Ryan Flynn
@raflynn5.bsky.social
RNA, Glycans, Space, Renewable Energy, and all technologies making lives more interesting.
PI at Boston Children’s Hospital SCP
Assistant Professor at Harvard SCRB
PI at Boston Children’s Hospital SCP
Assistant Professor at Harvard SCRB
Reposted by Ryan Flynn
Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info 👇
www.nature.com/articles/s41...
More info 👇
Membrane editing with proximity labeling reveals regulators of lipid homeostasis - Nature Chemical Biology
Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.
www.nature.com
January 7, 2026 at 2:59 PM
Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple question—how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info 👇
www.nature.com/articles/s41...
More info 👇
Reposted by Ryan Flynn
Incredible shot of Mt Rainier from the International Space Station. Puget Sound in the upper right.
📸NASA
📸NASA
January 6, 2026 at 4:32 PM
Incredible shot of Mt Rainier from the International Space Station. Puget Sound in the upper right.
📸NASA
📸NASA
Reposted by Ryan Flynn
Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Ninhydrin as a covalent warhead for chemical proteomic-enabled discovery and selective engagement of reactive arginines
Covalent molecules have emerged as next-generation therapeutics and as powerful tools for perturbing fundamental biological processes. Chemical proteomic methods to screen for reactive proteinaceous a...
www.biorxiv.org
January 6, 2026 at 3:40 PM
Is arginine the new cysteine?! Check out our lab's latest in collaboration with @ianseiple.bsky.social's team where we introduce ninhydrin as a selective covalent warhead and probe targeting reactive arginines.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Ryan Flynn
We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)
January 6, 2026 at 3:16 PM
We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)
Reposted by Ryan Flynn
Starting 2026 with Quan Pham's paper expanding the chemical toolbox for engineering AAV
- New bioorthogonal labeling, including IEDDA, for efficient macromolecule attachment
- Incorporation of two different chemistries for dual capsid labeling & much more:
onlinelibrary.wiley.com/doi/full/10....
- New bioorthogonal labeling, including IEDDA, for efficient macromolecule attachment
- Incorporation of two different chemistries for dual capsid labeling & much more:
onlinelibrary.wiley.com/doi/full/10....
An Expanded Toolbox for Versatile Chemical Editing of Adeno‐Associated Virus
We describe technology to introduce diverse non-natural chemical functionalities site-specifically into the capsid of adeno-associated virus through genetic code expansion, and using them to engineer...
onlinelibrary.wiley.com
January 6, 2026 at 11:09 AM
Starting 2026 with Quan Pham's paper expanding the chemical toolbox for engineering AAV
- New bioorthogonal labeling, including IEDDA, for efficient macromolecule attachment
- Incorporation of two different chemistries for dual capsid labeling & much more:
onlinelibrary.wiley.com/doi/full/10....
- New bioorthogonal labeling, including IEDDA, for efficient macromolecule attachment
- Incorporation of two different chemistries for dual capsid labeling & much more:
onlinelibrary.wiley.com/doi/full/10....
Reposted by Ryan Flynn
So proud of Dr. Tamara Rossy from our lab for presenting her exciting research as one of the BMES CMBE postdoc awardees! Our muscles never skip leg day 💪🏽
@bmes-cmbe.bsky.social #myoblue
@bmes-cmbe.bsky.social #myoblue
🏋️♀️🧬 Engineered muscle hits the gym.
Tamara Rossy, Postdoctoral Travel Awardee, shares approaches to enhance the maturity of human iPSC-derived skeletal muscle.
Because functional muscle doesn’t skip leg day. 💪
#CMBE2026
Tamara Rossy, Postdoctoral Travel Awardee, shares approaches to enhance the maturity of human iPSC-derived skeletal muscle.
Because functional muscle doesn’t skip leg day. 💪
#CMBE2026
January 5, 2026 at 3:28 PM
So proud of Dr. Tamara Rossy from our lab for presenting her exciting research as one of the BMES CMBE postdoc awardees! Our muscles never skip leg day 💪🏽
@bmes-cmbe.bsky.social #myoblue
@bmes-cmbe.bsky.social #myoblue
Reposted by Ryan Flynn
The cryo cyclical multiplexing expansion microscopy (Cy-ExM) preprint from
@seweryn-galecki.bsky.social , @kevin-dean.bsky.social et al is online.
20 targets across an entire cell. Mr. Snouty also joined the fun.
www.biorxiv.org/content/10.6...
@seweryn-galecki.bsky.social , @kevin-dean.bsky.social et al is online.
20 targets across an entire cell. Mr. Snouty also joined the fun.
www.biorxiv.org/content/10.6...
