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viennaairwaylab.bsky.social
Vienna Airway Lab
@viennaairwaylab.bsky.social
Immunology | Allergology | Type 2 Inflammation | Chronic Rhinosinusitis

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📷 instagram.com/viairlab
🔬 Run by dedicated Lab Members 🇦🇹 🇬🇧 🇪🇹 🇸🇾 🇬🇷 🇨🇳🇪‌🇱‌ 🏳️‍🌈
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Hello Bluesky!
We are very pleased to join you all here and are looking forward to a fun and inspirational time 😃
We are interested in immunology, specifically in the upper airway #ENT #ImmunoSky #MedSky #Mucosalimmunity #AcademicSky

Have a productive day everyone 🤗
In severe asthma, type 2 cytokines (IL-5/IL-4) drive harmful eosinophil inflammation. A multi-omics study shows all-trans retinoic acid (ATRA) counteracts this and maintains eosinophil homeostasis, offering novel insights and therapeutic hopes.

#Immunology #asthma #type2

🔗 doi.org/10.1016/j.ja...
November 11, 2025 at 8:24 AM
Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness ino.to/fg4HeLH
Peanut allergy oral immunotherapy drives single-cell multi-omic changes in peanut-reactive T cells associated with sustained unresponsiveness - Nature Immunology
Peanut oral immunotherapy reshapes T cell responses, suppressing allergy-associated type 2 helper T cells and boosting cytotoxic type 1 helper T cells, offering clues to long-term tolerance.
ino.to
November 6, 2025 at 8:26 PM
New murine study reveals characteristics of mature IgE PCs and localizes long-lived IgE PCs in the spleen in addition to bone marrow.
🔗 cell.com/immunity/fulltext/S1074-7613(25)00465-0
Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response
Allergies can persist even in the absence of allergen exposure. Miranda-Waldetario et al. find that IgE-producing plasma cells mature, acquire survival adaptations, and persist for extended periods of...
cell.com
November 3, 2025 at 6:28 AM
📣 Join our webinar 🖥️ today to hear about biomarkers 🧬 of #NRF2 activation and their role in fighting chronic diseases 💊

@benbedphar.bsky.social
#BenBedPhar #COST #NRF2 #redox

🔗 www.antiox.it/webinars2025...
October 28, 2025 at 6:19 AM
Reposted by Vienna Airway Lab
DOPAC, a microbial metabolite of quercetin, enhances CD8+ T cell-mediated anti-tumor immunity by activating NRF2-driven mitophagy, thereby improving T cell fitness and potentiating the response to immune checkpoint blockade @cp-cellmetabolism.bsky.social
www.cell.com/cell-metabol...
Quercetin-derived microbial metabolite DOPAC potentiates CD8+ T cell anti-tumor immunity via NRF2-mediated mitophagy
DOPAC, a microbial metabolite of quercetin, enhances CD8+ T cell-mediated anti-tumor immunity by activating NRF2-driven mitophagy, thereby improving T cell fitness and potentiating the response to imm...
www.cell.com
October 28, 2025 at 2:36 AM
Reposted by Vienna Airway Lab
Great energy at the COST Action BenBedPhar meeting in Istanbul! Researchers from across Europe discussed the latest on NRF2 and its translational potential in chronic diseases. Collaboration, science & progress at their best! 💡
#BenBedPhar #NRF2 #Science
October 20, 2025 at 7:34 AM
📣 Newsletter alert: Check out the latest and sadly the last newsletter 🗞️ by @benbedphar.bsky.social COST Action CA20121 on recent cutting-edge #NRF2 research 🔬. Don't miss it 🎉
#BenBedPhar #EU #COSTaction #OxidativeStress

🔗 benbedphar.org/issue-13-oct...
Issue 13, October 2025 - BenBedPhar
NRF2 in COST Action 20121 Our quarterly newsletter attempts to provide our latest news and also aims at becoming a forum for analysis of relevant topics on the field of NRF2 and provide comments to so...
benbedphar.org
October 23, 2025 at 4:17 PM
Reposted by Vienna Airway Lab
Eosinophil-derived IL-24 compromises epithelial integrity and aggravates airway remodeling in mouse models of allergic asthma @natcomms.nature.com
www.nature.com/articles/s41...
October 21, 2025 at 1:51 AM
Reposted by Vienna Airway Lab
TGFb mediates #macrophage specialisation and crosstalk with sensory #nerves in the #skin after injury. A beautiful study by Julia Kolter, Philipp Henneke and colleagues published in @cp-immunity.bsky.social #immunosky

www.cell.com/immunity/ful...
Sensory neurons shape local macrophage identity via TGF-β signaling
Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local i...
www.cell.com
October 16, 2025 at 9:00 AM
📚 Our new review is out! @benbedphar.bsky.social WG3 dives deep into measuring #NRF2 activity across diseases and how to translate these biomarkers into clinical practice for better patient care.
Massive thanks to the fantastic team behind this work! 🙌
#NCD #COST #stress

🔗 doi.org/10.1016/j.re...
October 14, 2025 at 7:46 AM
Great to be part of the United Airways Symposium in Linz!
I spoke about “Epithelium as the starting point of inflammation in the upper and lower respiratory tract.”
Thanks to Prof. Lamprecht and AstraZeneca for a well-organized and inspiring event.
#UnitedAirways #medsky #medunivienna
October 13, 2025 at 6:23 AM
A fantastic finale at Kadir Has Istanbul for the #BenBedPhar MC&Scientific Meeting. Delivered WG3 report, presented our new research, and chaired #NRF2 scientific session. Grateful for an incredible 4 years with this brilliant #COST Action community—a truly unique journey 🎉
@benbedphar.bsky.social
October 11, 2025 at 2:10 PM
A 16-week #dupilumab 💊 regimen for young kids with eczema restored skin barrier and suppressed local Th2 inflammation 🔥, with machine learning pinpointing new redox-related treatment targets 🎉
#Immunology #biologics #type2immunity #redox #ML

