Yosuke Kumamoto
@ykumamoto.bsky.social
Immunologist at Rutgers New Jersey Medical School. DCs, T cells and type 2 immunity. Opinions are my own.
A new review on cDC2 subsets in CD4T cell regulation is out!! cDC2サブセットによるCD4T細胞の制御に関する新しいレビューが出ました!!
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Functional Specialization and Collaboration of cDC2 Subsets in CD4+ T Cell Priming and Differentiation
Dendritic cells (DCs) play a crucial role in bridging innate and adaptive immunity by presenting antigens to prime antigen-specific T cells. Conventional DC (cDC) type 2 cells (cDC2s) are a phenotypi...
onlinelibrary.wiley.com
November 7, 2025 at 3:28 PM
A new review on cDC2 subsets in CD4T cell regulation is out!! cDC2サブセットによるCD4T細胞の制御に関する新しいレビューが出ました!!
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Yosuke Kumamoto
The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...
Research Specialist A/B
University Overview The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school co...
wd1.myworkdaysite.com
September 23, 2025 at 9:47 PM
The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...
Reposted by Yosuke Kumamoto
Happy to share that our collaboration with Christina
@stallingslab.bsky.social at WUSTL is out at @pnas.org ! Led by Erin Wang, they found that routing carbon away from peptidoglycans sensitizes Mtb to INH, even in DR-Mtb! Grateful to be part of this project!
www.pnas.org/doi/abs/10.1...
@stallingslab.bsky.social at WUSTL is out at @pnas.org ! Led by Erin Wang, they found that routing carbon away from peptidoglycans sensitizes Mtb to INH, even in DR-Mtb! Grateful to be part of this project!
www.pnas.org/doi/abs/10.1...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
September 16, 2025 at 2:45 PM
Happy to share that our collaboration with Christina
@stallingslab.bsky.social at WUSTL is out at @pnas.org ! Led by Erin Wang, they found that routing carbon away from peptidoglycans sensitizes Mtb to INH, even in DR-Mtb! Grateful to be part of this project!
www.pnas.org/doi/abs/10.1...
@stallingslab.bsky.social at WUSTL is out at @pnas.org ! Led by Erin Wang, they found that routing carbon away from peptidoglycans sensitizes Mtb to INH, even in DR-Mtb! Grateful to be part of this project!
www.pnas.org/doi/abs/10.1...
Happy to share this mini review on IL-2 in type 2 immunity. IL-2 may be an old cytokine but there's still a lot to learn!!
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
Frontiers | The role of IL-2 in type 2 immunity
Type 2 immune responses are essential for protective immunity against helminth parasites and for promoting tissue repair, but they can also drive allergic in...
www.frontiersin.org
September 13, 2025 at 1:00 AM
Happy to share this mini review on IL-2 in type 2 immunity. IL-2 may be an old cytokine but there's still a lot to learn!!
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
Reposted by Yosuke Kumamoto
AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity
@sciimmunology.bsky.social
@chschneider.bsky.social
www.science.org/doi/epdf/10....
@sciimmunology.bsky.social
@chschneider.bsky.social
www.science.org/doi/epdf/10....
August 9, 2025 at 3:15 AM
AT2 cell–derived GM-CSF is essential for establishing a terminally differentiated CD301b+ lung cDC2 compartment and type 2 immunity
@sciimmunology.bsky.social
@chschneider.bsky.social
www.science.org/doi/epdf/10....
@sciimmunology.bsky.social
@chschneider.bsky.social
www.science.org/doi/epdf/10....
Reposted by Yosuke Kumamoto
Big congratulations, Teruyuki Sano and his team on their publication in @nature.com ! It was great to collaborate this wonderful study with his team.
We continue to contribute more to science together, especallly in the field of immunology!
www.nature.com/articles/s41...
We continue to contribute more to science together, especallly in the field of immunology!
www.nature.com/articles/s41...
Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation - Nature
Dysregulated CD4 T cells that recognize gut commensal antigens are able to infiltrate the central nervous systems and are re-stimulated by host proteins, resulting in neuroinflammation.
www.nature.com
June 18, 2025 at 9:50 PM
Big congratulations, Teruyuki Sano and his team on their publication in @nature.com ! It was great to collaborate this wonderful study with his team.
