Vincent Graziano
@vinnieviruses.bsky.social
UConn Health PhD candidate - Rathinam Lab | Former postgrad in the Wilen Lab at Yale | RNA is life | Pizza is a love language
Pinned
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
www.nature.com
Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors www.nature.com/articles/s41...
Reposted by Vincent Graziano
Thanks to Autoimmunity podcast @kevinbonham.bsky.social & @woodrufflab.bsky.social for discussing our glycoRNA paper w/ @raflynn5.bsky.social @vinnieviruses.bsky.social
In our latest episode, @woodrufflab.bsky.social and @kevinbonham.com talk about glycoRNAs, and the way they're shielded from the immune system in a new paper from the labs of @raflynn5.bsky.social and @vijayrathinam.bsky.social 🧪
audiommunity.org/episodes/epi...
audiommunity.org/episodes/epi...
Episode 47 - When you're a hammer
YouTube video by Audiommunity
www.youtube.com
October 24, 2025 at 5:54 PM
Thanks to Autoimmunity podcast @kevinbonham.bsky.social & @woodrufflab.bsky.social for discussing our glycoRNA paper w/ @raflynn5.bsky.social @vinnieviruses.bsky.social
Reposted by Vincent Graziano
In our latest episode, @woodrufflab.bsky.social and @kevinbonham.com talk about glycoRNAs, and the way they're shielded from the immune system in a new paper from the labs of @raflynn5.bsky.social and @vijayrathinam.bsky.social 🧪
audiommunity.org/episodes/epi...
audiommunity.org/episodes/epi...
Episode 47 - When you're a hammer
YouTube video by Audiommunity
www.youtube.com
October 24, 2025 at 2:58 PM
In our latest episode, @woodrufflab.bsky.social and @kevinbonham.com talk about glycoRNAs, and the way they're shielded from the immune system in a new paper from the labs of @raflynn5.bsky.social and @vijayrathinam.bsky.social 🧪
audiommunity.org/episodes/epi...
audiommunity.org/episodes/epi...
Reposted by Vincent Graziano
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation: Molecular Cell www.cell.com/molecular-ce... @raflynn5.bsky.social @vinnieviruses.bsky.social
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
A new function of glycosylated RNAs has been discovered by Graziano et al. in which
the glycosylation of RNA molecules shields acp³U RNA modification from triggering
innate immune responses.
www.cell.com
October 18, 2025 at 1:20 PM
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation: Molecular Cell www.cell.com/molecular-ce... @raflynn5.bsky.social @vinnieviruses.bsky.social
Reposted by Vincent Graziano
Don’t trust the experts”? That’s not democracy, that’s recklessness.
On a plane, I want a pilot.
In a hospital, I want doctors and scientists who understand the evidence.
Expertise isn’t religion or authoritarianism — it’s training, accountability, and data.
Ignore it and we all pay the price.
On a plane, I want a pilot.
In a hospital, I want doctors and scientists who understand the evidence.
Expertise isn’t religion or authoritarianism — it’s training, accountability, and data.
Ignore it and we all pay the price.
RFK Jr: We need to stop trusting the experts... Trusting the experts is not a feature of science or democracy, it's a feature of religion and totalitarianism.
August 29, 2025 at 10:07 PM
Don’t trust the experts”? That’s not democracy, that’s recklessness.
On a plane, I want a pilot.
In a hospital, I want doctors and scientists who understand the evidence.
Expertise isn’t religion or authoritarianism — it’s training, accountability, and data.
Ignore it and we all pay the price.
On a plane, I want a pilot.
In a hospital, I want doctors and scientists who understand the evidence.
Expertise isn’t religion or authoritarianism — it’s training, accountability, and data.
Ignore it and we all pay the price.
Reposted by Vincent Graziano
🚨New Paper in Cell 🧵🔎
Happy to share our work led by the @camilahcoelho.bsky.social, on mAbs against mpox.
We were very excited (and lucky!) to contribute to this collab. effort.
