Carolina Lucas
@carolilucas.bsky.social
Assistant Professor YaleIbio |ImmunoVirus❤️ | Alum @Virusesimmunity lab | #womeninSTEM
🚨New Paper in Cell 🧵🔎
Happy to share our work led by the @camilahcoelho.bsky.social, on mAbs against mpox.
We were very excited (and lucky!) to contribute to this collab. effort.
🦠“Human monoclonal antibodies targeting A35 protect from death caused by mpox”🦠
doi.org/10.1016/j.cell.2025.08.004
Happy to share our work led by the @camilahcoelho.bsky.social, on mAbs against mpox.
We were very excited (and lucky!) to contribute to this collab. effort.
🦠“Human monoclonal antibodies targeting A35 protect from death caused by mpox”🦠
doi.org/10.1016/j.cell.2025.08.004
August 26, 2025 at 3:55 PM
🚨New Paper in Cell 🧵🔎
Happy to share our work led by the @camilahcoelho.bsky.social, on mAbs against mpox.
We were very excited (and lucky!) to contribute to this collab. effort.
🦠“Human monoclonal antibodies targeting A35 protect from death caused by mpox”🦠
doi.org/10.1016/j.cell.2025.08.004
Happy to share our work led by the @camilahcoelho.bsky.social, on mAbs against mpox.
We were very excited (and lucky!) to contribute to this collab. effort.
🦠“Human monoclonal antibodies targeting A35 protect from death caused by mpox”🦠
doi.org/10.1016/j.cell.2025.08.004
Reposted by Carolina Lucas
🚨 New Publication!!!
I’m thrilled to share our latest study, “Clonotype-Enriched Somatic Hypermutations Drive Affinity Maturation of a Public Human Antibody Targeting an Occluded Sarbecovirus Epitope”.
www.cell.com/cell-reports... [1/4]
I’m thrilled to share our latest study, “Clonotype-Enriched Somatic Hypermutations Drive Affinity Maturation of a Public Human Antibody Targeting an Occluded Sarbecovirus Epitope”.
www.cell.com/cell-reports... [1/4]
Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope
Rao et al. demonstrate that convergent somatic hypermutations in the light chain,
enriched within a sarbecovirus-specific public antibody clonotype, drive affinity
maturation. This antibody targets a ...
www.cell.com
August 12, 2025 at 6:52 PM
🚨 New Publication!!!
I’m thrilled to share our latest study, “Clonotype-Enriched Somatic Hypermutations Drive Affinity Maturation of a Public Human Antibody Targeting an Occluded Sarbecovirus Epitope”.
www.cell.com/cell-reports... [1/4]
I’m thrilled to share our latest study, “Clonotype-Enriched Somatic Hypermutations Drive Affinity Maturation of a Public Human Antibody Targeting an Occluded Sarbecovirus Epitope”.
www.cell.com/cell-reports... [1/4]
🧵 New collaborative study just published in Nature Biomedical Engineering:
“A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity”
doi.org/10.1038/s41551-025-01478-6
“A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity”
doi.org/10.1038/s41551-025-01478-6
A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity - Nature Biomedical Engineering
A modular platform for engineering immunogenic lipid nanoparticle mRNA vaccines is used to display antigens from a variety of pathogens to induce antigen responses.
doi.org
August 25, 2025 at 1:41 PM
🧵 New collaborative study just published in Nature Biomedical Engineering:
“A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity”
doi.org/10.1038/s41551-025-01478-6
“A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity”
doi.org/10.1038/s41551-025-01478-6
Reposted by Carolina Lucas
Check our important piece below 👇!
"We urge authors, reviewers, and editors to revise the default use of MSM as an epidemiological label. Our intention is not to dismiss important epidemiological context but to prevent the stigmatization of affected populations."
@thelancetinfdis.bsky.social
"We urge authors, reviewers, and editors to revise the default use of MSM as an epidemiological label. Our intention is not to dismiss important epidemiological context but to prevent the stigmatization of affected populations."
@thelancetinfdis.bsky.social
July 16, 2025 at 2:29 PM
Check our important piece below 👇!
"We urge authors, reviewers, and editors to revise the default use of MSM as an epidemiological label. Our intention is not to dismiss important epidemiological context but to prevent the stigmatization of affected populations."
@thelancetinfdis.bsky.social
"We urge authors, reviewers, and editors to revise the default use of MSM as an epidemiological label. Our intention is not to dismiss important epidemiological context but to prevent the stigmatization of affected populations."
