On one side: scientists engineering a nasal COVID vaccine that blocks Omicron transmission and boosts mucosal immunity
On the other: people still yelling “just a cold.”
Follow for science > vibes
#COVID19 #MucosalImmunity #VaccinesWork #PublicHealth #NextGenVaccines #MedSky
On the other: people still yelling “just a cold.”
Follow for science > vibes
#COVID19 #MucosalImmunity #VaccinesWork #PublicHealth #NextGenVaccines #MedSky
Intranasal vaccine combining adenovirus and trimeric subunit protein provides superior immunity against SARS-CoV-2 Omicron variant - Nature Biomedical Engineering
A combination of adenovirus-vectored and subunit protein intranasal vaccine enhances immune response against SARS-CoV-2 variants in animal models and humans.
www.nature.com
September 23, 2025 at 3:27 PM
On one side: scientists engineering a nasal COVID vaccine that blocks Omicron transmission and boosts mucosal immunity
On the other: people still yelling “just a cold.”
Follow for science > vibes
#COVID19 #MucosalImmunity #VaccinesWork #PublicHealth #NextGenVaccines #MedSky
On the other: people still yelling “just a cold.”
Follow for science > vibes
#COVID19 #MucosalImmunity #VaccinesWork #PublicHealth #NextGenVaccines #MedSky
#MedSky🧪#IDSky #Microbiology This study provides evidence regarding the critical role played by the degradative capabilities of the #gutmicrobiome in specific aspects of the #mucosalimmunity and intestinal barrier system.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Microbial hoolIgAn dismantles gut defenses
Immunoglobulin degradation by a gut bacterium causes immunodeficiency in mice
www.science.org
September 27, 2024 at 4:56 PM
#MedSky🧪#IDSky #Microbiology This study provides evidence regarding the critical role played by the degradative capabilities of the #gutmicrobiome in specific aspects of the #mucosalimmunity and intestinal barrier system.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Researchers highlight the vital role of #MucosalImmunity, detailing its #lymphoid structures, regulatory mechanisms, and emerging therapies, including #MucosalVaccines and inhalable antibodies. #SARSCoV2 #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
October 10, 2025 at 3:04 PM
Researchers highlight the vital role of #MucosalImmunity, detailing its #lymphoid structures, regulatory mechanisms, and emerging therapies, including #MucosalVaccines and inhalable antibodies. #SARSCoV2 #medsky
#OpenAccess in #STTT: doi.org/10.1038/s413...
#OpenAccess in #STTT: doi.org/10.1038/s413...
#Medsky🧪 #IDsky #virosky #immunosky #mucosalimmunity #publicheath Recent studies on mucosal #COVID vaccines have shown that they induce rapid, but often transient, IgA responses in respiratory secretions,
October 20, 2025 at 5:12 AM
#Medsky🧪 #IDsky #virosky #immunosky #mucosalimmunity #publicheath Recent studies on mucosal #COVID vaccines have shown that they induce rapid, but often transient, IgA responses in respiratory secretions,
#MedSky🧪 #IDsky #Immunosky #Mucosalimmunity overview of antiviral immune responses in the oral cavity in common viral infections & their manifestations in the oral mucosa.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Viral infection and antiviral immunity in the oral cavity - Nature Reviews Immunology
The oral mucosa is a critical barrier tissue that is continually exposed to pathogens, but antiviral immune responses in this tissue are poorly understood. Moreover, recent viral outbreaks, including ...
www.nature.com
November 13, 2024 at 6:05 AM
#MedSky🧪 #IDsky #Immunosky #Mucosalimmunity overview of antiviral immune responses in the oral cavity in common viral infections & their manifestations in the oral mucosa.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MedSky🧪 #IDSky #viralimmunology #immunology #Mucosalimmunity Understanding mucosal #antibody responses from #SARSCoV2 infection and/or #COVID19vaccination is crucial to develop strategies for longer term immunity, especially against emerging viral variants.
