Ivan Zanoni
@lozanzi.bsky.social
Associate Professor at Harvard Medical School, in love with a red-haired beautiful woman, his kids... and immunology. He/him/his. ๐ฎ๐น ๐บ๐ธ Views my own.
Join us!! ๐๐๐
๐ขDonโt forget to register and submit your abstract for talk consideration at the #IMMA Conference!
The chairs are excited to welcome both new and familiar faces to Mexico soon!
Click here to register: bit.ly/4rKrvxZ
The chairs are excited to welcome both new and familiar faces to Mexico soon!
Click here to register: bit.ly/4rKrvxZ
February 10, 2026 at 11:47 AM
Join us!! ๐๐๐
Reposted by Ivan Zanoni
I am excited to present our long-overdue lab website. Please visit us to learn who we are, our past work, and our current lines of research!
ahidalgolab.com
Thank you to Gerardo Barcia for his beautiful design and constant support in building it
ahidalgolab.com
Thank you to Gerardo Barcia for his beautiful design and constant support in building it
Hidalgo Lab | Mapping Innate Immunity
Research on neutrophil biology, innate immunity, and cardiovascular disease at Yale School of Medicine. Led by Dr. Andrรฉs Hidalgo.
ahidalgolab.com
February 7, 2026 at 3:59 PM
I am excited to present our long-overdue lab website. Please visit us to learn who we are, our past work, and our current lines of research!
ahidalgolab.com
Thank you to Gerardo Barcia for his beautiful design and constant support in building it
ahidalgolab.com
Thank you to Gerardo Barcia for his beautiful design and constant support in building it
#WeekendRead! #ImmunometabolismPower! #InflammasomePower! Liu, Yin &co show @cp-cellchembiol that lactate downstream of aerobic glycolysis is used to directly lactylates NLRP3 increasing ASC recruitment and inflammasome activation, which exacerbates lethality in sepsis! www.cell.com/cell-chemica...
Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation
Liu et al. reveal that lactate, an aerobic glycolysis product, promotes NLRP3 inflammasome
activation and pyroptosis. NLRP3 is identified as a target of lactylation, and K24
and K565 have potential to...
www.cell.com
February 7, 2026 at 3:59 PM
#WeekendRead! #ImmunometabolismPower! #InflammasomePower! Liu, Yin &co show @cp-cellchembiol that lactate downstream of aerobic glycolysis is used to directly lactylates NLRP3 increasing ASC recruitment and inflammasome activation, which exacerbates lethality in sepsis! www.cell.com/cell-chemica...
Reposted by Ivan Zanoni
Too much data, too little thinking.
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
On the balance of knowledge - Nature Reviews Immunology
Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.
www.nature.com
February 6, 2026 at 2:31 AM
Too much data, too little thinking.
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
Excited to be giving my first seminar of 2026 tomorrow @cedars-sinai.bsky.social! Stop by if you are around, it will be all about how we respond to microbial or sterile threats & the paramount roles played by PAMPs & DAMPs, with lot of unpublished data ๐
February 4, 2026 at 3:37 PM
Excited to be giving my first seminar of 2026 tomorrow @cedars-sinai.bsky.social! Stop by if you are around, it will be all about how we respond to microbial or sterile threats & the paramount roles played by PAMPs & DAMPs, with lot of unpublished data ๐
#WeekendRead! #SharingIsCaring! Ji, Xu &co show @nature.com that glia transfers mitochondria to sensory neurons via tunneling nanotubes, which are altered in #diabetes causing neuropathy!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Mitochondrial transfer from glia to neurons protects againstย peripheral neuropathy - Nature
Mitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuro...
doi.org
February 1, 2026 at 3:52 PM
#WeekendRead! #SharingIsCaring! Ji, Xu &co show @nature.com that glia transfers mitochondria to sensory neurons via tunneling nanotubes, which are altered in #diabetes causing neuropathy!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
#WeekendRead! #FirstLove #IL2power #IL10power #InterferonPower! Delaloy, Gauthier &co show @cp-immunity.bsky.social that IL2 favors a regulatory program in B cells that, together IFNg, induces IL10 production, protecting against neuroinflammation! Exciting paper ๐ค! www.cell.com/immunity/ful...
