Payal Yokota
@payalyokota.bsky.social
Postdoc, Immunologist, #GdTcellclub webinar series (founder/organizer)
#TrainedImmunity #TissueResMacrophages #DiseaseTolerance
payalyokota.com
#immunosky
#TrainedImmunity #TissueResMacrophages #DiseaseTolerance
payalyokota.com
#immunosky
Pinned
Happy Friday! We're so thrilled to share our review on #trainedimmunity out in @elife.bsky.social today. We had a great time writing this. Honored to be included in the special issue of trained immunity. Always an absolute treat to write with @khannakm.bsky.social
elifesciences.org/articles/108...
elifesciences.org/articles/108...
Reposted by Payal Yokota
1/ This Review Article from our new Focus Issue outlines how #epigenetic and metabolic rewiring enables innate immune cells to ‘remember’ past challenges, shaping protection, pathology, and new therapeutic strategies.
buff.ly/NHdWyKS
buff.ly/NHdWyKS
November 25, 2025 at 9:01 PM
1/ This Review Article from our new Focus Issue outlines how #epigenetic and metabolic rewiring enables innate immune cells to ‘remember’ past challenges, shaping protection, pathology, and new therapeutic strategies.
buff.ly/NHdWyKS
buff.ly/NHdWyKS
Reposted by Payal Yokota
Much needed but on first glance it seems more confident in the definition of mouse than human CD8s…. Do we know how to define short lived and long lived effectors in humans? And are LL effector memory always poor at dividing?
November 19, 2025 at 5:49 AM
Much needed but on first glance it seems more confident in the definition of mouse than human CD8s…. Do we know how to define short lived and long lived effectors in humans? And are LL effector memory always poor at dividing?
Reposted by Payal Yokota
As for this: “However, in humans, SLECs are characterized as CCR7−, CD45RA+, KLRG1+, TCF1low, T-bethi, CX3CR1+, CD127low, CD27− and CD57+” that’s quite a definition. How did we decide on this? Is “high or low” an objective criteria?
November 19, 2025 at 8:24 AM
As for this: “However, in humans, SLECs are characterized as CCR7−, CD45RA+, KLRG1+, TCF1low, T-bethi, CX3CR1+, CD127low, CD27− and CD57+” that’s quite a definition. How did we decide on this? Is “high or low” an objective criteria?
Excited for @terkild.bsky.social talk at @nyulangone.bsky.social today about subclonal evolution, bacterial toxins and malignant persistence. in T cell lymphoma. Hosted by @sbkoralov.bsky.social. Had a great time chatting about our #GdT pasts and shared interests in mucosal tissues.
November 17, 2025 at 6:04 PM
Excited for @terkild.bsky.social talk at @nyulangone.bsky.social today about subclonal evolution, bacterial toxins and malignant persistence. in T cell lymphoma. Hosted by @sbkoralov.bsky.social. Had a great time chatting about our #GdT pasts and shared interests in mucosal tissues.
Reposted by Payal Yokota
Pleased to share our review l.
Thank you @payalyokota.bsky.social
Thank you @payalyokota.bsky.social
Happy Friday! We're so thrilled to share our review on #trainedimmunity out in @elife.bsky.social today. We had a great time writing this. Honored to be included in the special issue of trained immunity. Always an absolute treat to write with @khannakm.bsky.social
elifesciences.org/articles/108...
elifesciences.org/articles/108...
November 14, 2025 at 6:15 PM
Pleased to share our review l.
Thank you @payalyokota.bsky.social
Thank you @payalyokota.bsky.social
Happy Friday! We're so thrilled to share our review on #trainedimmunity out in @elife.bsky.social today. We had a great time writing this. Honored to be included in the special issue of trained immunity. Always an absolute treat to write with @khannakm.bsky.social
elifesciences.org/articles/108...
elifesciences.org/articles/108...
November 14, 2025 at 6:08 PM
Happy Friday! We're so thrilled to share our review on #trainedimmunity out in @elife.bsky.social today. We had a great time writing this. Honored to be included in the special issue of trained immunity. Always an absolute treat to write with @khannakm.bsky.social
elifesciences.org/articles/108...
elifesciences.org/articles/108...
Reposted by Payal Yokota
Transient lung eosinophilia during breakthrough influenza infection in vaccinated mice is associated with protective and balanced Type 1/2 immune responses | Journal of Virology journals.asm.org/doi/10.1128/...
Transient lung eosinophilia during breakthrough influenza infection in vaccinated mice is associated with protective and balanced Type 1/2 immune responses | Journal of Virology
Our findings reveal that eosinophilic recruitment during influenza breakthrough infection
is non-pathological and represents a balanced immune response, distinct from highly
inflammatory environments ...
journals.asm.org
November 6, 2025 at 1:09 PM
Transient lung eosinophilia during breakthrough influenza infection in vaccinated mice is associated with protective and balanced Type 1/2 immune responses | Journal of Virology journals.asm.org/doi/10.1128/...
Really scary that the #GovtShutdown is still ongoing and affecting so many fed employees. Sending positive vibes and hopeful tides to all my friends. Stay strong, folks!