🦠“Human monoclonal antibodies targeting A35 protect from death caused by mpox”🦠
doi.org/10.1016/j.cell.2025.08.004
Happy to share our work led by the @camilahcoelho.bsky.social, on mAbs against mpox.
We were very excited (and lucky!) to contribute to this collab. effort.
🦠“Human monoclonal antibodies targeting A35 protect from death caused by mpox”🦠
doi.org/10.1016/j.cell.2025.08.004
August 26, 2025 at 3:55 PM
🚨New Paper in Cell 🧵🔎
Happy to share our work led by the @camilahcoelho.bsky.social, on mAbs against mpox.
We were very excited (and lucky!) to contribute to this collab. effort.
🦠“Human monoclonal antibodies targeting A35 protect from death caused by mpox”🦠
doi.org/10.1016/j.cell.2025.08.004
Happy to share our work led by the @camilahcoelho.bsky.social, on mAbs against mpox.
We were very excited (and lucky!) to contribute to this collab. effort.
🦠“Human monoclonal antibodies targeting A35 protect from death caused by mpox”🦠
doi.org/10.1016/j.cell.2025.08.004
Reposted by Vincent Graziano
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
August 21, 2025 at 3:20 PM
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
Reposted by Vincent Graziano
Another piece of the #glycoRNA puzzle revealed by @raflynn5.bsky.social and @vijayrathinam.bsky.social!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
www.nature.com
August 19, 2025 at 7:43 PM
Another piece of the #glycoRNA puzzle revealed by @raflynn5.bsky.social and @vijayrathinam.bsky.social!! RNAs with modified base acp3U activate TLR3/7, but not when acp3U is N-glycosylated. This is how cell surface/secreted glycoRNAs avoid stimulating autoimmunity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vincent Graziano
4/5 The Glycobiology Significant Achievement Award:
Dr. Ryan Flynn @raflynn5.bsky.social, Harvard University, 👏👏🥂
Dr. Ryan Flynn @raflynn5.bsky.social, Harvard University, 👏👏🥂
August 13, 2025 at 3:57 AM
4/5 The Glycobiology Significant Achievement Award:
Dr. Ryan Flynn @raflynn5.bsky.social, Harvard University, 👏👏🥂
Dr. Ryan Flynn @raflynn5.bsky.social, Harvard University, 👏👏🥂
Reposted by Vincent Graziano
@vijayrathinam.bsky.social @vinnieviruses.bsky.social @raflynn5.bsky.social discovers why RNA undergoes glycosylation: N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 6, 2025 at 6:27 PM
@vijayrathinam.bsky.social @vinnieviruses.bsky.social @raflynn5.bsky.social discovers why RNA undergoes glycosylation: N-glycans on glycoRNAs hide self-RNA from endosomal TLRs promoting ‘silent’ clearance of dead cells @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Vincent Graziano
Incredible discovery ! The first known role for sugar coated RNAs : immune evasion ! @raflynn5.bsky.social does it angain with @vinnieviruses.bsky.social @vijayrathinam.bsky.social and colleagues !
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
August 6, 2025 at 6:52 PM
Incredible discovery ! The first known role for sugar coated RNAs : immune evasion ! @raflynn5.bsky.social does it angain with @vinnieviruses.bsky.social @vijayrathinam.bsky.social and colleagues !
Reposted by Vincent Graziano
Check out this @nature.com paper from the brilliant scientist I get to call my husband!!!!
Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors www.nature.com/articles/s41...
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
www.nature.com
August 6, 2025 at 4:04 PM
Check out this @nature.com paper from the brilliant scientist I get to call my husband!!!!
