Jonathan Kagan
@jkagan1.bsky.social
Scientist at Boston Children's Hospital, Professor at Harvard Medical School, Husband, Father
Too much data, too little thinking.
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
On the balance of knowledge - Nature Reviews Immunology
Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.
www.nature.com
February 6, 2026 at 2:31 AM
Too much data, too little thinking.
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
Reposted by Jonathan Kagan
🌟 Congratulations to the 2026 Class of Distinguished Fellows of AAI (DFAAI)!
From groundbreaking research to dedicated service, these members represent the pinnacle of the immunology field. Check out this year’s honorees: https://bit.ly/DFAAI2026.
#DFAAI #Immunology #ScienceExcellence
From groundbreaking research to dedicated service, these members represent the pinnacle of the immunology field. Check out this year’s honorees: https://bit.ly/DFAAI2026.
#DFAAI #Immunology #ScienceExcellence
February 5, 2026 at 5:01 PM
🌟 Congratulations to the 2026 Class of Distinguished Fellows of AAI (DFAAI)!
From groundbreaking research to dedicated service, these members represent the pinnacle of the immunology field. Check out this year’s honorees: https://bit.ly/DFAAI2026.
#DFAAI #Immunology #ScienceExcellence
From groundbreaking research to dedicated service, these members represent the pinnacle of the immunology field. Check out this year’s honorees: https://bit.ly/DFAAI2026.
#DFAAI #Immunology #ScienceExcellence
A fantastic innate immunity conference coming soon. Join us!
youtu.be/xmQv36uYm7s?...
youtu.be/xmQv36uYm7s?...
Innate Immunity Meeting Promo
YouTube video by KeystoneSymposia
youtu.be
February 5, 2026 at 4:29 AM
A fantastic innate immunity conference coming soon. Join us!
youtu.be/xmQv36uYm7s?...
youtu.be/xmQv36uYm7s?...
Reposted by Jonathan Kagan
Cell is hiring!
Do you have a background in #neuroscience or #immunology? Better still, #neuroimmunology? Cell has an opening for a full-time scientific editor. Role will be based out of any one of our offices in Medford, MA, UK, Spain, Netherlands, China tinyurl.com/4ma236xn @cp-cell.bsky.social
Do you have a background in #neuroscience or #immunology? Better still, #neuroimmunology? Cell has an opening for a full-time scientific editor. Role will be based out of any one of our offices in Medford, MA, UK, Spain, Netherlands, China tinyurl.com/4ma236xn @cp-cell.bsky.social
Scientific Editor, Cell
Cell has an opening for a full-time scientific editor. If you are a passionate, mission-driven team player who loves thinking broadly about science and wants to have a positive impact, we invite you t...
nam11.safelinks.protection.outlook.com
February 3, 2026 at 8:27 PM
Cell is hiring!
Do you have a background in #neuroscience or #immunology? Better still, #neuroimmunology? Cell has an opening for a full-time scientific editor. Role will be based out of any one of our offices in Medford, MA, UK, Spain, Netherlands, China tinyurl.com/4ma236xn @cp-cell.bsky.social
Do you have a background in #neuroscience or #immunology? Better still, #neuroimmunology? Cell has an opening for a full-time scientific editor. Role will be based out of any one of our offices in Medford, MA, UK, Spain, Netherlands, China tinyurl.com/4ma236xn @cp-cell.bsky.social
Reposted by Jonathan Kagan
Today at Cell: A new #HallmarksofCancer review by Doug Hanahan: www.cell.com/cell/fulltex...
This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011.
@cp-cell.bsky.social @cellpress.bsky.social
This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011.
@cp-cell.bsky.social @cellpress.bsky.social
Hallmarks of cancer—Then and now, and beyond
Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years
of conceptual refinement into a multidimensional view of tumor biology. This review
highlights how aberrant capabilit...
www.cell.com
January 29, 2026 at 3:58 PM
Today at Cell: A new #HallmarksofCancer review by Doug Hanahan: www.cell.com/cell/fulltex...
This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011.
@cp-cell.bsky.social @cellpress.bsky.social
This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011.
@cp-cell.bsky.social @cellpress.bsky.social
Reposted by Jonathan Kagan
🎓 Early-career scientists - don’t miss out! Register by Jan 21 (11:59 PM MST) for the joint Keystone Symposia on Innate Immunity & Aging. Save $250 and attend two meetings for the price of one.
