Ivan Zanoni
@lozanzi.bsky.social
Associate Professor at Harvard Medical School, in love with a red-haired beautiful woman, his kids... and immunology. He/him/his. 🇮🇹 🇺🇸 Views my own.
#WeekendRead! #FroendsOrFoes?! Benamar, Chatila &co identify @cp-immunity.bsky.social a #GutBrain axis leading to microbiota- & TLR-dependent induction of Notch3+ Tregs in the gut that in multiple sclerosis migrate to the CNS & interacting with microglia become pathogenic Th17 cells!
Notch3 destabilizes regulatory T cells to drive autoimmune neuroinflammation in multiple sclerosis
Benamar et al. demonstrate that Notch3+ Treg cells are increased in multiple sclerosis
and in EAE. They are induced in the gut by microbiota and translocate to the CNS to
degenerate into pathogenic Th...
www.cell.com
November 29, 2025 at 5:31 PM
#WeekendRead! #FroendsOrFoes?! Benamar, Chatila &co identify @cp-immunity.bsky.social a #GutBrain axis leading to microbiota- & TLR-dependent induction of Notch3+ Tregs in the gut that in multiple sclerosis migrate to the CNS & interacting with microglia become pathogenic Th17 cells!
#NoTimeToDie! Welcome mitoxyperiosis! Kanneganti, Wang &co show @cp-cell.bsky.social that energy starvation via carbon deprivation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria-driven plasma membrane oxidative damage!
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by
the synergy of innate immune activation and metabolic stress. This process is regulated
by mTORC2 and involves persis...
www.cell.com
November 28, 2025 at 4:56 PM
#NoTimeToDie! Welcome mitoxyperiosis! Kanneganti, Wang &co show @cp-cell.bsky.social that energy starvation via carbon deprivation in the presence of innate immune stimuli triggers a new form of cell death dependent on mitochondria-driven plasma membrane oxidative damage!
Reposted by Ivan Zanoni
Honored to be included in Clarivate's Highly Cited Researcher list for 2025. Working with the best people in the business makes the discoveries easier, and more fun. Cheers to my lab (present and former).
@clarivatelsh.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social
@clarivatelsh.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social
November 26, 2025 at 1:53 PM
Honored to be included in Clarivate's Highly Cited Researcher list for 2025. Working with the best people in the business makes the discoveries easier, and more fun. Cheers to my lab (present and former).
@clarivatelsh.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social
@clarivatelsh.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social
Reposted by Ivan Zanoni
We're hiring for tenure-track faculty! Please apply if you have interests in immune responses to microbes and/or cancer, immune regulation, microbial infections (bacteria, viruses, parasites, fungi), the microbiota, and/or interests that span these disciplines.
arizona.csod.com/ux/ats/caree...
arizona.csod.com/ux/ats/caree...
Assistant/Associate/Full Professor (T/TE)
Establish or continue a successful, extramurally funded research program that will advance knowledge in the broad areas of immunobiology, as defined a...
arizona.csod.com
November 24, 2025 at 8:02 PM
We're hiring for tenure-track faculty! Please apply if you have interests in immune responses to microbes and/or cancer, immune regulation, microbial infections (bacteria, viruses, parasites, fungi), the microbiota, and/or interests that span these disciplines.
arizona.csod.com/ux/ats/caree...
arizona.csod.com/ux/ats/caree...
#WeekendRead! #LocationLocationLocation! #EveryCellIsAnImmuneCell! Turley Muller Wu Lane &co show @natimmunol.nature.com that fibroblastic reticular cells in lymph nodes produce Flt3l to support survival & proliferation of dendritic cells allowing T cell responses during immunization or infection!!
Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche - Nature Immunology
Turley and colleagues find that Gremlin1-expressing lymph node fibroblastic reticular cells support dendritic cell homeostasis via provision of FLT3L.
www.nature.com
November 22, 2025 at 3:58 PM
#WeekendRead! #LocationLocationLocation! #EveryCellIsAnImmuneCell! Turley Muller Wu Lane &co show @natimmunol.nature.com that fibroblastic reticular cells in lymph nodes produce Flt3l to support survival & proliferation of dendritic cells allowing T cell responses during immunization or infection!!
