Nature Reviews Immunology
@natrevimmunol.nature.com
Bluesky account for the journal Nature Reviews Immunology https://www.nature.com/nri/ Skyquakes from the editors.
Reposted by Nature Reviews Immunology
CAR T cells are a promising and effective cancer therapy but are difficult to regulate once implanted. This study in Nature Reviews Chemistry covers an emerging wave of small-molecule-based systems developed to control, augment and direct CAR T cell therapeutics. go.nature.com/47RdzK8 🔒
November 20, 2025 at 5:07 PM
CAR T cells are a promising and effective cancer therapy but are difficult to regulate once implanted. This study in Nature Reviews Chemistry covers an emerging wave of small-molecule-based systems developed to control, augment and direct CAR T cell therapeutics. go.nature.com/47RdzK8 🔒
Reposted by Nature Reviews Immunology
ICYMI🚨 In light of the #NobelPrize recognizing discoveries in peripheral immune tolerance, our article "Regulatory T cells in the tumour microenvironment" is now free to read.
Discover how #Tregs shape cancer immunity 📖 👇
Discover how #Tregs shape cancer immunity 📖 👇
Regulatory T cells in the tumour microenvironment - Nature Reviews Cancer
This Review by Imianowski et al. outlines the various contributions that regulatory T cells, present in the tumour microenvironment, make towards tumour progression and highlight the ways in which they represent attractive next-generation immunotherapeutic targets.
bit.ly
November 20, 2025 at 4:17 PM
ICYMI🚨 In light of the #NobelPrize recognizing discoveries in peripheral immune tolerance, our article "Regulatory T cells in the tumour microenvironment" is now free to read.
Discover how #Tregs shape cancer immunity 📖 👇
Discover how #Tregs shape cancer immunity 📖 👇
Reposted by Nature Reviews Immunology
It has been a real pleasure to dive deep into the wonderful world of the unique and peculiar shape of the neutrophil nucleus, together with Ananda and Irina in the @udalovalab.bsky.social, and I'm proud this literature review is now out in @natrevimmunol.nature.com.
rdcu.be/ePKFk
rdcu.be/ePKFk
November 14, 2025 at 9:33 PM
It has been a real pleasure to dive deep into the wonderful world of the unique and peculiar shape of the neutrophil nucleus, together with Ananda and Irina in the @udalovalab.bsky.social, and I'm proud this literature review is now out in @natrevimmunol.nature.com.
rdcu.be/ePKFk
rdcu.be/ePKFk
Three new #immunology #preprint Journal Clubs from @preprintclub.bsky.social now online: thanks to all our contributors!
November 11, 2025 at 4:39 PM
Three new #immunology #preprint Journal Clubs from @preprintclub.bsky.social now online: thanks to all our contributors!
Reposted by Nature Reviews Immunology
We (@walmsley-lab.bsky.social) are thrilled to have our pre-print highlighted by the Journal Club from @natrevimmunol.nature.com
We think single cell proteomics has the capacity to revolutionise our understanding of neutrophil functional heterogeneity, shown here in glioblastoma.
We think single cell proteomics has the capacity to revolutionise our understanding of neutrophil functional heterogeneity, shown here in glioblastoma.
Single-cell proteomics sheds light on neutrophil diversity in glioblastoma - Nature Reviews Immunology
A preprint by Sadiku et al. characterizes neutrophil diversity in glioblastoma using a new workflow for single-cell proteomic profiling.
www.nature.com
November 11, 2025 at 2:25 PM
We (@walmsley-lab.bsky.social) are thrilled to have our pre-print highlighted by the Journal Club from @natrevimmunol.nature.com
We think single cell proteomics has the capacity to revolutionise our understanding of neutrophil functional heterogeneity, shown here in glioblastoma.
We think single cell proteomics has the capacity to revolutionise our understanding of neutrophil functional heterogeneity, shown here in glioblastoma.
