American Journal of Kidney Diseases
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American Journal of Kidney Diseases
@ajkd.bsky.social
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AJKD, official journal of @kidney.org, is the leading source of information devoted to clinical nephrology research and practice. AJKD.org | AJKDblog.org | Organizer of #NephMadness @nephmadness.bsky.social
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American Journal of Kidney Diseases @ajkd.bsky.social · 4d
The January 2026 issue is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters:

bit.ly/4q2QuMj
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#Quiz from October 2025:

A 16-year-old male patient presented to an ED with a 3-week history of progressive headaches, nausea, vomiting, and bilateral blurry vision. Over the past 3 days, he developed chest pain and shortness of breath.

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(A) Diffuse medium and small renal arterial stenoses (yellow arrows) and microaneurysms (red arrows). (B) Intact large abdominal vessel angiogram and a small splenic artery aneurysm (red arrow in inset). (C). Distended arteriole occluded by a thrombus (arrowhead), consistent with thrombotic microangiopathy (PAS stain, ×200).
January 10, 2026 at 11:00 AM
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Hematologic Considerations in Kidney Transplantation: Core Curriculum 2025

bit.ly/3Khhecs (FREE)
Typical patterns of drug-induced neutropenia.
January 9, 2026 at 11:00 PM
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Care Processes and Clinical Responses to Newly Detected Albuminuria: The Stockholm Creatinine Measurements (SCREAM) Project

bit.ly/44KGFu7 (OPEN ACCESS)
One-year care trajectories in individuals with albuminuria >30mg/g, without (A) or with (B) diabetes. Among 215,035 individuals with newly detected elevated albuminuria, including 174,006 without diabetes (A) and 41,029 with diabetes (B), the figure illustrates: (1) the proportion of patients identified using a semi-quantitative (dipstick) or quantitative method (UACR, UPCR, or 24-hour urine collection); (2) the proportion of patients who underwent re-testing and the method used ; (3) the proportion of patients with sustained elevated albuminuria (>30mg/g) when a confirmation test was performed; and (4) the proportion of patients treated with RASi or SGLT2i, or who experienced KFRT or death, 12 months after initial albuminuria detection.
January 9, 2026 at 5:03 PM
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What's New in Membranous Nephropathy and How to Incorporate New Antigen Discoveries into Clinical Practice?

REVIEW by Ladan Zand, Fernando C. Fervenza, and Sanjeev Sethi

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January 9, 2026 at 11:00 AM
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Mini-Review:

Metabolic Bariatric Surgery in Kidney Transplant Candidates

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Suggested weight loss treatment pathways to achieve eligibility for kidney transplantation for patients with advanced kidney disease. aGLP1/GIP RA should be considered in all kidney transplant candidates as either a bridge to MBS, an alternative to MBS, or to enhance the weight loss effect of MBS. bNo rigid upper age limit for bariatric surgery. Frailty, not chronological age, should guide decision making. Abbreviations: BMI, body mass index; eGFR, estimated glomerular filtration rate; GIP, glucose-dependent insulinotropic polypeptide; GLP1 RA, glucagon-like peptide-1 receptor agonist; MBS, metabolic bariatric surgery; T1D, type 1 diabetes; T2D, type 2 diabetes; SPK, simultaneous pancreas and kidney transplant.
January 8, 2026 at 11:01 PM
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EDITORIAL: Health-Related Quality of Life After Living Kidney Donation: Insights From a Contemporary Meta-Analysis

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January 8, 2026 at 5:01 PM
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Happy New Year from AJKD!

Turning the calendar gives us the opportunity to look back on the top ten AJKDBlog posts of 2025.

Special thanks go out to the AJKDBlog Commentaries Editor, Pascale Khairallah, and Interviews Editor, Timothy Yau, and to all of our contributors!

bit.ly/49cgGOL
January 8, 2026 at 11:00 AM
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Assessing Deceased-Donor Kidneys Through Posttransplant Survival Prediction Algorithms

bit.ly/45liR0b (OPEN ACCESS)
Calibration plot for the Cox regression model for 3-year allograft survival in the primary cohort (20% testing data split). Calibration assesses how close a risk score’s prediction of the expected outcome is to the observed outcome. iAUC, integrated (time-dependent) area under the curve.
January 7, 2026 at 11:01 PM
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Family Physicians’ Perspectives on Providing Living Kidney Donor Care

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Challenges perceived by family physicians with the current living kidney donation processes
January 7, 2026 at 5:01 PM
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EDITORIAL: Breaking Down Barriers to Reproductive Health Care in CKD

bit.ly/48wkB7l (FREE)
January 7, 2026 at 11:00 AM
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In A Few Words essay by Yuki Teramoto, MD, PhD:

The Paper Balloon

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January 6, 2026 at 11:00 PM
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Complement Inhibition in Immunoglobulin A Nephropathy: A Mini-Review

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January 6, 2026 at 2:01 PM
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Living Kidney Donors’ Residential Neighborhoods: Driver or Barrier of Postdonation Follow-Up?

bit.ly/3X7hi13 (FREE)
January 6, 2026 at 11:00 AM
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The January 2026 issue is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters:

bit.ly/4q2QuMj
January 5, 2026 at 11:01 PM
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Effectiveness and Safety of Apixaban Initiation Following Newly-Diagnosed Atrial Fibrillation in Patients With Kidney Failure on Hemodialysis