We continue to contribute more to science together, especallly in the field of immunology!
www.nature.com/articles/s41...
We continue to contribute more to science together, especallly in the field of immunology!
www.nature.com/articles/s41...
Reposted by Yosuke Kumamoto
Thrilled to share that our paper is now published in Immunity @cp-immunity.bsky.social ! 🎉 It’s been a long journey, and I’m incredibly grateful to all my co-authors—especially Dr. Teruyuki_Sano—for your dedication. This wouldn’t have been possible without you!
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis
Immune-microbiota interactions are required to maintain host homeostasis. Kim et al.
identified that steady-state sensing of IL-10 by interstitial macrophages (IMs) prevents
spontaneous lung inflammat...
www.cell.com
April 29, 2025 at 3:52 PM
Thrilled to share that our paper is now published in Immunity @cp-immunity.bsky.social ! 🎉 It’s been a long journey, and I’m incredibly grateful to all my co-authors—especially Dr. Teruyuki_Sano—for your dedication. This wouldn’t have been possible without you!
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Yosuke Kumamoto
March 12-13 are Rutgers Giving Days! Rutgers researchers at the Child Health Institute of NJ need your support to continue innovating, discovering, and combating childhood diseases.
Contribution will be match up to $5000 in donations by a generous donor.
Contribution will be match up to $5000 in donations by a generous donor.
RWJMS Child Health Institute of New Jersey Support Fund (CHINJ) | Rutgers University Foundationlabel.header.loginSubmit search keywordsSubmit search keywordsView CartView CartsearchView CartSubmit sea...
<p>Your gift supports the mission of the Child Health Institute of New Jersey to improve the health of children everywhere by studying the causes of childhood illnesses and developing new treatments a...
nam02.safelinks.protection.outlook.com
March 12, 2025 at 2:48 AM
March 12-13 are Rutgers Giving Days! Rutgers researchers at the Child Health Institute of NJ need your support to continue innovating, discovering, and combating childhood diseases.
Contribution will be match up to $5000 in donations by a generous donor.
Contribution will be match up to $5000 in donations by a generous donor.
Reposted by Yosuke Kumamoto
Finally online - sharing our findings that #Lyme disease bacteria can live in female reproductive organs for over a year and increase risk for gynecological disease!!! We found this increased risk in mice and humans! 😱 (thread below)
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
March 6, 2025 at 10:52 PM
Finally online - sharing our findings that #Lyme disease bacteria can live in female reproductive organs for over a year and increase risk for gynecological disease!!! We found this increased risk in mice and humans! 😱 (thread below)
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Yosuke Kumamoto
So happy to share our latest paper on #AlveolarMacrophage responses to low-dose #LPS led by @pamelialim.bsky.social!AM #innate responses are enhanced by IFN-beta due to low c-Maf and IL-10 expression, with implications for AM responses to respiratory infections and environmental exposure. #ImmunoSky
Absence of c-Maf and IL-10 enables type I IFN enhancement of innate responses to LPS in alveolar macrophages
Abstract. Alveolar macrophages (AMs) are lung-resident myeloid cells and airway sentinels for inhaled pathogens and environmental particles. While AMs can
academic.oup.com
March 4, 2025 at 2:21 PM
So happy to share our latest paper on #AlveolarMacrophage responses to low-dose #LPS led by @pamelialim.bsky.social!AM #innate responses are enhanced by IFN-beta due to low c-Maf and IL-10 expression, with implications for AM responses to respiratory infections and environmental exposure. #ImmunoSky
Reposted by Yosuke Kumamoto
CD301b+ DC-derived IL-2 dictates CD4+ T helper cell differentiation
www.nature.com/articles/s41...
@naturecomms.bsky.social
www.nature.com/articles/s41...
@naturecomms.bsky.social
CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation - Nature Communications
A subset of migratory type 2 conventional dendritic cells marked by CD301b expression (CD301b+DC), are required specifically for the development of Th2 cells. Here authors show that at the mechanistic...
www.nature.com
February 26, 2025 at 8:05 PM
CD301b+ DC-derived IL-2 dictates CD4+ T helper cell differentiation
www.nature.com/articles/s41...
