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Follow @ai.nejm.org for medical AI content.
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A new Double Take video reviews evidence-based recommendations on measles prevention and management and explores commonly asked questions about the measles virus and infection. Watch on YouTube: youtu.be/PI6M680p9i0
In a meta-analysis involving 17,801 patients with myocardial infarction and preserved LVEF (≥50%), beta-blockers did not reduce death, MI, or heart failure over a median 3.6 years of follow-up. Full trial results and Research Summary: nej.md/43U5Ppo
February 9, 2026 at 5:05 PM
In a meta-analysis involving 17,801 patients with myocardial infarction and preserved LVEF (≥50%), beta-blockers did not reduce death, MI, or heart failure over a median 3.6 years of follow-up. Full trial results and Research Summary: nej.md/43U5Ppo
Phase 3 EMBARK trial: Patients with high-risk biochemical recurrence of prostate cancer face an increased risk of disease progression. Findings about long-term survival with enzalutamide are summarized in a new Quick Take video. nej.md/4atcZVk
February 9, 2026 at 2:07 PM
Phase 3 EMBARK trial: Patients with high-risk biochemical recurrence of prostate cancer face an increased risk of disease progression. Findings about long-term survival with enzalutamide are summarized in a new Quick Take video. nej.md/4atcZVk
Coronary artery disease develops from an interplay of behavioral, environmental, genetic, and stochastic factors. A new review focuses on recent discoveries regarding coronary atherosclerosis and discusses current and potential clinical uses of this information. Learn more: nej.md/4tmGZtI
February 9, 2026 at 2:02 PM
Coronary artery disease develops from an interplay of behavioral, environmental, genetic, and stochastic factors. A new review focuses on recent discoveries regarding coronary atherosclerosis and discusses current and potential clinical uses of this information. Learn more: nej.md/4tmGZtI
DESTINY-Breast09: For patients with HER2-positive metastatic breast cancer, standard first-line therapy includes a taxane plus trastuzumab and pertuzumab. Research evaluating trastuzumab deruxtecan plus pertuzumab as initial treatment is summarized in a Quick Take video. nej.md/4rzbdb9
February 8, 2026 at 8:00 PM
DESTINY-Breast09: For patients with HER2-positive metastatic breast cancer, standard first-line therapy includes a taxane plus trastuzumab and pertuzumab. Research evaluating trastuzumab deruxtecan plus pertuzumab as initial treatment is summarized in a Quick Take video. nej.md/4rzbdb9
In the phase 3 CORALreef Lipids trial, the oral PCSK9 inhibitor enlicitide reduced LDL cholesterol by 57% at 24 weeks and also lowered non-HDL cholesterol, apolipoprotein B, and lipoprotein(a). Adverse events were similar in the two groups. Full trial results and Research Summary: nej.md/4qhQPtQ
February 8, 2026 at 5:02 PM
In the phase 3 CORALreef Lipids trial, the oral PCSK9 inhibitor enlicitide reduced LDL cholesterol by 57% at 24 weeks and also lowered non-HDL cholesterol, apolipoprotein B, and lipoprotein(a). Adverse events were similar in the two groups. Full trial results and Research Summary: nej.md/4qhQPtQ
A 49-year-old man with acute myeloid leukemia who had been admitted to the hospital for induction chemotherapy was evaluated for prolonged neutropenic fever. On physical examination, crackles were identified at the lung bases. 1/2
#MedSky
#MedSky
February 8, 2026 at 2:01 PM