Reposted by Ivan Zanoni
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice - Nature Communications
Inherited mitochondrial DNA mutations can result in diverse clinical phenotypes. Here, the authors characterise a heteroplasmic tRNAAla mutation (m.5019A>G) in mice and demonstrate that macrophages...
www.nature.com
November 20, 2025 at 4:09 PM
Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
This work was led by postdoc Eloise marques with many important contributions from all of our co-authors.
Please check it out!
www.nature.com/articles/s41...
Reposted by Ivan Zanoni
November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
NINJ1 blocks HSV-1 entry into macrophages to impact viral replication and immunity | EMBO reports
imageimageNINJ1 blocks HSV-1 entry into mouse macrophages independent of its role in cell death, resulting in greater secretion of pro inflammatory cytokines downstream of infection. Mouse macrophages lacking NINJ1 are more permissive to HSV-1 ...
www.embopress.org
November 20, 2025 at 3:15 PM
November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
#InflammasomePower! #EveryCellIsAnImmuneCell! #MysterySolved!
@brozlab.bsky.social @alexandraboegli.bsky.social
&co show @embojournal.org that in intestinal epithelial cells, NLRP6 senses endosomal damage to trigger GSDMD-dependent IL1 release & pyroptosis against bacterial invasion & more!
@brozlab.bsky.social @alexandraboegli.bsky.social
&co show @embojournal.org that in intestinal epithelial cells, NLRP6 senses endosomal damage to trigger GSDMD-dependent IL1 release & pyroptosis against bacterial invasion & more!
You (bacteria) shall not pass: NLRP6 can sense you! - The EMBO Journal
The EMBO Journal - The ability of intracellular bacteria to spread directly from one cell to the next, avoiding extracellular immune defenses and drugs, is essential for pathogen dissemination and,...
link.springer.com
November 20, 2025 at 5:41 PM
#InflammasomePower! #EveryCellIsAnImmuneCell! #MysterySolved!
@brozlab.bsky.social @alexandraboegli.bsky.social
&co show @embojournal.org that in intestinal epithelial cells, NLRP6 senses endosomal damage to trigger GSDMD-dependent IL1 release & pyroptosis against bacterial invasion & more!
@brozlab.bsky.social @alexandraboegli.bsky.social
&co show @embojournal.org that in intestinal epithelial cells, NLRP6 senses endosomal damage to trigger GSDMD-dependent IL1 release & pyroptosis against bacterial invasion & more!
Reposted by Ivan Zanoni
New review out in @cp-trendsimmuno.bsky.social! With @valentinavenzin.bsky.social, we revisit IL-27 as a central regulator of CD8⁺ T cell fate — integrating insights from infection, cancer, and autoimmunity, and outlining its therapeutic potential. www.sciencedirect.com/science/arti...
Reframing IL-27: a central regulator of CD8+ T cell immunity
Interleukin-27 (IL-27), a member of the IL-12 cytokine family, was long viewed primarily as a regulator of CD4+ T cell immunity. Subsequent studies re…
www.sciencedirect.com
November 20, 2025 at 6:24 AM
New review out in @cp-trendsimmuno.bsky.social! With @valentinavenzin.bsky.social, we revisit IL-27 as a central regulator of CD8⁺ T cell fate — integrating insights from infection, cancer, and autoimmunity, and outlining its therapeutic potential. www.sciencedirect.com/science/arti...
#WeekendRead! #FriendOrFoes?! Zhang &co show @cp-immunity.bsky.social that herpes simplex virus #HSV1 exploits changes in membrane integrity to activate a GPI-anchored hydrolase which degrades cGAMP preventing #cGAS/#STING activation & favoring virus infection
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation
Wang et al. find that cell membrane stress upon viral infection induces expression
and stabilization of host sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B),
which, in turn, degrades cGAMP to s...
www.cell.com
November 16, 2025 at 4:37 PM
#WeekendRead! #FriendOrFoes?! Zhang &co show @cp-immunity.bsky.social that herpes simplex virus #HSV1 exploits changes in membrane integrity to activate a GPI-anchored hydrolase which degrades cGAMP preventing #cGAS/#STING activation & favoring virus infection
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
#WeekendRead! #EveryCellIsAnImmuneCell! Riedel, Mattavelli, Helal &co show @cp-immunity.bsky.social that fibroblasts in breast cancer metastatic lymph nodes sense tumor-derived TLR4 agonists to attract monocytes & form an immunosuppressive niche, favoring lung metastasis!