@naturecomms.bsky.social
www.nature.com/articles/s41...
@naturecomms.bsky.social
Excited to see this finally out!! We found IL-2 made by CD301b+ DCs critical for the Th2 fate decision of CD4T cells and skewing them away from the Tfh fate. They also seem to use their own CD25 to direct IL-2 to the cognate clone.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation - Nature Communications
A subset of migratory type 2 conventional dendritic cells marked by CD301b expression (CD301b+DC), are required specifically for the development of Th2 cells. Here authors show that at the mechanistic...
www.nature.com
February 26, 2025 at 10:06 PM
Excited to see this finally out!! We found IL-2 made by CD301b+ DCs critical for the Th2 fate decision of CD4T cells and skewing them away from the Tfh fate. They also seem to use their own CD25 to direct IL-2 to the cognate clone.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Yosuke Kumamoto
Come join our faculty! We’re hiring.
February 13, 2025 at 9:18 PM
Come join our faculty! We’re hiring.
Reposted by Yosuke Kumamoto
Interested in cellular cross-talks between dendritic cells and T lymphocytes in lung cancer? Our team is recruiting a postdoctoral associate in immunology at Institut Pasteur Paris!
research.pasteur.fr/fr/job/post-...
research.pasteur.fr/fr/job/post-...
Post-Doctoral position in cancer immunology and immunotherapy, Institut Pasteur, Paris, France - Research
Deciphering the role of intra-tumoral dendritic cells in the dynamic controlof CD4+ and CD8+ lymphocytes in lung cancer. A 3-year, post-doctoral position is available in the Guermonprez lab at Institu...
research.pasteur.fr
February 12, 2025 at 4:46 PM
Interested in cellular cross-talks between dendritic cells and T lymphocytes in lung cancer? Our team is recruiting a postdoctoral associate in immunology at Institut Pasteur Paris!
research.pasteur.fr/fr/job/post-...
research.pasteur.fr/fr/job/post-...
Reposted by Yosuke Kumamoto
Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Sign the Petition
Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
chng.it
February 10, 2025 at 5:49 PM
Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Sign the Petition: chng.it/kK2HMP5pGk
"Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
Reposted by Yosuke Kumamoto
Hello all. Finally made my way to 🦋. Looking for my people in host defense, innate immunology, bacterial pathogenesis and lung biology! Please help me find you!
January 31, 2025 at 3:01 PM
Hello all. Finally made my way to 🦋. Looking for my people in host defense, innate immunology, bacterial pathogenesis and lung biology! Please help me find you!
Reposted by Yosuke Kumamoto
Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...
Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation
Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...
www.science.org
January 30, 2025 at 8:31 PM
Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...
Reposted by Yosuke Kumamoto
*PhD project available funded by BBSRC WoH DLP,*. Are you interested in viral and fungal immunity? Keen to use learn the latest cutting edge technologies to address this working with partners at UKHSA? If yes then please reach out. Further details at: www.surrey.ac.uk/bbsrc-wessex...
BBSRC Wessex One Health (WOH) Doctoral Landscape Award | University of Surrey
17 PhD studentships for October 2025 start: Interdisciplinary approaches to Infection Biosciences to combat disease threats to human and animal health.
www.surrey.ac.uk
January 29, 2025 at 11:02 AM
*PhD project available funded by BBSRC WoH DLP,*. Are you interested in viral and fungal immunity? Keen to use learn the latest cutting edge technologies to address this working with partners at UKHSA? If yes then please reach out. Further details at: www.surrey.ac.uk/bbsrc-wessex...
Reposted by Yosuke Kumamoto
Hello Friends, I created a 5th #immunology Starter Pack. If you're an immunologist and you don't see yourself on the lists, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
go.bsky.app/Mdbpk7h
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
go.bsky.app/Mdbpk7h
Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
January 25, 2025 at 5:51 PM
Hello Friends, I created a 5th #immunology Starter Pack. If you're an immunologist and you don't see yourself on the lists, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
go.bsky.app/Mdbpk7h
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
go.bsky.app/Mdbpk7h
Reposted by Yosuke Kumamoto
Our manuscript preprint is out!
