Michelle Rheault, MD
@rheaultm.bsky.social
Ped nephrologist, Division director, #NephJC, MN girl, COI: several. Alis volat propriis. Breast cancer survivor, Pronounced “row”, (she/her). Bluesky is not a dating app.
Pinned
Reposted by Michelle Rheault, MD
A follow-up report showed that the overall benefit of machine perfusion over cold storage in kidney graft survival remained present 10 years after transplantation. Read the full report: nej.md/4hDQNK4
#MedSky #Nephrology #Surgery
#MedSky #Nephrology #Surgery
November 10, 2025 at 6:31 PM
A follow-up report showed that the overall benefit of machine perfusion over cold storage in kidney graft survival remained present 10 years after transplantation. Read the full report: nej.md/4hDQNK4
#MedSky #Nephrology #Surgery
#MedSky #Nephrology #Surgery
Reposted by Michelle Rheault, MD
Summary from the #NephJC team of day 3
www.nephjc.com/news/2025/11...
Since we had only two trials simul-published today at #KidneyWk we took some creative license on what to include !
@nephroseeker.medsky.social with the beautiful graphics and tables apart from the lion’s share of writing!
www.nephjc.com/news/2025/11...
Since we had only two trials simul-published today at #KidneyWk we took some creative license on what to include !
@nephroseeker.medsky.social with the beautiful graphics and tables apart from the lion’s share of writing!
Kidney Week in Houston: Day 3 — NephJC
Day 3 of Kidney Week. Sibeprenlimab and Balcinrenone on NEJM and Lancet, plus a couple of other non-kidneywk studies,
www.nephjc.com
November 9, 2025 at 4:28 AM
Summary from the #NephJC team of day 3
www.nephjc.com/news/2025/11...
Since we had only two trials simul-published today at #KidneyWk we took some creative license on what to include !
@nephroseeker.medsky.social with the beautiful graphics and tables apart from the lion’s share of writing!
www.nephjc.com/news/2025/11...
Since we had only two trials simul-published today at #KidneyWk we took some creative license on what to include !
@nephroseeker.medsky.social with the beautiful graphics and tables apart from the lion’s share of writing!
Reposted by Michelle Rheault, MD
Late breakers that included children:
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
November 8, 2025 at 10:29 PM
Late breakers that included children:
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
November 8, 2025 at 8:27 PM
Late breakers that included children:
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
✅Setanaxib in Alport (12+)
Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk
Reposted by Michelle Rheault, MD
And another ns-MRA
Balcinrenone added to Dapa in proteinuric CKD
#KidneyWK
@thelancet.com
www.thelancet.com/journals/lan...
Balcinrenone added to Dapa in proteinuric CKD
#KidneyWK
@thelancet.com
www.thelancet.com/journals/lan...
Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinica...
In participants with chronic kidney disease at increased risk of disease progression,
a fixed dose combination of balcinrenone and dapagliflozin was superior to dapagliflozin
alone in reducing albumin...
www.thelancet.com
November 8, 2025 at 6:18 PM
And another ns-MRA
Balcinrenone added to Dapa in proteinuric CKD
#KidneyWK
@thelancet.com
www.thelancet.com/journals/lan...
Balcinrenone added to Dapa in proteinuric CKD
#KidneyWK
@thelancet.com
www.thelancet.com/journals/lan...
Reposted by Michelle Rheault, MD
Reposted by Michelle Rheault, MD
In an interim analysis, sibeprenlimab, a humanized IgG2 monoclonal antibody that inhibits the proliferation-inducing ligand APRIL (a key driver of IgA nephropathy), reduced proteinuria as compared with placebo. nej.md/493Xtza
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
November 8, 2025 at 4:35 PM
In an interim analysis, sibeprenlimab, a humanized IgG2 monoclonal antibody that inhibits the proliferation-inducing ligand APRIL (a key driver of IgA nephropathy), reduced proteinuria as compared with placebo. nej.md/493Xtza
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
Reposted by Michelle Rheault, MD
Today’s LBCTs and late breaking science!
Morning:
- an Alport trial!
- Telitacicept
- REGENCY biopsy data
- Vitamin R updated in Membranous
- another sibeprenlimab slice
- Balcinrenine + Dapa in CKD
#KidneyWk
Morning:
- an Alport trial!
- Telitacicept
- REGENCY biopsy data
- Vitamin R updated in Membranous
- another sibeprenlimab slice
- Balcinrenine + Dapa in CKD
#KidneyWk
November 8, 2025 at 2:11 PM
Today’s LBCTs and late breaking science!
Morning:
- an Alport trial!
- Telitacicept
- REGENCY biopsy data
- Vitamin R updated in Membranous
- another sibeprenlimab slice
- Balcinrenine + Dapa in CKD
#KidneyWk
Morning:
- an Alport trial!
- Telitacicept
- REGENCY biopsy data
- Vitamin R updated in Membranous
- another sibeprenlimab slice
- Balcinrenine + Dapa in CKD
#KidneyWk
Reposted by Michelle Rheault, MD
Missing all the overwhelming amount of science coming out of #KidneyWk?
The #NephJC crew has got you covered
Day 2 edition www.nephjc.com/news/kidneyw... via @nephroseeker.medsky.social & moi
The #NephJC crew has got you covered
Day 2 edition www.nephjc.com/news/kidneyw... via @nephroseeker.medsky.social & moi
Kidney Week in Houston: Day 2 — NephJC
in this edition: Fish Oil, GBD, Flozination meta-analysis, CHW intervention in Hispanic/Latino patients, and much more
www.nephjc.com
November 8, 2025 at 2:06 PM
Missing all the overwhelming amount of science coming out of #KidneyWk?