January 2, 2026 at 7:39 PM
The cryo cyclical multiplexing expansion microscopy (Cy-ExM) preprint from
@seweryn-galecki.bsky.social , @kevin-dean.bsky.social et al is online.
20 targets across an entire cell. Mr. Snouty also joined the fun.
www.biorxiv.org/content/10.6...
@seweryn-galecki.bsky.social , @kevin-dean.bsky.social et al is online.
20 targets across an entire cell. Mr. Snouty also joined the fun.
www.biorxiv.org/content/10.6...
Reposted by Ryan Flynn
Which cysteines are hyper-reactive in specific cancer types and tissues?
The lab of @balynzaro.bsky.social addresses this question by measuring cysteine reactivity across the NCI-60 panel that includes 9 different cancer types.(1/2)
www.cell.com/cell-chemica...
#ChemBio #ChemSky #ChemicalProteomics
The lab of @balynzaro.bsky.social addresses this question by measuring cysteine reactivity across the NCI-60 panel that includes 9 different cancer types.(1/2)
www.cell.com/cell-chemica...
#ChemBio #ChemSky #ChemicalProteomics
An interactive resource mapping the proteome and reactive cysteine landscape across the NCI-60 reveals cell and tissue-specific profiles
Montaño et al. generate an integrated proteomic and cysteine reactivity resource for
the NCI-60 cancer cell line panel, offering quantitative data on over 12,000 proteins
and 36,000 cysteines to enabl...
www.cell.com
January 2, 2026 at 5:10 PM
Which cysteines are hyper-reactive in specific cancer types and tissues?
The lab of @balynzaro.bsky.social addresses this question by measuring cysteine reactivity across the NCI-60 panel that includes 9 different cancer types.(1/2)
www.cell.com/cell-chemica...
#ChemBio #ChemSky #ChemicalProteomics
The lab of @balynzaro.bsky.social addresses this question by measuring cysteine reactivity across the NCI-60 panel that includes 9 different cancer types.(1/2)
www.cell.com/cell-chemica...
#ChemBio #ChemSky #ChemicalProteomics
Reposted by Ryan Flynn
No one organization can fill the gaps created by federal funding cuts to research. But as an independent funder, Damon Runyon is committed to ensuring that our scientists can continue their lifesaving work in 2026 and beyond. Until midnight, all gifts will be fully matched: damonrunyon.org/donate
Damon Runyon scientists on the impact of slashing research funding
Damon Runyon scientists explain how drastic cuts in federal research funding threaten progress in cancer research, and how Damon Runyon can help protect the breakthroughs…
vimeo.com
December 31, 2025 at 6:07 PM
No one organization can fill the gaps created by federal funding cuts to research. But as an independent funder, Damon Runyon is committed to ensuring that our scientists can continue their lifesaving work in 2026 and beyond. Until midnight, all gifts will be fully matched: damonrunyon.org/donate
Reposted by Ryan Flynn
A free, open-access library of high-quality organism illustrations for science communication
A free, open-access library of high-quality organism illustrations for science communication
We create vector graphics of model organisms and emerging biological research organisms to enhance our publications. We’re sharing these editable graphics under a CC0 license for other scientists to...
doi.org
December 29, 2025 at 6:03 PM
A free, open-access library of high-quality organism illustrations for science communication
Reposted by Ryan Flynn
Now online! Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly
Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly
Cryo-EM structures of HSV-1 helicase-primase and replication fork complexes reveal mechanisms of drug inhibition, features that explain drug selectivity, and the molecular basis of replication fork complex assembly during herpesvirus DNA replication.
dlvr.it
December 29, 2025 at 7:52 PM
Now online! Mechanisms of HSV-1 helicase-primase inhibition and replication fork complex assembly
Reposted by Ryan Flynn
Wrapping up an incredible 2025 with the Raman Lab squad - we flexed our muscles and pumped out 14 exciting papers, preprints, and reviews! Stay tuned for lots more to come in 2026 from this dynamic team 💪🏽
ramanlab.mit.edu/publications/
#myoblue
ramanlab.mit.edu/publications/
#myoblue
December 29, 2025 at 3:05 PM
Wrapping up an incredible 2025 with the Raman Lab squad - we flexed our muscles and pumped out 14 exciting papers, preprints, and reviews! Stay tuned for lots more to come in 2026 from this dynamic team 💪🏽
ramanlab.mit.edu/publications/
#myoblue
ramanlab.mit.edu/publications/
#myoblue
Reposted by Ryan Flynn
It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...
December 16, 2025 at 8:17 AM
It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...
Reposted by Ryan Flynn
Each Friday, we’re sharing highlights from our Top of the Charts, a look back at our most popular charts, articles, & more in 2025.
Today we give you our top 5 most-read topic pages this year. 🧵
1. CO₂ and Greenhouse Gas Emissions
→ ourworldindata.org/co2-and-gree...
