Peter Cook
@drpetercook.bsky.social
Enthusiastically attempting to understand why fungi cause allergy. Still trying to dabble with running…
https://experts.exeter.ac.uk/35000-peter-cook
https://experts.exeter.ac.uk/35000-peter-cook
Check out our latest preprint, tracking fungal spores we were able to make some fascinating insights on how dendritic cells cause #fungal allergy. #immunosky.
Huge thanks to our awesome collaborators who helped with this study!
www.biorxiv.org/content/10.1...
Huge thanks to our awesome collaborators who helped with this study!
www.biorxiv.org/content/10.1...
Mgl2+ cDC2 triggering of fungal allergic inflammation depends on a spore induced glycolytic shift fuelled by local availability of glucose
Fungal spores are a major cause of severe asthmatic disease. However, the precise events that cause individuals to become sensitised to spores are poorly understood. Mgl2+ type 2 conventional dendriti...
www.biorxiv.org
July 18, 2025 at 3:31 PM
Check out our latest preprint, tracking fungal spores we were able to make some fascinating insights on how dendritic cells cause #fungal allergy. #immunosky.
Huge thanks to our awesome collaborators who helped with this study!
www.biorxiv.org/content/10.1...
Huge thanks to our awesome collaborators who helped with this study!
www.biorxiv.org/content/10.1...
Reposted by Peter Cook
Thanks to new funding from @wellcometrust.bsky.social we will soon be advertising two postdoc positions! Interested? Please get in touch in the first instance and I'll provide more info on the projects. You can also learn more on our lab website www.theradlab.co.uk
#immunosky 🧪
#immunosky 🧪
The RAD fungal infection lab
www.theradlab.co.uk
June 23, 2025 at 1:24 PM
Thanks to new funding from @wellcometrust.bsky.social we will soon be advertising two postdoc positions! Interested? Please get in touch in the first instance and I'll provide more info on the projects. You can also learn more on our lab website www.theradlab.co.uk
#immunosky 🧪
#immunosky 🧪
After a period of silence, delighted to share our latest work has come out as a pre print. Check it out. Huge thanks to the amazing efforts of co-authors and most importantly the generosity of the patients in providing samples. www.medrxiv.org/content/10.1...
Activation status of immune cells in the airway is a defining feature of severe fungal asthma.
Airborne fungi are potent inducers of respiratory disease and cause the debilitating conditions severe asthma with fungal sensitisation (SAFS) and allergic bronchopulmonary aspergillosis (ABPA). Howev...
www.medrxiv.org
May 16, 2025 at 6:04 PM
After a period of silence, delighted to share our latest work has come out as a pre print. Check it out. Huge thanks to the amazing efforts of co-authors and most importantly the generosity of the patients in providing samples. www.medrxiv.org/content/10.1...
Reposted by Peter Cook
The past several weeks have taken a toll on all of us. We wrote this before the thick fog fell over science, out now, highlighting the exciting collective progress in the area of #microbiota and #IBD. Hoping reason prevails—for the sake of all and the collective progress of #science
New online! Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities
Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities
Nature Reviews Microbiology, Published online: 10 March 2025; doi:10.1038/s41579-025-01163-0In this Review, Iliev, Ananthakrishnan and Guo explore the gut microbiota in inflammatory bowel disease, highlighting bacterial and fungal components, immune…
www.nature.com
March 12, 2025 at 2:16 PM
The past several weeks have taken a toll on all of us. We wrote this before the thick fog fell over science, out now, highlighting the exciting collective progress in the area of #microbiota and #IBD. Hoping reason prevails—for the sake of all and the collective progress of #science
Reposted by Peter Cook
Excited to see this finally out!! We found IL-2 made by CD301b+ DCs critical for the Th2 fate decision of CD4T cells and skewing them away from the Tfh fate. They also seem to use their own CD25 to direct IL-2 to the cognate clone.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation - Nature Communications
A subset of migratory type 2 conventional dendritic cells marked by CD301b expression (CD301b+DC), are required specifically for the development of Th2 cells. Here authors show that at the mechanistic...
www.nature.com
February 26, 2025 at 10:06 PM
Excited to see this finally out!! We found IL-2 made by CD301b+ DCs critical for the Th2 fate decision of CD4T cells and skewing them away from the Tfh fate. They also seem to use their own CD25 to direct IL-2 to the cognate clone.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Peter Cook
Out today - a new role for MAIT cells. We've shown MAIT cells are antibacterial; antiviral; and promote tissue repair. In this paper from our group we show MAIT cells are recruited and activated to protect tissues in sterile lung injury, and potentially in IPF - enjoy!
doi.org/10.1016/j.ce...
doi.org/10.1016/j.ce...