Reposted by Vincent Graziano
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
August 6, 2025 at 3:36 PM
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
Reposted by Vincent Graziano
Big congrats to Vinnie Graziano @vinnieviruses.bsky.social who led the project and huge thanks to our great collaborators: Jennifer Porat, Thomas Carell, Franck Barrat, Beiyan Zhou, Sivapriya Kailasan Vanaja, Michael Wilson, and Penghua Wang!! #innate_immunity #interferon #celldeath
August 6, 2025 at 3:39 PM
Big congrats to Vinnie Graziano @vinnieviruses.bsky.social who led the project and huge thanks to our great collaborators: Jennifer Porat, Thomas Carell, Franck Barrat, Beiyan Zhou, Sivapriya Kailasan Vanaja, Michael Wilson, and Penghua Wang!! #innate_immunity #interferon #celldeath
Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors www.nature.com/articles/s41...
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...
www.nature.com
August 6, 2025 at 3:47 PM
Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors www.nature.com/articles/s41...
Reposted by Vincent Graziano
Wow
Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions
ki.se/en/about-ki/...
Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions
ki.se/en/about-ki/...
Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
ki.se
July 25, 2025 at 10:29 PM
Wow
Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions
ki.se/en/about-ki/...
Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions
ki.se/en/about-ki/...
Reposted by Vincent Graziano
The science being done in my lab right now is the best in my 20 years as a professor at UW. It's just incredible whiplash to flip between that the science funding situation here in the US, and to think about the societal abandonment of the brilliant young trainees who are pushing the work forward.
July 11, 2025 at 12:58 AM
The science being done in my lab right now is the best in my 20 years as a professor at UW. It's just incredible whiplash to flip between that the science funding situation here in the US, and to think about the societal abandonment of the brilliant young trainees who are pushing the work forward.
Reposted by Vincent Graziano
My next paper is going to be written like a Choose your own Adventure:
To do a Western Blot from the pulldown, go to page 7
To CRISPR out the functional domains, go to page 46
To skip till the Acknowledgements, go to page 52
To do a Western Blot from the pulldown, go to page 7
To CRISPR out the functional domains, go to page 46
To skip till the Acknowledgements, go to page 52
July 9, 2025 at 7:40 PM
My next paper is going to be written like a Choose your own Adventure:
To do a Western Blot from the pulldown, go to page 7
To CRISPR out the functional domains, go to page 46
To skip till the Acknowledgements, go to page 52
To do a Western Blot from the pulldown, go to page 7
To CRISPR out the functional domains, go to page 46
To skip till the Acknowledgements, go to page 52
Reposted by Vincent Graziano
**US-CAN Doctoral Excellence Award @WesternU
-$160,000 to 25 PhD students for up to 4 years.
- Must've had offer rescinded/cancelled from US school.
-Expedited admission process.
-Feel free to reach out, if interested in a PhD in inorganic chem!
www.forbes.com/sites/michae...
-$160,000 to 25 PhD students for up to 4 years.
- Must've had offer rescinded/cancelled from US school.
-Expedited admission process.
-Feel free to reach out, if interested in a PhD in inorganic chem!
www.forbes.com/sites/michae...
A Leading Canadian University Makes A Pitch For Top U.S. PhD Students
Western University, one of Canada’s leading public research universities, is launching an initiative aimed at luring away PhD students from premier U.S. institutions.
www.forbes.com
July 9, 2025 at 4:27 PM
**US-CAN Doctoral Excellence Award @WesternU
-$160,000 to 25 PhD students for up to 4 years.
- Must've had offer rescinded/cancelled from US school.
-Expedited admission process.
-Feel free to reach out, if interested in a PhD in inorganic chem!
www.forbes.com/sites/michae...
-$160,000 to 25 PhD students for up to 4 years.
- Must've had offer rescinded/cancelled from US school.
-Expedited admission process.
-Feel free to reach out, if interested in a PhD in inorganic chem!
www.forbes.com/sites/michae...
Reposted by Vincent Graziano
If you were too young in 2003 here is what Bush told the American people:
1) The Iraq War won’t cost a lot of money
3) We won’t need a lot of troops
4) We’ll bring peace and freedom to Iraq
5) We’ll find WMDs
6) We’ll be welcomed as liberators
7) It will be easy
8) It won’t take long
All lies.