A 49-year-old man with acute myeloid leukemia who had been admitted to the hospital for induction chemotherapy was evaluated for prolonged neutropenic fever. On physical examination, crackles were identified at the lung bases. 1/2
#MedSky
#MedSky
For patients with a preserved left ventricular ejection fraction after myocardial infarction, the benefit of beta-blockers is unclear. Research findings from a meta-analysis of five trials are summarized in a Quick Take video. nej.md/3MoSjoj
#MedSky #CardioSky
#MedSky #CardioSky
February 7, 2026 at 8:01 PM
For patients with a preserved left ventricular ejection fraction after myocardial infarction, the benefit of beta-blockers is unclear. Research findings from a meta-analysis of five trials are summarized in a Quick Take video. nej.md/3MoSjoj
#MedSky #CardioSky
#MedSky #CardioSky
Shift work disorder (SWD), which is characterized by excessive sleepiness during nocturnal wakefulness, affects 26.5% of shift workers. This RCT tests a new agent for treating excessive sleepiness among early-morning shift workers with SWD. Full results in NEJM Evidence: eviden.cc/3ZpGHnU
February 7, 2026 at 5:02 PM
Shift work disorder (SWD), which is characterized by excessive sleepiness during nocturnal wakefulness, affects 26.5% of shift workers. This RCT tests a new agent for treating excessive sleepiness among early-morning shift workers with SWD. Full results in NEJM Evidence: eviden.cc/3ZpGHnU
A 39-year-old woman with obesity presented with a 6-week history of foreign-body sensation and tearing in both eyes. She reported daytime fatigue and snoring. Examination showed marked laxity of the upper eyelids. Read the full case details: nej.md/4rnbM7y
#MedSky #Ophthalmology
#MedSky #Ophthalmology
February 7, 2026 at 2:01 PM
A 39-year-old woman with obesity presented with a 6-week history of foreign-body sensation and tearing in both eyes. She reported daytime fatigue and snoring. Examination showed marked laxity of the upper eyelids. Read the full case details: nej.md/4rnbM7y
#MedSky #Ophthalmology
#MedSky #Ophthalmology
Phase 3 CORALreef Lipids trial: PCSK9 inhibitors are an effective alternative to statins for lowering LDL cholesterol, but current formulations are available only in an injectable form. Research findings on an oral PCSK9 inhibitor are summarized in a new Quick Take video. nej.md/4a8fxXz
#MedSky
#MedSky
February 6, 2026 at 8:07 PM
Phase 3 CORALreef Lipids trial: PCSK9 inhibitors are an effective alternative to statins for lowering LDL cholesterol, but current formulations are available only in an injectable form. Research findings on an oral PCSK9 inhibitor are summarized in a new Quick Take video. nej.md/4a8fxXz
#MedSky
#MedSky
Presented at #WORLDSymposia:
In nine patients with GM1 gangliosidosis, a fatal neurodegenerative disease, AAV9 β-galactosidase gene therapy was associated with short-lived adverse events, increased β-galactosidase levels, and delayed progression. Full trial results: nej.md/4rxOZpP
#MedSky
In nine patients with GM1 gangliosidosis, a fatal neurodegenerative disease, AAV9 β-galactosidase gene therapy was associated with short-lived adverse events, increased β-galactosidase levels, and delayed progression. Full trial results: nej.md/4rxOZpP
#MedSky
February 6, 2026 at 5:06 PM
Presented at #WORLDSymposia:
In nine patients with GM1 gangliosidosis, a fatal neurodegenerative disease, AAV9 β-galactosidase gene therapy was associated with short-lived adverse events, increased β-galactosidase levels, and delayed progression. Full trial results: nej.md/4rxOZpP
#MedSky
