Jason Yang
@jasonyanglab.org
Assistant Professor at Rutgers New Jersey Medical School | Systems Biology, Synthetic Biology, Machine Learning, Antibiotic Resistance, Tuberculosis, Heart Failure, Immunoengineering
Very happy to share some more good news. Our collaboration with Jeffrey Boyd's lab is now published at J Inorganic Biochemistry! Here, Jeff found that iron limitation reprograms S. aureus metabolism towards fermentation. We're grateful to be part of this study.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Fermentative growth decreases the iron demand of Staphylococcus aureus
Iron (Fe) is an essential nutrient for S. aureus survivability and pathogenesis, but excess Fe can catalyze the formation of toxic oxygen radicals, em…
www.sciencedirect.com
September 30, 2025 at 1:25 PM
Very happy to share some more good news. Our collaboration with Jeffrey Boyd's lab is now published at J Inorganic Biochemistry! Here, Jeff found that iron limitation reprograms S. aureus metabolism towards fermentation. We're grateful to be part of this study.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Happy to share that our collaboration with Christina
@stallingslab.bsky.social at WUSTL is out at @pnas.org ! Led by Erin Wang, they found that routing carbon away from peptidoglycans sensitizes Mtb to INH, even in DR-Mtb! Grateful to be part of this project!
www.pnas.org/doi/abs/10.1...
@stallingslab.bsky.social at WUSTL is out at @pnas.org ! Led by Erin Wang, they found that routing carbon away from peptidoglycans sensitizes Mtb to INH, even in DR-Mtb! Grateful to be part of this project!
www.pnas.org/doi/abs/10.1...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
September 16, 2025 at 2:45 PM
Happy to share that our collaboration with Christina
@stallingslab.bsky.social at WUSTL is out at @pnas.org ! Led by Erin Wang, they found that routing carbon away from peptidoglycans sensitizes Mtb to INH, even in DR-Mtb! Grateful to be part of this project!
www.pnas.org/doi/abs/10.1...
@stallingslab.bsky.social at WUSTL is out at @pnas.org ! Led by Erin Wang, they found that routing carbon away from peptidoglycans sensitizes Mtb to INH, even in DR-Mtb! Grateful to be part of this project!
www.pnas.org/doi/abs/10.1...
Reposted by Jason Yang
I am recruiting a Ph.D. student in microbial ecology, evolution, and systems biology for fall 2026. Please share!
Details: qevomicrolab.org/Documents/Gr...
Apply by October 1 here: forms.gle/38pPS1Ky84HB...
Details: qevomicrolab.org/Documents/Gr...
Apply by October 1 here: forms.gle/38pPS1Ky84HB...
September 2, 2025 at 5:24 PM
I am recruiting a Ph.D. student in microbial ecology, evolution, and systems biology for fall 2026. Please share!
Details: qevomicrolab.org/Documents/Gr...
Apply by October 1 here: forms.gle/38pPS1Ky84HB...
Details: qevomicrolab.org/Documents/Gr...
Apply by October 1 here: forms.gle/38pPS1Ky84HB...
I'm pleased to share that the preprint for our collaboration study on MIS-C in pediatric COVID-19 patients is now available on medRxiv. In this study led by Marila Gennaro at Rutgers NJMS, we report that antibody repertories vary with clinical presentation of COVID-19 in children.
Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection https://www.medrxiv.org/content/10.1101/2025.07.22.25331300v1
September 2, 2025 at 12:13 AM
I'm pleased to share that the preprint for our collaboration study on MIS-C in pediatric COVID-19 patients is now available on medRxiv. In this study led by Marila Gennaro at Rutgers NJMS, we report that antibody repertories vary with clinical presentation of COVID-19 in children.
It's nearing the end of the summer and our undergrads have been presenting on their research at their respective summer research symposia. Terrific work by Jonah Simone at the Rutgers Health BMIHAI Symposium and Gianna Elie at the NJMS URSE Symposium!
August 8, 2025 at 2:04 AM
It's nearing the end of the summer and our undergrads have been presenting on their research at their respective summer research symposia. Terrific work by Jonah Simone at the Rutgers Health BMIHAI Symposium and Gianna Elie at the NJMS URSE Symposium!
I'm excited to share that we've received a NIBIB Trailblazer Award to advance our work on engineering therapeutic macrophages! Grateful for our team and excited to launch this collaboration with the Caleb @bashorlab.bsky.social at Rice!