🔗 keysym.us/KSInnateImmu...
🔗 keysym.us/KSAging26
@jkagan1.bsky.social
#KSInnateImmune26 #KSAging26
🔗 keysym.us/KSInnateImmu...
🔗 keysym.us/KSAging26
@jkagan1.bsky.social
#KSInnateImmune26 #KSAging26
January 20, 2026 at 4:46 PM
🎓 Early-career scientists - don’t miss out! Register by Jan 21 (11:59 PM MST) for the joint Keystone Symposia on Innate Immunity & Aging. Save $250 and attend two meetings for the price of one.
🔗 keysym.us/KSInnateImmu...
🔗 keysym.us/KSAging26
@jkagan1.bsky.social
#KSInnateImmune26 #KSAging26
🔗 keysym.us/KSInnateImmu...
🔗 keysym.us/KSAging26
@jkagan1.bsky.social
#KSInnateImmune26 #KSAging26
Reposted by Jonathan Kagan
Been hearing some horrifying chatter about dealing with the new #NIH common form and #ScienCV system, so I put together a short video with some tricks for mitigating some of those pain points.
Hope it helps? 🧪
open.substack.com/pub/emptymod...
Hope it helps? 🧪
open.substack.com/pub/emptymod...
Dealing with ScienCV formatting
Some tips for composing and making your new NIH biosketch not look like garbage
open.substack.com
January 17, 2026 at 3:28 AM
Been hearing some horrifying chatter about dealing with the new #NIH common form and #ScienCV system, so I put together a short video with some tricks for mitigating some of those pain points.
Hope it helps? 🧪
open.substack.com/pub/emptymod...
Hope it helps? 🧪
open.substack.com/pub/emptymod...
Reposted by Jonathan Kagan
What goes into planning the world's largest all-immunology event? Join AAI President Dr. Uli von Andrian and Program Chair Dr. Shekhar Pasare for a preview of #IMMUNOLOGY2026™!
🧬 Presidential Symposium
🔬 Special Sessions
🎓 Trainee Programs
🔗 immunology2026.aai.org
🧬 Presidential Symposium
🔬 Special Sessions
🎓 Trainee Programs
🔗 immunology2026.aai.org
January 15, 2026 at 4:56 PM
What goes into planning the world's largest all-immunology event? Join AAI President Dr. Uli von Andrian and Program Chair Dr. Shekhar Pasare for a preview of #IMMUNOLOGY2026™!
🧬 Presidential Symposium
🔬 Special Sessions
🎓 Trainee Programs
🔗 immunology2026.aai.org
🧬 Presidential Symposium
🔬 Special Sessions
🎓 Trainee Programs
🔗 immunology2026.aai.org
Reposted by Jonathan Kagan
#CyclopsPower👁️ Lu, Choi, Huh &co describe @cp-cell.bsky.social a new reporter system to detect cells that respond to a cytokine & utilize it to identify ileal epithelial cells that respond to IL17 or IFNg responsive CD8 T cell within tumors which are hypofunctional!
In vivo detection of immune responses via cytokine activity labeling
While much is known about the identity and regulation of cytokine-producing cells, the cell types that respond to cytokines remain largely uncharacter…
www.sciencedirect.com
January 7, 2026 at 4:29 PM
#CyclopsPower👁️ Lu, Choi, Huh &co describe @cp-cell.bsky.social a new reporter system to detect cells that respond to a cytokine & utilize it to identify ileal epithelial cells that respond to IL17 or IFNg responsive CD8 T cell within tumors which are hypofunctional!
A must read! Highly recommend.
January 5, 2026 at 10:52 PM
A must read! Highly recommend.
Reposted by Jonathan Kagan
💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...
Molecular, Cellular, Tissue, and Organismal Functions of Type III Interferons
Type III interferons are essential immune mediators playing pleiotropic roles during health and disease. In this review, we highlight the molecular and cellular pathways that lead to the production of...
doi.org
January 5, 2026 at 5:50 PM
💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...