February 7, 2025 at 8:27 AM
Out today - a new role for MAIT cells. We've shown MAIT cells are antibacterial; antiviral; and promote tissue repair. In this paper from our group we show MAIT cells are recruited and activated to protect tissues in sterile lung injury, and potentially in IPF - enjoy!
doi.org/10.1016/j.ce...
doi.org/10.1016/j.ce...
*PhD project available funded by BBSRC WoH DLP,*. Are you interested in viral and fungal immunity? Keen to use learn the latest cutting edge technologies to address this working with partners at UKHSA? If yes then please reach out. Further details at: www.surrey.ac.uk/bbsrc-wessex...
BBSRC Wessex One Health (WOH) Doctoral Landscape Award | University of Surrey
17 PhD studentships for October 2025 start: Interdisciplinary approaches to Infection Biosciences to combat disease threats to human and animal health.
www.surrey.ac.uk
January 29, 2025 at 11:02 AM
*PhD project available funded by BBSRC WoH DLP,*. Are you interested in viral and fungal immunity? Keen to use learn the latest cutting edge technologies to address this working with partners at UKHSA? If yes then please reach out. Further details at: www.surrey.ac.uk/bbsrc-wessex...
Completely agree @profandrewmac.bsky.social! A pleasure to work with wonderful colleagues at several institutions including @mrccmm.bsky.social, @lydiabeckeriii.bsky.social and @uoe-eid.bsky.social. Fungi are major causes of asthma but why our immune cells do this is poorly understood.
Delighted to see our study on #DendriticCell control of #fungal #allergic airway #inflammation finally out in the wild! Spearheaded by @drpetercook.bsky.social, with so many fantastic collaborators - thanks to all! #ImmunoSky 🧪
rdcu.be/d68MU @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social
rdcu.be/d68MU @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social
Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice
Nature Communications - Fungal spores can promote immune responses of both type 2 (IL-4 / IL-5 / IL-13) and type 17 (IL-17). Here the authors characterise the subsets of cDC2 associated with type 2...
rdcu.be
January 22, 2025 at 6:30 PM
Completely agree @profandrewmac.bsky.social! A pleasure to work with wonderful colleagues at several institutions including @mrccmm.bsky.social, @lydiabeckeriii.bsky.social and @uoe-eid.bsky.social. Fungi are major causes of asthma but why our immune cells do this is poorly understood.
Reposted by Peter Cook
Maternal type 2 immunity promotes a microchimeric transfer of systemic type 2 immunity to offspring. https://www.biorxiv.org/content/10.1101/2025.01.03.631175v1
January 3, 2025 at 6:16 PM
Maternal type 2 immunity promotes a microchimeric transfer of systemic type 2 immunity to offspring. https://www.biorxiv.org/content/10.1101/2025.01.03.631175v1
Reposted by Peter Cook
🌟 Join #RTI2025 in Glasgow, Feb 3-5, 2025!
Prof. Cilloniz will dive into CAP & Pneumococcal Disease:
• Evolving CAP trends
• Streptococcus pneumoniae & viruses
• Vaccination strategies
🎁 30% discount: use RTIXMAS25 (first 20 only)
👉 rti-forum.org/2025
#Vaccination #CAP #RespiratoryTractInfections
Prof. Cilloniz will dive into CAP & Pneumococcal Disease:
• Evolving CAP trends
• Streptococcus pneumoniae & viruses
• Vaccination strategies
🎁 30% discount: use RTIXMAS25 (first 20 only)
👉 rti-forum.org/2025
#Vaccination #CAP #RespiratoryTractInfections
December 19, 2024 at 11:08 AM
🌟 Join #RTI2025 in Glasgow, Feb 3-5, 2025!