In nine patients with GM1 gangliosidosis, a fatal neurodegenerative disease, AAV9 β-galactosidase gene therapy was associated with short-lived adverse events, increased β-galactosidase levels, and delayed progression. Full trial results: nej.md/4rxOZpP
#MedSky
A rare case of spontaneous heparin-induced thrombocytopenia occurred after hip arthroplasty despite no heparin exposure. Severe thromboses developed, but the patient recovered with bivalirudin and IVIG. Full case details: nej.md/3ZOKprn
#MedSky #Hematology #Surgery
#MedSky #Hematology #Surgery
February 6, 2026 at 2:04 PM
A rare case of spontaneous heparin-induced thrombocytopenia occurred after hip arthroplasty despite no heparin exposure. Severe thromboses developed, but the patient recovered with bivalirudin and IVIG. Full case details: nej.md/3ZOKprn
#MedSky #Hematology #Surgery
#MedSky #Hematology #Surgery
A 29-year-old woman with active opioid, alcohol, benzodiazepine, tobacco, and cocaine use disorders and recent intravenous drug use presented with acute onset of chills and increased pain and drainage of chronic wounds in both legs. Read the full case details: nej.md/4ql7ehk
February 5, 2026 at 8:30 PM
A 29-year-old woman with active opioid, alcohol, benzodiazepine, tobacco, and cocaine use disorders and recent intravenous drug use presented with acute onset of chills and increased pain and drainage of chronic wounds in both legs. Read the full case details: nej.md/4ql7ehk
New in the February 5, 2026, issue of NEJM:
A Placebo-Controlled Trial of Enlicitide (phase 3 CORALreef Lipids trial) nej.md/4qhQPtQ
Beta-Blockers after Myocardial Infarction nej.md/43U5Ppo
#MedSky
A Placebo-Controlled Trial of Enlicitide (phase 3 CORALreef Lipids trial) nej.md/4qhQPtQ
Beta-Blockers after Myocardial Infarction nej.md/43U5Ppo
#MedSky
February 5, 2026 at 2:02 PM
New in the February 5, 2026, issue of NEJM:
A Placebo-Controlled Trial of Enlicitide (phase 3 CORALreef Lipids trial) nej.md/4qhQPtQ
Beta-Blockers after Myocardial Infarction nej.md/43U5Ppo
#MedSky
A Placebo-Controlled Trial of Enlicitide (phase 3 CORALreef Lipids trial) nej.md/4qhQPtQ
Beta-Blockers after Myocardial Infarction nej.md/43U5Ppo
#MedSky
A 63-year-old man presented with a 3-month history of chest tightness, palpitations, and abdominal pain. Laboratory studies showed an elevated erythrocyte sedimentation rate and an elevated C-reactive protein level. Read the full case details: nej.md/4keccuG
#MedSky #Rheumatology #CardioSky
#MedSky #Rheumatology #CardioSky
February 4, 2026 at 11:00 PM
A 63-year-old man presented with a 3-month history of chest tightness, palpitations, and abdominal pain. Laboratory studies showed an elevated erythrocyte sedimentation rate and an elevated C-reactive protein level. Read the full case details: nej.md/4keccuG
#MedSky #Rheumatology #CardioSky
#MedSky #Rheumatology #CardioSky
Genetic analyses of coronary artery disease have led to advances in therapy, prevention, and risk prediction. Genetic risk scores may guide prevention, but questions remain about implementation. Learn more in a new Review Article: nej.md/4tmGZtI
#MedSky #CardioSky #Genetics
#MedSky #CardioSky #Genetics
February 4, 2026 at 10:40 PM
Genetic analyses of coronary artery disease have led to advances in therapy, prevention, and risk prediction. Genetic risk scores may guide prevention, but questions remain about implementation. Learn more in a new Review Article: nej.md/4tmGZtI
#MedSky #CardioSky #Genetics
#MedSky #CardioSky #Genetics
