buff.ly/4grnf18
By @nandangokhale.bsky.social with @ramlabuw.bsky.social et al.
An unstructured region within MAVS interacts with cellular, rather than viral, RNA. This alters how MAVS interacts with other proteins and influences antiviral responses.
https://buff.ly/4grnf18
By @nandangokhale.bsky.social with @ramlabuw.bsky.social et al.
December 19, 2024 at 8:05 PM
#Immunology out now @science.org
An unstructured region within MAVS interacts with cellular, rather than viral, RNA. This alters how MAVS interacts with other proteins and influences antiviral responses.
https://buff.ly/4grnf18
By @nandangokhale.bsky.social with @ramlabuw.bsky.social et al.
An unstructured region within MAVS interacts with cellular, rather than viral, RNA. This alters how MAVS interacts with other proteins and influences antiviral responses.
https://buff.ly/4grnf18
By @nandangokhale.bsky.social with @ramlabuw.bsky.social et al.
#Immunology out now @science.org
Biased antibody responses to influenza strains in vaccines are strongly linked to genetics. Coupling antigens from different strains together may broaden antibody responses.
https://buff.ly/4flV5TK
By Vamsee Mallajosyula, Mark Davis et al.
Biased antibody responses to influenza strains in vaccines are strongly linked to genetics. Coupling antigens from different strains together may broaden antibody responses.
https://buff.ly/4flV5TK
By Vamsee Mallajosyula, Mark Davis et al.
December 19, 2024 at 8:02 PM
#Immunology out now @science.org
Biased antibody responses to influenza strains in vaccines are strongly linked to genetics. Coupling antigens from different strains together may broaden antibody responses.
https://buff.ly/4flV5TK
By Vamsee Mallajosyula, Mark Davis et al.
Biased antibody responses to influenza strains in vaccines are strongly linked to genetics. Coupling antigens from different strains together may broaden antibody responses.
https://buff.ly/4flV5TK
By Vamsee Mallajosyula, Mark Davis et al.