Ryan Flynn
@raflynn5.bsky.social
RNA, Glycans, Space, Renewable Energy, and all technologies making lives more interesting.
PI at Boston Children’s Hospital SCP
Assistant Professor at Harvard SCRB
PI at Boston Children’s Hospital SCP
Assistant Professor at Harvard SCRB
Reposted by Ryan Flynn
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
November 11, 2025 at 1:20 AM
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
Reposted by Ryan Flynn
Meet the Raman Lab at #TERMISAM2025! Excited to share presentations from Angel Bu, Jessica Shah, Dr. Tamara Rossy, Brandon Rios, and Dr. Ferdows Afghah highlighting our latest efforts in #TissueEngineering.
@termisam.bsky.social
@termisam.bsky.social
November 10, 2025 at 2:34 PM
Meet the Raman Lab at #TERMISAM2025! Excited to share presentations from Angel Bu, Jessica Shah, Dr. Tamara Rossy, Brandon Rios, and Dr. Ferdows Afghah highlighting our latest efforts in #TissueEngineering.
@termisam.bsky.social
@termisam.bsky.social
Reposted by Ryan Flynn
Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.
Scripps Research team identifies sugar molecules that trigger placental formation
ow.ly
November 8, 2025 at 12:25 AM
Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.
Reposted by Ryan Flynn
Oh, and this also means it would be possible for multiple journals in parallel to highlight your paper. You won't be restricted to just one (similarly to how the BBC, NYT and Scientific American can all highlighted your journal-published paper today).
November 8, 2025 at 8:01 AM
Oh, and this also means it would be possible for multiple journals in parallel to highlight your paper. You won't be restricted to just one (similarly to how the BBC, NYT and Scientific American can all highlighted your journal-published paper today).
Reposted by Ryan Flynn
You’ll be proud that your reviewed preprint was highlighted by Nature, just like you’re proud when your paper is highlighted by the New York Times. You'll add that to your C.V. You'll still read them because they'll have good content (2/2).
November 8, 2025 at 6:02 AM
You’ll be proud that your reviewed preprint was highlighted by Nature, just like you’re proud when your paper is highlighted by the New York Times. You'll add that to your C.V. You'll still read them because they'll have good content (2/2).
Reposted by Ryan Flynn
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
November 8, 2025 at 6:02 AM
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
Reposted by Ryan Flynn
This is what every single person with any experience in China has been warning about from the start.
Very good WaPo story by Katrina Northrop and Rudy Lu. www.washingtonpost.com/world/2025/1... And good, clear headline!
Very good WaPo story by Katrina Northrop and Rudy Lu. www.washingtonpost.com/world/2025/1... And good, clear headline!
November 7, 2025 at 4:20 AM
This is what every single person with any experience in China has been warning about from the start.
Very good WaPo story by Katrina Northrop and Rudy Lu. www.washingtonpost.com/world/2025/1... And good, clear headline!
Very good WaPo story by Katrina Northrop and Rudy Lu. www.washingtonpost.com/world/2025/1... And good, clear headline!
Reposted by Ryan Flynn
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
openrxiv.org
November 6, 2025 at 2:32 PM
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Reposted by Ryan Flynn
Please read the thoughtful Blog that @richardsever.bsky.social and the @openrxiv.bsky.social team wrote on integrating pre-prints with AI review openrxiv.org/enabling-rev...
November 6, 2025 at 3:11 PM
Please read the thoughtful Blog that @richardsever.bsky.social and the @openrxiv.bsky.social team wrote on integrating pre-prints with AI review openrxiv.org/enabling-rev...
Reposted by Ryan Flynn
And you can of course also go through to the q.e.d website: www.qedscience.com
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
www.qedscience.com
November 6, 2025 at 3:05 PM
And you can of course also go through to the q.e.d website: www.qedscience.com
Reposted by Ryan Flynn
Here's how you can go to @qedscience.bsky.social from the @openrxiv.bsky.social @biorxivpreprint.bsky.social website, when you submit a manuscript:
November 6, 2025 at 2:49 PM
Here's how you can go to @qedscience.bsky.social from the @openrxiv.bsky.social @biorxivpreprint.bsky.social website, when you submit a manuscript:
Reposted by Ryan Flynn
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
Reposted by Ryan Flynn
If you're looking for a faculty position at the intersection of ecology and computing (both broadly defined), please apply to this joint search between the CEE Department and the College of Computing at MIT: cee.mit.edu/people/share...
Faculty Position in the Department of Civil and Environmental Engineering and the Schwarzman College of Computing - cee.mit.edu
The Department of Civil and Environmental Engineering (CEE), together with the Schwarzman College of Computing (SCC) at the Massachusetts Institute of Technology (MIT) in Cambridge MA, seeks candidate...
cee.mit.edu
November 5, 2025 at 7:27 PM
If you're looking for a faculty position at the intersection of ecology and computing (both broadly defined), please apply to this joint search between the CEE Department and the College of Computing at MIT: cee.mit.edu/people/share...
Reposted by Ryan Flynn
Visionary talk from Jennifer Lewis yesterday at the MIT.nano Dresselhaus Lecture, highlighting opportunities for 3D printing in soft robotics & tissue engineering! You can watch the full lecture and the q&a session (moderated by me!) here: mitnano.mit.edu/events/dress...
@wyssinstitute.bsky.social
@wyssinstitute.bsky.social
November 4, 2025 at 4:01 PM
Visionary talk from Jennifer Lewis yesterday at the MIT.nano Dresselhaus Lecture, highlighting opportunities for 3D printing in soft robotics & tissue engineering! You can watch the full lecture and the q&a session (moderated by me!) here: mitnano.mit.edu/events/dress...
