TRAstonDrs
@castltrastondrs.bsky.social
"Not all those who wander are lost" JR Tolkien
#Clinicalresearcher #DrugDevelopment
#Clinicaltrials & Registration
🧬🔬📚🔎🦠🧫 📌
Melbourne 🇦🇺 Oxford 🇬🇧& 🏴 #MedSky🧪
#Clinicalresearcher #DrugDevelopment
#Clinicaltrials & Registration
🧬🔬📚🔎🦠🧫 📌
Melbourne 🇦🇺 Oxford 🇬🇧& 🏴 #MedSky🧪
Pinned
Our greatest strength lies in the gentleness and tenderness of our heart.
Rumi
Rumi
True beauty is not of the body or of the face.
It is a thing of the soul.
Of fire, air, breath, spirit, something brave and unafraid.
S Amil
It is a thing of the soul.
Of fire, air, breath, spirit, something brave and unafraid.
S Amil
November 11, 2025 at 2:36 AM
True beauty is not of the body or of the face.
It is a thing of the soul.
Of fire, air, breath, spirit, something brave and unafraid.
S Amil
It is a thing of the soul.
Of fire, air, breath, spirit, something brave and unafraid.
S Amil
Reposted by TRAstonDrs
1. He overstates the risk. Guillain-Barre from the influenza vaccine is 1-2 additional cases per million doses given.
2. Only 30% of patients require mechanical ventilation.
3. A hospitalist would consult with their affiliated OB-Gyn, not a "Locum Independent Contractor"
2. Only 30% of patients require mechanical ventilation.
3. A hospitalist would consult with their affiliated OB-Gyn, not a "Locum Independent Contractor"
November 10, 2025 at 6:32 PM
1. He overstates the risk. Guillain-Barre from the influenza vaccine is 1-2 additional cases per million doses given.
2. Only 30% of patients require mechanical ventilation.
3. A hospitalist would consult with their affiliated OB-Gyn, not a "Locum Independent Contractor"
2. Only 30% of patients require mechanical ventilation.
3. A hospitalist would consult with their affiliated OB-Gyn, not a "Locum Independent Contractor"
#Medsky🧪 #IDsky #pedsky #publichealth
The study ( 110 ➡️ 90 A & 20 Childrens ) highlights that mild #COVID can lead to lingering, subtle 🫁 function impairments, particularly in peripheral airways, that may be missed by routine spirometry. The LCI is a more sensitive tool for detecting these changes.
The study ( 110 ➡️ 90 A & 20 Childrens ) highlights that mild #COVID can lead to lingering, subtle 🫁 function impairments, particularly in peripheral airways, that may be missed by routine spirometry. The LCI is a more sensitive tool for detecting these changes.
Pulmonary function in non-hospitalized adults and children after mild COVID-19: a single-centre prospective cohort study - BMC Pulmonary Medicine
Background Although the majority of patients suffering from COVID-19 (coronavirus disease 2019) did not require hospitalization, data on the persistence of pulmonary sequelae after a mild SARS-CoV-2 (...
bmcpulmmed.biomedcentral.com
November 10, 2025 at 6:19 PM
#Medsky🧪 #IDsky #pedsky #publichealth
The study ( 110 ➡️ 90 A & 20 Childrens ) highlights that mild #COVID can lead to lingering, subtle 🫁 function impairments, particularly in peripheral airways, that may be missed by routine spirometry. The LCI is a more sensitive tool for detecting these changes.
The study ( 110 ➡️ 90 A & 20 Childrens ) highlights that mild #COVID can lead to lingering, subtle 🫁 function impairments, particularly in peripheral airways, that may be missed by routine spirometry. The LCI is a more sensitive tool for detecting these changes.
Witnessing the struggles of colleagues who face significant physical challenges, such as difficulties with gait, paralysis, or memory loss, can be a powerful reminder of how important 😷 , 💉 & our precious health & our basic functions are.
November 10, 2025 at 5:57 PM
Witnessing the struggles of colleagues who face significant physical challenges, such as difficulties with gait, paralysis, or memory loss, can be a powerful reminder of how important 😷 , 💉 & our precious health & our basic functions are.
Reposted by TRAstonDrs
Early in my career, a recruiter asked me to leave my practice & join a private clinic instead.
I said no.
Here's why:
www.thestar.com/opinion/cont...
I said no.
Here's why:
www.thestar.com/opinion/cont...
I was recruited to join a private health centre as a doctor. Here is why I said no
Years ago, I received an unsolicited recruitment letter inviting me to join a “private health centre” in another province. I was struck by how enticing it sounded. The recruiter promised
www.thestar.com
November 10, 2025 at 2:08 PM
Early in my career, a recruiter asked me to leave my practice & join a private clinic instead.
I said no.
Here's why:
www.thestar.com/opinion/cont...