@thelancetinfdis.bsky.social
Words matter. Scientific language shapes public perception and policy. Framing mpox as a disease of GBMSM may have reflected early patterns, but continuing this narrative misrepresents transmission risks and reinforces stigma.
With Camila Coelho, Vries & Zucker 🌈
www.thelancet.com/journals/lan...
With Camila Coelho, Vries & Zucker 🌈
www.thelancet.com/journals/lan...
A call to move beyond MSM-centric framing in mpox research
The resurgence of mpox poses urgent public health challenges, and the scientific community
has mobilised admirably to understand its transmission, immunity, and therapeutics.1,2
However, the language ...
www.thelancet.com
July 16, 2025 at 2:07 PM
Words matter. Scientific language shapes public perception and policy. Framing mpox as a disease of GBMSM may have reflected early patterns, but continuing this narrative misrepresents transmission risks and reinforces stigma.
With Camila Coelho, Vries & Zucker 🌈
www.thelancet.com/journals/lan...
With Camila Coelho, Vries & Zucker 🌈
www.thelancet.com/journals/lan...
Reposted by Carolina Lucas
Day 3: Carolina Lucas (Yale) @carolilucas.bsky.social discussing with students and postdocs how her research in immunity to viruses (especially emerging pathogens) shifted from mouse to human systems & the surprises along the way.
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/events/
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/events/
July 2, 2025 at 11:38 PM
Day 3: Carolina Lucas (Yale) @carolilucas.bsky.social discussing with students and postdocs how her research in immunity to viruses (especially emerging pathogens) shifted from mouse to human systems & the surprises along the way.
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/events/
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/events/
Reposted by Carolina Lucas
Our April issue is now online:
www.thelancet.com/journals/lan...
Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #SARS-CoV-2 #COVID-19 #chikungunya #Neisseria #CHIM #mpox #BSI #Ecoli #Klebsiella #Mycoplasma
#IDSky #ClinMicro #OA
www.thelancet.com/journals/lan...
Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #SARS-CoV-2 #COVID-19 #chikungunya #Neisseria #CHIM #mpox #BSI #Ecoli #Klebsiella #Mycoplasma
#IDSky #ClinMicro #OA
April 1, 2025 at 7:38 AM
Our April issue is now online:
www.thelancet.com/journals/lan...
Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #SARS-CoV-2 #COVID-19 #chikungunya #Neisseria #CHIM #mpox #BSI #Ecoli #Klebsiella #Mycoplasma
#IDSky #ClinMicro #OA
www.thelancet.com/journals/lan...
Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #SARS-CoV-2 #COVID-19 #chikungunya #Neisseria #CHIM #mpox #BSI #Ecoli #Klebsiella #Mycoplasma
#IDSky #ClinMicro #OA
Reposted by Carolina Lucas
New research article
The impact of #orthopoxvirus vaccination and #Mpox infection on cross-protective immunity: a multicohort observational study
www.thelancet.com/journals/lan...
#IDSky #ViroSky #ClinMicro #OpenAccess #OA
The impact of #orthopoxvirus vaccination and #Mpox infection on cross-protective immunity: a multicohort observational study
www.thelancet.com/journals/lan...
#IDSky #ViroSky #ClinMicro #OpenAccess #OA
April 28, 2025 at 2:54 PM
New research article
The impact of #orthopoxvirus vaccination and #Mpox infection on cross-protective immunity: a multicohort observational study
www.thelancet.com/journals/lan...
#IDSky #ViroSky #ClinMicro #OpenAccess #OA
The impact of #orthopoxvirus vaccination and #Mpox infection on cross-protective immunity: a multicohort observational study
www.thelancet.com/journals/lan...
#IDSky #ViroSky #ClinMicro #OpenAccess #OA
🚨 Our new study is live in The Lancet Microbe!
“The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study” Led by @jaycrandell.bsky.social , Valter Monteiro and Lauren Pischel
www.sciencedirect.com/science/arti...
A thread 🧵!
“The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study” Led by @jaycrandell.bsky.social , Valter Monteiro and Lauren Pischel
www.sciencedirect.com/science/arti...
A thread 🧵!
The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study
Cross-reactive immune memory responses to orthopoxviruses in humans remain poorly characterised despite their relevance for vaccine design and outbrea…
www.sciencedirect.com
April 28, 2025 at 7:01 PM
🚨 Our new study is live in The Lancet Microbe!
