Ryan Flynn
@raflynn5.bsky.social
RNA, Glycans, Space, Renewable Energy, and all technologies making lives more interesting.
PI at Boston Children’s Hospital SCP
Associate Professor at Harvard SCRB
PI at Boston Children’s Hospital SCP
Associate Professor at Harvard SCRB
Reposted by Ryan Flynn
Grab ur weekend coffee and treat yourself with the latest Flynn wisdom
www.nature.com/articles/s41...
@raflynn5.bsky.social Consistently advancing the RNA biology through beautiful and inspirational discoveries.
👏🏾👏🏾👏🏾👏🏾👏🏾
www.nature.com/articles/s41...
@raflynn5.bsky.social Consistently advancing the RNA biology through beautiful and inspirational discoveries.
👏🏾👏🏾👏🏾👏🏾👏🏾
GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling - Nature
Heparan sulfate proteoglycans facilitate the assembly of clusters of glycoRNAs and cell surface RNA-binding proteins, which negatively modulate VEGF-A signalling and angiogenesis.
www.nature.com
January 31, 2026 at 9:43 AM
Grab ur weekend coffee and treat yourself with the latest Flynn wisdom
www.nature.com/articles/s41...
@raflynn5.bsky.social Consistently advancing the RNA biology through beautiful and inspirational discoveries.
👏🏾👏🏾👏🏾👏🏾👏🏾
www.nature.com/articles/s41...
@raflynn5.bsky.social Consistently advancing the RNA biology through beautiful and inspirational discoveries.
👏🏾👏🏾👏🏾👏🏾👏🏾
Reposted by Ryan Flynn
My quote of the day
We have also arranged things so that almost no one understands science and technology. This is a prescription for disaster. We might get away with it for a while, but sooner or later this combustible mixture of ignorance and power is going to blow up in our faces.
Carl Sagan
We have also arranged things so that almost no one understands science and technology. This is a prescription for disaster. We might get away with it for a while, but sooner or later this combustible mixture of ignorance and power is going to blow up in our faces.
Carl Sagan
January 31, 2026 at 12:15 PM
My quote of the day
We have also arranged things so that almost no one understands science and technology. This is a prescription for disaster. We might get away with it for a while, but sooner or later this combustible mixture of ignorance and power is going to blow up in our faces.
Carl Sagan
We have also arranged things so that almost no one understands science and technology. This is a prescription for disaster. We might get away with it for a while, but sooner or later this combustible mixture of ignorance and power is going to blow up in our faces.
Carl Sagan
Reposted by Ryan Flynn
Today at Cell: A new #HallmarksofCancer review by Doug Hanahan: www.cell.com/cell/fulltex...
This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011.
@cp-cell.bsky.social @cellpress.bsky.social
This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011.
@cp-cell.bsky.social @cellpress.bsky.social
Hallmarks of cancer—Then and now, and beyond
Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years
of conceptual refinement into a multidimensional view of tumor biology. This review
highlights how aberrant capabilit...
www.cell.com
January 29, 2026 at 3:58 PM
Today at Cell: A new #HallmarksofCancer review by Doug Hanahan: www.cell.com/cell/fulltex...
This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011.
@cp-cell.bsky.social @cellpress.bsky.social
This review marks 25 years since the original seminal Cell review by Hanahan & Robert Weinberg and its impactful follow up in 2011.
@cp-cell.bsky.social @cellpress.bsky.social
Reposted by Ryan Flynn
Follow up to Doug Hanahan’s visionary article about the stages of cancer development from back in the 1990s
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Hallmarks of cancer—Then and now, and beyond
Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years
of conceptual refinement into a multidimensional view of tumor biology. This review
highlights how aberrant capabilit...
www.cell.com
January 30, 2026 at 7:30 PM
Follow up to Doug Hanahan’s visionary article about the stages of cancer development from back in the 1990s
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Ryan Flynn
Out today in Nature Electronics: we share our perspective on how instrumenting biohybrid robots with onboard #bioelectronics capable of integrated sensing, control, and power can enable real-world deployment of muscle-powered machines.
www.nature.com/articles/s41...
#Robotics #TissueEngineering
www.nature.com/articles/s41...
#Robotics #TissueEngineering
Using electronics to build biohybrid robots with physical intelligence - Nature Electronics
Biohybrid robots, which rely on living muscles to drive force generation, could be of use in applications ranging from microsurgery to unmanned exploration. But the development of untethered and auton...
www.nature.com
January 30, 2026 at 4:10 PM
Out today in Nature Electronics: we share our perspective on how instrumenting biohybrid robots with onboard #bioelectronics capable of integrated sensing, control, and power can enable real-world deployment of muscle-powered machines.
www.nature.com/articles/s41...
#Robotics #TissueEngineering
www.nature.com/articles/s41...
