Ivan Zanoni
@lozanzi.bsky.social
Associate Professor at Harvard Medical School, in love with a red-haired beautiful woman, his kids... and immunology. He/him/his. 🇮🇹 🇺🇸 Views my own.
Reposted by Ivan Zanoni
I am excited to present our long-overdue lab website. Please visit us to learn who we are, our past work, and our current lines of research!
ahidalgolab.com
Thank you to Gerardo Barcia for his beautiful design and constant support in building it
ahidalgolab.com
Thank you to Gerardo Barcia for his beautiful design and constant support in building it
Hidalgo Lab | Mapping Innate Immunity
Research on neutrophil biology, innate immunity, and cardiovascular disease at Yale School of Medicine. Led by Dr. Andrés Hidalgo.
ahidalgolab.com
February 7, 2026 at 3:59 PM
I am excited to present our long-overdue lab website. Please visit us to learn who we are, our past work, and our current lines of research!
ahidalgolab.com
Thank you to Gerardo Barcia for his beautiful design and constant support in building it
ahidalgolab.com
Thank you to Gerardo Barcia for his beautiful design and constant support in building it
#WeekendRead! #ImmunometabolismPower! #InflammasomePower! Liu, Yin &co show @cp-cellchembiol that lactate downstream of aerobic glycolysis is used to directly lactylates NLRP3 increasing ASC recruitment and inflammasome activation, which exacerbates lethality in sepsis! www.cell.com/cell-chemica...
Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation
Liu et al. reveal that lactate, an aerobic glycolysis product, promotes NLRP3 inflammasome
activation and pyroptosis. NLRP3 is identified as a target of lactylation, and K24
and K565 have potential to...
www.cell.com
February 7, 2026 at 3:59 PM
#WeekendRead! #ImmunometabolismPower! #InflammasomePower! Liu, Yin &co show @cp-cellchembiol that lactate downstream of aerobic glycolysis is used to directly lactylates NLRP3 increasing ASC recruitment and inflammasome activation, which exacerbates lethality in sepsis! www.cell.com/cell-chemica...
Reposted by Ivan Zanoni
Too much data, too little thinking.
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
On the balance of knowledge - Nature Reviews Immunology
Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.
www.nature.com
February 6, 2026 at 2:31 AM
Too much data, too little thinking.
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
Excited to be giving my first seminar of 2026 tomorrow @cedars-sinai.bsky.social! Stop by if you are around, it will be all about how we respond to microbial or sterile threats & the paramount roles played by PAMPs & DAMPs, with lot of unpublished data 😉
February 4, 2026 at 3:37 PM
Excited to be giving my first seminar of 2026 tomorrow @cedars-sinai.bsky.social! Stop by if you are around, it will be all about how we respond to microbial or sterile threats & the paramount roles played by PAMPs & DAMPs, with lot of unpublished data 😉
#WeekendRead! #SharingIsCaring! Ji, Xu &co show @nature.com that glia transfers mitochondria to sensory neurons via tunneling nanotubes, which are altered in #diabetes causing neuropathy!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Mitochondrial transfer from glia to neurons protects against peripheral neuropathy - Nature
Mitochondria that are transported from satellite glial cells in dorsal root ganglia to peripheral sensory neurons through tunneling nanotube-like structures provide protection against peripheral neuro...
doi.org
February 1, 2026 at 3:52 PM
#WeekendRead! #SharingIsCaring! Ji, Xu &co show @nature.com that glia transfers mitochondria to sensory neurons via tunneling nanotubes, which are altered in #diabetes causing neuropathy!
doi.org/10.1038/s415...
doi.org/10.1038/s415...
#WeekendRead! #FirstLove #IL2power #IL10power #InterferonPower! Delaloy, Gauthier &co show @cp-immunity.bsky.social that IL2 favors a regulatory program in B cells that, together IFNg, induces IL10 production, protecting against neuroinflammation! Exciting paper 🤗! www.cell.com/immunity/ful...
B cell-intrinsic IL-2 signaling regulates inflammation by promoting IL-10 expression in CD25+ age-associated B cells
B cells transiently increase interleukin (IL)-2 receptor expression upon activation.
Gauthier et al. examine the B cell-intrinsic role of IL-2 and define an IL-2-MAF axis
that promotes the differentia...
www.cell.com
January 31, 2026 at 3:57 PM
#WeekendRead! #FirstLove #IL2power #IL10power #InterferonPower! Delaloy, Gauthier &co show @cp-immunity.bsky.social that IL2 favors a regulatory program in B cells that, together IFNg, induces IL10 production, protecting against neuroinflammation! Exciting paper 🤗! www.cell.com/immunity/ful...
Excited to have the one and only @labwaggoner.bsky.social posting our @annualreviews.bsky.social Immunology paper on the biology of #Type_3_Interferons!! Check it out! www.annualreviews.org/content/jour...