August 1, 2025 at 11:14 AM
I'm excited to share that we've received a NIBIB Trailblazer Award to advance our work on engineering therapeutic macrophages! Grateful for our team and excited to launch this collaboration with the Caleb @bashorlab.bsky.social at Rice!
Many thanks to ScienceNews.dk for highlighting our work!
Stressed bacteria develop antibiotic resistance more easily
When bacteria are under energy stress – burning more energy than they produce, it increases their chances of developing antibiotic resistance. A new study offers new insight into how antibiotic...
sciencenews.dk
July 31, 2025 at 10:11 PM
Many thanks to ScienceNews.dk for highlighting our work!
Thank you @njmicrobe.bsky.social for this really nice writeup about our work!
Bacteria under energy stress evolve antibiotic resistance faster. New work from Jason Yang’s lab, Rutgers shows how ATP imbalance drives mutagenesis, ROS production, and persistence. A big leap in understanding AMR. go.njmicrobe.org/Fs4R5J #AMR #Microbiology #JasonYang #Rutgers #AntibioticResistance
Fueling the Fight: How Bacterial Metabolism Drives Antibiotic Resistance and Persistence
The global rise of antimicrobial resistance (AMR) is a daunting challenge for modern medicine, directly contributing to over a million deaths in 2019 alone. Understanding the complex ways bacteria eva...
go.njmicrobe.org
June 26, 2025 at 7:27 PM
Thank you @njmicrobe.bsky.social for this really nice writeup about our work!
Reposted by Jason Yang
A study in Nature Communications shows that constitutive hydrolysis of ATP and NADH, or ‘bioenergetic stress,’ potentiates the evolution of antibiotic resistance and persistence in E. coli. #medsky 🧪
Bioenergetic stress potentiates antimicrobial resistance and persistence - Nature Communications
The bactericidal action of some antibiotics is associated with increased ATP consumption, cellular respiration, and reactive oxygen species formation. Here, Li et al. show that constitutive hydrolysis of ATP and NADH (or ‘bioenergetic stress’) potentiates the evolution of antibiotic resistance and persistence in E. coli.
go.nature.com
June 18, 2025 at 4:48 PM
A study in Nature Communications shows that constitutive hydrolysis of ATP and NADH, or ‘bioenergetic stress,’ potentiates the evolution of antibiotic resistance and persistence in E. coli. #medsky 🧪
@rutgersu.bsky.social published a very nice article about our work!
www.rutgers.edu/news/rutgers...
@njms-mdphd.bsky.social
www.rutgers.edu/news/rutgers...
@njms-mdphd.bsky.social
Rutgers Health Research Identifies New Trigger Accelerating Antibiotic Resistance
New Jersey Medical School study finds metabolic stress drives antibiotic tolerance and speeds resistance.
www.rutgers.edu
June 11, 2025 at 1:05 PM
@rutgersu.bsky.social published a very nice article about our work!
www.rutgers.edu/news/rutgers...
@njms-mdphd.bsky.social
www.rutgers.edu/news/rutgers...
@njms-mdphd.bsky.social
I'm thrilled to share the newest paper from the Yang Lab! Ever wonder how bacterial metabolism affects antibiotic resistance #AMR? In this study, Barry Li, a former MD/PhD student in the lab, took on this question using a systems and #synthetic_biology approach. 1/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bioenergetic stress potentiates antimicrobial resistance and persistence - Nature Communications
The bactericidal action of some antibiotics is associated with increased ATP consumption, cellular respiration, and reactive oxygen species formation. Here, Li et al. show that constitutive hydrolysis...
www.nature.com
June 9, 2025 at 7:15 PM
I'm thrilled to share the newest paper from the Yang Lab! Ever wonder how bacterial metabolism affects antibiotic resistance #AMR? In this study, Barry Li, a former MD/PhD student in the lab, took on this question using a systems and #synthetic_biology approach. 1/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Honored to receive this year's Young Investigator Award from our local ASM branch!