#Robotics #TissueEngineering
Reposted by Ryan Flynn
Clusters of glycoRNAs & cell surface ribonucleoproteins negatively modulate heparan sulfate-mediated signalling in the context of angiogenesis driven by VEGF-A @nature.com @bostonchildrens.bsky.social @raflynn5.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 28, 2026 at 11:14 PM
Clusters of glycoRNAs & cell surface ribonucleoproteins negatively modulate heparan sulfate-mediated signalling in the context of angiogenesis driven by VEGF-A @nature.com @bostonchildrens.bsky.social @raflynn5.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ryan Flynn
Huge advance in glycoRNA biology. Congrats to @raflynn5.bsky.social and all of the wonderful authors! Can’t wait to see what you guys do next!
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
January 28, 2026 at 11:24 PM
Huge advance in glycoRNA biology. Congrats to @raflynn5.bsky.social and all of the wonderful authors! Can’t wait to see what you guys do next!
Reposted by Ryan Flynn
A new function for GlycoRNAs!! The GlycoRNA-Heparan sulfate complex on the cell surface controls VEGF-A signaling and angiogenesis. Superexciting findings from Ryan Flynn's lab. Congratulations to all authors!! @raflynn5.bsky.social www.nature.com/articles/s41...
GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling - Nature
Heparan sulfate proteoglycans facilitate the assembly of clusters of glycoRNAs and cell surface RNA-binding proteins, which negatively modulate VEGF-A signalling and angiogenesis.
www.nature.com
January 28, 2026 at 7:09 PM
A new function for GlycoRNAs!! The GlycoRNA-Heparan sulfate complex on the cell surface controls VEGF-A signaling and angiogenesis. Superexciting findings from Ryan Flynn's lab. Congratulations to all authors!! @raflynn5.bsky.social www.nature.com/articles/s41...
Reposted by Ryan Flynn
Out today in Nature - our collaborative work with Ryan Flynn's lab, led by Dr. Peiyuan Chai with support from Dr. @sinakheiri.bsky.social and @shahjess.bsky.social from our group. Exciting findings showcasing how glycoRNAs can modulate angiogenesis!
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
January 28, 2026 at 7:02 PM
Out today in Nature - our collaborative work with Ryan Flynn's lab, led by Dr. Peiyuan Chai with support from Dr. @sinakheiri.bsky.social and @shahjess.bsky.social from our group. Exciting findings showcasing how glycoRNAs can modulate angiogenesis!
Reposted by Ryan Flynn
New #glycotime discovery from @raflynn5.bsky.social’s lab @bostonchildrens.bsky.social @harvard.edu, cell surface glycoRNA-RBP complexes organized by heparan sulfate PG nanoclusters that modulate VEGF signaling
www.nature.com/articles/s41...
www.nature.com/articles/s41...
GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling - Nature
Heparan sulfate proteoglycans facilitate the assembly of clusters of glycoRNAs and cell surface RNA-binding proteins, which negatively modulate VEGF-A signalling and angiogenesis.
www.nature.com
January 28, 2026 at 5:37 PM
New #glycotime discovery from @raflynn5.bsky.social’s lab @bostonchildrens.bsky.social @harvard.edu, cell surface glycoRNA-RBP complexes organized by heparan sulfate PG nanoclusters that modulate VEGF signaling
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
January 28, 2026 at 5:45 PM
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
Reposted by Ryan Flynn
Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Population-scale sequencing resolves determinants of persistent EBV DNA - Nature
Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...
www.nature.com
January 28, 2026 at 5:07 PM
Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection.
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social
www.nature.com/articles/s41...
Reposted by Ryan Flynn
“Sustained, strong science, as with all public goods, requires government investment if it is to deliver long-term societal benefit.”
donmoynihan.substack.com/p/american-b...
donmoynihan.substack.com/p/american-b...
American biomedical science in 2026
Where we are, how we got here, and what to do next
donmoynihan.substack.com
January 27, 2026 at 4:28 PM
“Sustained, strong science, as with all public goods, requires government investment if it is to deliver long-term societal benefit.”
donmoynihan.substack.com/p/american-b...
donmoynihan.substack.com/p/american-b...
Reposted by Ryan Flynn
Reposted by Ryan Flynn
Like the genetic code, bitcoin, or national borders, our methods for evaluating science are a "frozen accident": things that were formed from historical circumstances rather than careful design, and that persist not because they are optimal, but because replacing them is extraordinarily difficult.
January 26, 2026 at 3:22 PM
Like the genetic code, bitcoin, or national borders, our methods for evaluating science are a "frozen accident": things that were formed from historical circumstances rather than careful design, and that persist not because they are optimal, but because replacing them is extraordinarily difficult.