1) The Iraq War won’t cost a lot of money
3) We won’t need a lot of troops
4) We’ll bring peace and freedom to Iraq
5) We’ll find WMDs
6) We’ll be welcomed as liberators
7) It will be easy
8) It won’t take long
All lies.
June 22, 2025 at 2:47 AM
If you were too young in 2003 here is what Bush told the American people:
1) The Iraq War won’t cost a lot of money
3) We won’t need a lot of troops
4) We’ll bring peace and freedom to Iraq
5) We’ll find WMDs
6) We’ll be welcomed as liberators
7) It will be easy
8) It won’t take long
All lies.
1) The Iraq War won’t cost a lot of money
3) We won’t need a lot of troops
4) We’ll bring peace and freedom to Iraq
5) We’ll find WMDs
6) We’ll be welcomed as liberators
7) It will be easy
8) It won’t take long
All lies.
Reposted by Vincent Graziano
Can confirm: 60 Minutes will be worth watching tonight about #NIH.
TV watching recommendations
The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration.
1/2
The lead story on 60 Minutes tonight is about NIH and concerns about damage done and continuing during the current administration.
1/2
April 27, 2025 at 11:25 AM
Can confirm: 60 Minutes will be worth watching tonight about #NIH.
Reposted by Vincent Graziano
Pope Francis lifted the world as he led the Church with his profound moral voice. As he returns to God, may his call to humility and concern for the least among us continue to resound.
April 21, 2025 at 12:11 PM
Pope Francis lifted the world as he led the Church with his profound moral voice. As he returns to God, may his call to humility and concern for the least among us continue to resound.
Reposted by Vincent Graziano
From a source at NIH:
“Right now NIH’s ability to buy things is dead. Nearly all people with the power to make an order — purchasing people — have been removed.
The NIH hospital can’t buy medicines, the labs can’t buy petri dishes. X-Ray machine breaks? Too bad.
Everything is stopped”
“Right now NIH’s ability to buy things is dead. Nearly all people with the power to make an order — purchasing people — have been removed.
The NIH hospital can’t buy medicines, the labs can’t buy petri dishes. X-Ray machine breaks? Too bad.
Everything is stopped”
April 4, 2025 at 12:10 PM
From a source at NIH:
“Right now NIH’s ability to buy things is dead. Nearly all people with the power to make an order — purchasing people — have been removed.
The NIH hospital can’t buy medicines, the labs can’t buy petri dishes. X-Ray machine breaks? Too bad.
Everything is stopped”
“Right now NIH’s ability to buy things is dead. Nearly all people with the power to make an order — purchasing people — have been removed.
The NIH hospital can’t buy medicines, the labs can’t buy petri dishes. X-Ray machine breaks? Too bad.
Everything is stopped”
Reposted by Vincent Graziano
Reposted by Vincent Graziano
“This will go down as one of the darkest days in modern scientific history” 🧪 www.nature.com/articles/d41...
‘One of the darkest days’: NIH purges agency leadership amid mass layoffs
In shock move, four institute directors at the US biomedical agency are removed from their posts.
www.nature.com
April 1, 2025 at 9:31 PM
“This will go down as one of the darkest days in modern scientific history” 🧪 www.nature.com/articles/d41...
Reposted by Vincent Graziano
There is no other way to say this: Today is the day the CDC was essentially dissolved. What's left is a husk. People will die as a direct result.
www.wired.com/story/cdc-gu...
www.wired.com/story/cdc-gu...
The CDC Has Been Gutted
Thousands of CDC employees who worked on things like preventing HIV and lead poisoning have been told they were subject to a reduction in force. Experts say people will die.
www.wired.com
April 1, 2025 at 3:32 PM
There is no other way to say this: Today is the day the CDC was essentially dissolved. What's left is a husk. People will die as a direct result.
www.wired.com/story/cdc-gu...
www.wired.com/story/cdc-gu...