dlvr.it/TPCYjz
dlvr.it/TPCYjz
A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is characterized by high risks of relapse or
metastatic disease. Mattavelli et al. identify a chemokine axis that recruits immunosuppressive
monocytes to tumor-dra...
dlvr.it
November 15, 2025 at 3:54 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Riedel, Mattavelli, Helal &co show @cp-immunity.bsky.social that fibroblasts in breast cancer metastatic lymph nodes sense tumor-derived TLR4 agonists to attract monocytes & form an immunosuppressive niche, favoring lung metastasis!
dlvr.it/TPCYjz
dlvr.it/TPCYjz
Reposted by Ivan Zanoni
Thank you for your contribution, Ivan. It was great working with you!✨
November 13, 2025 at 2:54 PM
Thank you for your contribution, Ivan. It was great working with you!✨
Fantastic @ Nature Biotechnology by @bocklab.bsky.social &co, link to go and whisper to your cells 👉 doi.org/10.1038/s415...
November 12, 2025 at 12:03 PM
Fantastic @ Nature Biotechnology by @bocklab.bsky.social &co, link to go and whisper to your cells 👉 doi.org/10.1038/s415...
#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
November 10, 2025 at 5:26 PM
#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇
#WeekendRead! #EveryCellIsAnImmuneCell! #SmartTumors. Ji Zhang &co show @cp-cell.bsky.social that tumor cells undergo ER stress under immune pressure leading to activation of nociceptive neurons which signal in draining lymph node driving immune suppression via decreased CCL5 & favoring tumor growth
Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance
Cancer cells exploit distant tissues and organs to escape immune surveillance by activating
nociceptive neurons, which remodel tumor-draining lymph nodes into an immune-suppressed
state. Blocking this...
www.cell.com
November 8, 2025 at 4:39 PM
#WeekendRead! #EveryCellIsAnImmuneCell! #SmartTumors. Ji Zhang &co show @cp-cell.bsky.social that tumor cells undergo ER stress under immune pressure leading to activation of nociceptive neurons which signal in draining lymph node driving immune suppression via decreased CCL5 & favoring tumor growth
Fascinating as always @reisesousalab.bsky.social &co! 1 aminoacid makes the difference between a CLR that drives cross-presentation or immune activation!! Kudos to all authors of this cool paper! 👇👇👇
Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation | The EMBO Journal
imageimageDNGR-1 (CLEC9A) is a C-type lectin receptor of type-1 conventional dendritic cells (cDC1s) with an important role in cross-presentation of dead cell antigens. This study explores how it equips cDC1s with the ability to cross-present such ...
www.embopress.org
November 3, 2025 at 10:45 PM
Fascinating as always @reisesousalab.bsky.social &co! 1 aminoacid makes the difference between a CLR that drives cross-presentation or immune activation!! Kudos to all authors of this cool paper! 👇👇👇
Reposted by Ivan Zanoni
#cytokines2025
Day 2 starts with a major symposium with Charlie Rice as the keynote! This session highlights my favorite cytokine -interferons!
#interferons #seattle #conference
Day 2 starts with a major symposium with Charlie Rice as the keynote! This session highlights my favorite cytokine -interferons!
#interferons #seattle #conference
November 3, 2025 at 2:48 PM
#cytokines2025
Day 2 starts with a major symposium with Charlie Rice as the keynote! This session highlights my favorite cytokine -interferons!
#interferons #seattle #conference
Day 2 starts with a major symposium with Charlie Rice as the keynote! This session highlights my favorite cytokine -interferons!
#interferons #seattle #conference
Reposted by Ivan Zanoni
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.
Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...
www.biorxiv.org
October 31, 2025 at 3:49 PM
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Reposted by Ivan Zanoni
#Cytokines2025 will kick off with two special symposia! Check in early, get your badges, to attend these sessions.
November 2, 2025 at 5:19 PM
#Cytokines2025 will kick off with two special symposia! Check in early, get your badges, to attend these sessions.
Reposted by Ivan Zanoni
Welcome to #Cytokines2025!