@wyssinstitute.bsky.social
@wyssinstitute.bsky.social
Reposted by Ryan Flynn
When ChatGPT was asked to rate 40,000 résumés, it ranked the older male candidates as better quality than the younger female applicants.
Age and gender distortion in online media and large language models - Nature
Stereotypes of age-related gender bias are socially distorted, as evidenced by the age gap in the representations of women and men across various media and algorithms, despite no systematic age differ...
www.nature.com
November 2, 2025 at 9:47 PM
When ChatGPT was asked to rate 40,000 résumés, it ranked the older male candidates as better quality than the younger female applicants.
Reposted by Ryan Flynn
Some iocaine perhaps to jog his memory?
On the other site, an 18-year-old Zohran canvasser described the legendary Wallace Shawn as "the actor who plays Dr. Sturgis on Young Sheldon" which is honestly adorable
November 2, 2025 at 9:13 PM
Some iocaine perhaps to jog his memory?
Interesting work profiling surface proteins from the Kossiakoff lab U Chicago. Corroborates the concept of @oawlab.bsky.social on cancer specific csU5-snRNP200 and our work on csNPM1 but here with more than 500 (!) novel Fabs and 40 antibodies developed. Very cool www.biorxiv.org/content/10.1...
Dynamic translocation of Inside-Out proteins to the cell surface underlies cellular adaptation to cancer-induced stress
Inside-out (I-O) protein display, the non-canonical surface localization of intracellular proteins, represents an underexplored feature of tumor cell biology. Here, we map the molecular landscape and ...
www.biorxiv.org
November 2, 2025 at 7:44 PM
Interesting work profiling surface proteins from the Kossiakoff lab U Chicago. Corroborates the concept of @oawlab.bsky.social on cancer specific csU5-snRNP200 and our work on csNPM1 but here with more than 500 (!) novel Fabs and 40 antibodies developed. Very cool www.biorxiv.org/content/10.1...
Reposted by Ryan Flynn
Some charts for those who don't know the extent of the US public (and private) investment in research (particularly in biomedical research) compared to other countries and institutions. The destruction of the US' scientific institutions has global implications.
November 2, 2025 at 10:52 AM
Some charts for those who don't know the extent of the US public (and private) investment in research (particularly in biomedical research) compared to other countries and institutions. The destruction of the US' scientific institutions has global implications.
Reposted by Ryan Flynn
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.
Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...
www.biorxiv.org
October 31, 2025 at 3:49 PM
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Lab organized a pretty good costume
October 31, 2025 at 6:07 PM
Lab organized a pretty good costume
Reposted by Ryan Flynn
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
October 31, 2025 at 5:45 PM
What a gem from @dudinlab.bsky.social @gautamdey.bsky.social @centriolelab.bsky.social in Cell! Expansion microscopy atlas of >200 eukaryotes comparing cytoskeletal architectures revealing structures not seen before. Stunning visualisation! Exactly the kind of transformative cell biology we need.
Reposted by Ryan Flynn
Science brings us new miracles every day. Update from a mother whose son was the first patient dosed with Grace Science's gene therapy for NGly1 deficiency (GS-100). Video can be seen on YouTube. #glycotime
www.youtube.com/watch?v=tdNn...
www.youtube.com/watch?v=tdNn...
www.youtube.com
October 31, 2025 at 4:24 PM
Science brings us new miracles every day. Update from a mother whose son was the first patient dosed with Grace Science's gene therapy for NGly1 deficiency (GS-100). Video can be seen on YouTube. #glycotime
www.youtube.com/watch?v=tdNn...
www.youtube.com/watch?v=tdNn...
Reposted by Ryan Flynn
This is heartbreaking 💔 to read. Thank you 🙏 for sharing this with us. I want to apologize to you on behalf of real Americans. It’s a painful reminder that we must keep resisting these harmful policies so we don’t lose more people like @wwenneuro.bsky.social, whom we spent over a decade training.
After 13 years in the US, I’ve made the difficult decision to leave. Having packed up everything and rethought about priorities, rather painstakingly, while I’m sad to leave the life I’ve made here, I’m also relieved that I won’t have to plan my life around immigration policies anymore.
October 31, 2025 at 12:18 PM
This is heartbreaking 💔 to read. Thank you 🙏 for sharing this with us. I want to apologize to you on behalf of real Americans. It’s a painful reminder that we must keep resisting these harmful policies so we don’t lose more people like @wwenneuro.bsky.social, whom we spent over a decade training.
Reposted by Ryan Flynn
Science needs to be part of our day to traditions. For many years - I have continued to give Foldscope @teamfoldscope.bsky.social with the candy on Halloween. Try it out and surprise the kids with the capacity to see and discover real #microMonsters crawling on our planet. 🎃👻
#FoldscopeHalloween
#FoldscopeHalloween
October 30, 2025 at 10:02 PM
Science needs to be part of our day to traditions. For many years - I have continued to give Foldscope @teamfoldscope.bsky.social with the candy on Halloween. Try it out and surprise the kids with the capacity to see and discover real #microMonsters crawling on our planet. 🎃👻
#FoldscopeHalloween
#FoldscopeHalloween
Reposted by Ryan Flynn
Well reported story on the PBS News Hour about science cuts and the ongoing and potential brain drain.
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
Top researchers consider leaving U.S. amid funding cuts: 'The science world is ending'
YouTube video by PBS NewsHour
www.youtube.com
October 30, 2025 at 11:36 AM
Well reported story on the PBS News Hour about science cuts and the ongoing and potential brain drain.
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7
www.youtube.com/watch?v=yLvO...
Thanks to Terrance Tao and other scientists at various career stages for having the courage to speak out.
Watch and share!
1/7