October 6, 2023 at 9:18 PM
MedSky🧪 #IDSky #viralimmunology #immunology #Mucosalimmunity Understanding mucosal #antibody responses from #SARSCoV2 infection and/or #COVID19vaccination is crucial to develop strategies for longer term immunity, especially against emerging viral variants.
don’t elicit adequate #mucosalimmunity in the nose & mouth #SARSCoV2 ’s entry points into the body. Once 🦠 slips past those entry points, systemic immunity generated by #COVID19 💉 & previous infections protects against severe disease. @jama.com
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Why COVID-19 Vaccines Don’t Stop Transmission
This Medial News article discusses recent research showing that current COVID-19 vaccines fail to elicit enough of a mucosal immune response to prevent infection.
jamanetwork.com
December 20, 2024 at 5:34 PM
don’t elicit adequate #mucosalimmunity in the nose & mouth #SARSCoV2 ’s entry points into the body. Once 🦠 slips past those entry points, systemic immunity generated by #COVID19 💉 & previous infections protects against severe disease. @jama.com
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
#mucosalimmunity
link.springer.com/article/10.1...
www.mdpi.com/2218-273X/15...
onlinelibrary.wiley.com/doi/full/10....
pmc.ncbi.nlm.nih.gov/articles/PMC...
papers.ssrn.com/sol3/papers....
link.springer.com/article/10.1...
www.mdpi.com/2218-273X/15...
onlinelibrary.wiley.com/doi/full/10....
pmc.ncbi.nlm.nih.gov/articles/PMC...
papers.ssrn.com/sol3/papers....
Viruses and neurodegeneration: a growing concern - Journal of Translational Medicine
Neurodegenerative diseases (NDDs) cause a progressive loss of neurons. Since NDDs are multifactorial, the precise etiology varies on the basis of the type of disease and patient history. Cohort studie...
link.springer.com
May 31, 2025 at 4:13 AM
#Mucosalimmunity in the upper respiratory tract is a first line of defense against respiratory infections. Higher levels of salivary antibodies, especially anti-RBD secretory IgA, are associated with protection against breakthrough #COVID19
October 6, 2023 at 9:22 PM
#Mucosalimmunity in the upper respiratory tract is a first line of defense against respiratory infections. Higher levels of salivary antibodies, especially anti-RBD secretory IgA, are associated with protection against breakthrough #COVID19
Hello Bluesky!
We are very pleased to join you all here and are looking forward to a fun and inspirational time 😃
We are interested in immunology, specifically in the upper airway #ENT #ImmunoSky #MedSky #Mucosalimmunity #AcademicSky
Have a productive day everyone 🤗
We are very pleased to join you all here and are looking forward to a fun and inspirational time 😃
We are interested in immunology, specifically in the upper airway #ENT #ImmunoSky #MedSky #Mucosalimmunity #AcademicSky
Have a productive day everyone 🤗
November 14, 2024 at 9:01 AM
Hello Bluesky!
We are very pleased to join you all here and are looking forward to a fun and inspirational time 😃
We are interested in immunology, specifically in the upper airway #ENT #ImmunoSky #MedSky #Mucosalimmunity #AcademicSky
Have a productive day everyone 🤗
We are very pleased to join you all here and are looking forward to a fun and inspirational time 😃
We are interested in immunology, specifically in the upper airway #ENT #ImmunoSky #MedSky #Mucosalimmunity #AcademicSky
Have a productive day everyone 🤗
This review focuses on the multifaceted dimensions of #MucosalImmunity, highlighting its pivotal roles in countering mucosal-related diseases & conditions and underscoring its importance in the development of novel therapeutic approaches. #SARSCoV2 #medsky
Read in #STTT #OpenAccess: buff.ly/cDI6LaK
Read in #STTT #OpenAccess: buff.ly/cDI6LaK
August 11, 2025 at 8:02 PM
This review focuses on the multifaceted dimensions of #MucosalImmunity, highlighting its pivotal roles in countering mucosal-related diseases & conditions and underscoring its importance in the development of novel therapeutic approaches. #SARSCoV2 #medsky
Read in #STTT #OpenAccess: buff.ly/cDI6LaK
Read in #STTT #OpenAccess: buff.ly/cDI6LaK
#MedSky🧪 #IDSky #ImmunoSky #Mucosalimmunity Overview Sublingual immune cell clusters and #dendriticcell distribution in the oral cavity
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
November 10, 2024 at 4:29 PM
#MedSky🧪 #IDSky #ImmunoSky #Mucosalimmunity Overview Sublingual immune cell clusters and #dendriticcell distribution in the oral cavity
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
These findings highlight the potential role of boosters or alternative strategies to sustain #mucosalimmunity in Cancer patients with on going Cancer therapy . cancer patients who received dual-dose BNT162b2 vaccination
June 28, 2025 at 5:53 AM
These findings highlight the potential role of boosters or alternative strategies to sustain #mucosalimmunity in Cancer patients with on going Cancer therapy . cancer patients who received dual-dose BNT162b2 vaccination
#MedSky🧪 #IDSky #Immunosky #Publichealth #Publichealth #Mucosalimmunity #Autoantibodies targeting interferon-α (#IFNα) have been found in the circulation of those with severe #COVID19 and are considered a bad sign for disease progression.