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Time to Treatment Discontinuation among Apixaban Users and Time to Initiation of Oral Anticoagulation Among Matched Non-Users. Note: OAC – oral anticoagulant. Apixaban users (in red) had filled their first apixaban prescription within 30 days from their new diagnosis with atrial fibrillation. Continued use was present when a subsequent apixaban prescription was filled within no more than 7 days after the most recent supply was exhausted. If no refill occurred, 7 days were added to the most recent days’ supply. Apixaban use also ended when a prescription for a different OAC was filled. Non-users (in blue) of an oral anticoagulant within the same number of days from their new diagnosis with atrial fibrillation as their matched apixaban user were followed for any subsequent initiation of any oral anticoagulant.
January 5, 2026 at 5:00 PM
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Interpreting Metabolomics and Proteomics in Kidney Disease: A Practical Guide

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General workflow and considerations for interpreting metabolomics and proteomics studies in kidney disease research. Created with BioRender.com.
January 5, 2026 at 11:00 AM
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EDITORIAL: Toward Smarter Allocation by Rethinking Kidney Donor Profile Index

bit.ly/3YmVmzW (FREE)
January 4, 2026 at 11:00 PM
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#renalpath Dense deposit disease with mesangial proliferation, double contours of glomerular basement membrane (GBM), and cellular interposition, without evident eosinophilic immune complex–type deposits.

bit.ly/49zgtoR (FREE)
January 4, 2026 at 5:00 PM
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2025 NKF Mission Award winner:

Patient Education for CKD and Decision Support in Primary Care: Findings From the EPIK Pilot Study

bit.ly/3QFxsf1 (FREE)

#NKFClinicals
January 4, 2026 at 11:00 AM
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Trajectories of Experiences and Health-Related Quality of Life of Informal Caregivers of Home and In-Center Dialysis Patients: A Multicenter Longitudinal Cohort Study

bit.ly/3Mm91Va (OPEN ACCESS)
Informal caregiver outcomes over the first year of dialysis. Graphs show estimated marginal means of the outcomes with the corresponding 95% CIs. Betas represent the mean change over time. Mean scores are estimated using imputed linear mixed models.
January 3, 2026 at 11:00 PM
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A 40-year-old Brazilian male presented to the ED after experiencing syncope. Over the past 4 months, he was fatigued and diagnosed with folate- and iron-deficiency anemia, for which he received treatment.

How should this patient be managed?

bit.ly/3LidFDa (FREE)
January 3, 2026 at 5:00 PM
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Monoallelic IFT140 Variants Causing Childhood-Onset Autosomal Dominant Polycystic Kidney Disease

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Radiology imaging of pediatric ADPKD-IFT140 cases. (A, B) Case IFT1-IV-2: MRI at 17 years of age showing 12 cysts on the right kidney and 16 on the left. The largest measures 26 mm on the lower pole of the right and 4 cm on the upper pole of the left. The majority are <5 mm in length. A: Coronal T2 image (MRI) with the arrow pointing to the 4 cm cyst with internal septation located at the upper pole of the left kidney. B: Coronal T2 MRI with the arrow pointing at the 26 mm simple cyst on the lower pole of the right kidney. (C, D) Case IFT1-IV-4: Ultrasound imaging at 4 years of age showing 3 cysts on the right kidney and none on the left. All cysts measured 2-5 mm. Longitudinal ultrasound pictures of the right kidney with the arrow pointing at the cysts. (E, F) Case IFT2-III-5: Ultrasound imaging at 9 months old showing multiple cysts on the right kidney with a 3 cm cyst on the upper pole and a 0.7 cm cyst on the left kidney.
January 2, 2026 at 11:00 PM
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EDITORIAL: Chronic Pain in Hemodialysis: Beyond the Biochemical Paradigm

bit.ly/3LgciVy (FREE)
January 2, 2026 at 5:00 PM
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Perspective by Richard H. Sterns and Helbert Rondon-Berrios:

Revisiting New Data on the Mortality Benefit of Rapid Correction of Hyponatremia: Déjà vu All Over Again

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Potential confounders in studies identifying associations between plasma sodium correction rates and mortality. Na = sodium, AVP = arginine vasopressin A) A perceived causal relationship between an exposure and an outcome can be distorted by a third variable, known as a confounder. B) The serum sodium correction rate is the exposure, mortality is the outcome, and certain comorbidities and their severity act as confounders influencing both variables. C) Advanced stages cirrhosis, heart failure, and cancer are linked to higher mortality risk, sustained AVP release, and reduced kidney function, leading to impaired water excretion and slow serum sodium correction. D) In early stages of these conditions—or in their absence—patients exhibit better survival and, because hyponatremia is usually the result of reversible conditions with relatively preserved kidney function, serum sodium can rise rapidly through large-volume water diuresis.
January 2, 2026 at 11:00 AM
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Skin Disorders in Kidney Disease: Core Curriculum 2026

bit.ly/4pE1cZ8 (FREE)
A 52-year-old man with kidney failure due to type 1 diabetes mellitus who is receiving hemodialysis presents with generalized xerosis of the bilateral shins and ankles with areas of ichthyosiform change and scattered lightly hyperpigmented macules and patches.
January 1, 2026 at 11:00 PM