Today we give you our top 5 most-read topic pages this year. 🧵
1. CO₂ and Greenhouse Gas Emissions
→ ourworldindata.org/co2-and-gree...
December 26, 2025 at 4:46 PM
Each Friday, we’re sharing highlights from our Top of the Charts, a look back at our most popular charts, articles, & more in 2025.
Today we give you our top 5 most-read topic pages this year. 🧵
1. CO₂ and Greenhouse Gas Emissions
→ ourworldindata.org/co2-and-gree...
Today we give you our top 5 most-read topic pages this year. 🧵
1. CO₂ and Greenhouse Gas Emissions
→ ourworldindata.org/co2-and-gree...
Reposted by Ryan Flynn
Enjoying this report by David Hart who argues that the smarter strategy for the US is to compete with China in the EV space. Electric vehicles are a superior technology & will eventually displace ICE vehicles. Abandoning the contest will leave the US behind. www.cfr.org/report/compe...
Compete, Don’t Retreat
The primary U.S. response to China’s first-mover advantages in emerging auto technologies has been protection. A smarter strategy would seek to compete by supporting producers and collaborating with …
www.cfr.org
December 25, 2025 at 9:59 PM
Enjoying this report by David Hart who argues that the smarter strategy for the US is to compete with China in the EV space. Electric vehicles are a superior technology & will eventually displace ICE vehicles. Abandoning the contest will leave the US behind. www.cfr.org/report/compe...
Reposted by Ryan Flynn
Our scientists explain what support from Damon Runyon has meant during a turbulent year for cancer research.
To everyone in our Damon Runyon community, happy holidays and thank you!
To everyone in our Damon Runyon community, happy holidays and thank you!
A message of gratitude from our scientists
Damon Runyon scientists explain what your support has meant during a difficult year for cancer researchers. Help protect their progress in 2026 at at damonrunyon.org.
vimeo.com
December 24, 2025 at 5:46 PM
Our scientists explain what support from Damon Runyon has meant during a turbulent year for cancer research.
To everyone in our Damon Runyon community, happy holidays and thank you!
To everyone in our Damon Runyon community, happy holidays and thank you!
Reposted by Ryan Flynn
New issue alert! 👉 cell.com/cell/current
On the cover: the adrenergic system stimulates body-wide stem cell activation to mediate enhanced limb regeneration in response to amputation in axolotls. The image shows a white axolotl perched on a rock with forelimbs and gills visible.
On the cover: the adrenergic system stimulates body-wide stem cell activation to mediate enhanced limb regeneration in response to amputation in axolotls. The image shows a white axolotl perched on a rock with forelimbs and gills visible.
December 24, 2025 at 5:43 PM
New issue alert! 👉 cell.com/cell/current
On the cover: the adrenergic system stimulates body-wide stem cell activation to mediate enhanced limb regeneration in response to amputation in axolotls. The image shows a white axolotl perched on a rock with forelimbs and gills visible.
On the cover: the adrenergic system stimulates body-wide stem cell activation to mediate enhanced limb regeneration in response to amputation in axolotls. The image shows a white axolotl perched on a rock with forelimbs and gills visible.
Reposted by Ryan Flynn
OSTP has issued a request for information, please share with them your ideas for how to improve government functions related to science funding and policy
www.federalregister.gov/documents/20...
www.federalregister.gov/documents/20...
Notice of Request for Information; Accelerating the American Scientific Enterprise
The Office of Science and Technology Policy (OSTP) requests input from all interested parties on Federal policy updates that aim to accelerate the American scientific enterprise, enable groundbreaking...
www.federalregister.gov
December 23, 2025 at 10:56 PM
OSTP has issued a request for information, please share with them your ideas for how to improve government functions related to science funding and policy
www.federalregister.gov/documents/20...
www.federalregister.gov/documents/20...
Reposted by Ryan Flynn
Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm - Nature Cell Biology
Schooley et al. find that mitotically bookmarked loci drive a transient chromosome folding state during G1 entry that is subsequently modulated by factors inherited through the cytoplasm.
www.nature.com
December 22, 2025 at 11:45 AM
Exciting new paper out! @allanaschooley.bsky.social and Sergey Venev led this project that let to the discovery of two chromosome folding programs: one inherited via mitotic chromosomes and one mitotic inherited through the cytoplasm!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ryan Flynn
Hmmm ... sperm RNAs? Paternal effects? It's like an early Christmas present! Very nice article by Ivan Amato, including quotes and work from some excellent scientists like @colinconine.bsky.social ... and me, as well. ;)
www.quantamagazine.org/how-dads-fit...
www.quantamagazine.org/how-dads-fit...