I said no.
Here's why:
www.thestar.com/opinion/cont...
Reposted by TRAstonDrs
Blood Pressure After Changes in Light-to-Moderate Alcohol Consumption in Women and Men: Longitudinal Japanese Annual Checkup Analysis
"Even at low levels, drinking was associated with higher BP, and cessation was associated with lower BP in both sexes."
www.jacc.org/doi/10.1016/...
"Even at low levels, drinking was associated with higher BP, and cessation was associated with lower BP in both sexes."
www.jacc.org/doi/10.1016/...
November 10, 2025 at 12:53 AM
Blood Pressure After Changes in Light-to-Moderate Alcohol Consumption in Women and Men: Longitudinal Japanese Annual Checkup Analysis
"Even at low levels, drinking was associated with higher BP, and cessation was associated with lower BP in both sexes."
www.jacc.org/doi/10.1016/...
"Even at low levels, drinking was associated with higher BP, and cessation was associated with lower BP in both sexes."
www.jacc.org/doi/10.1016/...
Reposted by TRAstonDrs
Fascinating paper suggesting the assumption that there is a sigmoid dose response relationship and threshold effect ( "all-or-nothing") for loop diuretics rests on repeated misinterpretation of original studies from the 70s and 80s. #nephsky #cardiosky #emimcc academic.oup.com/ehjcvp/artic...
What are the pharmacodynamics of loop diuretics?
A recent editorial was entitled ‘Loop diuretics in heart failure: few facts and lots of prejudice’.1 I would argue that we have forgotten or distorted some
academic.oup.com
November 9, 2025 at 6:40 PM
Fascinating paper suggesting the assumption that there is a sigmoid dose response relationship and threshold effect ( "all-or-nothing") for loop diuretics rests on repeated misinterpretation of original studies from the 70s and 80s. #nephsky #cardiosky #emimcc academic.oup.com/ehjcvp/artic...
lykke
(LOO-kah) noun
[Danish]
The quiet joy of simply being content.
Happiness in life's small moments: a warm cup of coffee in a break, shared laughter, a cozy 🌧️ autumn day . Not seeking more, just peace in enough.
(LOO-kah) noun
[Danish]
The quiet joy of simply being content.
Happiness in life's small moments: a warm cup of coffee in a break, shared laughter, a cozy 🌧️ autumn day . Not seeking more, just peace in enough.
November 10, 2025 at 2:10 PM
lykke
(LOO-kah) noun
[Danish]
The quiet joy of simply being content.
Happiness in life's small moments: a warm cup of coffee in a break, shared laughter, a cozy 🌧️ autumn day . Not seeking more, just peace in enough.
(LOO-kah) noun
[Danish]
The quiet joy of simply being content.
Happiness in life's small moments: a warm cup of coffee in a break, shared laughter, a cozy 🌧️ autumn day . Not seeking more, just peace in enough.
#Medsky🧪 #IDsky #pedsky #immunosky #Episky #pharmasky @lancetgh.bsky.social
Over 1 year of follow-up after the 3rd vaccine dose, vaccination with RTS,S/AS01E in real-world settings showed significant reductions in #malaria burden.
Over 1 year of follow-up after the 3rd vaccine dose, vaccination with RTS,S/AS01E in real-world settings showed significant reductions in #malaria burden.
November 10, 2025 at 1:47 PM
#Medsky🧪 #IDsky #pedsky #immunosky #Episky #pharmasky @lancetgh.bsky.social
Over 1 year of follow-up after the 3rd vaccine dose, vaccination with RTS,S/AS01E in real-world settings showed significant reductions in #malaria burden.
Over 1 year of follow-up after the 3rd vaccine dose, vaccination with RTS,S/AS01E in real-world settings showed significant reductions in #malaria burden.
#Medsky🧪 #publichealth DECAF
Does Eliminating Coffee Avoid Fibrillation?
clinicaltrialresults.org/wp-content/u...
@jama.com
jamanetwork.com/journals/jam...
@americanheartj.bsky.social
newsroom.heart.org/news/cup-of-...
www.northumbria.nhs.uk/media-centre....
Does Eliminating Coffee Avoid Fibrillation?
clinicaltrialresults.org/wp-content/u...
@jama.com
jamanetwork.com/journals/jam...
@americanheartj.bsky.social
newsroom.heart.org/news/cup-of-...
www.northumbria.nhs.uk/media-centre....
Cup of coffee a day may not be harmful for some adults with AFib and could lower episodes
Research Highlights: During the 6 months after treatment to restore a normal heart rhythm, adults with atrial fibrillation (AFib) who were randomly assigned to drink coffee every day were 39% less lik...
newsroom.heart.org
November 10, 2025 at 7:52 AM
#Medsky🧪 #publichealth DECAF
Does Eliminating Coffee Avoid Fibrillation?
clinicaltrialresults.org/wp-content/u...