Congrats to Dr. Jason Yang, winner of the 2025 TSS Young Investigator Award! His work at Rutgers uses machine learning & systems biology to tackle AMR, TB & more. A rising leader in biomedical science. Read more here: wix.to/tL2l4fi #Leadership #Microbiology #Innovation #SystemsBiology #Rutgers
Honoring Innovation and Resilience: Dr. Jason Yang Receives the 2025 Theobald Smith Young Investigator Award
The Theobald Smith Society is proud to present the 14th Young Investigator Award to Dr. Jason H. Yang, Assistant Professor and Chancellor Scholar at Rutgers New Jersey Medical School. A rising star in...
wix.to
May 14, 2025 at 10:08 PM
Honored to receive this year's Young Investigator Award from our local ASM branch!
Yang Lab had a terrific time at Rutgers' Biomedical Health Informatics and Artificial Intelligence Symposium yesterday. Great jobs by Yiqi Yan, Oliver Gu, and Reuven Rosen who presented on their work!
May 14, 2025 at 12:16 PM
Yang Lab had a terrific time at Rutgers' Biomedical Health Informatics and Artificial Intelligence Symposium yesterday. Great jobs by Yiqi Yan, Oliver Gu, and Reuven Rosen who presented on their work!
I'm so proud of my technician Lia Goodwin who presented a poster at her first conference at the CSHL Systems Immunology meeting yesterday!
April 24, 2025 at 5:45 PM
I'm so proud of my technician Lia Goodwin who presented a poster at her first conference at the CSHL Systems Immunology meeting yesterday!
Ever wonder how Mycobacterium #tuberculosis deals with stressful environments? I'm pleased to share that in a second piece of good news this week, our recent work in collaboration with Shuyi Ma (Seattle Children's) was published at Frontiers in Tuberculosis. 1/n
www.frontiersin.org/journals/tub...
www.frontiersin.org/journals/tub...
Frontiers | Predicting fitness in Mycobacterium tuberculosis with transcriptional regulatory network-informed interpretable machine learning
www.frontiersin.org
April 3, 2025 at 6:41 PM
Ever wonder how Mycobacterium #tuberculosis deals with stressful environments? I'm pleased to share that in a second piece of good news this week, our recent work in collaboration with Shuyi Ma (Seattle Children's) was published at Frontiers in Tuberculosis. 1/n
www.frontiersin.org/journals/tub...
www.frontiersin.org/journals/tub...
I am thrilled to share that our rock star MD/PhD student Barry Li successfully defended his PhD today entitled "Bioenergetic stress potentiates antimicrobial resistance evolution and persistence"! Barry is our first student to finish his PhD and I am so incredibly proud of him!
April 2, 2025 at 6:29 PM
I am thrilled to share that our rock star MD/PhD student Barry Li successfully defended his PhD today entitled "Bioenergetic stress potentiates antimicrobial resistance evolution and persistence"! Barry is our first student to finish his PhD and I am so incredibly proud of him!
Pleased to share our papers are highlighted by the editors at Nature Communications: www.nature.com/collections/...
Microbiology and infectious diseases
This page highlights recent articles on all aspects of bacteriology, mycology, parasitology and virology, covering the biology of pathogens, host-pathogen ...
www.nature.com
December 3, 2024 at 3:12 PM
Pleased to share our papers are highlighted by the editors at Nature Communications: www.nature.com/collections/...
Rutgers published a very nice story on our recent work!
www.rutgers.edu/news/researc...
www.rutgers.edu/news/researc...
Researchers Reveal Why a Key Tuberculosis Drug Works Against Resistant Strains
Rutgers Health study uncovers vulnerabilities in drug-resistant TB, offering hope for improved treatments.
www.rutgers.edu
November 14, 2024 at 1:59 PM
Rutgers published a very nice story on our recent work!
www.rutgers.edu/news/researc...
www.rutgers.edu/news/researc...
Thrilled to share that we have 2 new manuscripts on drug-resistant #tuberculosis out at @NatureComms ! In this pair of manuscripts, we investigated changes in #mtb physiology associated with INH resistance. 1/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Catalase activity deficiency sensitizes multidrug-resistant Mycobacterium tuberculosis to the ATP synthase inhibitor bedaquiline - Nature Communications
Multidrug-resistant (MDR) tuberculosis threatens global control of tuberculosis disease. Here, the authors investigate mechanisms underlying the collateral sensitivity of MDR Mycobacterium tuberculosi...
www.nature.com
November 13, 2024 at 1:25 PM
Thrilled to share that we have 2 new manuscripts on drug-resistant #tuberculosis out at @NatureComms ! In this pair of manuscripts, we investigated changes in #mtb physiology associated with INH resistance. 1/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...