🔗 ino.to/2rLyiTE
Dupilumab in Children Under 6 Years With Moderate‐to‐Severe Atopic Dermatitis: A 16‐Week Real‐World Prospective Study on Efficacy, Safety, and Local‐Systemic Immune Responses
Sixteen-week dupilumab improved clinical outcomes in young children with AD, restoring skin barrier and suppressing local Th2 inflammation. However, persistent systemic inflammation suggests a need f...
ino.to
October 8, 2025 at 9:59 AM
Reposted by Vienna Airway Lab
Thrilled to see immunological research recognized with this year’s #NobelPrize! ✨
Congratulations to the laureates, Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi, for their discoveries on peripheral immune tolerance—a landmark achievement for #immunology!
www.nobelprize.org/prizes/medic...
Nobel Prize in Physiology or Medicine 2025
The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
www.nobelprize.org
October 6, 2025 at 12:00 PM
To optimise treatment for chronic rhinosinusitis with polyps, precise diagnosis is key, as Western patients often have Type 2 inflammation (treated with #biologics) while Eastern patients more commonly have non-Type 2 inflammation (use of macrolide antibiotics).
#Immunology #CRSwNP
🔗 ino.to/MJfod3w
Treatment Approach to Chronic Rhinosinusitis Based on Endotype: Difference Between East and West
Heterogeneity among CRSwNP patients in Western and Eastern countries leads to differences in management. Type 2 (T2) inflammation accounts for the majority of CRSwNP patients in Western countries, wh...
ino.to
October 6, 2025 at 7:02 AM
More highlights from the ENT Congress 🇦🇹

Our team contributed across many areas:
🔬 Christina on machine learning in CRS
🤧 Mo on allergies in the upper airway
🧬 Linda on oxidative stress & NRF2 signaling
💡 Sven in clinical dialogue & interactive sessions

#ENT #Allergy #Science #Medicine #Research
September 19, 2025 at 1:16 PM
🇦🇹 First highlight from the Austrian ENT Conference: Vienna Airway Lab!

✨ Tina Bartosik gave a talk in the Allergology session on “Indicating Biologicals – What Role Do Allergies Play?”

🏆 Sven Schneider was elected Chair of the Working Group on Rhinology and Skull Base Surgery.

#ENT #Immunosky
September 18, 2025 at 9:38 AM
🎥 CRS Research in Focus
Christina Morgenstern breaks down her latest study on chronic rhinosinusitis in a short, easy-to-follow video.

📲 Scan the QR code to watch the full video and get a quick overview of the research!
#Immunosky #Medsky
September 18, 2025 at 8:50 AM
🧬 New insights in Immunity: Using single cell RNA sequencing as well as spatial transcriptomics the authors reveal that basal & tuft epithelial populations orchestrate remodeling programs in nasal polyps. Significant step toward unraveling CRS mechanisms.
👉 www.cell.com/immunity/ful...
#immunosky
Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation
Chronic rhinosinusitis (CRS) is driven by poorly understood immune-epithelial crosstalk. Liao et al. present a single-cell and spatial transcriptomic atlas of CRS, revealing how immune and epithelial ...
www.cell.com
September 17, 2025 at 10:50 AM
🎉 Our new paper on proteomic signatures 🧪 and Machine Learning 🖥️ defining Chronic Rhinosinusitis (#CRS) endotypes 👃 is now published in JACI! Dive into the deep science or enjoy the fantastic comic version by Sara Miranda.
#Proteomics #AI #ML #biomarker #Immunology #SciComm

🔗 tinyurl.com/d5eup39j
September 11, 2025 at 3:00 PM
🧬 New issue of HNO (9/2025) focuses on the microbiome – in German and written for doctors.
From the Vienna Airway Lab:
✨ Julia Eckl-Dorna+ Petra Pjevac explain the basics of microbiome research
✨ Tina Bartosik explores the microbiome in nasal diseases

👉 www.springermedizin.de/hno-9-2025/5...
HNO 9/2025
Mikrobiom Das Mikrobiom spielt eine entscheidende Rolle in der HNO-Heilkunde und beeinflusst sowohl lokale als auch systemische Gesundheit. Das aktuelle Themenheft beleuchtet, wie eine Dysbiose Infektionen und Tumoren fördern kann. Von zentraler Bedeutung sind dabei die mikrobielle Vielfalt und das Potenzial mikrobiommodulierender Maßnahmen zur Therapieverbesserung und Risikostratifizierung.
www.springermedizin.de
September 10, 2025 at 1:40 PM
Reposted by Vienna Airway Lab
Constant loss of smell, facial pain and a blocked nose are a reality for the 10 per cent of people living with chronic rhinosinusitis, a disease long-neglected by research. Targeting the nasal microbiome, though, is offering hope.
Can a strange new treatment finally relieve chronic sinus infections?
Constant loss of smell, facial pain and a blocked nose are a reality for the 10 per cent of people living with chronic rhinosinusitis, a disease long-neglected by research. Targeting the nasal microbiome, though, is offering hope
www.newscientist.com
September 9, 2025 at 10:20 AM
Excellent review summarizes the current evidence on omics studies in NSAID‐Exacerbated Respiratory Disease (N-ERD). A systems-level understanding of #N-ERD is definitely necessary to identify biomarkers and novel therapies 💊 for this debilitating disease.

##CRS #omics #ImmunoSky

🔗 ino.to/hiZcmXM
September 9, 2025 at 6:41 AM