@jama.com
jamanetwork.com/journals/jam...
@americanheartj.bsky.social
newsroom.heart.org/news/cup-of-...
www.northumbria.nhs.uk/media-centre....
Does Eliminating Coffee Avoid Fibrillation?
clinicaltrialresults.org/wp-content/u...
@jama.com
jamanetwork.com/journals/jam...
@americanheartj.bsky.social
newsroom.heart.org/news/cup-of-...
www.northumbria.nhs.uk/media-centre....
We should talk about the ultimate cause of war. It's a question we should never stop asking, because if we do, there's a chance, however remote, that we might miss an opportunity to reduce the occurrence of war.
#JaronLanier
#JaronLanier
November 9, 2025 at 4:20 PM
We should talk about the ultimate cause of war. It's a question we should never stop asking, because if we do, there's a chance, however remote, that we might miss an opportunity to reduce the occurrence of war.
#JaronLanier
#JaronLanier
Reposted by TRAstonDrs
I like old cameras.
These were all taken with a Canon 40D. None of the lenses used were particularly expensive, and several were forty years old, from the film era.
There is something very satisfying about it all.
#photography
These were all taken with a Canon 40D. None of the lenses used were particularly expensive, and several were forty years old, from the film era.
There is something very satisfying about it all.
#photography
November 9, 2025 at 3:10 PM
I like old cameras.
These were all taken with a Canon 40D. None of the lenses used were particularly expensive, and several were forty years old, from the film era.
There is something very satisfying about it all.
#photography
These were all taken with a Canon 40D. None of the lenses used were particularly expensive, and several were forty years old, from the film era.
There is something very satisfying about it all.
#photography
The blue soul has closed mute,
Through the open window
descends The brown forest
Georg Trakl
Through the open window
descends The brown forest
Georg Trakl
November 9, 2025 at 3:19 PM
The blue soul has closed mute,
Through the open window
descends The brown forest
Georg Trakl
Through the open window
descends The brown forest
Georg Trakl
Music speaks what cannot be expressed, soothes the mind and gives it rest; heals the heart and makes it whole, flows from heaven to the soul…
music.apple.com/au/album/ga%...
music.apple.com/au/album/ga%...
Gaïa by Gautier Capuçon on Apple Music
Album · 2025 · 17 Songs
music.apple.com
November 9, 2025 at 1:45 PM
Music speaks what cannot be expressed, soothes the mind and gives it rest; heals the heart and makes it whole, flows from heaven to the soul…
music.apple.com/au/album/ga%...
music.apple.com/au/album/ga%...
#Medsky🧪#IDsky #immunosky #publichealth #COVID19 Report
Last updated on Thurs, 6 th Nov 2025 at 04:00pm 🇬🇧 @ukhsa.bsky.social
ukhsa-dashboard.data.gov.uk/respiratory-...
And Global Covid variants by @mikehoney.bsky.social from below 🧵👇🏿
Last updated on Thurs, 6 th Nov 2025 at 04:00pm 🇬🇧 @ukhsa.bsky.social
ukhsa-dashboard.data.gov.uk/respiratory-...
And Global Covid variants by @mikehoney.bsky.social from below 🧵👇🏿
November 9, 2025 at 11:04 AM
#Medsky🧪#IDsky #immunosky #publichealth #COVID19 Report
Last updated on Thurs, 6 th Nov 2025 at 04:00pm 🇬🇧 @ukhsa.bsky.social
ukhsa-dashboard.data.gov.uk/respiratory-...
And Global Covid variants by @mikehoney.bsky.social from below 🧵👇🏿
Last updated on Thurs, 6 th Nov 2025 at 04:00pm 🇬🇧 @ukhsa.bsky.social
ukhsa-dashboard.data.gov.uk/respiratory-...
And Global Covid variants by @mikehoney.bsky.social from below 🧵👇🏿
Mask & covid pandemic last for generation…
November 9, 2025 at 7:45 AM
Mask & covid pandemic last for generation…
dogs and flowers are the best things to talk about in a chaotic world & this early hours of Sunday morning
November 9, 2025 at 6:38 AM
dogs and flowers are the best things to talk about in a chaotic world & this early hours of Sunday morning
#Medsky🧪 #publichealth Why the media talks about “ #immunitydebt” and why it's controversial ?
The term accurately describes a population-level epidemiological phenomenon but has been widely misunderstood, misused, and exploited for political purposes.
The term accurately describes a population-level epidemiological phenomenon but has been widely misunderstood, misused, and exploited for political purposes.
November 9, 2025 at 5:30 AM
#Medsky🧪 #publichealth Why the media talks about “ #immunitydebt” and why it's controversial ?
