Michelle Rheault, MD
@rheaultm.bsky.social
Ped nephrologist, Division director, #NephJC, MN girl, COI: several. Alis volat propriis. Breast cancer survivor, Pronounced “row”, (she/her). Bluesky is not a dating app.
From RAAS blockade to regenerative medicine: evolving treatment strategies in #Alport syndrome pubmed.ncbi.nlm.nih.gov/41243004/
November 17, 2025 at 3:54 PM
From RAAS blockade to regenerative medicine: evolving treatment strategies in #Alport syndrome pubmed.ncbi.nlm.nih.gov/41243004/
Some days you just deserve ice cream. 🍦
November 15, 2025 at 11:34 PM
Some days you just deserve ice cream. 🍦
Clinical Variability of ADPKD in Monozygotic Twins www.kireports.org/article/S246...
November 15, 2025 at 2:50 PM
Clinical Variability of ADPKD in Monozygotic Twins www.kireports.org/article/S246...
Astrid Weins presents unpublished data showing that presence of anti nephrin antibodies doesn’t predict steroid responsiveness in children. #KidneyWk
November 7, 2025 at 9:28 PM
Astrid Weins presents unpublished data showing that presence of anti nephrin antibodies doesn’t predict steroid responsiveness in children. #KidneyWk
25 patients with type 4 collagen variants were enrolled in the DUPLEX study. Sparsentan treated patients had lower proteinuria compared to irbesartan control. #KidneyWk
November 7, 2025 at 6:07 PM
25 patients with type 4 collagen variants were enrolled in the DUPLEX study. Sparsentan treated patients had lower proteinuria compared to irbesartan control. #KidneyWk
35 children with FSGS were enrolled in the DUPLEX study. Sparsentan treated patients had lower proteinuria and less frequent kidney failure compared to irbesartan control. #KidneyWk
November 7, 2025 at 5:50 PM
35 children with FSGS were enrolled in the DUPLEX study. Sparsentan treated patients had lower proteinuria and less frequent kidney failure compared to irbesartan control. #KidneyWk
Finally, a large group of patients are those with heterozygous COL4A3 and COL4A4 variants who do well long term with only microscopic hematuria. The problem is that you don't know which patients will fall into this bucket and which will fall into the buckets above by genotyping alone. #KidneyWk
November 6, 2025 at 6:39 PM
Finally, a large group of patients are those with heterozygous COL4A3 and COL4A4 variants who do well long term with only microscopic hematuria. The problem is that you don't know which patients will fall into this bucket and which will fall into the buckets above by genotyping alone. #KidneyWk
The third group presents with nephrotic syndrome and type IV collagen variant. Are these variants causal? Incidental? Not sure but they seem to behave differently that other groups. Optimal treatment is unknown. #KidneyWk
November 6, 2025 at 6:39 PM
The third group presents with nephrotic syndrome and type IV collagen variant. Are these variants causal? Incidental? Not sure but they seem to behave differently that other groups. Optimal treatment is unknown. #KidneyWk
Women with XL #Alport syndrome or those with AD Alport syndrome generally have a more slowly progressive kidney phenotype but are still at risk of kidney failure in some patients. Treatment of this group when they have albuminuria is recommended. You must screen them to know when this is. #KidneyWk
November 6, 2025 at 6:39 PM
I like to lump patients with type IV collagen variants into 4 main categories that can help predict risk of progression and recommended treatment. #KidneyWk
November 6, 2025 at 6:39 PM
I like to lump patients with type IV collagen variants into 4 main categories that can help predict risk of progression and recommended treatment. #KidneyWk
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
November 6, 2025 at 6:39 PM
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
The 4 pillars of CKD management:
RAASi
SGLT2i
MRA
GLP-1 agonists
#KidneyWk
Dr Perkovic calls for combination therapy, but need properly run trials.
RAASi
SGLT2i
MRA
GLP-1 agonists
#KidneyWk
Dr Perkovic calls for combination therapy, but need properly run trials.
November 6, 2025 at 2:39 PM
The 4 pillars of CKD management:
RAASi
SGLT2i
MRA
GLP-1 agonists
#KidneyWk
Dr Perkovic calls for combination therapy, but need properly run trials.
RAASi
SGLT2i
MRA
GLP-1 agonists
#KidneyWk
Dr Perkovic calls for combination therapy, but need properly run trials.
Shane Bobart provides an overview of membranous nephropathy #KidneyWk
Nice to see some new faces as speakers for the glomerular disease pre-conference. Fresh perspectives!
Nice to see some new faces as speakers for the glomerular disease pre-conference. Fresh perspectives!
November 5, 2025 at 9:08 PM
Shane Bobart provides an overview of membranous nephropathy #KidneyWk
Nice to see some new faces as speakers for the glomerular disease pre-conference. Fresh perspectives!
Nice to see some new faces as speakers for the glomerular disease pre-conference. Fresh perspectives!
