Andrew S. MacDonald
@profandrewmac.bsky.social
Prof at Edinburgh University. #Immunologist. #Inflammation, #infection, #helminths, #allergy, #metabolism and the #microbiome.
https://scholar.google.com/citations?user=gcuDni4AAAAJ&hl=en&oi=ao
Not interested in pitchfork politics of any flavour…
https://scholar.google.com/citations?user=gcuDni4AAAAJ&hl=en&oi=ao
Not interested in pitchfork politics of any flavour…
Reposted by Andrew S. MacDonald
#TissueTregs have now been found in essentially all tissues, and have broadly conserved properties of enhancing repair and rejuvenation as well as controlling local inflammation. While the impact on tissues differ, molecular mediators are largely shared across tissues.
February 16, 2026 at 9:56 AM
#TissueTregs have now been found in essentially all tissues, and have broadly conserved properties of enhancing repair and rejuvenation as well as controlling local inflammation. While the impact on tissues differ, molecular mediators are largely shared across tissues.
Reposted by Andrew S. MacDonald
-> 𝗥𝗲𝗴𝗶𝘀𝘁𝗿𝗮𝘁𝗶𝗼𝗻 and 𝗔𝗯𝘀𝘁𝗿𝗮𝗰𝘁 𝘀𝘂𝗯𝗺𝗶𝘀𝘀𝗶𝗼𝗻 for BSP 2026 in Glasgow are open!
The deadline for abstracts for oral presentations is 17 February while the deadline for poster abstracts is 28 February.
lnkd.in/eJqXD3DY
The deadline for abstracts for oral presentations is 17 February while the deadline for poster abstracts is 28 February.
lnkd.in/eJqXD3DY
January 30, 2026 at 10:35 AM
-> 𝗥𝗲𝗴𝗶𝘀𝘁𝗿𝗮𝘁𝗶𝗼𝗻 and 𝗔𝗯𝘀𝘁𝗿𝗮𝗰𝘁 𝘀𝘂𝗯𝗺𝗶𝘀𝘀𝗶𝗼𝗻 for BSP 2026 in Glasgow are open!
The deadline for abstracts for oral presentations is 17 February while the deadline for poster abstracts is 28 February.
lnkd.in/eJqXD3DY
The deadline for abstracts for oral presentations is 17 February while the deadline for poster abstracts is 28 February.
lnkd.in/eJqXD3DY
Reposted by Andrew S. MacDonald
On World NTD Day, we are highlighting innovative approaches to fighting NTDs.
A recent paper from Swiss TPH shows the potential repurposing of tuberculosis drug candidates to fight Buruli ulcer, a chronic skin disease caused by M. ulcerans.
👉Read more: bit.ly/47WdrXA
A recent paper from Swiss TPH shows the potential repurposing of tuberculosis drug candidates to fight Buruli ulcer, a chronic skin disease caused by M. ulcerans.
👉Read more: bit.ly/47WdrXA
January 30, 2024 at 10:12 AM
On World NTD Day, we are highlighting innovative approaches to fighting NTDs.
A recent paper from Swiss TPH shows the potential repurposing of tuberculosis drug candidates to fight Buruli ulcer, a chronic skin disease caused by M. ulcerans.
👉Read more: bit.ly/47WdrXA
A recent paper from Swiss TPH shows the potential repurposing of tuberculosis drug candidates to fight Buruli ulcer, a chronic skin disease caused by M. ulcerans.
👉Read more: bit.ly/47WdrXA
Reposted by Andrew S. MacDonald
Two decades of progress against neglected tropical diseases are now at risk – from funding cuts, climate change, and conflict. This World NTD Day, we must protect progress, unlock financing, and accelerate action.
#WorldNTDDay #BeatNTD
#WorldNTDDay #BeatNTD
January 29, 2026 at 7:40 PM
Two decades of progress against neglected tropical diseases are now at risk – from funding cuts, climate change, and conflict. This World NTD Day, we must protect progress, unlock financing, and accelerate action.
