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frenchdcsociety.bsky.social
The French DC Society - Club Francophone des DC (CFCD)
@frenchdcsociety.bsky.social
370 followers 1.2K following 66 posts
We are mononuclear phagocytes enthusiasts and we organise biennial international meetings on the topic in France...

https://www.cfcd.fr
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frenchdcsociety.bsky.social
The French DC Society - Club Francophone des DC (CFCD) @frenchdcsociety.bsky.social Β· Jun 3
Registration Open for the 2025 French Dendritic Cell Society (CFCD) !!

www.cfcd.fr/meeting/prog...
When: December 4th - 5th, 2025

Where: Institut Curie in Paris

How: πŸ‘‡πŸ‘‡πŸ‘‡
docs.google.com/forms/d/e/1F...

Deadlines
- October 15th, 2025: Early Birds + Abstracts
- November 15th, 2025: Late abstracts
frenchdcsociety.bsky.social
Congrats to Mei Li and team for this nice story in @natimmunol.nature.com showing "that TSLP from keratinocytes activates transitional DC-derived DC2 to promote GATA3+ regulatory T cells and mediate immunosuppression during inflammation and cancer".

www.nature.com/articles/s41...
TSLP promotes GATA3-expressing effector regulatory T cells via DC2 derived from transitional DCs - Nature Immunology
Recent work has revealed that dendritic cells (DCs) are more heterogeneous than previously thought, yet the functional roles of these newly described DC subsets remain unclear. Here, Li et al. find th...
www.nature.com
January 30, 2026 at 9:01 AM
frenchdcsociety.bsky.social
Really nice study in @natimmunol.nature.com dissecting thymic DC subsets and demonstrating that crosstalk with thymocytes is essential for thymic DC activation, maturation, and function.
www.nature.com/articles/s41...
The differentiation and function of heterogeneous thymic dendritic cell subsets require signals provided by distinct thymocyte cell types - Nature Immunology
Dendritic cells (DCs) are required to establish thymic central tolerance. Here Srinivasan et al. use single-cell transcriptomics to define thymic conventional dendritic cell (cDC) subsets and find tha...
www.nature.com
January 15, 2026 at 3:24 PM
frenchdcsociety.bsky.social
@salva-iborra.bsky.social and Co in @jem.org elegantly sow that plasmacytoid DCs expand tissue-resident memory CD8+ T cell responses during viral reinfection

rupress.org/jem/article/...
January 13, 2026 at 8:08 AM
frenchdcsociety.bsky.social
In @nature.com the team of E.G Engleman shows that Erythropoietin receptor on cDC1s dictates their ability to induce immune tolerance.

www.nature.com/articles/s41...
January 9, 2026 at 9:50 AM
frenchdcsociety.bsky.social
Very interesting work in @jem.org showing an important role of Claudin 1 expression by thymic conventional DC1 for the maintenance of central tolerance.

rupress.org/jem/article/...
Claudin 1–mediated positioning of DC1 to mTECs is essential for maintenance of central tolerance | Journal of Experimental Medicine | Rockefeller University Press
BΕ™ezina et al. demonstrate that Claudin 1 enables thymic type 1 dendritic cells to localize within proximity to medullary thymic epithelial cells. This spa
rupress.org
January 7, 2026 at 9:18 AM
Reposted by The French DC Society - Club Francophone des DC (CFCD)
science.org
DNA-damaging chemotherapy leads to repopulation of the resident cardiac macrophage population, protecting the heart against injury in mice.

Learn more in #ScienceImmunology: https://scim.ag/49gYQJg
DNA-damaging chemotherapy reshapes cardiac-resident macrophage composition and function
Carboplatin reshapes macrophages to protect the heart through type I IFN signaling in mouse models.
scim.ag
January 6, 2026 at 4:07 PM
frenchdcsociety.bsky.social
Congrats to the team of @reisesousalab.bsky.social for this beautiful work in @natimmunol.nature.com showing that "Neoantigen cross-presentation by cDC1 can determine the immune visibility of the tumor mutational landscape and sculpt cancer evolution by immunoediting"