We are thrilled to have you in Seattle for cytokines2025. Check in starts at 11 am, join us for cutting-edge scientific sessions, celebrate excellence at the award ceremony, and connect at the welcome reception. Enjoy the meeting and Seattle! 🌲🧬✨ #Cytokines25 #Immunology
We are thrilled to have you in Seattle for cytokines2025. Check in starts at 11 am, join us for cutting-edge scientific sessions, celebrate excellence at the award ceremony, and connect at the welcome reception. Enjoy the meeting and Seattle! 🌲🧬✨ #Cytokines25 #Immunology
November 2, 2025 at 2:56 PM
Welcome to #Cytokines2025!
We are thrilled to have you in Seattle for cytokines2025. Check in starts at 11 am, join us for cutting-edge scientific sessions, celebrate excellence at the award ceremony, and connect at the welcome reception. Enjoy the meeting and Seattle! 🌲🧬✨ #Cytokines25 #Immunology
We are thrilled to have you in Seattle for cytokines2025. Check in starts at 11 am, join us for cutting-edge scientific sessions, celebrate excellence at the award ceremony, and connect at the welcome reception. Enjoy the meeting and Seattle! 🌲🧬✨ #Cytokines25 #Immunology
#WeekendRead! #SmartTumor
Zhao, Huang &co show @natimmunol.nature.com that within tumormicro environment, sensing of dead cells by macrophages via TIM4 inhibits a mitochondrial chaperone protein enhancing mitochondrial functions & epigenetically enforcing immunesuppression doi.org/10.1038/s415...
Zhao, Huang &co show @natimmunol.nature.com that within tumormicro environment, sensing of dead cells by macrophages via TIM4 inhibits a mitochondrial chaperone protein enhancing mitochondrial functions & epigenetically enforcing immunesuppression doi.org/10.1038/s415...
Cancer suppresses mitochondrial chaperone activity in macrophages to drive immune evasion - Nature Immunology
Huang and colleagues report that TIM4–AMPK signaling induces downregulation of the mitochondrial HSP90 chaperone TRAP1 in tumor-associated macrophages, thereby enhancing their immunoinhibitory functio...
doi.org
November 1, 2025 at 3:56 PM
#WeekendRead! #SmartTumor
Zhao, Huang &co show @natimmunol.nature.com that within tumormicro environment, sensing of dead cells by macrophages via TIM4 inhibits a mitochondrial chaperone protein enhancing mitochondrial functions & epigenetically enforcing immunesuppression doi.org/10.1038/s415...
Zhao, Huang &co show @natimmunol.nature.com that within tumormicro environment, sensing of dead cells by macrophages via TIM4 inhibits a mitochondrial chaperone protein enhancing mitochondrial functions & epigenetically enforcing immunesuppression doi.org/10.1038/s415...
So blessed to have the possibility to work with some of the smartest & nicest people I ever met. #LoveMyLab #LoveScience #LoveImmunology #Halloween #LabParty
November 1, 2025 at 1:50 PM
So blessed to have the possibility to work with some of the smartest & nicest people I ever met. #LoveMyLab #LoveScience #LoveImmunology #Halloween #LabParty
Reposted by Ivan Zanoni
An authoritative review on phagosome immunobiology by David Underhill and Kai Li. Highly recommend for anyone interested in innate immunity, antigen presentation, infection and host defense.
@cedarssinai.bsky.social
rdcu.be/eNIFY
@cedarssinai.bsky.social
rdcu.be/eNIFY
Phagocytosis: a process that shapes immune responses to engulfed meals
Nature Reviews Immunology - In this Review, Li and Underhill discuss recent advances in understanding the process of phagocytosis. The authors highlight how phagocytosis is integral for innate...
rdcu.be
October 31, 2025 at 7:22 PM
An authoritative review on phagosome immunobiology by David Underhill and Kai Li. Highly recommend for anyone interested in innate immunity, antigen presentation, infection and host defense.
@cedarssinai.bsky.social
rdcu.be/eNIFY
@cedarssinai.bsky.social
rdcu.be/eNIFY
Reposted by Ivan Zanoni
#SpookyInflammasome 🎃
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.
Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...
www.biorxiv.org
October 31, 2025 at 5:37 PM
#SpookyInflammasome 🎃
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.
Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...
www.biorxiv.org
October 31, 2025 at 3:49 PM
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