#WorldNTDDay #BeatNTD
#WorldNTDDay #BeatNTD
Reposted by Andrew S. MacDonald
🤩 Thrilled our research is a JACI Editor's Choice! 🎉
We identified distinct protein fingerprints (GDNF/CLC) for noninvasive diagnosis of chronic rhinosinusitis with nasal polyps (DOI: 10.1016/j.jaci.2025.08.025)🔬
#CRS #PrecisionMedicine #Proteomics #Immunology
🔗 ino.to/wu9XyBl
We identified distinct protein fingerprints (GDNF/CLC) for noninvasive diagnosis of chronic rhinosinusitis with nasal polyps (DOI: 10.1016/j.jaci.2025.08.025)🔬
#CRS #PrecisionMedicine #Proteomics #Immunology
🔗 ino.to/wu9XyBl
January 27, 2026 at 7:39 AM
🤩 Thrilled our research is a JACI Editor's Choice! 🎉
We identified distinct protein fingerprints (GDNF/CLC) for noninvasive diagnosis of chronic rhinosinusitis with nasal polyps (DOI: 10.1016/j.jaci.2025.08.025)🔬
#CRS #PrecisionMedicine #Proteomics #Immunology
🔗 ino.to/wu9XyBl
We identified distinct protein fingerprints (GDNF/CLC) for noninvasive diagnosis of chronic rhinosinusitis with nasal polyps (DOI: 10.1016/j.jaci.2025.08.025)🔬
#CRS #PrecisionMedicine #Proteomics #Immunology
🔗 ino.to/wu9XyBl
Reposted by Andrew S. MacDonald
hard times in UK for research sector as MRC have announced a funding pause in light of the science secretary announcing an overhaul of how the agency would divide its budget which will dramatically change research....🧪🧵
UKRI pauses several funding calls amid priorities shake-up - Research Professional News
“Period of transition” at funding agency sees some Medical Research Council funding opportunities on hiatus
www.researchprofessionalnews.com
January 26, 2026 at 4:57 PM
hard times in UK for research sector as MRC have announced a funding pause in light of the science secretary announcing an overhaul of how the agency would divide its budget which will dramatically change research....🧪🧵
Lovely to catch up with some of the Manchester crew this afternoon, including new addition Maya 👶, for a Christmas get together 😊🎄🎅🏻 @lydiabeckeriii.bsky.social
December 15, 2025 at 5:00 PM
Lovely to catch up with some of the Manchester crew this afternoon, including new addition Maya 👶, for a Christmas get together 😊🎄🎅🏻 @lydiabeckeriii.bsky.social
Reposted by Andrew S. MacDonald
Its my great pleasure to say the latest paper from our group is now out: www.mucosalimmunology.org/article/S193...
Check it out! We found that immune cell activation in the sputum identifies severe asthma patients. Massive thanks to the patients for agreeing to give sputum and blood samples.
Check it out! We found that immune cell activation in the sputum identifies severe asthma patients. Massive thanks to the patients for agreeing to give sputum and blood samples.
Activation status of airway immune cells is a defining feature of severe asthma, regardless of fungal sensitisation
Global estimates of asthma prevalence are rising, with an estimated 262 million affected
individuals in 2019.1 Purported reasons for this rapid rise include urbanisation of
lower- and middle-income co...
www.mucosalimmunology.org
December 3, 2025 at 7:51 AM
Its my great pleasure to say the latest paper from our group is now out: www.mucosalimmunology.org/article/S193...
Check it out! We found that immune cell activation in the sputum identifies severe asthma patients. Massive thanks to the patients for agreeing to give sputum and blood samples.
Check it out! We found that immune cell activation in the sputum identifies severe asthma patients. Massive thanks to the patients for agreeing to give sputum and blood samples.
Reposted by Andrew S. MacDonald
Birds but they get spookier each time. 🎃👻
Enter if you dare...🚪
Enter if you dare...🚪
October 31, 2025 at 9:24 AM
Birds but they get spookier each time. 🎃👻
Enter if you dare...🚪
Enter if you dare...🚪
Reposted by Andrew S. MacDonald
Here in the uk, the government has found that £1 of spending on R&D results in £8 of benefit: www.gov.uk/government/p...
The value of public R&D
www.gov.uk
October 30, 2025 at 10:53 PM
Here in the uk, the government has found that £1 of spending on R&D results in £8 of benefit: www.gov.uk/government/p...
Reposted by Andrew S. MacDonald
Insights from Andrea Cooper: Mtb drives expression of type I IFN–mediated #neutrophil accumulation, which limits interaction btwn CD4 T cells & macrophages. Failure to limit type I IFN very early in the process allows rapid progression of disease rupress.org/jem/article/...