www.nature.com/articles/s41...
Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology
Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...
www.nature.com
January 6, 2026 at 12:51 PM
Reposted by The French DC Society - Club Francophone des DC (CFCD)
magarianblander.bsky.social
@drjonlim.bsky.social & @reisesousalab.bsky.social show cDC1s & DNGR1 favor "tethered" neoantigens from F-actin proteins, trapping them in necrotic debris for better cross-presentation! Calls for prioritizing these neoantigens for cancer vaccine design #Immunotherapy www.nature.com/articles/s41...
Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology
Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...
www.nature.com
January 2, 2026 at 7:19 PM
Reposted by The French DC Society - Club Francophone des DC (CFCD)
labwaggoner.bsky.social
Sideways lipid presentation by the antigen-presenting molecule CD1c @natcomms.nature.com @monashuniversity.bsky.social
www.nature.com/articles/s41...
January 2, 2026 at 1:16 AM
Reposted by The French DC Society - Club Francophone des DC (CFCD)
labwaggoner.bsky.social
Positioning and reversible suppression of CCR7+ dendritic cells in perivascular tumor niches shape cancer immunity @cp-immunity.bsky.social @beatricezitti.bsky.social @biology-unige.bsky.social
www.cell.com/immunity/ful...
December 21, 2025 at 5:24 PM
frenchdcsociety.bsky.social
The French DC society started with a session on intestinal tolerance induction by specialised subset of antigen presenting cells (Thetis Cell aka Tol DCs, aka Rorgt APC...) by @chrysothemisbrown.bsky.social, Rab iUPADHYAY and Helena Paidassi.
December 4, 2025 at 9:32 AM
frenchdcsociety.bsky.social
🚨 This Thursday the biennial meeting of the French DCs society at the institut Curie in Paris will start🚨.
Some last seats are available if interested...
Registration and Final Program here: www.cfcd.fr/meeting/prog...
December 2, 2025 at 8:50 AM
Reposted by The French DC Society - Club Francophone des DC (CFCD)
labwaggoner.bsky.social
IL-10–producing tolerogenic DC dampen B cell responses via T cell inhibition, offering a targeted strategy for specific B cell modulation
www.science.org/doi/10.1126/...
November 21, 2025 at 7:35 PM
frenchdcsociety.bsky.social
Fascinating new study from the B. Reizis group in @natimmunol.nature.com

Tonic type I IFN signaling restrains pDC cytokine production & survival β€” yet makes them tougher against viruses.
πŸ‘‰ A fine-tuned balance for optimal antiviral immunity

www.nature.com/articles/s41...
Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells - Nature Immunology
Pucella, Maqueda-Alfaro and colleagues distinguish three developmentally related subsets of mouse plasmacytoid dendritic cells that differ in their ability to produce type I interferon and their susce...
www.nature.com
October 20, 2025 at 8:06 AM
frenchdcsociety.bsky.social
🚨 The early bird registration deadline for the French DC Society meeting has been extended to October 24th, 2025!

Don’t miss the chance β€” register now!

RegistrationπŸ‘‡
docs.google.com/forms/d/e/1F...

Program πŸ‘‡
www.cfcd.fr/meeting/prog...
October 15, 2025 at 3:54 PM
Reposted by The French DC Society - Club Francophone des DC (CFCD)
sebbontempsgallo.bsky.social
🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨 (2.5y)

🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a @anrs-mie.bsky.social PEPR-funded project!

πŸ”¬ Profile: PhD in microbiology

#Postdoc #Microbiology #YersiniaPestis #ResearchJobs
October 5, 2025 at 3:08 PM
frenchdcsociety.bsky.social
⏰ Only until 15 Oct 2025 to submit your abstract & grab early-bird registration!

Join us in Paris for the French DCs Meeting β€” featuring an outstanding speaker lineup.

Program πŸ‘‡
www.cfcd.fr/meeting/prog...

Registration πŸ‘‡
docs.google.com/forms/d/e/1F...

#DCMeeting2025 #Immunology
October 2, 2025 at 7:30 AM
frenchdcsociety.bsky.social
E. Tomasello & team at @ciml.bsky.social challenge the prevailing dogma of plasmacytoid DC's role in anti-viral immunity, by showing that they are deleterious in respiratory viral infections.