Reposted by Jonathan Kagan
Working with a great team to organize @keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March! Join us to explore emerging research in Banff! keysym.us/KSInnateImmune26 #KSInnateImmune26
Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia
Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!
keysym.us
January 1, 2026 at 11:22 PM
Working with a great team to organize @keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March! Join us to explore emerging research in Banff! keysym.us/KSInnateImmune26 #KSInnateImmune26
Harvard profiles the discovery of how inflammatory caspases detect bacterial infection. And how our own lipids bind caspases in the same manner.
Kudos to Anh Cao, who made these discoveries.
@harvardmed.bsky.social @harvard.edu
gsas.harvard.edu/news/crackin...
Kudos to Anh Cao, who made these discoveries.
@harvardmed.bsky.social @harvard.edu
gsas.harvard.edu/news/crackin...
Cracking the Code of Immunity
Immunologists have long studied how our body fights pathogens, but the precise patterns of molecules required to trigger an immune response weren’t fully understood. As a PhD student, Anh Cao took the...
gsas.harvard.edu
December 28, 2025 at 9:14 PM
Harvard profiles the discovery of how inflammatory caspases detect bacterial infection. And how our own lipids bind caspases in the same manner.
Kudos to Anh Cao, who made these discoveries.
@harvardmed.bsky.social @harvard.edu
gsas.harvard.edu/news/crackin...
Kudos to Anh Cao, who made these discoveries.
@harvardmed.bsky.social @harvard.edu
gsas.harvard.edu/news/crackin...
www.forbes.com
December 24, 2025 at 7:05 PM
Reposted by Jonathan Kagan
1/2: YouTube knows what I was up to last summer:
www.youtube.com/watch?v=UV7r...
Many thanks again to @hfspo.bsky.social for inviting me to the Awardees Meeting in Melbourne this July 😁
www.youtube.com/watch?v=UV7r...
Many thanks again to @hfspo.bsky.social for inviting me to the Awardees Meeting in Melbourne this July 😁
MOLECULAR DEFINITION OF THE ENDOGENOUS TOLL-LIKE RECEPTOR SIGNALING PATHWAY
YouTube video by HFSP
www.youtube.com
December 23, 2025 at 4:48 PM
1/2: YouTube knows what I was up to last summer:
www.youtube.com/watch?v=UV7r...
Many thanks again to @hfspo.bsky.social for inviting me to the Awardees Meeting in Melbourne this July 😁
www.youtube.com/watch?v=UV7r...
Many thanks again to @hfspo.bsky.social for inviting me to the Awardees Meeting in Melbourne this July 😁
Many congrats on this recognition for your outstanding work. Can't wait to learn what you discover next!
December 21, 2025 at 2:17 AM
Many congrats on this recognition for your outstanding work. Can't wait to learn what you discover next!
For additional reading: Original study describing how NLRP3-stimulatory vaccines induce CD4 T cell mediated anti-tumor immunity.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Correction of age-associated defects in dendritic cells enables CD4+ T cells to eradicate tumors
Adjuvants known as hyperactivators can correct age-associated defects in dendritic
cells, enabling anti-tumor T cell responses in old and young mice. The protective
immunity elicited by hyperactive de...
www.cell.com
December 20, 2025 at 10:40 PM
For additional reading: Original study describing how NLRP3-stimulatory vaccines induce CD4 T cell mediated anti-tumor immunity.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Evidence continues to accumulate that CD4 T cells are important for vaccine induced anti-tumor immunity. A new study links CD27 to the generation of long-lived protective CD4 T cells. Kudos to the authors on this exciting finding.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
CD27 agonism enhances long-lived CD4 T cell vaccine responses critical for antitumor immunity
CD27 agonism enhances vaccine-induced CD4 T cell responses, enabling durable antitumor immunity not entirely dependent on CD8 T cells.
www.science.org
December 20, 2025 at 10:40 PM
Evidence continues to accumulate that CD4 T cells are important for vaccine induced anti-tumor immunity. A new study links CD27 to the generation of long-lived protective CD4 T cells. Kudos to the authors on this exciting finding.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Jonathan Kagan
#Evavold Lab 2025 Holiday memories.
It's been a challenging year, but these hurdles led to many scientific and personal reasons to celebrate.
Macrophage Interest Group with Garris lab and Prof. Eric Dang!
@ragoninstitute.bsky.social @harvardmed.bsky.social @massgeneralbrigham.bsky.social
It's been a challenging year, but these hurdles led to many scientific and personal reasons to celebrate.
Macrophage Interest Group with Garris lab and Prof. Eric Dang!