Repetitive stimulation modifies network characteristics of neural organoid circuits https://www.biorxiv.org/content/10.1101/2025.01.16.633310v1
January 17, 2025 at 9:15 AM
Our manuscript preprint is out!
Reposted by Yosuke Kumamoto
We are looking for a research faculty to join the lab. Taking tissue engineering and regenerative immunology to the next level - deciphering immune-stromal networks that regulate tissue structure in health, injury and disease, especially aging! apply.interfolio.com/161101
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
January 22, 2025 at 5:55 PM
We are looking for a research faculty to join the lab. Taking tissue engineering and regenerative immunology to the next level - deciphering immune-stromal networks that regulate tissue structure in health, injury and disease, especially aging! apply.interfolio.com/161101
Nice work by @drpetercook.bsky.social, @profandrewmac.bsky.social & Co. Congratulations to the team!! www.nature.com/articles/s41...
Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice - Nature Communications
Fungal spores can promote immune responses of both type 2 (IL-4 / IL-5 / IL-13) and type 17 (IL-17). Here the authors characterise the subsets of cDC2 associated with type 2 and type 17 allergic respo...
www.nature.com
January 22, 2025 at 3:08 PM
Nice work by @drpetercook.bsky.social, @profandrewmac.bsky.social & Co. Congratulations to the team!! www.nature.com/articles/s41...
Reposted by Yosuke Kumamoto
#postdoc opportunity in #immunology and #microbiome research at Weill Cornell Medicine - Cornell University in New York City! For details about the position see the image below. For details about the lab: robertsinstitute.weill.cornell.edu/arifuzzaman-...
Please share!
Please share!
January 17, 2025 at 4:35 PM
#postdoc opportunity in #immunology and #microbiome research at Weill Cornell Medicine - Cornell University in New York City! For details about the position see the image below. For details about the lab: robertsinstitute.weill.cornell.edu/arifuzzaman-...
Please share!
Please share!
Reposted by Yosuke Kumamoto
Hi Bluesky! I’m Priya Devarajan, an immunologist studying how our immune system fights respiratory infections like influenza. My new lab @Stony Brook Medicine studies B/T cell responses, tissue-resident memory, respiratory immunity, and immune aging (www.thedevarajanlab.com). Excited to connect!
January 13, 2025 at 2:44 PM
Hi Bluesky! I’m Priya Devarajan, an immunologist studying how our immune system fights respiratory infections like influenza. My new lab @Stony Brook Medicine studies B/T cell responses, tissue-resident memory, respiratory immunity, and immune aging (www.thedevarajanlab.com). Excited to connect!
Reposted by Yosuke Kumamoto
Working with a great team to organize
@keystonesymposia.bsky.social on "#LongCOVID and Other Post-Acute Infection Syndromes #PAIS" #KSLongCOVID26
@patientled.bsky.social @daltmann.bsky.social
August 10-13, 2025 | Santa Fe
Hope to see you there!
keysym.us/KSLongCOVID26
@keystonesymposia.bsky.social on "#LongCOVID and Other Post-Acute Infection Syndromes #PAIS" #KSLongCOVID26
@patientled.bsky.social @daltmann.bsky.social
August 10-13, 2025 | Santa Fe
Hope to see you there!
keysym.us/KSLongCOVID26
January 12, 2025 at 3:05 PM
Working with a great team to organize
@keystonesymposia.bsky.social on "#LongCOVID and Other Post-Acute Infection Syndromes #PAIS" #KSLongCOVID26
@patientled.bsky.social @daltmann.bsky.social
August 10-13, 2025 | Santa Fe
Hope to see you there!
keysym.us/KSLongCOVID26
@keystonesymposia.bsky.social on "#LongCOVID and Other Post-Acute Infection Syndromes #PAIS" #KSLongCOVID26
@patientled.bsky.social @daltmann.bsky.social
August 10-13, 2025 | Santa Fe
Hope to see you there!
keysym.us/KSLongCOVID26