CONGRATS 🍾 can't wait to hear more about it the next French DC society meetingπŸ‘‡
www.cfcd.fr/meeting/prog...
Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections - Nature Immunology
Previous research has suggested that pDCs are required for an effective antiviral immune response, but direct experimental evidence to support this is lacking. Here Ngo et al. develop a pDC knockin mouse model and find that pDCs are dispensable for an antiviral immune response to mouse cytomegalovirus and may be detrimental during influenza or SARS-CoV-2 infection.
www.nature.com
October 1, 2025 at 3:58 PM
frenchdcsociety.bsky.social
🚨A new study in @elife.bsky.social "reveals crucial roles of cDC1 in atherosclerosis progression and provides insights into the development of therapies by targeting cDC1 through Xcl1"🚨
πŸ‘‡πŸ‘‡

elifesciences.org/articles/107...
September 18, 2025 at 3:10 PM
frenchdcsociety.bsky.social
The 8th Symposium of the French Network on Monocytes-Macrophages (SoMM2025), will take place in Lyon, France, on November 7th, 2025

πŸ“ Registration (free but mandatory) and abstract submission are now open until October 10th, 2025 : somm2025.sciencesconf.org

Amazing line up
πŸ‘‡πŸ‘‡πŸ‘‡
September 12, 2025 at 10:08 AM
Reposted by The French DC Society - Club Francophone des DC (CFCD)
labwaggoner.bsky.social
A targetable epigenetic node of myeloid progenitor dysregulation that sustains immunosuppressive lung tumor microenvironment, a target for improving immunotherapy outcomes @nature.com @miriammerad.bsky.social
@sinaiimmuno.bsky.social
www.nature.com/articles/s41...
September 10, 2025 at 4:55 PM
Reposted by The French DC Society - Club Francophone des DC (CFCD)
plosbiology.org
Myeloid cells drive #neuroinflammation in #MultipleSclerosis by promoting immune activation in the #CentralNervousSystem. This study identifies SLAMF5 as a key myeloid receptor that regulates this process, showing that its blockade reduces disease progression @plosbiology.org πŸ§ͺ plos.io/3Vb7xhx
Left: Representative samples from the cervical (a + b), thoracic (c + d), and sacral (e + f) spinal cord comparing the degree of inflammation and white matter damage in control (a, c, e) and cKO (b, d, f) mice. Arrowheads mark foci with lymphocytic-dominant infiltration. In some cases, the infiltrate is associated with white matter damage, seen as pallor at this magnification. Right: Suggested model, created using Biorender.
September 10, 2025 at 1:03 PM
Reposted by The French DC Society - Club Francophone des DC (CFCD)
embo.org
Congratulations to Carola GarcΓ­a de Vinuesa on receiving the 2026 FEBS | EMBO #WomenInScience Award! She is recognized for advancing the understanding of autoimmune diseases and for her impact within the #LifeSciences community, in particular in public engagement: www.embo.org/press-releas... πŸ§ͺ
FEBS | EMBO Women in Science Award 2026 for Carola GarcΓ­a de Vinuesa – Press releases – EMBO
She is recognized for advancing the understanding of autoimmune diseases and bringing science into the public eye
www.embo.org
September 9, 2025 at 12:13 PM
frenchdcsociety.bsky.social
Exciting work in @scienceimmuno.bsky.social : boosting Dendritic Cells with FLT3L + CD40 agonists reactivates T cell immunity in pancreatic cancerβ€”shown in both mice and patients.
πŸ‘‡
www.science.org/doi/10.1126/...
Combined Flt3L and CD40 agonism restores dendritic cell–driven T cell immunity in pancreatic cancer
Flt3L and CD40 agonism enhance dendritic cell immunosurveillance in human and murine pancreatic cancer and engage type I immunity.
www.science.org
September 10, 2025 at 9:01 AM
Reposted by The French DC Society - Club Francophone des DC (CFCD)
lozanzi.bsky.social
Fantastic new story @jkagan1.bsky.social & friends showing that human dendritic cells can become hyperactive activating the inflammasome without dying, & that this approach can be used in mice and NHPs to potentiate anti-influenza vaccine responses! πŸ‘‡πŸ‘‡πŸ‘‡
September 8, 2025 at 8:30 PM