How Dad’s Fitness May Be Packaged and Passed Down in Sperm RNA | Quanta Magazine
Research into how a father’s choices — such as diet, exercise, stress, nicotine use — may transfer traits to his children has become impossible to ignore.
www.quantamagazine.org
December 22, 2025 at 5:59 PM
Hmmm ... sperm RNAs? Paternal effects? It's like an early Christmas present! Very nice article by Ivan Amato, including quotes and work from some excellent scientists like @colinconine.bsky.social ... and me, as well. ;)
www.quantamagazine.org/how-dads-fit...
www.quantamagazine.org/how-dads-fit...
Reposted by Ryan Flynn
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Recent discoveries on the acquisition of the highest levels of human performance
Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...
www.science.org
December 20, 2025 at 11:49 PM
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Ryan Flynn
Two pieces of fun news:
1. We've launched a new website for our lab: www.brysonlab.org
2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!
1. We've launched a new website for our lab: www.brysonlab.org
2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!
The Bryson Lab | Vaccine Development & Research at MIT
Developing effective accessible vaccines to end tuberculosis worldwide. Combining immunoengineering, molecular microbiology & systems biology at MIT.
www.brysonlab.org
December 18, 2025 at 6:29 PM
Two pieces of fun news:
1. We've launched a new website for our lab: www.brysonlab.org
2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!
1. We've launched a new website for our lab: www.brysonlab.org
2. With some new funding, we are recruiting for new postdocs and graduate students. The projects build upon our previous studies of antigen presentation and phagosome biology and go into new exciting dimensions!
Reposted by Ryan Flynn
And here's the report @qedscience.bsky.social generated for our new paper, summarizing what's new and what was already known before. I'm planning to submit q.e.d's reports as cover letters together with my pre-prints from now on (and so should you!)
December 18, 2025 at 11:30 AM
And here's the report @qedscience.bsky.social generated for our new paper, summarizing what's new and what was already known before. I'm planning to submit q.e.d's reports as cover letters together with my pre-prints from now on (and so should you!)
Reposted by Ryan Flynn
Flu infection flips a “PAR switch”:
instead of hitting new targets, cells lengthen poly(ADP-ribose) (PAR) chains on the same proteins to slow the virus.
Flu NS1 suppresses this; PARP1 drives it.
ELTA revealed both site & length changes.
www.nature.com/articles/s41...
instead of hitting new targets, cells lengthen poly(ADP-ribose) (PAR) chains on the same proteins to slow the virus.
Flu NS1 suppresses this; PARP1 drives it.
ELTA revealed both site & length changes.
www.nature.com/articles/s41...
Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection - Nature Communications
Influenza A virus infection causes a dramatic upregulation of ADP-ribosylation that as part of the cellular antiviral response, a process that is counteracted by the viral NS1 protein.
www.nature.com
December 18, 2025 at 2:11 AM
Flu infection flips a “PAR switch”:
instead of hitting new targets, cells lengthen poly(ADP-ribose) (PAR) chains on the same proteins to slow the virus.
Flu NS1 suppresses this; PARP1 drives it.
ELTA revealed both site & length changes.
www.nature.com/articles/s41...
instead of hitting new targets, cells lengthen poly(ADP-ribose) (PAR) chains on the same proteins to slow the virus.
Flu NS1 suppresses this; PARP1 drives it.
ELTA revealed both site & length changes.
www.nature.com/articles/s41...
Reposted by Ryan Flynn
🚀New pre-print from the lab, led by PhD candidate Xiaolin Dong! www.biorxiv.org/content/10.6...
In this study, we uncovered crosstalk between mucin-type O-glycans and HSPGs, showing that truncated O-GalNAc glycans destabilize proteoglycans, impair FGF signaling, & disrupt chondrogenesis. #glycotime
In this study, we uncovered crosstalk between mucin-type O-glycans and HSPGs, showing that truncated O-GalNAc glycans destabilize proteoglycans, impair FGF signaling, & disrupt chondrogenesis. #glycotime
Mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation
O -glycosylation is a ubiquitous post-translational modification essential for protein stability, cell signaling, and tissue organization, yet how distinct O -glycan subclasses coordinate tissue devel...
www.biorxiv.org
December 18, 2025 at 3:08 AM
🚀New pre-print from the lab, led by PhD candidate Xiaolin Dong! www.biorxiv.org/content/10.6...
In this study, we uncovered crosstalk between mucin-type O-glycans and HSPGs, showing that truncated O-GalNAc glycans destabilize proteoglycans, impair FGF signaling, & disrupt chondrogenesis. #glycotime
In this study, we uncovered crosstalk between mucin-type O-glycans and HSPGs, showing that truncated O-GalNAc glycans destabilize proteoglycans, impair FGF signaling, & disrupt chondrogenesis. #glycotime