B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells
B cells transiently increase interleukin (IL)-2 receptor expression upon activation.
Gauthier et al. examine the B cell-intrinsic role of IL-2 and define an IL-2-MAF axis
that promotes the differentia...
www.cell.com
January 31, 2026 at 3:57 PM
#WeekendRead! #FirstLove #IL2power #IL10power #InterferonPower! Delaloy, Gauthier &co show @cp-immunity.bsky.social that IL2 favors a regulatory program in B cells that, together IFNg, induces IL10 production, protecting against neuroinflammation! Exciting paper ๐ค! www.cell.com/immunity/ful...
Excited to have the one and only @labwaggoner.bsky.social posting our @annualreviews.bsky.social Immunology paper on the biology of #Type_3_Interferons!! Check it out! www.annualreviews.org/content/jour...
January 30, 2026 at 12:18 AM
Excited to have the one and only @labwaggoner.bsky.social posting our @annualreviews.bsky.social Immunology paper on the biology of #Type_3_Interferons!! Check it out! www.annualreviews.org/content/jour...
Thanks for sharing ๐ค
January 30, 2026 at 12:15 AM
Thanks for sharing ๐ค
Reposted by Ivan Zanoni
#Epithelialmechanics fans...interferons protect against viruses but also impair recovery post-infection. In new work @plosbiology.org we show that interferons block epithelial repair by co-opting the Hippo pathway #innateimmunity #lungs #respiratory journals.plos.org/plosbiology/...
Dose-dependent activation of the Hippo pathway by Type I and Type III interferons suppresses tissue repair by human bronchial epithelial cells
Interferons (IFNs) initiate antiviral defence when infected cells sense a virus protecting against infection via JAK/STAT signaling, but can hinder recovery by impairing tissue repair by an unknown me...
journals.plos.org
January 29, 2026 at 3:43 PM
#Epithelialmechanics fans...interferons protect against viruses but also impair recovery post-infection. In new work @plosbiology.org we show that interferons block epithelial repair by co-opting the Hippo pathway #innateimmunity #lungs #respiratory journals.plos.org/plosbiology/...
#DirtyIsBetter! @rmedzhitov.bsky.social, Erickson &co show @nature.com that pet shop mice are protected from #allergy thanks to cross reactive type I (or tolerogenic) immune memory that prevents type II allergen-driven responses! doi.org/10.1038/s415...
Environmentally driven immune imprinting protects against allergy - Nature
In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship be...
doi.org
January 28, 2026 at 10:37 PM
#DirtyIsBetter! @rmedzhitov.bsky.social, Erickson &co show @nature.com that pet shop mice are protected from #allergy thanks to cross reactive type I (or tolerogenic) immune memory that prevents type II allergen-driven responses! doi.org/10.1038/s415...
Always super cool! ๐
January 28, 2026 at 9:30 PM
Always super cool! ๐
Reposted by Ivan Zanoni
Science update from my postdoc Peiyuan Chai - his work โglycoRNA complexed with heparan sulfate regulates VEGF-A signalingโ is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
January 28, 2026 at 5:45 PM
Science update from my postdoc Peiyuan Chai - his work โglycoRNA complexed with heparan sulfate regulates VEGF-A signalingโ is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
Reposted by Ivan Zanoni
A new function for GlycoRNAs!! The GlycoRNA-Heparan sulfate complex on the cell surface controls VEGF-A signaling and angiogenesis. Superexciting findings from Ryan Flynn's lab. Congratulations to all authors!! @raflynn5.bsky.social www.nature.com/articles/s41...
GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling - Nature
Heparan sulfate proteoglycans facilitate the assembly of clusters of glycoRNAs and cell surface RNA-binding proteins, which negatively modulate VEGF-A signalling and angiogenesis.
www.nature.com
January 28, 2026 at 7:09 PM
A new function for GlycoRNAs!! The GlycoRNA-Heparan sulfate complex on the cell surface controls VEGF-A signaling and angiogenesis. Superexciting findings from Ryan Flynn's lab. Congratulations to all authors!! @raflynn5.bsky.social www.nature.com/articles/s41...
#InterferonFriendsOrFoes? Another cool one @ellenfoxman.bsky.social &friends out @plosbiology.org about how excessive #IFNs delay repair by activating LATS & degrading YAP/TAZ in the Hippo ๐ฆ pathway! journals.plos.org/plosbiology/... ๐๐๐
January 27, 2026 at 8:33 PM
#InterferonFriendsOrFoes? Another cool one @ellenfoxman.bsky.social &friends out @plosbiology.org about how excessive #IFNs delay repair by activating LATS & degrading YAP/TAZ in the Hippo ๐ฆ pathway! journals.plos.org/plosbiology/... ๐๐๐
#WeekendRead! #LocationLocationLocation! Sng, Andoniou,
@the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...
@the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...
Fibroblastic reticular cells direct theย initiation of T cell responses via CD44 - Nature
CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune r...
doi.org
January 24, 2026 at 3:46 PM
#WeekendRead! #LocationLocationLocation! Sng, Andoniou,
@the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...
@the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...
Super interesting ๐ช
January 24, 2026 at 3:12 PM
Super interesting ๐ช
Reposted by Ivan Zanoni
Great story from the Nieswandt lab in Science: uncovering a non-classical platelet mechanism that drives inflammation via integrin- and tetraspanin-rich tethers. A fresh angle on thrombo-inflammation. Happy to be part of this work!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation
Platelet integrin ฮฑIIbฮฒ3 is essential for hemostasis, thrombosis, and inflammation. We found that ligation of ฮฑIIbฮฒ3 by von Willebrand factor or fibrin under flow triggered its accumulation in plasma ...
www.science.org
January 24, 2026 at 2:51 PM
Great story from the Nieswandt lab in Science: uncovering a non-classical platelet mechanism that drives inflammation via integrin- and tetraspanin-rich tethers. A fresh angle on thrombo-inflammation. Happy to be part of this work!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Ivan Zanoni
Excited to share: We show that basal IFNฮป2/3 signaling helps human intestinal epithelial cells stay ready for viral infections, even before an acute infection. A reminder that a lot of innate immune defense happens quietly in the background. journals.plos.org/plospathogen...
Basal IFNฮป2/3 signaling is required for ISG expression and viral control in human intestinal epithelial cells
Author summary Interferon-lambdas (IFNฮปs) are antiviral molecules that help protect the surfaces of our body, such as the gut and lungs, from infection. While IFNฮปs are best known for being produced d...
journals.plos.org
January 22, 2026 at 4:46 PM
Excited to share: We show that basal IFNฮป2/3 signaling helps human intestinal epithelial cells stay ready for viral infections, even before an acute infection. A reminder that a lot of innate immune defense happens quietly in the background. journals.plos.org/plospathogen...
Fantastic work @ellenfoxman.bsky.social &co! If you block the #InterferonPower, Rhinovirus activates NFkB & NLRP1 #inflammasome leading to IL1b secretion & excessive mucus production!
Rhinoviruses cause common cold & asthma attacks but are also often benign. Using nasal organoids, we learned how the community of cells in the lining the nasal passages coordinates to respond to rhinovirus and which responses lead to excess mucus & inflammation. www.cell.com/cell-press-b...
Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling
Rhinoviruses are the most frequent cause of common colds and also a major cause of
respiratory distress in high-risk groups. Using single-cell sequencing of rhinovirus-infected
nasal epithelial organo...
www.cell.com
January 22, 2026 at 2:23 AM
Fantastic work @ellenfoxman.bsky.social &co! If you block the #InterferonPower, Rhinovirus activates NFkB & NLRP1 #inflammasome leading to IL1b secretion & excessive mucus production!
#NoTimeToDie! Ayres &co show @nature.com that young & aged mice initiate different disease tolerance mechanisms to survive #sepsis. Dying young mice have cardiomegaly while aged mice cardiac atrophy. Opposite in surviving mice, with Foxo1 ๐ฆ being protective in young & detrimental in aged mice!
Disease tolerance and infection pathogenesis age-related tradeoffs in mice - Nature
Disease course and pathology an infection may cause can change owing to the structural and functional physiological changes that accumulate with age, but therapy can be tailored accordingly; disease t...
doi.org
January 19, 2026 at 4:21 PM
#NoTimeToDie! Ayres &co show @nature.com that young & aged mice initiate different disease tolerance mechanisms to survive #sepsis. Dying young mice have cardiomegaly while aged mice cardiac atrophy. Opposite in surviving mice, with Foxo1 ๐ฆ being protective in young & detrimental in aged mice!
#WeekendRead #MicrobiotaPower! Tsai, @diehllab.bsky.social &co show @ Science Immunology that E. coli flagellin is recognized by TLR5 on intestinal epithelial stem cells to recruit gut protective CCR2+ monocyte-derived macrophages, decreasing colitis! #IBDs doi.org/10.1126/sciimmunol.adr4057
Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophages
Colonic stem cell TLR5 sensing of microbes promotes macrophage recruitment and maturation to support intestinal barrier repair.
doi.org
January 18, 2026 at 4:34 PM
#WeekendRead #MicrobiotaPower! Tsai, @diehllab.bsky.social &co show @ Science Immunology that E. coli flagellin is recognized by TLR5 on intestinal epithelial stem cells to recruit gut protective CCR2+ monocyte-derived macrophages, decreasing colitis! #IBDs doi.org/10.1126/sciimmunol.adr4057
#WeekendRead! #SmartTumor! #SharingIsCaring! #InterferonFriendOrFoe?! Lot in this @cp-cellmetabolism.bsky.social paper from Okwan-Duodu &co showing that tumor cells steal #mitochondria from immune cells to impair their activity & to produce immune suppressive type I #IFNs via cGAS-STING!
Mitochondrial transfer from immune to tumor cells enables lymph node metastasis
Although the immune system is a significant barrier to tumor growth and spread, established tumors evade immune attack and frequently colonize immune โฆ
www.sciencedirect.com
January 17, 2026 at 4:14 PM
#WeekendRead! #SmartTumor! #SharingIsCaring! #InterferonFriendOrFoe?! Lot in this @cp-cellmetabolism.bsky.social paper from Okwan-Duodu &co showing that tumor cells steal #mitochondria from immune cells to impair their activity & to produce immune suppressive type I #IFNs via cGAS-STING!
Many congrats! ๐๐ช
January 17, 2026 at 12:29 AM
Many congrats! ๐๐ช
Reposted by Ivan Zanoni
Registration for the 2026 Henry Kunkel Society Meeting is well underway! ๐ @rockefeller.edu | ๐ April 16โ18 Join us for three days focused on โAutoantibodies Against Cytokinesโ. ๐ Register now: henrykunkelsociety.app.neoncrm.com/eventReg.jsp... ๐ค Meeting in partnership with @jem.org
January 16, 2026 at 3:54 PM
Registration for the 2026 Henry Kunkel Society Meeting is well underway! ๐ @rockefeller.edu | ๐ April 16โ18 Join us for three days focused on โAutoantibodies Against Cytokinesโ. ๐ Register now: henrykunkelsociety.app.neoncrm.com/eventReg.jsp... ๐ค Meeting in partnership with @jem.org