January 30, 2026 at 12:18 AM
Excited to have the one and only @labwaggoner.bsky.social posting our @annualreviews.bsky.social Immunology paper on the biology of #Type_3_Interferons!! Check it out! www.annualreviews.org/content/jour...
Reposted by Ivan Zanoni
#Epithelialmechanics fans...interferons protect against viruses but also impair recovery post-infection. In new work @plosbiology.org we show that interferons block epithelial repair by co-opting the Hippo pathway #innateimmunity #lungs #respiratory journals.plos.org/plosbiology/...
Dose-dependent activation of the Hippo pathway by Type I and Type III interferons suppresses tissue repair by human bronchial epithelial cells
Interferons (IFNs) initiate antiviral defence when infected cells sense a virus protecting against infection via JAK/STAT signaling, but can hinder recovery by impairing tissue repair by an unknown me...
journals.plos.org
January 29, 2026 at 3:43 PM
#Epithelialmechanics fans...interferons protect against viruses but also impair recovery post-infection. In new work @plosbiology.org we show that interferons block epithelial repair by co-opting the Hippo pathway #innateimmunity #lungs #respiratory journals.plos.org/plosbiology/...
#DirtyIsBetter! @rmedzhitov.bsky.social, Erickson &co show @nature.com that pet shop mice are protected from #allergy thanks to cross reactive type I (or tolerogenic) immune memory that prevents type II allergen-driven responses! doi.org/10.1038/s415...
Environmentally driven immune imprinting protects against allergy - Nature
In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship be...
doi.org
January 28, 2026 at 10:37 PM
#DirtyIsBetter! @rmedzhitov.bsky.social, Erickson &co show @nature.com that pet shop mice are protected from #allergy thanks to cross reactive type I (or tolerogenic) immune memory that prevents type II allergen-driven responses! doi.org/10.1038/s415...
Reposted by Ivan Zanoni
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
January 28, 2026 at 5:45 PM
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
Reposted by Ivan Zanoni
A new function for GlycoRNAs!! The GlycoRNA-Heparan sulfate complex on the cell surface controls VEGF-A signaling and angiogenesis. Superexciting findings from Ryan Flynn's lab. Congratulations to all authors!! @raflynn5.bsky.social www.nature.com/articles/s41...
GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling - Nature
Heparan sulfate proteoglycans facilitate the assembly of clusters of glycoRNAs and cell surface RNA-binding proteins, which negatively modulate VEGF-A signalling and angiogenesis.
www.nature.com
January 28, 2026 at 7:09 PM
A new function for GlycoRNAs!! The GlycoRNA-Heparan sulfate complex on the cell surface controls VEGF-A signaling and angiogenesis. Superexciting findings from Ryan Flynn's lab. Congratulations to all authors!! @raflynn5.bsky.social www.nature.com/articles/s41...
#InterferonFriendsOrFoes? Another cool one @ellenfoxman.bsky.social &friends out @plosbiology.org about how excessive #IFNs delay repair by activating LATS & degrading YAP/TAZ in the Hippo 🦛 pathway! journals.plos.org/plosbiology/... 👇👇👇
January 27, 2026 at 8:33 PM
#InterferonFriendsOrFoes? Another cool one @ellenfoxman.bsky.social &friends out @plosbiology.org about how excessive #IFNs delay repair by activating LATS & degrading YAP/TAZ in the Hippo 🦛 pathway! journals.plos.org/plosbiology/... 👇👇👇
#WeekendRead! #LocationLocationLocation! Sng, Andoniou,
@the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...
@the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 - Nature
CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune r...
doi.org
January 24, 2026 at 3:46 PM
#WeekendRead! #LocationLocationLocation! Sng, Andoniou,
@the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...
@the-de-lab.bsky.social &co show @nature.com that fibrobalstic reticular cell (FRC) CD44 interacts with hyaluronic acid to correctly position dendritic cells within the spleen allowing anti-viral CD8T cell responses! doi.org/10.1038/s415...
Reposted by Ivan Zanoni
Great story from the Nieswandt lab in Science: uncovering a non-classical platelet mechanism that drives inflammation via integrin- and tetraspanin-rich tethers. A fresh angle on thrombo-inflammation. Happy to be part of this work!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation
Platelet integrin αIIbβ3 is essential for hemostasis, thrombosis, and inflammation. We found that ligation of αIIbβ3 by von Willebrand factor or fibrin under flow triggered its accumulation in plasma ...
www.science.org
January 24, 2026 at 2:51 PM
Great story from the Nieswandt lab in Science: uncovering a non-classical platelet mechanism that drives inflammation via integrin- and tetraspanin-rich tethers. A fresh angle on thrombo-inflammation. Happy to be part of this work!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Ivan Zanoni
Excited to share: We show that basal IFNλ2/3 signaling helps human intestinal epithelial cells stay ready for viral infections, even before an acute infection. A reminder that a lot of innate immune defense happens quietly in the background. journals.plos.org/plospathogen...
