4/ Structural studies revealed all 3 mAbs target a highly conserved epitope in the A35 dimer groove, shared across orthopoxviruses. This explains their breadth and potency.

3/ These A35-specific mAbs:

• Block viral spread in vitro
• Protect mice from lethal mpox & vaccinia infection
• Function via viral spread block + Fc-dependent mechanisms

2/ From an mpox-convalescent individual, we isolated 3 human monoclonal antibodies (mAbs) (EV35-2, EV35-6, EV35-7) that target the extracellular virion protein A35, essential for viral spread.

🚨New Paper in Cell 🧵🔎

Happy to share our work led by the @camilahcoelho.bsky.social, on mAbs against mpox.

We were very excited (and lucky!) to contribute to this collab. effort.

🦠“Human monoclonal antibodies targeting A35 protect from death caused by mpox”🦠
doi.org/10.1016/j.cell.2025.08.004

Our study looked at the blood of people who got CoronaVac and then got a booster shot of either CoronaVac, Pfizer or AstraZeneca.

All three booster increased the levels of IgG antibodies in the blood, but people who got the same vaccine for their booster shot had lower levels.

I would like to thank our Yale, Dominican Republic 🇩🇴and Brazilian 🇧🇷collaborators.

🚨Hiring opportunities coming soon🚨

Nessa versão,⬆️ o n do estudo e incluímos analises temporais.

1⃣O tempo entre a 2 e 3 dose vacinal tem implicações no título de anticorpos neutralizantes gerados após a terceira dose? (40-140 dias)
Não! O intervalo entre a 2 e 3 dose não impactam no título de NAbs

4⃣No entanto, apesar desse aumento, os niveis de anticorpos neutralizantes ainda estao reduzidos 6.3 e 2.7 vezes para Omicron em comparação com o virus ancestral ou Delta.

4⃣ However, despite this increase, neutralizing antibody titers were reduced by 7.3-fold and 2.7-fold for Omicron compared to ancestral virus and Delta variant, respectively.