American Journal of Kidney Diseases
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American Journal of Kidney Diseases
@ajkd.bsky.social
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AJKD, official journal of @kidney.org, is the leading source of information devoted to clinical nephrology research and practice. AJKD.org | AJKDblog.org | Organizer of #NephMadness @nephmadness.bsky.social
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American Journal of Kidney Diseases @ajkd.bsky.social · 1d
The January 2026 issue is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters:

bit.ly/4q2QuMj
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In A Few Words essay by Yuki Teramoto, MD, PhD:

The Paper Balloon

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January 6, 2026 at 11:00 PM
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Complement Inhibition in Immunoglobulin A Nephropathy: A Mini-Review

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January 6, 2026 at 2:01 PM
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Living Kidney Donors’ Residential Neighborhoods: Driver or Barrier of Postdonation Follow-Up?

bit.ly/3X7hi13 (FREE)
January 6, 2026 at 11:00 AM
ajkd.bsky.social
The January 2026 issue is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters:

bit.ly/4q2QuMj
January 5, 2026 at 11:01 PM
ajkd.bsky.social
Effectiveness and Safety of Apixaban Initiation Following Newly-Diagnosed Atrial Fibrillation in Patients With Kidney Failure on Hemodialysis

bit.ly/44IMgkk
Time to Treatment Discontinuation among Apixaban Users and Time to Initiation of Oral Anticoagulation Among Matched Non-Users. Note: OAC – oral anticoagulant. Apixaban users (in red) had filled their first apixaban prescription within 30 days from their new diagnosis with atrial fibrillation. Continued use was present when a subsequent apixaban prescription was filled within no more than 7 days after the most recent supply was exhausted. If no refill occurred, 7 days were added to the most recent days’ supply. Apixaban use also ended when a prescription for a different OAC was filled. Non-users (in blue) of an oral anticoagulant within the same number of days from their new diagnosis with atrial fibrillation as their matched apixaban user were followed for any subsequent initiation of any oral anticoagulant.
January 5, 2026 at 5:00 PM
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Interpreting Metabolomics and Proteomics in Kidney Disease: A Practical Guide

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General workflow and considerations for interpreting metabolomics and proteomics studies in kidney disease research. Created with BioRender.com.
January 5, 2026 at 11:00 AM
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EDITORIAL: Toward Smarter Allocation by Rethinking Kidney Donor Profile Index

bit.ly/3YmVmzW (FREE)
January 4, 2026 at 11:00 PM
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#renalpath Dense deposit disease with mesangial proliferation, double contours of glomerular basement membrane (GBM), and cellular interposition, without evident eosinophilic immune complex–type deposits.

bit.ly/49zgtoR (FREE)
January 4, 2026 at 5:00 PM
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2025 NKF Mission Award winner:

Patient Education for CKD and Decision Support in Primary Care: Findings From the EPIK Pilot Study

bit.ly/3QFxsf1 (FREE)

#NKFClinicals
January 4, 2026 at 11:00 AM
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Trajectories of Experiences and Health-Related Quality of Life of Informal Caregivers of Home and In-Center Dialysis Patients: A Multicenter Longitudinal Cohort Study

bit.ly/3Mm91Va (OPEN ACCESS)
Informal caregiver outcomes over the first year of dialysis. Graphs show estimated marginal means of the outcomes with the corresponding 95% CIs. Betas represent the mean change over time. Mean scores are estimated using imputed linear mixed models.
January 3, 2026 at 11:00 PM
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A 40-year-old Brazilian male presented to the ED after experiencing syncope. Over the past 4 months, he was fatigued and diagnosed with folate- and iron-deficiency anemia, for which he received treatment.

How should this patient be managed?

bit.ly/3LidFDa (FREE)
January 3, 2026 at 5:00 PM
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Monoallelic IFT140 Variants Causing Childhood-Onset Autosomal Dominant Polycystic Kidney Disease

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Radiology imaging of pediatric ADPKD-IFT140 cases. (A, B) Case IFT1-IV-2: MRI at 17 years of age showing 12 cysts on the right kidney and 16 on the left. The largest measures 26 mm on the lower pole of the right and 4 cm on the upper pole of the left. The majority are <5 mm in length. A: Coronal T2 image (MRI) with the arrow pointing to the 4 cm cyst with internal septation located at the upper pole of the left kidney. B: Coronal T2 MRI with the arrow pointing at the 26 mm simple cyst on the lower pole of the right kidney. (C, D) Case IFT1-IV-4: Ultrasound imaging at 4 years of age showing 3 cysts on the right kidney and none on the left. All cysts measured 2-5 mm. Longitudinal ultrasound pictures of the right kidney with the arrow pointing at the cysts. (E, F) Case IFT2-III-5: Ultrasound imaging at 9 months old showing multiple cysts on the right kidney with a 3 cm cyst on the upper pole and a 0.7 cm cyst on the left kidney.
January 2, 2026 at 11:00 PM
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EDITORIAL: Chronic Pain in Hemodialysis: Beyond the Biochemical Paradigm

bit.ly/3LgciVy (FREE)
January 2, 2026 at 5:00 PM
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Perspective by Richard H. Sterns and Helbert Rondon-Berrios:

Revisiting New Data on the Mortality Benefit of Rapid Correction of Hyponatremia: Déjà vu All Over Again