In the phase 3 CORALreef Lipids trial, the oral PCSK9 inhibitor enlicitide reduced LDL cholesterol by 57% at 24 weeks and also lowered non-HDL cholesterol, apolipoprotein B, and lipoprotein(a). Adverse events were similar in the two groups. Full trial results: nej.md/4qhQPtQ
#MedSky #CardioSky
#MedSky #CardioSky
February 4, 2026 at 10:10 PM
In the phase 3 CORALreef Lipids trial, the oral PCSK9 inhibitor enlicitide reduced LDL cholesterol by 57% at 24 weeks and also lowered non-HDL cholesterol, apolipoprotein B, and lipoprotein(a). Adverse events were similar in the two groups. Full trial results: nej.md/4qhQPtQ
#MedSky #CardioSky
#MedSky #CardioSky
Peripheral artery disease is linked to cardiovascular risk and impaired mobility. Diagnosis relies on ankle–brachial index testing, and management involves cardiovascular risk reduction, exercise, and selective revascularization. Learn more: nej.md/4sZujsh
#MedSky #CardioSky
#MedSky #CardioSky
February 4, 2026 at 8:03 PM
Peripheral artery disease is linked to cardiovascular risk and impaired mobility. Diagnosis relies on ankle–brachial index testing, and management involves cardiovascular risk reduction, exercise, and selective revascularization. Learn more: nej.md/4sZujsh
#MedSky #CardioSky
#MedSky #CardioSky
In mobile stroke units, a teleneurologist model of care is superior to an onboard neurologist model based on a composite hierarchical outcome of safety, timeliness, and physician efficiency. Learn more in an article published in 𝘕𝘌𝘑𝘔 𝘌𝘷𝘪𝘥𝘦𝘯𝘤𝘦: eviden.cc/4pYer7x
#MedSky #NeuroSky
#MedSky #NeuroSky
February 4, 2026 at 5:14 PM
In mobile stroke units, a teleneurologist model of care is superior to an onboard neurologist model based on a composite hierarchical outcome of safety, timeliness, and physician efficiency. Learn more in an article published in 𝘕𝘌𝘑𝘔 𝘌𝘷𝘪𝘥𝘦𝘯𝘤𝘦: eviden.cc/4pYer7x
#MedSky #NeuroSky
#MedSky #NeuroSky
In metastatic hormone-receptor–positive, HER2-positive breast cancer, maintenance palbociclib plus anti-HER2 and endocrine therapies extended progression-free survival but increased toxic effects such as neutropenia. Full phase 3 PATINA trial results and Research Summary: nej.md/3ZEyWdO
February 4, 2026 at 2:02 PM
In metastatic hormone-receptor–positive, HER2-positive breast cancer, maintenance palbociclib plus anti-HER2 and endocrine therapies extended progression-free survival but increased toxic effects such as neutropenia. Full phase 3 PATINA trial results and Research Summary: nej.md/3ZEyWdO
Our latest video in our partnership with @glaucomflecken.bsky.social summarizes the POTCAST trial, which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular arrhythmias. Read the full study for free: nej.md/DrG35
February 3, 2026 at 8:06 PM
Our latest video in our partnership with @glaucomflecken.bsky.social summarizes the POTCAST trial, which assessed a strategy of actively increasing plasma potassium levels to the high-normal range in patients at high risk for ventricular arrhythmias. Read the full study for free: nej.md/DrG35
NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD, explains recent research into routine antibiotics for hospitalized patients with community-acquired pneumonia and a positive respiratory viral assay. Full context and comment by Dr. Aaron J. Calderon: jwat.ch/4t1rNC5
#MedSky
#MedSky
February 3, 2026 at 6:12 PM
NEJM Clinician Editor-in-Chief Raja-Elie Abdulnour, MD, explains recent research into routine antibiotics for hospitalized patients with community-acquired pneumonia and a positive respiratory viral assay. Full context and comment by Dr. Aaron J. Calderon: jwat.ch/4t1rNC5
#MedSky
#MedSky
𝐍𝐨𝐰 𝐚𝐯𝐚𝐢𝐥𝐚𝐛𝐥𝐞 𝐢𝐧 𝑵𝑬𝑱𝑴 𝑬𝒗𝒊𝒅𝒆𝒏𝒄𝒆!