Reposted by Ryan Flynn
I’m happy to share the main result of my PhD, which you can find on bioRxiv www.biorxiv.org/content/10.6.... If you are interested in learning about a new way to perform DNA-PAINT multiplexing, which we call Combi-PAINT, or if you are interested in the study of mRNA conformation, keep reading! 1/10
January 26, 2026 at 11:31 AM
I’m happy to share the main result of my PhD, which you can find on bioRxiv www.biorxiv.org/content/10.6.... If you are interested in learning about a new way to perform DNA-PAINT multiplexing, which we call Combi-PAINT, or if you are interested in the study of mRNA conformation, keep reading! 1/10
Reposted by Ryan Flynn
The final version of our new paper is out now - and open access @acs.org Central Science!!
Such a fun collaboration!
pubs.acs.org/doi/10.1021/...
Such a fun collaboration!
pubs.acs.org/doi/10.1021/...
January 25, 2026 at 1:05 AM
The final version of our new paper is out now - and open access @acs.org Central Science!!
Such a fun collaboration!
pubs.acs.org/doi/10.1021/...
Such a fun collaboration!
pubs.acs.org/doi/10.1021/...
Reposted by Ryan Flynn
Congratulations to Cynthia Dwork, Harvard CS Professor and Harvard Stats Affiliate for being award the 2026 Japan Prize. In statistics her most celebrated work is on founding differential privacy.
www.japanprize.jp/en/prize_pas...
www.japanprize.jp/en/prize_pas...
The Japan Prize Foundation
The Japan Prize Foundation , Japan Prize , OFFICIAL
www.japanprize.jp
January 23, 2026 at 9:16 PM
Congratulations to Cynthia Dwork, Harvard CS Professor and Harvard Stats Affiliate for being award the 2026 Japan Prize. In statistics her most celebrated work is on founding differential privacy.
www.japanprize.jp/en/prize_pas...
www.japanprize.jp/en/prize_pas...
Reposted by Ryan Flynn
2/2: Hynes discovered key molecules involved in cell adhesion, driving a better understanding of development and cancer metastasis. Their enormous contributions to basic science and human health live on.
January 23, 2026 at 10:13 PM
2/2: Hynes discovered key molecules involved in cell adhesion, driving a better understanding of development and cancer metastasis. Their enormous contributions to basic science and human health live on.
Reposted by Ryan Flynn
1/2: It is with deep sadness that we share the passing of Joel Habener and Richard Hynes, members of the HHMI Investigator community for more than 3 decades. Habener's discoveries helped transform the treatment of diabetes, obesity, and related conditions.
January 23, 2026 at 10:13 PM
1/2: It is with deep sadness that we share the passing of Joel Habener and Richard Hynes, members of the HHMI Investigator community for more than 3 decades. Habener's discoveries helped transform the treatment of diabetes, obesity, and related conditions.
Reposted by Ryan Flynn
First preprint of the year! New work from @jimmy-ly.bsky.social revealing unexpected roles for 5' UTR length in controlling alternate translational isoforms - important implications for both physiological cell function and rare disease. Small changes -> big impacts.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 23, 2026 at 11:39 AM
First preprint of the year! New work from @jimmy-ly.bsky.social revealing unexpected roles for 5' UTR length in controlling alternate translational isoforms - important implications for both physiological cell function and rare disease. Small changes -> big impacts.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Ryan Flynn
Join us in congratulating Philip J. Kranzusch (@kranzuschlab.bsky.social) of @danafarber.bsky.social and @harvardmed.bsky.social, winner of the 2026 NAS Award in Molecular Biology for his groundbreaking work advancing understanding of innate immunity! www.nasonline.org/award/nas-aw... #NASaward
January 22, 2026 at 4:04 PM
Join us in congratulating Philip J. Kranzusch (@kranzuschlab.bsky.social) of @danafarber.bsky.social and @harvardmed.bsky.social, winner of the 2026 NAS Award in Molecular Biology for his groundbreaking work advancing understanding of innate immunity! www.nasonline.org/award/nas-aw... #NASaward
Reposted by Ryan Flynn
Tom Cech on RNA research in Davos (video): www.weforum.org/meetings/wor...
January 21, 2026 at 9:24 PM
Tom Cech on RNA research in Davos (video): www.weforum.org/meetings/wor...
Reposted by Ryan Flynn
An eye-popping discovery: early vertebrates had four eyes rather than two @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
An eye-popping discovery: early vertebrates had four eyes rather than two
Eyes on a face’s front or side enable a brain to perceive images. Fossil evidence suggests that two light-sensitive organs on top of ancient vertebrate heads generated images, too.
www.nature.com
January 22, 2026 at 1:56 AM
An eye-popping discovery: early vertebrates had four eyes rather than two @nature.com
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