“The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study” Led by @jaycrandell.bsky.social , Valter Monteiro and Lauren Pischel
www.sciencedirect.com/science/arti...
A thread 🧵!
“The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study” Led by @jaycrandell.bsky.social , Valter Monteiro and Lauren Pischel
www.sciencedirect.com/science/arti...
A thread 🧵!
Reposted by Carolina Lucas
March 10, 2025 at 5:12 PM
Reposted by Carolina Lucas
“Americans who value the spirit of discovery — and eagerly await new ways to confront disease, strengthen our economy and improve the quality of human life — need to issue a strong outcry… This is not a fight that our country can afford to lose.” Indeed
www.nytimes.com/2025/02/14/o...
www.nytimes.com/2025/02/14/o...
Opinion | American Science is Under Attack
The Trump administration hobbles research and endangers the public health.
www.nytimes.com
February 15, 2025 at 12:55 PM
“Americans who value the spirit of discovery — and eagerly await new ways to confront disease, strengthen our economy and improve the quality of human life — need to issue a strong outcry… This is not a fight that our country can afford to lose.” Indeed
www.nytimes.com/2025/02/14/o...
www.nytimes.com/2025/02/14/o...
Reposted by Carolina Lucas
Use this form to tell us how the new US administration is affecting your research, or suggest future coverage
https://go.nature.com/4aYn9Me
https://go.nature.com/4aYn9Me
Are the Trump team’s actions affecting your research? How to contact Nature
Use this form to share information with Nature’s news team, or to make suggestions for future coverage.
go.nature.com
February 15, 2025 at 12:26 PM
Use this form to tell us how the new US administration is affecting your research, or suggest future coverage
https://go.nature.com/4aYn9Me
https://go.nature.com/4aYn9Me
Reposted by Carolina Lucas
The set up:
"This extensive use of antibiotics is based on the assumption that, other than toxicity issues when used in large doses, antibiotics disrupt biological processes in microbes and not the host."
www.science.org/doi/10.1126/...
"This extensive use of antibiotics is based on the assumption that, other than toxicity issues when used in large doses, antibiotics disrupt biological processes in microbes and not the host."
www.science.org/doi/10.1126/...
Antibiotics damage the colonic mucus barrier in a microbiota-independent manner
Antibiotics inhibit production of the protective mucus in the colon, thus predisposing to gut inflammation.
www.science.org
December 8, 2024 at 12:18 PM
The set up:
"This extensive use of antibiotics is based on the assumption that, other than toxicity issues when used in large doses, antibiotics disrupt biological processes in microbes and not the host."
www.science.org/doi/10.1126/...
"This extensive use of antibiotics is based on the assumption that, other than toxicity issues when used in large doses, antibiotics disrupt biological processes in microbes and not the host."
www.science.org/doi/10.1126/...
Reposted by Carolina Lucas
For those wondering why we seem to be so behind when it comes to effective mucosal vaccines against respiratory viruses, this really excellent overview from leaders in the field offers a great summary:
www.nature.com/articles/s41...
few additional points for those who want a bit more detail🧵:
www.nature.com/articles/s41...
few additional points for those who want a bit more detail🧵:
Challenges for developing broad-based mucosal vaccines for respiratory viruses - Nature Biotechnology
Nature Biotechnology - Challenges for developing broad-based mucosal vaccines for respiratory viruses
www.nature.com
December 7, 2024 at 2:41 PM
For those wondering why we seem to be so behind when it comes to effective mucosal vaccines against respiratory viruses, this really excellent overview from leaders in the field offers a great summary:
www.nature.com/articles/s41...
few additional points for those who want a bit more detail🧵:
www.nature.com/articles/s41...
few additional points for those who want a bit more detail🧵:
Reposted by Carolina Lucas
So we haven’t seen this occur in nature and there are other hurdles H5N1 would have to surmount to efficiently spread human to human. www.science.org/doi/10.1126/...
A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors
In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-to-h...
www.science.org
December 6, 2024 at 11:35 AM
So we haven’t seen this occur in nature and there are other hurdles H5N1 would have to surmount to efficiently spread human to human. www.science.org/doi/10.1126/...