November 7, 2024 at 9:29 AM
#MedSky🧪 #IDSky #Immunosky #Publichealth #Publichealth #Mucosalimmunity #Autoantibodies targeting interferon-α (#IFNα) have been found in the circulation of those with severe #COVID19 and are considered a bad sign for disease progression.
#MedSky🧪#IDSky #Mucosalimmunity #publichealth this systematic review shows that the composition of the intestinal #microbiota can impact responses to oral & parental vaccines, affecting bothhumoral & cellular responses. Despite some variability in results amongstudies,
Another interesting review from Zimmermann, Curtis and team
Our systematic review highlights that the #intestinal_microbiota influences responses to vaccines. We observed a beneficial impact of Bifidobacterium, and a detrimental effect of Pseudomonadota, notably Gammaproteobacteria. Thank you to @nigelcurtis.bsky.social @Cristina Adura
rdcu.be/d4fB5
rdcu.be/d4fB5
December 24, 2024 at 7:26 PM
#MedSky🧪#IDSky #Mucosalimmunity #publichealth this systematic review shows that the composition of the intestinal #microbiota can impact responses to oral & parental vaccines, affecting bothhumoral & cellular responses. Despite some variability in results amongstudies,
Last week, our lab was invited to talk at @keystonesymposia.bsky.social, where we talked about FMT & IBD and investigations on triggers towards healing. #gutmicrobiome #mucosalimmunity #fmt #ibd We would like to thank the organizers for a great meeting. Speaker: @patrickschimmel.bsky.social
February 24, 2025 at 1:26 PM
Last week, our lab was invited to talk at @keystonesymposia.bsky.social, where we talked about FMT & IBD and investigations on triggers towards healing. #gutmicrobiome #mucosalimmunity #fmt #ibd We would like to thank the organizers for a great meeting. Speaker: @patrickschimmel.bsky.social
Looking for the part that says in humans instead of in mice. But seeing "mucosal Immunity" was particularly gratifying. scitechdaily.com/needle-free-...
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/pdf/10.1...
#mice #human #vaccine #COVID-19 #intranasal #mucosalImmunity
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/pdf/10.1...
#mice #human #vaccine #COVID-19 #intranasal #mucosalImmunity
Needle-Free: New Nano-Vaccine Effective Against All COVID-19 Variants
A new nano-vaccine developed by TAU and the University of Lisbon offers a needle-free, room-temperature-storable solution against COVID-19, targeting all key variants effectively. Professor Ronit Satc...
scitechdaily.com
December 9, 2024 at 1:00 AM
Looking for the part that says in humans instead of in mice. But seeing "mucosal Immunity" was particularly gratifying. scitechdaily.com/needle-free-...
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/pdf/10.1...
#mice #human #vaccine #COVID-19 #intranasal #mucosalImmunity
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/pdf/10.1...
#mice #human #vaccine #COVID-19 #intranasal #mucosalImmunity
Studies indicate that IgA subtype dynamics differ between the upper (nasal) and lower (sputum) respiratory tracts, highlighting the complexity of #mucosalimmunity
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
October 20, 2025 at 5:46 AM
Studies indicate that IgA subtype dynamics differ between the upper (nasal) and lower (sputum) respiratory tracts, highlighting the complexity of #mucosalimmunity
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
#Medsky🧪 #IDsky #immunosky #oncosky #publichealth #Immunoglobulin (Ig) A antibodies are involved in #mucosalimmunity and eliminate pathogens immediately at the point of entry.
July 3, 2025 at 1:15 PM
#Medsky🧪 #IDsky #immunosky #oncosky #publichealth #Immunoglobulin (Ig) A antibodies are involved in #mucosalimmunity and eliminate pathogens immediately at the point of entry.