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Potential confounders in studies identifying associations between plasma sodium correction rates and mortality. Na = sodium, AVP = arginine vasopressin A) A perceived causal relationship between an exposure and an outcome can be distorted by a third variable, known as a confounder. B) The serum sodium correction rate is the exposure, mortality is the outcome, and certain comorbidities and their severity act as confounders influencing both variables. C) Advanced stages cirrhosis, heart failure, and cancer are linked to higher mortality risk, sustained AVP release, and reduced kidney function, leading to impaired water excretion and slow serum sodium correction. D) In early stages of these conditions—or in their absence—patients exhibit better survival and, because hyponatremia is usually the result of reversible conditions with relatively preserved kidney function, serum sodium can rise rapidly through large-volume water diuresis.
January 2, 2026 at 11:00 AM
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Skin Disorders in Kidney Disease: Core Curriculum 2026

bit.ly/4pE1cZ8 (FREE)
A 52-year-old man with kidney failure due to type 1 diabetes mellitus who is receiving hemodialysis presents with generalized xerosis of the bilateral shins and ankles with areas of ichthyosiform change and scattered lightly hyperpigmented macules and patches.
January 1, 2026 at 11:00 PM
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Perspective by Taylor R. House, Ryan J. Coller, and Aaron Wightman:

Optimal Care to Promote Flourishing: Articulating the Purpose of Pediatric Nephrology

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Possible conceptions of optimal care in pediatric nephrology
January 1, 2026 at 11:00 AM
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What's New in Membranous Nephropathy and How to Incorporate New Antigen Discoveries into Clinical Practice?

REVIEW by Ladan Zand, Fernando C. Fervenza, and Sanjeev Sethi

bit.ly/3J9d1qO
December 31, 2025 at 11:00 PM
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In A Few Words essay by Robert Sanchez, MPS:

Why This Research Matters

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December 31, 2025 at 5:00 PM
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Mini Review by Angelique Savelberg et al:

Management of Chronic Hyponatremia in the Outpatient Setting

bit.ly/3Jjsa8S #OpenAccess
Underlying causes of the syndrome of inappropriate antidiuresis stratified according to anatomical location. The etiologies in bold are more common in ambulatory patients and should be considered actively. The other causes should be assessed based on clinical signs using imaging of the head, nasal sinuses, chest, and abdomen. Created with BioRender.com. *There is also evidence that drugs associated with stimulating AVP release could, instead or additionally, enhance the effect of AVP on the kidney, thereby causing a nephrogenic form of inappropriate antidiuresis.
December 31, 2025 at 11:00 AM
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Contraceptive Use and Reproductive Health in Women With CKD: A Qualitative Study Of Nephrologists in the United States

bit.ly/4gEzLey #OpenAccess

#VisualAbstract
December 30, 2025 at 11:00 PM
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Corticosteroid, Parathyroid Hormone, and Body Composition Associations With Bone Density and Structure Following Kidney Transplantation

bit.ly/47wHN6h #OpenAccess
December 30, 2025 at 5:00 PM
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Effects of Empagliflozin on Urine Biomarkers in EMPA-KIDNEY

bit.ly/3WA9uoy (OPEN ACCESS)
Effect of empagliflozin versus placebo on study average concentration of urine biomarkers (indexed to urine creatinine). The MMRM model was adjusted for the prognostic variables specified in the minimized randomization algorithm (i.e., age, sex, prior diabetes, eGFR, uACR, and trial site region) in the same categories used in the minimization process, initial freezer storage temperature (-20°C versus below -20°C) and baseline log2-transformed urine biomarker-creatinine ratio. A weighted average of 2- and 18- month values proportional to the amount of time between visits was used to estimate the study average log2-transformed urine biomarker-to-creatinine ratio in each arm. Absolute values indicate geometric mean (approximate SE) creatinine-indexed urine biomarker concentration in the units specified. The size of the boxes represents the amount of information estimated.
December 29, 2025 at 5:00 PM
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The January 2026 issue is available now: bit.ly/45ofoh1

Highlights:
- Contraceptive Use and Reproductive Health in Women With CKD
- Association of Influenza Vaccination With Acute Kidney Injury
- Environmental Impacts of Kidney Replacement Therapies
December 29, 2025 at 11:00 AM
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Mini Review by Kristen L. Nowak and Michel Chonchol:

Targeting Inflammation in CKD

bit.ly/46TMzsY (FREE)
Inflammatory Signaling and Potential Therapeutic Targets in CKD. Sterile inflammation triggered by innate immune system activation is a key driver of both chronic kidney disease (CKD) and associated atherosclerosis and cardiovascular disease (CVD), in part via activation of the NLRP3 inflammasome. Recent and ongoing clinical trials are testing therapeutics targeting the NLRP3 inflammasome, interleukin-1 (IL-1) and its receptor (IL-1R), interleukin-6 (IL-6) and its receptor (IL6R), as represented in this schematic.
December 28, 2025 at 11:00 PM
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FREE #RenalPath Cryoglobulinemic glomerulonephritis (GN) is caused by intracapillary, capillary wall (often subendothelial), and mesangial cryoglobulin deposits, giving a membranoproliferative pattern of injury

bit.ly/498FKET
December 28, 2025 at 5:00 PM