Reposted by Carolina Lucas
ICYMI: Analysis of blood serum found #LongCOVID was characterized by altered levels of certain immune complement proteins. These changes linked to complement activation and signs of dysregulation of the coagulation system. #Immunosky
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
Analysis of blood revealed that Long COVID is characterized by changes to complement proteins and platelet activation.
www.science.org
December 2, 2024 at 6:14 PM
ICYMI: Analysis of blood serum found #LongCOVID was characterized by altered levels of certain immune complement proteins. These changes linked to complement activation and signs of dysregulation of the coagulation system. #Immunosky
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Carolina Lucas
Fascinating new paper about how commensal #fungi can promote #type2 responses in mice, a process involving fungal induction of #IL-33 🍄 🧪 #ImmunoSky www.nature.com/articles/s41...
Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature
Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.
www.nature.com
November 29, 2024 at 12:05 PM
Fascinating new paper about how commensal #fungi can promote #type2 responses in mice, a process involving fungal induction of #IL-33 🍄 🧪 #ImmunoSky www.nature.com/articles/s41...
Reposted by Carolina Lucas
✨ Ever wondered why B cells are so fond of IL-2? Wonder no more! Our study is now published in Immunity @cellpress.bsky.social 🔍📑 A truly perfect Thanksgiving gift! 🧑🔬💉🔬https://authors.elsevier.com/c/1kAq43qNrUxuTR
November 28, 2024 at 7:33 PM
✨ Ever wondered why B cells are so fond of IL-2? Wonder no more! Our study is now published in Immunity @cellpress.bsky.social 🔍📑 A truly perfect Thanksgiving gift! 🧑🔬💉🔬https://authors.elsevier.com/c/1kAq43qNrUxuTR
Reposted by Carolina Lucas
The danger theory of immunity strikes back... rdcu.be/d1uQN
November 26, 2024 at 6:13 PM
The danger theory of immunity strikes back... rdcu.be/d1uQN
Reposted by Carolina Lucas
The measles vaccine is given as a shot but it is surprisingly good at inducing protective immunity in the respiratory tract (mucosal IgA). Our new study provides some clues about why...a thread (1/8) #IDSky #MedSky #lungs #immunology #ImmunoSky academic.oup.com/jid/advance-...
Validate User
academic.oup.com
November 25, 2024 at 3:05 PM
The measles vaccine is given as a shot but it is surprisingly good at inducing protective immunity in the respiratory tract (mucosal IgA). Our new study provides some clues about why...a thread (1/8) #IDSky #MedSky #lungs #immunology #ImmunoSky academic.oup.com/jid/advance-...
Reposted by Carolina Lucas
Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏
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🦠🧪🧫🧬
November 10, 2024 at 1:13 PM
Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏
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🦠🧪🧫🧬
🧪Today, our lab group decided to take a break from scientific experiments and embrace tranquility with some llama yoga! Lhamaste🦙🧘♂️
November 20, 2024 at 12:58 PM
🧪Today, our lab group decided to take a break from scientific experiments and embrace tranquility with some llama yoga! Lhamaste🦙🧘♂️
The COVID-19 pandemic is now more challenging due to the Omicron variants. Robust public health measures, research and global cooperation are critical in addressing this crisis. Our recent @ScienceTM study is particularly important for countries relying on CoronaVac vaccines👇👇
November 20, 2024 at 12:58 PM
The COVID-19 pandemic is now more challenging due to the Omicron variants. Robust public health measures, research and global cooperation are critical in addressing this crisis. Our recent @ScienceTM study is particularly important for countries relying on CoronaVac vaccines👇👇
In case you were wondering how a lab with Brazilians looks like during the World Cup 🏆…
November 20, 2024 at 12:58 PM
In case you were wondering how a lab with Brazilians looks like during the World Cup 🏆…
Our newest study is out! We report an age-dependent impairment in antibody responses elicited by homologous, but not heterologous CoronaVac booster dose during the Omicron wave.
https://www.medrxiv.org/content/10.1101/2022.10.04.22280704v1
Special thanks to @mab_sp125 @ValterVSM and...
https://www.medrxiv.org/content/10.1101/2022.10.04.22280704v1
Special thanks to @mab_sp125 @ValterVSM and...
Age-dependent impairment in antibody responses elicited b...
The emergence of the SARS-CoV-2 Omicron sublineages resul...
www.medrxiv.org
November 20, 2024 at 12:59 PM
Our newest study is out! We report an age-dependent impairment in antibody responses elicited by homologous, but not heterologous CoronaVac booster dose during the Omicron wave.
https://www.medrxiv.org/content/10.1101/2022.10.04.22280704v1
Special thanks to @mab_sp125 @ValterVSM and...
https://www.medrxiv.org/content/10.1101/2022.10.04.22280704v1
Special thanks to @mab_sp125 @ValterVSM and...