@ragoninstitute.bsky.social @harvardmed.bsky.social @massgeneralbrigham.bsky.social
December 19, 2025 at 6:07 PM
#Evavold Lab 2025 Holiday memories.
It's been a challenging year, but these hurdles led to many scientific and personal reasons to celebrate.
Macrophage Interest Group with Garris lab and Prof. Eric Dang!
@ragoninstitute.bsky.social @harvardmed.bsky.social @massgeneralbrigham.bsky.social
It's been a challenging year, but these hurdles led to many scientific and personal reasons to celebrate.
Macrophage Interest Group with Garris lab and Prof. Eric Dang!
@ragoninstitute.bsky.social @harvardmed.bsky.social @massgeneralbrigham.bsky.social
Reposted by Jonathan Kagan
#WeekendRead! #EveryCellIsAnImmuneCell! #MysterySolved! Clevers &co reveal @nature the differentiation trajectory of human intestinal M cells & show they respond to GM-CSF, express PRRs, & present antigen via MHC-II as dendritic cells, contributing to anti-gluten responses!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Human gut M cells resemble dendritic cells and present gluten antigen - Nature
An intestinal organoid model recapitulates human microfold (M) cell function and transcriptomic profiling and biochemical assays demonstrate that M cells uptake and present antigens to the immune syst...
doi.org
December 13, 2025 at 3:57 PM
#WeekendRead! #EveryCellIsAnImmuneCell! #MysterySolved! Clevers &co reveal @nature the differentiation trajectory of human intestinal M cells & show they respond to GM-CSF, express PRRs, & present antigen via MHC-II as dendritic cells, contributing to anti-gluten responses!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
For background reading on this technology:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Correction of age-associated defects in dendritic cells enables CD4+ T cells to eradicate tumors
Adjuvants known as hyperactivators can correct age-associated defects in dendritic
cells, enabling anti-tumor T cell responses in old and young mice. The protective
immunity elicited by hyperactive de...
www.cell.com
December 10, 2025 at 2:16 AM
For background reading on this technology:
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Want to stay healthy into old age?
Check this fantastic Ted Talk, which discusses a new technology to revitalize the aging immune system to fight cancer. Ponce de Leon would be proud.
Kudos to Dania Zhivaki and Nick Seaver for masterful oration.
www.youtube.com/watch?v=8jTQ...
Check this fantastic Ted Talk, which discusses a new technology to revitalize the aging immune system to fight cancer. Ponce de Leon would be proud.
Kudos to Dania Zhivaki and Nick Seaver for masterful oration.
www.youtube.com/watch?v=8jTQ...
The Longevity Revolution Starts With Your Immune System | Nick Seaver & Dania Zhivaki | TEDxBoston
YouTube video by TEDx Talks
www.youtube.com
December 10, 2025 at 2:16 AM
Want to stay healthy into old age?
Check this fantastic Ted Talk, which discusses a new technology to revitalize the aging immune system to fight cancer. Ponce de Leon would be proud.
Kudos to Dania Zhivaki and Nick Seaver for masterful oration.
www.youtube.com/watch?v=8jTQ...
Check this fantastic Ted Talk, which discusses a new technology to revitalize the aging immune system to fight cancer. Ponce de Leon would be proud.
Kudos to Dania Zhivaki and Nick Seaver for masterful oration.
www.youtube.com/watch?v=8jTQ...
First study linking oxidized lipids to immunity in primates
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
An NLRP3-stimulatory adjuvant improves the immunogenicity of influenza virus vaccines in mice and non-human primates | mBio
The generation of vaccines that stimulate T cell activities is an unmet need for the
scientific community, as T cells are the primary mediators of immune memory. In this
study, we report a new vaccine...
journals.asm.org
December 7, 2025 at 3:21 AM
First study linking oxidized lipids to immunity in primates
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Original study linking oxidized lipids to inflammasomes in anti-tumor immunity.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity
Central to anti-tumor immunity are dendritic cells (DCs), which stimulate long-lived protective T cell responses. Recent studies have demonstrated that DCs can achieve a state of hyperactivation, which is associated with inflammasome activities ...
pmc.ncbi.nlm.nih.gov
December 7, 2025 at 3:18 AM
Original study linking oxidized lipids to inflammasomes in anti-tumor immunity.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...