The term accurately describes a population-level epidemiological phenomenon but has been widely misunderstood, misused, and exploited for political purposes.
The term accurately describes a population-level epidemiological phenomenon but has been widely misunderstood, misused, and exploited for political purposes.
Reposted by TRAstonDrs
#Medsky🧪 #IDsky #immunosky #publichealth
The findings of 50 participants with a median age of 58 years (interquartile range, IQR 52, 66), all previously primed with at least 4 monovalent mRNA doses, received either Nuvaxovid (n=24) or mRNA vaccine (n=26),
The findings of 50 participants with a median age of 58 years (interquartile range, IQR 52, 66), all previously primed with at least 4 monovalent mRNA doses, received either Nuvaxovid (n=24) or mRNA vaccine (n=26),
November 9, 2025 at 4:44 AM
#Medsky🧪 #IDsky #immunosky #publichealth
The findings of 50 participants with a median age of 58 years (interquartile range, IQR 52, 66), all previously primed with at least 4 monovalent mRNA doses, received either Nuvaxovid (n=24) or mRNA vaccine (n=26),
The findings of 50 participants with a median age of 58 years (interquartile range, IQR 52, 66), all previously primed with at least 4 monovalent mRNA doses, received either Nuvaxovid (n=24) or mRNA vaccine (n=26),
Reposted by TRAstonDrs
Late breakers that included children:
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
November 8, 2025 at 8:27 PM
Late breakers that included children:
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
Reposted by TRAstonDrs
Do they think people have forgotten about Omicron and how South Africa was treated when they told the world about that variant?
I don't like the sound of this: www.theguardian.com/global-devel...
US to demand countries share data on ‘pathogens with epidemic potential’ in return for health aid
Draft template seen by the Guardian has no reference to countries receiving benefits for sharing information, such as guaranteed access to medicines developed as a result
www.theguardian.com
November 9, 2025 at 2:10 AM
Do they think people have forgotten about Omicron and how South Africa was treated when they told the world about that variant?
Life will surprise you. If there's anything I've learned lately, it's that life is full of surprises.
Both the good kind and the not so good kind.
You can be having the best year of your life and then it can throw you the biggest curve ball you've ever encountered.
Both the good kind and the not so good kind.
You can be having the best year of your life and then it can throw you the biggest curve ball you've ever encountered.
November 8, 2025 at 10:34 PM
Life will surprise you. If there's anything I've learned lately, it's that life is full of surprises.
Both the good kind and the not so good kind.
You can be having the best year of your life and then it can throw you the biggest curve ball you've ever encountered.
Both the good kind and the not so good kind.
You can be having the best year of your life and then it can throw you the biggest curve ball you've ever encountered.
#Medsky🧪 #IDsky #immunosky #publichealth @bhanlon15.bsky.social via @thelancet.com
#LongCOVID's heterogeneous nature, characterized by widely diverse symptoms & underlying biology, has contributed to -ve or inconclusive results in #clinicaltrials.
#LongCOVID's heterogeneous nature, characterized by widely diverse symptoms & underlying biology, has contributed to -ve or inconclusive results in #clinicaltrials.
Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease
Long COVID is an umbrella term for the heterogeneous long-term consequences of SARS-CoV-2
infection. It encompasses a wide spectrum of phenotypes (sometimes overlapping), and
its underlying mechanisms...
www.thelancet.com
November 8, 2025 at 4:31 PM
#Medsky🧪 #IDsky #immunosky #publichealth @bhanlon15.bsky.social via @thelancet.com
#LongCOVID's heterogeneous nature, characterized by widely diverse symptoms & underlying biology, has contributed to -ve or inconclusive results in #clinicaltrials.
#LongCOVID's heterogeneous nature, characterized by widely diverse symptoms & underlying biology, has contributed to -ve or inconclusive results in #clinicaltrials.
#Medsky🧪 #IDsky #immunosky #pharmsky #publichealth @nature.com
Future antibody therapies are being designed to reduce the severity of infections like H5N1 avian influenza virus, HIV & other chronic conditions.
www.nature.com/articles/d41...
Future antibody therapies are being designed to reduce the severity of infections like H5N1 avian influenza virus, HIV & other chronic conditions.
www.nature.com/articles/d41...
Antibody drugs show promise for treating bird flu and HIV
Scientists are developing antibodies to track the evolution of these viruses and better treat infections.
www.nature.com
November 8, 2025 at 2:50 PM
#Medsky🧪 #IDsky #immunosky #pharmsky #publichealth @nature.com
Future antibody therapies are being designed to reduce the severity of infections like H5N1 avian influenza virus, HIV & other chronic conditions.
www.nature.com/articles/d41...
Future antibody therapies are being designed to reduce the severity of infections like H5N1 avian influenza virus, HIV & other chronic conditions.
www.nature.com/articles/d41...