Basal IFNλ2/3 signaling is required for ISG expression and viral control in human intestinal epithelial cells
Author summary Interferon-lambdas (IFNλs) are antiviral molecules that help protect the surfaces of our body, such as the gut and lungs, from infection. While IFNλs are best known for being produced d...
journals.plos.org
January 22, 2026 at 4:46 PM
Excited to share: We show that basal IFNλ2/3 signaling helps human intestinal epithelial cells stay ready for viral infections, even before an acute infection. A reminder that a lot of innate immune defense happens quietly in the background. journals.plos.org/plospathogen...
Fantastic work @ellenfoxman.bsky.social &co! If you block the #InterferonPower, Rhinovirus activates NFkB & NLRP1 #inflammasome leading to IL1b secretion & excessive mucus production!
Rhinoviruses cause common cold & asthma attacks but are also often benign. Using nasal organoids, we learned how the community of cells in the lining the nasal passages coordinates to respond to rhinovirus and which responses lead to excess mucus & inflammation. www.cell.com/cell-press-b...
Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling
Rhinoviruses are the most frequent cause of common colds and also a major cause of
respiratory distress in high-risk groups. Using single-cell sequencing of rhinovirus-infected
nasal epithelial organo...
www.cell.com
January 22, 2026 at 2:23 AM
Fantastic work @ellenfoxman.bsky.social &co! If you block the #InterferonPower, Rhinovirus activates NFkB & NLRP1 #inflammasome leading to IL1b secretion & excessive mucus production!
#NoTimeToDie! Ayres &co show @nature.com that young & aged mice initiate different disease tolerance mechanisms to survive #sepsis. Dying young mice have cardiomegaly while aged mice cardiac atrophy. Opposite in surviving mice, with Foxo1 🦊 being protective in young & detrimental in aged mice!
Disease tolerance and infection pathogenesis age-related tradeoffs in mice - Nature
Disease course and pathology an infection may cause can change owing to the structural and functional physiological changes that accumulate with age, but therapy can be tailored accordingly; disease t...
doi.org
January 19, 2026 at 4:21 PM
#NoTimeToDie! Ayres &co show @nature.com that young & aged mice initiate different disease tolerance mechanisms to survive #sepsis. Dying young mice have cardiomegaly while aged mice cardiac atrophy. Opposite in surviving mice, with Foxo1 🦊 being protective in young & detrimental in aged mice!
#WeekendRead #MicrobiotaPower! Tsai, @diehllab.bsky.social &co show @ Science Immunology that E. coli flagellin is recognized by TLR5 on intestinal epithelial stem cells to recruit gut protective CCR2+ monocyte-derived macrophages, decreasing colitis! #IBDs doi.org/10.1126/sciimmunol.adr4057
Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophages
Colonic stem cell TLR5 sensing of microbes promotes macrophage recruitment and maturation to support intestinal barrier repair.
doi.org
January 18, 2026 at 4:34 PM
#WeekendRead #MicrobiotaPower! Tsai, @diehllab.bsky.social &co show @ Science Immunology that E. coli flagellin is recognized by TLR5 on intestinal epithelial stem cells to recruit gut protective CCR2+ monocyte-derived macrophages, decreasing colitis! #IBDs doi.org/10.1126/sciimmunol.adr4057
#WeekendRead! #SmartTumor! #SharingIsCaring! #InterferonFriendOrFoe?! Lot in this @cp-cellmetabolism.bsky.social paper from Okwan-Duodu &co showing that tumor cells steal #mitochondria from immune cells to impair their activity & to produce immune suppressive type I #IFNs via cGAS-STING!
Mitochondrial transfer from immune to tumor cells enables lymph node metastasis
Although the immune system is a significant barrier to tumor growth and spread, established tumors evade immune attack and frequently colonize immune …
www.sciencedirect.com
January 17, 2026 at 4:14 PM
#WeekendRead! #SmartTumor! #SharingIsCaring! #InterferonFriendOrFoe?! Lot in this @cp-cellmetabolism.bsky.social paper from Okwan-Duodu &co showing that tumor cells steal #mitochondria from immune cells to impair their activity & to produce immune suppressive type I #IFNs via cGAS-STING!