The #NephJC crew has got you covered
Day 2 edition www.nephjc.com/news/kidneyw... via @nephroseeker.medsky.social & moi
The #NephJC crew has got you covered
Day 2 edition www.nephjc.com/news/kidneyw... via @nephroseeker.medsky.social & moi
Sparsentan reduces proteinuria, slows kidney decline in pediatric FSGS #KidneyWk www.healio.com/news/nephrol...
Sparsentan reduces proteinuria, slows kidney decline in pediatric FSGS
HOUSTON — Sparsentan therapy was associated with sustained decline in proteinuria and lower likelihood of progression to kidney failure vs. irbesartan for pediatric patients with focal segmental glome...
www.healio.com
November 8, 2025 at 1:45 AM
Sparsentan reduces proteinuria, slows kidney decline in pediatric FSGS #KidneyWk www.healio.com/news/nephrol...
Astrid Weins presents unpublished data showing that presence of anti nephrin antibodies doesn’t predict steroid responsiveness in children. #KidneyWk
November 7, 2025 at 9:28 PM
Astrid Weins presents unpublished data showing that presence of anti nephrin antibodies doesn’t predict steroid responsiveness in children. #KidneyWk
25 patients with type 4 collagen variants were enrolled in the DUPLEX study. Sparsentan treated patients had lower proteinuria compared to irbesartan control. #KidneyWk
November 7, 2025 at 6:07 PM
25 patients with type 4 collagen variants were enrolled in the DUPLEX study. Sparsentan treated patients had lower proteinuria compared to irbesartan control. #KidneyWk
Reposted by Michelle Rheault, MD
Got #KidneyWk FOMO like @nephroseeker.medsky.social ?
We got you covered with daily coverage of the simultaneous publications!
www.nephjc.com/news/kidneyw...
We got you covered with daily coverage of the simultaneous publications!
www.nephjc.com/news/kidneyw...
Kidney Week in Houston: Day 1 — NephJC
in this edition: Atacicept in IgAN; Albuminuria as a surrogate outcome, Renal Remission and additional CONFIDENCE analysis
www.nephjc.com
November 7, 2025 at 5:58 PM
Got #KidneyWk FOMO like @nephroseeker.medsky.social ?
We got you covered with daily coverage of the simultaneous publications!
www.nephjc.com/news/kidneyw...
We got you covered with daily coverage of the simultaneous publications!
www.nephjc.com/news/kidneyw...
Reposted by Michelle Rheault, MD
Shocking first high impact trial of the day. Fish oil reduces CV events in dialysis patients! #Pisces #kidneywk
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
November 7, 2025 at 4:45 PM
Shocking first high impact trial of the day. Fish oil reduces CV events in dialysis patients! #Pisces #kidneywk
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
Reposted by Michelle Rheault, MD
We are 2 for 2 with positive trials so far. LIBERATE-D shows benefit with a conservative vs conventional dialysis strategy in AKI-D. The difference in mortality is concerning though? Simultaneous pub 👇🏾 #kidneywk
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
November 7, 2025 at 5:10 PM
We are 2 for 2 with positive trials so far. LIBERATE-D shows benefit with a conservative vs conventional dialysis strategy in AKI-D. The difference in mortality is concerning though? Simultaneous pub 👇🏾 #kidneywk
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Michelle Rheault, MD
#SGLT2 inhibitors reduced #KidneyDisease progression, hospitalizations, and mortality in CKD, regardless of #diabetes status or albuminuria level, supporting broader use in clinical guidelines.
#KidneyWK @asnkidney.bsky.social
ja.ma/47ufLIG
#KidneyWK @asnkidney.bsky.social
ja.ma/47ufLIG
November 7, 2025 at 5:50 PM
#SGLT2 inhibitors reduced #KidneyDisease progression, hospitalizations, and mortality in CKD, regardless of #diabetes status or albuminuria level, supporting broader use in clinical guidelines.
#KidneyWK @asnkidney.bsky.social
ja.ma/47ufLIG
#KidneyWK @asnkidney.bsky.social
ja.ma/47ufLIG
35 children with FSGS were enrolled in the DUPLEX study. Sparsentan treated patients had lower proteinuria and less frequent kidney failure compared to irbesartan control. #KidneyWk
November 7, 2025 at 5:50 PM
35 children with FSGS were enrolled in the DUPLEX study. Sparsentan treated patients had lower proteinuria and less frequent kidney failure compared to irbesartan control. #KidneyWk
Reposted by Michelle Rheault, MD
“Indeed”
Academic tip: sometimes you have to write "Importantly," to get a sentence started and then you can go back and delete it.
November 7, 2025 at 3:24 AM
“Indeed”
Reposted by Michelle Rheault, MD
Awesome slides and summary thread.
New group showing up in my clinic are prospective parents who have undergone genetic screening prior to conception and found to have pathogenic type IV collagen gene variants
Not getting identified because of blood/urine testing but because of genetic screening!
New group showing up in my clinic are prospective parents who have undergone genetic screening prior to conception and found to have pathogenic type IV collagen gene variants
Not getting identified because of blood/urine testing but because of genetic screening!
November 6, 2025 at 8:49 PM
Awesome slides and summary thread.
New group showing up in my clinic are prospective parents who have undergone genetic screening prior to conception and found to have pathogenic type IV collagen gene variants
Not getting identified because of blood/urine testing but because of genetic screening!
New group showing up in my clinic are prospective parents who have undergone genetic screening prior to conception and found to have pathogenic type IV collagen gene variants
Not getting identified because of blood/urine testing but because of genetic screening!
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
November 6, 2025 at 6:39 PM
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