#Tuberculosis
#Tuberculosis
October 28, 2025 at 4:01 PM
Insights from Andrea Cooper: Mtb drives expression of type I IFN–mediated #neutrophil accumulation, which limits interaction btwn CD4 T cells & macrophages. Failure to limit type I IFN very early in the process allows rapid progression of disease rupress.org/jem/article/...
#Tuberculosis
#Tuberculosis
Reposted by Andrew S. MacDonald
Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.
NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM
#structuralimmunity #immunosky
#structuralimmunity #immunosky
Structural immunity: immune cells as architects of tissue barriers - Nature Reviews Immunology
This Perspective presents a framework of ‘structural immunity’ that positions immune cells as architects of tissue structure. Beyond their roles in antimicrobial defence, we posit that immune cells co...
www.nature.com
October 28, 2025 at 4:41 PM
Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.
Reposted by Andrew S. MacDonald
Delighted to share this story from my PhD! 🎉 🪱
Latest McSorley lab paper is out! Led by Vivien @vshek.bsky.social, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta www.sciencedirect.com/science/arti...
September 29, 2025 at 7:36 AM
Delighted to share this story from my PhD! 🎉 🪱
Reposted by Andrew S. MacDonald
In schistosome 🪱-endemic areas, people are repeatedly reinfected — but we still don’t fully understand how T cell responses develop in these cycles.
In my first ever last-author paper (😱) we investigate this, comparing endemic and repeat controlled human schistosome infection: rdcu.be/exH58
In my first ever last-author paper (😱) we investigate this, comparing endemic and repeat controlled human schistosome infection: rdcu.be/exH58
T cell responses in repeated controlled human schistosome infection compared to natural exposure
Nature Communications - In schistosomiasis-endemic regions, the cyclical nature of infection and treatment complicates understanding of host immune responses. Repeated controlled human Schistosoma...
rdcu.be
July 31, 2025 at 3:15 PM
In schistosome 🪱-endemic areas, people are repeatedly reinfected — but we still don’t fully understand how T cell responses develop in these cycles.
In my first ever last-author paper (😱) we investigate this, comparing endemic and repeat controlled human schistosome infection: rdcu.be/exH58
In my first ever last-author paper (😱) we investigate this, comparing endemic and repeat controlled human schistosome infection: rdcu.be/exH58
Reposted by Andrew S. MacDonald
🚨 Want to find interesting cells in single-cell RNAseq data independently of clusters? Try our method to identify transcriptional shifts using OAR scores!
Pre-print: doi.org/10.1101/2025...
R tool and tutorials: sanin-lab.github.io/OARscRNA/
@biorxiv-bioinfo.bsky.social
1/n
Pre-print: doi.org/10.1101/2025...
R tool and tutorials: sanin-lab.github.io/OARscRNA/
@biorxiv-bioinfo.bsky.social
1/n
Missing data in single-cell transcriptomes reveals transcriptional shifts
Profiling thousands of single cell transcriptomes is routine, yet cell prioritization based on response to biological perturbations is challenging and confounded by clustering, normalization and dimen...
doi.org
August 22, 2025 at 2:11 AM
🚨 Want to find interesting cells in single-cell RNAseq data independently of clusters? Try our method to identify transcriptional shifts using OAR scores!
Pre-print: doi.org/10.1101/2025...
R tool and tutorials: sanin-lab.github.io/OARscRNA/
@biorxiv-bioinfo.bsky.social
1/n
Pre-print: doi.org/10.1101/2025...
R tool and tutorials: sanin-lab.github.io/OARscRNA/
@biorxiv-bioinfo.bsky.social
1/n
Reposted by Andrew S. MacDonald
Aberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...
Lecturer in Neuroimmunology, Medicine, Medical Sciences & Nutrition (MED243A) | The University of Aberdeen
Browse and apply for current job openings at the University of Aberdeen across various schools, departments and roles, including admin and academic.
www.abdn.ac.uk
September 19, 2025 at 7:55 AM
Aberdeen is hiring - Neuroimmunology Lectureship! Really exciting opportunity to join our supportive, collaborative and multidisciplinary Institute to carry out cutting edge translation research. Not to mention the scenery in the North East of Scotland is amazing www.abdn.ac.uk/jobs/vacanci...