Reposted by Ivan Zanoni
Registration for the 2026 Henry Kunkel Society Meeting is well underway! 📍 @rockefeller.edu | 🗓 April 16–18 Join us for three days focused on “Autoantibodies Against Cytokines”. 🔗 Register now: henrykunkelsociety.app.neoncrm.com/eventReg.jsp... 🤝 Meeting in partnership with @jem.org
January 16, 2026 at 3:54 PM
Registration for the 2026 Henry Kunkel Society Meeting is well underway! 📍 @rockefeller.edu | 🗓 April 16–18 Join us for three days focused on “Autoantibodies Against Cytokines”. 🔗 Register now: henrykunkelsociety.app.neoncrm.com/eventReg.jsp... 🤝 Meeting in partnership with @jem.org
Reposted by Ivan Zanoni
Another superb study of human TLR7 GOF:
Novel TLR7 gain-of-function variant and review of the associated disease spectrum url: rupress.org/jhi/article/...
Novel TLR7 gain-of-function variant and review of the associated disease spectrum url: rupress.org/jhi/article/...
Novel TLR7 gain-of-function variant and review of the associated disease spectrum | Journal of Human Immunity | Rockefeller University Press
This study identifies a novel TLR7 variant causing monogenic lupus, recurrent infections, and neuroinflammation. The phenotype resembles type I interferono
rupress.org
January 12, 2026 at 9:25 PM
Another superb study of human TLR7 GOF:
Novel TLR7 gain-of-function variant and review of the associated disease spectrum url: rupress.org/jhi/article/...
Novel TLR7 gain-of-function variant and review of the associated disease spectrum url: rupress.org/jhi/article/...
Reposted by Ivan Zanoni
An intriguing observation:
Increased prevalence of autoantibodies neutralizing IFNλ2/3 in young individuals with cystic fibrosis url: rupress.org/jhi/article/...
Increased prevalence of autoantibodies neutralizing IFNλ2/3 in young individuals with cystic fibrosis url: rupress.org/jhi/article/...
Increased prevalence of autoantibodies neutralizing IFNλ2/3 in young individuals with cystic fibrosis | Journal of Human Immunity | Rockefeller University Press
Groen et al. identify neutralizing interferon-λ2/3 autoantibodies in 11.8% of individuals with cystic fibrosis, a greater than 10-fold higher prevalence th
rupress.org
January 12, 2026 at 9:26 PM
An intriguing observation:
Increased prevalence of autoantibodies neutralizing IFNλ2/3 in young individuals with cystic fibrosis url: rupress.org/jhi/article/...
Increased prevalence of autoantibodies neutralizing IFNλ2/3 in young individuals with cystic fibrosis url: rupress.org/jhi/article/...
#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...
TLR4al senses heme as a key damage/danger-associated molecular pattern to activate immune responses in lower vertebrates
Abstract. Toll-like receptor 4 (TLR4), a critical pattern recognition receptor, detects microbe- and damage/danger-associated molecular patterns to trigger
academic.oup.com
January 11, 2026 at 3:58 PM
#WeekendRead! #SameSameButDifferent! #FirstLove! Its discovery changed our understanding of the functioning of innate immunity and of the immune response in general, but actually not all TLR4s are equal, check this out @jimmunol.bsky.social 👇👇👇 academic.oup.com/jimmunol/art...
#WeekendRead! #SmartTumor! Liu, Kroemer, Tang, Wang &co show @cp-cell.bsky.social that ferroptotic tumor cells release GPX4 dampening anti-tumor responses by signaling in DCs via ZP3 receptors, thus blocking glycolysis & impairing cytotoxic T cell activation!
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors
GPX4 released by ferroptotic cancer cells suppresses dendritic cell maturation and
T cell priming by binding to ZP3. Blocking the GPX4-ZP3 interaction restores dendritic
activity, boosts cytotoxic T c...
www.cell.com
January 10, 2026 at 4:34 PM
#WeekendRead! #SmartTumor! Liu, Kroemer, Tang, Wang &co show @cp-cell.bsky.social that ferroptotic tumor cells release GPX4 dampening anti-tumor responses by signaling in DCs via ZP3 receptors, thus blocking glycolysis & impairing cytotoxic T cell activation!
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
#CyclopsPower👁️ Lu, Choi, Huh &co describe @cp-cell.bsky.social a new reporter system to detect cells that respond to a cytokine & utilize it to identify ileal epithelial cells that respond to IL17 or IFNg responsive CD8 T cell within tumors which are hypofunctional!
In vivo detection of immune responses via cytokine activity labeling
While much is known about the identity and regulation of cytokine-producing cells, the cell types that respond to cytokines remain largely uncharacter…
www.sciencedirect.com
January 7, 2026 at 4:29 PM
#CyclopsPower👁️ Lu, Choi, Huh &co describe @cp-cell.bsky.social a new reporter system to detect cells that respond to a cytokine & utilize it to identify ileal epithelial cells that respond to IL17 or IFNg responsive CD8 T cell within tumors which are hypofunctional!