November 4, 2025 at 2:25 PM
Really scary that the #GovtShutdown is still ongoing and affecting so many fed employees. Sending positive vibes and hopeful tides to all my friends. Stay strong, folks!
Reposted by Payal Yokota
Fascinating new study from the B. Reizis group in @natimmunol.nature.com
Tonic type I IFN signaling restrains pDC cytokine production & survival — yet makes them tougher against viruses.
👉 A fine-tuned balance for optimal antiviral immunity
www.nature.com/articles/s41...
Tonic type I IFN signaling restrains pDC cytokine production & survival — yet makes them tougher against viruses.
👉 A fine-tuned balance for optimal antiviral immunity
www.nature.com/articles/s41...
Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells - Nature Immunology
Pucella, Maqueda-Alfaro and colleagues distinguish three developmentally related subsets of mouse plasmacytoid dendritic cells that differ in their ability to produce type I interferon and their susce...
www.nature.com
October 20, 2025 at 8:06 AM
Fascinating new study from the B. Reizis group in @natimmunol.nature.com
Tonic type I IFN signaling restrains pDC cytokine production & survival — yet makes them tougher against viruses.
👉 A fine-tuned balance for optimal antiviral immunity
www.nature.com/articles/s41...
Tonic type I IFN signaling restrains pDC cytokine production & survival — yet makes them tougher against viruses.
👉 A fine-tuned balance for optimal antiviral immunity
www.nature.com/articles/s41...
I've had an incredible couple days hanging out with family, having delicious coffee and cake and coloring with my nephew and niece. Looking forward to ringing in the new year with inspiration, gratitude and fantastic science. From our home, to yours. Happy Diwali! 🪔🎆✨️
October 19, 2025 at 11:31 PM
I've had an incredible couple days hanging out with family, having delicious coffee and cake and coloring with my nephew and niece. Looking forward to ringing in the new year with inspiration, gratitude and fantastic science. From our home, to yours. Happy Diwali! 🪔🎆✨️
Here it is.. my annual plug to nominate #MurakamiHaruki for the Nobel prize in literature. @nobelprize.bsky.social ... I implore you.
My #windupbirdchronicles about a #1Q84 esque #wildsheepchase in this #Hardboiledwonderland is so #Kafkaontheshore!
#LitNobel2025campaign
My #windupbirdchronicles about a #1Q84 esque #wildsheepchase in this #Hardboiledwonderland is so #Kafkaontheshore!
#LitNobel2025campaign
October 8, 2025 at 1:58 PM
Here it is.. my annual plug to nominate #MurakamiHaruki for the Nobel prize in literature. @nobelprize.bsky.social ... I implore you.
My #windupbirdchronicles about a #1Q84 esque #wildsheepchase in this #Hardboiledwonderland is so #Kafkaontheshore!
#LitNobel2025campaign
My #windupbirdchronicles about a #1Q84 esque #wildsheepchase in this #Hardboiledwonderland is so #Kafkaontheshore!
#LitNobel2025campaign
One of my favorite immunologists, hands down. Oh, and she is a far better human. Follow Dr. Khader (@khadershabaana.bsky.social) for all things pulmonary immunology/ Tb related cutting edge science and guiding the future generations into excellence. 👇👇👇
#Immunosky
#Immunosky
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
October 7, 2025 at 6:26 PM
One of my favorite immunologists, hands down. Oh, and she is a far better human. Follow Dr. Khader (@khadershabaana.bsky.social) for all things pulmonary immunology/ Tb related cutting edge science and guiding the future generations into excellence. 👇👇👇
#Immunosky
#Immunosky
I had an incredible day learning science at the #Enclosure2025 retreat at Princeton University hosted by the unparalleled Prof Andrea Graham. Magnificent data, profound new frontiers, yummy lunch (+cider donuts). Thank you to @grahammunology.bsky.social and team, and the enclosure team. #Bestdayever
October 3, 2025 at 10:36 PM
I had an incredible day learning science at the #Enclosure2025 retreat at Princeton University hosted by the unparalleled Prof Andrea Graham. Magnificent data, profound new frontiers, yummy lunch (+cider donuts). Thank you to @grahammunology.bsky.social and team, and the enclosure team. #Bestdayever
Beautiful talk by @ikinglab.bsky.social today @nyulangone.bsky.social talking IFNg, type 2, parasites, disease tolerance and gut:stroma axis. gorgeous microscopy and insightful new Frontiers in Hpb infections. 👏👏
October 2, 2025 at 4:09 PM
Beautiful talk by @ikinglab.bsky.social today @nyulangone.bsky.social talking IFNg, type 2, parasites, disease tolerance and gut:stroma axis. gorgeous microscopy and insightful new Frontiers in Hpb infections. 👏👏
10 review requests in the last 3 months. Very much looking forward to my life as a PI one day 🫣
September 27, 2025 at 1:50 AM
10 review requests in the last 3 months. Very much looking forward to my life as a PI one day 🫣
Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer | PNAS www.pnas.org/doi/abs/10.1...
congratulations to Joe Saglimbeni and Boris Reizis lab!
congratulations to Joe Saglimbeni and Boris Reizis lab!
Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer | PNAS
Breast tumors harbor dynamic microenvironments, with multiple immune cell types playing
opposing roles during tumor progression and/or response to ...
www.pnas.org
September 20, 2025 at 11:10 PM
Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer | PNAS www.pnas.org/doi/abs/10.1...
congratulations to Joe Saglimbeni and Boris Reizis lab!
congratulations to Joe Saglimbeni and Boris Reizis lab!
Beautiful highlight of 10 brilliant scientists that talk about their journey to independent research careers. Shoutout to @aweinstock.bsky.social and Anushka! #WomeninSTEM
Women in STEM becoming independent: Asking for help creates opportunities for connections and kindness
rupress.org/jem/article/...
#WomeninSTEM
@jem.org Michela @quinascience.bsky.social @aweinstock.bsky.social Anushka Hsu Osterhout Globig Ramanan Therrien McCubbrey
rupress.org/jem/article/...
#WomeninSTEM
@jem.org Michela @quinascience.bsky.social @aweinstock.bsky.social Anushka Hsu Osterhout Globig Ramanan Therrien McCubbrey
September 19, 2025 at 3:38 AM
Beautiful highlight of 10 brilliant scientists that talk about their journey to independent research careers. Shoutout to @aweinstock.bsky.social and Anushka! #WomeninSTEM
Please join us for the upcoming September #GDTcellclub Virtual talks by Drs. Daniel P. Inacio and Octavio A. Gonzalez on Sept 18 at 12pm NY/5pm Lisbon
Bookmark for up-to-date announcements 👇
payalyokota.com/gamma-delta-...
Zoom: nyulangone.zoom.us/j/9589051706...
@forum-gd.bsky.social
Bookmark for up-to-date announcements 👇
payalyokota.com/gamma-delta-...
Zoom: nyulangone.zoom.us/j/9589051706...
@forum-gd.bsky.social
September 18, 2025 at 2:53 AM
Please join us for the upcoming September #GDTcellclub Virtual talks by Drs. Daniel P. Inacio and Octavio A. Gonzalez on Sept 18 at 12pm NY/5pm Lisbon
Bookmark for up-to-date announcements 👇
payalyokota.com/gamma-delta-...
Zoom: nyulangone.zoom.us/j/9589051706...
@forum-gd.bsky.social
Bookmark for up-to-date announcements 👇
payalyokota.com/gamma-delta-...
Zoom: nyulangone.zoom.us/j/9589051706...
@forum-gd.bsky.social
Reposted by Payal Yokota
Glad to finally have this out. NHP microscopy was not easy with having to validate antibodies. Altered distribution of tissue galectins correlates with mucosal dysregulation in SIV infection url: academic.oup.com/jimmunol/art... #NewPI @aai.org @jimmunol.bsky.social @weillcornell.bsky.social
Altered distribution of tissue galectins correlates with mucosal dysregulation in SIV infection
Abstract. The intestinal mucosa in individuals with chronic human immunodeficiency virus (HIV) infection remains a site of viral persistence and immune dys
academic.oup.com
September 17, 2025 at 11:59 PM
Glad to finally have this out. NHP microscopy was not easy with having to validate antibodies. Altered distribution of tissue galectins correlates with mucosal dysregulation in SIV infection url: academic.oup.com/jimmunol/art... #NewPI @aai.org @jimmunol.bsky.social @weillcornell.bsky.social
major fomo about missing the #EMDS2025 this year in Edinburgh. Thank you, @profandrewmac.bsky.social and others for posting about the science being shared this week.
#EMDS2025 begins! Looking forward to a few days of exciting science about all things #macrophage, #dendriticcells and #monocytes in beautiful Edinburgh
September 17, 2025 at 8:12 AM
major fomo about missing the #EMDS2025 this year in Edinburgh. Thank you, @profandrewmac.bsky.social and others for posting about the science being shared this week.
Reposted by Payal Yokota
Three Associate Professor (or Professor) positions available at Oxford Biology. Come be my colleague! www.biology.ox.ac.uk/article/we-a...
We are hiring! Oxford biology has three associate professorships available as we move to new state-of-the-art facilities
www.biology.ox.ac.uk
September 15, 2025 at 11:22 AM
Three Associate Professor (or Professor) positions available at Oxford Biology. Come be my colleague! www.biology.ox.ac.uk/article/we-a...
Our fearless leader, Prof and Dept Chair - Ben tenOever kicking off the academic year with our weekly seminar today. #NYUMicro @nyulangone.bsky.social
Inspiring and energizing talk, reconnecting us to determinism with thoughtful connections between microbes and those who study them. 👏👏
Inspiring and energizing talk, reconnecting us to determinism with thoughtful connections between microbes and those who study them. 👏👏
September 12, 2025 at 4:49 PM
Our fearless leader, Prof and Dept Chair - Ben tenOever kicking off the academic year with our weekly seminar today. #NYUMicro @nyulangone.bsky.social
Inspiring and energizing talk, reconnecting us to determinism with thoughtful connections between microbes and those who study them. 👏👏
Inspiring and energizing talk, reconnecting us to determinism with thoughtful connections between microbes and those who study them. 👏👏