#MedSky🧪#IDSky #Immunosky #Pulichealth There is reason why you are still wearing 😷 when you had already vaccinated . Ideally, #COVID19vaccines protect against not only severe #COVID but also infection to limit 🦠 circulation. Achieving this goal requires the induction of #mucosalimmunity through 💉
October 24, 2024 at 5:52 AM
#MedSky🧪#IDSky #Immunosky #Pulichealth There is reason why you are still wearing 😷 when you had already vaccinated . Ideally, #COVID19vaccines protect against not only severe #COVID but also infection to limit 🦠 circulation. Achieving this goal requires the induction of #mucosalimmunity through 💉
Don’t miss Dr. Ana Caetano Faria at SMI's 2025 Principles of Mucosal Immunology Virtual Course as she presents “Oral tolerance: past and present insights.” 🧬
Join 250+ immunologists already registered!
www.socmucimm.org/meetings-eve...
#Immunology #MucosalImmunity #SMICourse2025
Join 250+ immunologists already registered!
www.socmucimm.org/meetings-eve...
#Immunology #MucosalImmunity #SMICourse2025
June 2, 2025 at 3:33 PM
Don’t miss Dr. Ana Caetano Faria at SMI's 2025 Principles of Mucosal Immunology Virtual Course as she presents “Oral tolerance: past and present insights.” 🧬
Join 250+ immunologists already registered!
www.socmucimm.org/meetings-eve...
#Immunology #MucosalImmunity #SMICourse2025
Join 250+ immunologists already registered!
www.socmucimm.org/meetings-eve...
#Immunology #MucosalImmunity #SMICourse2025
NanoSTING‑SN: Houston’s intranasal pan‑coronavirus vaccine aims for sterilizing immunity + no transmission.
Strong animal data. Human trials pending funding.
This could be the endgame for COVID spread.
🔗 www.uh.edu/news-events/... #NextGenVaccines #MucosalImmunity
Strong animal data. Human trials pending funding.
This could be the endgame for COVID spread.
🔗 www.uh.edu/news-events/... #NextGenVaccines #MucosalImmunity
University of Houston Researchers Create New Treatment and Vaccine for Flu and Various Coronaviruses
Two new nasal sprays to fight coronavirus and flu developed @UHouston: one, a vaccine and one an immune activator.
www.uh.edu
September 3, 2025 at 5:20 PM
NanoSTING‑SN: Houston’s intranasal pan‑coronavirus vaccine aims for sterilizing immunity + no transmission.
Strong animal data. Human trials pending funding.
This could be the endgame for COVID spread.
🔗 www.uh.edu/news-events/... #NextGenVaccines #MucosalImmunity
Strong animal data. Human trials pending funding.
This could be the endgame for COVID spread.
🔗 www.uh.edu/news-events/... #NextGenVaccines #MucosalImmunity
Upper airway swabs reveal rich, stable immune memory crucial for respiratory defense 🔬🧬🦠 www.news-medical.net/news/2024080... #Immunology #UpperAirway #COVID19 #ImmuneMemory #MucosalImmunity #Research #Virology #InfectionDefense #BCells #TCells @natureportfolio.bsky.social
Upper airway swabs reveal rich, stable immune memory crucial for respiratory defense
Researchers discovered diverse and stable immune cell populations in the upper respiratory tract, highlighting the critical role of mucosal immunity in COVID-19 and other respiratory diseases.
www.news-medical.net
August 2, 2024 at 2:47 AM
Upper airway swabs reveal rich, stable immune memory crucial for respiratory defense 🔬🧬🦠 www.news-medical.net/news/2024080... #Immunology #UpperAirway #COVID19 #ImmuneMemory #MucosalImmunity #Research #Virology #InfectionDefense #BCells #TCells @natureportfolio.bsky.social
#MedSky🧪 #IDSky #Academicsky #Clinicalresearch #publichealth #Mucosalimmunity Beyong #Gutbrainaxis Intestinal epithelial barrier-integrity is essential for human health, and its disruption induces and exacerbates intestinal inflammatory disorders.
December 23, 2024 at 3:40 AM
#MedSky🧪 #IDSky #Academicsky #Clinicalresearch #publichealth #Mucosalimmunity Beyong #Gutbrainaxis Intestinal epithelial barrier-integrity is essential for human health, and its disruption induces and exacerbates intestinal inflammatory disorders.
#MedSky #IDSky #Mucosalimmunity #Tcells are crucial in preventing persistent #SARSCoV2 infection in the nasal cavity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
CD4+ and CD8+ T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment
CD4+ and CD8+ T cells protect against SARS-CoV-2 viral persistence within the upper respiratory tract.
www.science.org
August 24, 2024 at 10:52 AM
#MedSky #IDSky #Mucosalimmunity #Tcells are crucial in preventing persistent #SARSCoV2 infection in the nasal cavity
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...