Reposted by Andrew S. MacDonald
Fantastic thread on budgeting from @labliston.bsky.social . Great advice for new (and not so new!) PIs. I would add awareness of how psychology impacts spending based on moving from low budget to high budget setting and vice versa....
🧵How to write and manage your first research budgets
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
September 20, 2025 at 8:15 AM
Fantastic thread on budgeting from @labliston.bsky.social . Great advice for new (and not so new!) PIs. I would add awareness of how psychology impacts spending based on moving from low budget to high budget setting and vice versa....
Reposted by Andrew S. MacDonald
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
currentprotocols.onlinelibrary.wiley.com
September 19, 2025 at 2:39 PM
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Andrew S. MacDonald
A massive thanks to all the #EMDS2025 speakers, delegates, sponsors & @edinburgh-uni.bsky.social staff for making @emds2025.bsky.social such a success.
We had a great time, we hope you did too and your travel home was smooth.
Here's to #EMDS2026 in Amsterdam @immunometlab.bsky.social
We had a great time, we hope you did too and your travel home was smooth.
Here's to #EMDS2026 in Amsterdam @immunometlab.bsky.social
September 19, 2025 at 2:57 PM
A massive thanks to all the #EMDS2025 speakers, delegates, sponsors & @edinburgh-uni.bsky.social staff for making @emds2025.bsky.social such a success.
We had a great time, we hope you did too and your travel home was smooth.
Here's to #EMDS2026 in Amsterdam @immunometlab.bsky.social
We had a great time, we hope you did too and your travel home was smooth.
Here's to #EMDS2026 in Amsterdam @immunometlab.bsky.social
The end of #EMDS2025 - so much amazing science, and great to meet up in person with so many friends and colleagues (and make some new ones!). Very proud of @vshek.bsky.social and @nwasowska.bsky.social winning poster prizes for the team - well done both!
September 18, 2025 at 5:14 PM
The end of #EMDS2025 - so much amazing science, and great to meet up in person with so many friends and colleagues (and make some new ones!). Very proud of @vshek.bsky.social and @nwasowska.bsky.social winning poster prizes for the team - well done both!
A fantastic talk from David Russell to end #EMDS2025 - about #macrophage subset responses to #Mycobaterium tuberculosis, and their re-programming to improve drug efficacy in vitro and in vivo
September 18, 2025 at 5:01 PM
A fantastic talk from David Russell to end #EMDS2025 - about #macrophage subset responses to #Mycobaterium tuberculosis, and their re-programming to improve drug efficacy in vitro and in vivo
Reposted by Andrew S. MacDonald
A cracking meal complete with piper & Ceilidh to round off the second day of #EMDS2025 in #Edinburgh
September 17, 2025 at 11:37 PM
A cracking meal complete with piper & Ceilidh to round off the second day of #EMDS2025 in #Edinburgh
Reposted by Andrew S. MacDonald
Heading home after a fabulous few days in Edinburgh @emds2025.bsky.social Excellent venue, amazing programme, thanks @bainlab.bsky.social @profandrewmac.bsky.social and Samanta Mariani #EMDS2025 #Macrophage #DCs ♥️
September 18, 2025 at 2:28 PM
Heading home after a fabulous few days in Edinburgh @emds2025.bsky.social Excellent venue, amazing programme, thanks @bainlab.bsky.social @profandrewmac.bsky.social and Samanta Mariani #EMDS2025 #Macrophage #DCs ♥️
Beautiful data from Franca Ronchese, all the way from @malaghan.bsky.social in New Zealand, about generation and function of subsets of skin #DendriticCells in #allergic responses #EMDS2025
September 18, 2025 at 10:46 AM
Beautiful data from Franca Ronchese, all the way from @malaghan.bsky.social in New Zealand, about generation and function of subsets of skin #DendriticCells in #allergic responses #EMDS2025
Another great talk from @immunobladder.bsky.social about #macrophage subsets in the #bladder, including in memory response to bacterial infection and key differences in males vs females #EMDS2025
September 18, 2025 at 10:38 AM
Another great talk from @immunobladder.bsky.social about #macrophage subsets in the #bladder, including in memory response to bacterial infection and key differences in males vs females #EMDS2025