Prof. Cilloniz will dive into CAP & Pneumococcal Disease:
• Evolving CAP trends
• Streptococcus pneumoniae & viruses
• Vaccination strategies
🎁 30% discount: use RTIXMAS25 (first 20 only)
👉 rti-forum.org/2025
#Vaccination #CAP #RespiratoryTractInfections
Prof. Cilloniz will dive into CAP & Pneumococcal Disease:
• Evolving CAP trends
• Streptococcus pneumoniae & viruses
• Vaccination strategies
🎁 30% discount: use RTIXMAS25 (first 20 only)
👉 rti-forum.org/2025
#Vaccination #CAP #RespiratoryTractInfections
Reposted by Peter Cook
So chuffed with how many people were in the room for our Exeter Respiratory Research meeting last week!! Ready for an exciting set of talks in the New Year 🫁🤙
Special thanks to our theme reps Adilia (@adilia12.bsky.social), Michael, Chris and Owen for presenting this time around.
Special thanks to our theme reps Adilia (@adilia12.bsky.social), Michael, Chris and Owen for presenting this time around.
December 9, 2024 at 9:49 PM
So chuffed with how many people were in the room for our Exeter Respiratory Research meeting last week!! Ready for an exciting set of talks in the New Year 🫁🤙
Special thanks to our theme reps Adilia (@adilia12.bsky.social), Michael, Chris and Owen for presenting this time around.
Special thanks to our theme reps Adilia (@adilia12.bsky.social), Michael, Chris and Owen for presenting this time around.
Reposted by Peter Cook
Join the Sutherland Lab in Aberdeen! We have a research fellow opening to explore IL-13 regulation of hyaluronan extracellular matrices drug lung injury, repair and chronic pathology with funding from @wellcometrust.bsky.social www.abdn.ac.uk/research/job...
Research Fellow, Medicine, Medical Sciences & Nutrition (IMS301R) | The University of Aberdeen
www.abdn.ac.uk
December 5, 2024 at 10:15 AM
Join the Sutherland Lab in Aberdeen! We have a research fellow opening to explore IL-13 regulation of hyaluronan extracellular matrices drug lung injury, repair and chronic pathology with funding from @wellcometrust.bsky.social www.abdn.ac.uk/research/job...
A pleasure to congratulate Dr Daniel Conn (not on here yet) from the group who successfully passed his PhD viva today. What a fanatastic journey it’s been @mrccmm.bsky.social
Huge thanks to the awesome examiners @billhorsnell.bsky.social, @lloydlab.bsky.social and Mark Ramsdale.
Huge thanks to the awesome examiners @billhorsnell.bsky.social, @lloydlab.bsky.social and Mark Ramsdale.
November 28, 2024 at 9:36 PM
A pleasure to congratulate Dr Daniel Conn (not on here yet) from the group who successfully passed his PhD viva today. What a fanatastic journey it’s been @mrccmm.bsky.social
Huge thanks to the awesome examiners @billhorsnell.bsky.social, @lloydlab.bsky.social and Mark Ramsdale.
Huge thanks to the awesome examiners @billhorsnell.bsky.social, @lloydlab.bsky.social and Mark Ramsdale.
First 🦋 post (great to join everyone here) about our paper that's been published in JACI: www.jacionline.org/article/S009...
Check it out if you have ever wondered how fungal spore growth controls how dendritic cells (clearly THE best immune cell) trigger inflammation that causes asthma...
Check it out if you have ever wondered how fungal spore growth controls how dendritic cells (clearly THE best immune cell) trigger inflammation that causes asthma...
DEFINE_ME
www.jacionline.org
November 25, 2024 at 1:35 PM
First 🦋 post (great to join everyone here) about our paper that's been published in JACI: www.jacionline.org/article/S009...
Check it out if you have ever wondered how fungal spore growth controls how dendritic cells (clearly THE best immune cell) trigger inflammation that causes asthma...
Check it out if you have ever wondered how fungal spore growth controls how dendritic cells (clearly THE best immune cell) trigger inflammation that causes asthma...