A new Public Health Alerts report, published in partnership with @cidrap.bsky.social: 𝘗𝘢𝘦𝘯𝘪𝘣𝘢𝘤𝘪𝘭𝘭𝘶𝘴 𝘥𝘦𝘯𝘥𝘳𝘪𝘵𝘪𝘧𝘰𝘳𝘮𝘪𝘴 as a Cause of Destructive Meningitis in Infants eviden.cc/4tdRdw5
#MedSky #IDSky #PedSky
A new Public Health Alerts report, published in partnership with @cidrap.bsky.social: 𝘗𝘢𝘦𝘯𝘪𝘣𝘢𝘤𝘪𝘭𝘭𝘶𝘴 𝘥𝘦𝘯𝘥𝘳𝘪𝘵𝘪𝘧𝘰𝘳𝘮𝘪𝘴 as a Cause of Destructive Meningitis in Infants eviden.cc/4tdRdw5
#MedSky #IDSky #PedSky
February 3, 2026 at 6:10 PM
𝐍𝐨𝐰 𝐚𝐯𝐚𝐢𝐥𝐚𝐛𝐥𝐞 𝐢𝐧 𝑵𝑬𝑱𝑴 𝑬𝒗𝒊𝒅𝒆𝒏𝒄𝒆!
A new Public Health Alerts report, published in partnership with @cidrap.bsky.social: 𝘗𝘢𝘦𝘯𝘪𝘣𝘢𝘤𝘪𝘭𝘭𝘶𝘴 𝘥𝘦𝘯𝘥𝘳𝘪𝘵𝘪𝘧𝘰𝘳𝘮𝘪𝘴 as a Cause of Destructive Meningitis in Infants eviden.cc/4tdRdw5
#MedSky #IDSky #PedSky
A new Public Health Alerts report, published in partnership with @cidrap.bsky.social: 𝘗𝘢𝘦𝘯𝘪𝘣𝘢𝘤𝘪𝘭𝘭𝘶𝘴 𝘥𝘦𝘯𝘥𝘳𝘪𝘵𝘪𝘧𝘰𝘳𝘮𝘪𝘴 as a Cause of Destructive Meningitis in Infants eviden.cc/4tdRdw5
#MedSky #IDSky #PedSky
𝐕𝐚𝐬𝐜𝐮𝐥𝐚𝐫 𝐞𝐧𝐝𝐨𝐭𝐡𝐞𝐥𝐢𝐚𝐥 𝐠𝐫𝐨𝐰𝐭𝐡 𝐟𝐚𝐜𝐭𝐨𝐫 𝐀 (𝐕𝐄𝐆𝐅-𝐀) is a dimeric glycoprotein, commonly referred to as VEGF, that binds (i.e., it is a ligand of) vascular endothelial growth factor receptor 2 (VEGF-R2) on endothelial cells. Full definition of this NEJM Illustrated Glossary term: nej.md/3NCrAVI
#MedSky
#MedSky
February 3, 2026 at 5:02 PM
𝐕𝐚𝐬𝐜𝐮𝐥𝐚𝐫 𝐞𝐧𝐝𝐨𝐭𝐡𝐞𝐥𝐢𝐚𝐥 𝐠𝐫𝐨𝐰𝐭𝐡 𝐟𝐚𝐜𝐭𝐨𝐫 𝐀 (𝐕𝐄𝐆𝐅-𝐀) is a dimeric glycoprotein, commonly referred to as VEGF, that binds (i.e., it is a ligand of) vascular endothelial growth factor receptor 2 (VEGF-R2) on endothelial cells. Full definition of this NEJM Illustrated Glossary term: nej.md/3NCrAVI
#MedSky
#MedSky
In acute central retinal artery occlusion treated within 4.5 hours after onset, intravenous tenecteplase did not result in greater recovery of vision at 30 days than aspirin and was associated with serious safety concerns. Full phase 3 TenCRAOS trial results and Research Summary: nej.md/3NU6BgZ
February 3, 2026 at 2:01 PM
In acute central retinal artery occlusion treated within 4.5 hours after onset, intravenous tenecteplase did not result in greater recovery of vision at 30 days than aspirin and was associated with serious safety concerns. Full phase 3 TenCRAOS trial results and Research Summary: nej.md/3NU6BgZ