Highlight of @natimmunol.nature.com paper by @mas-g.bsky.social @walmsley-lab.bsky.social showing epigenetic reprogramming of neutrophils in response to hypoxia to reduce lung tissue damage
#immunosky
#immunosky
Hypoxia-induced epigenetic reprogramming of neutrophil progenitors - Nature Reviews Immunology
Sanchez-Garcia et al. report that systemic hypoxia-induced epigenetic reprogramming of neutrophil progenitors in the bone marrow reduces their effector function to limit lung tissue damage.
www.nature.com
November 5, 2025 at 11:43 AM
Highlight of @natimmunol.nature.com paper by @mas-g.bsky.social @walmsley-lab.bsky.social showing epigenetic reprogramming of neutrophils in response to hypoxia to reduce lung tissue damage
#immunosky
#immunosky
Reposted by Nature Reviews Immunology
#Medsky🧪 #immunosky @natrevimmunol.nature.com
In this Review, the researchers examine recent data supporting the idea that the process of #phagocytosis is an integral mechanism of #innateimmune sensing & current efforts to comprehensively define the innate mechanisms at work inside #phagosomes
In this Review, the researchers examine recent data supporting the idea that the process of #phagocytosis is an integral mechanism of #innateimmune sensing & current efforts to comprehensively define the innate mechanisms at work inside #phagosomes
October 31, 2025 at 7:55 PM
#Medsky🧪 #immunosky @natrevimmunol.nature.com
In this Review, the researchers examine recent data supporting the idea that the process of #phagocytosis is an integral mechanism of #innateimmune sensing & current efforts to comprehensively define the innate mechanisms at work inside #phagosomes
In this Review, the researchers examine recent data supporting the idea that the process of #phagocytosis is an integral mechanism of #innateimmune sensing & current efforts to comprehensively define the innate mechanisms at work inside #phagosomes
Reposted by Nature Reviews Immunology
Great to see our review on the role of microglia, the 'gardeners' of the brain, in modulating the gut-brain axis make the cover of this months @natrevimmunol.nature.com
November issue now online www.nature.com/nri/volumes/...
Cover art inspired by a Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social on the role of microglia, the 'gardeners' of the brain, in modulating the gut-brain axis
www.nature.com/articles/s41...
Cover art inspired by a Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social on the role of microglia, the 'gardeners' of the brain, in modulating the gut-brain axis
www.nature.com/articles/s41...
October 30, 2025 at 4:52 PM
Great to see our review on the role of microglia, the 'gardeners' of the brain, in modulating the gut-brain axis make the cover of this months @natrevimmunol.nature.com
Reposted by Nature Reviews Immunology
Thrilled to share our Perspective on structural immunity, where we discuss how immune cells double as architects, weaving and reshaping the fabric of our tissues. Grateful to @drusqui.bsky.social, all co-authors, and the wonderful @natrevimmunol.nature.com team for making it such a joy to write!
NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM
#structuralimmunity #immunosky
#structuralimmunity #immunosky
Structural immunity: immune cells as architects of tissue barriers - Nature Reviews Immunology
This Perspective presents a framework of ‘structural immunity’ that positions immune cells as architects of tissue structure. Beyond their roles in antimicrobial defence, we posit that immune cells co...
www.nature.com
October 28, 2025 at 7:54 PM
Thrilled to share our Perspective on structural immunity, where we discuss how immune cells double as architects, weaving and reshaping the fabric of our tissues. Grateful to @drusqui.bsky.social, all co-authors, and the wonderful @natrevimmunol.nature.com team for making it such a joy to write!
November issue now online www.nature.com/nri/volumes/...
Cover art inspired by a Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social on the role of microglia, the 'gardeners' of the brain, in modulating the gut-brain axis
www.nature.com/articles/s41...
Cover art inspired by a Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social on the role of microglia, the 'gardeners' of the brain, in modulating the gut-brain axis
www.nature.com/articles/s41...
October 29, 2025 at 10:11 AM
November issue now online www.nature.com/nri/volumes/...
Cover art inspired by a Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social on the role of microglia, the 'gardeners' of the brain, in modulating the gut-brain axis
www.nature.com/articles/s41...
Cover art inspired by a Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social on the role of microglia, the 'gardeners' of the brain, in modulating the gut-brain axis
www.nature.com/articles/s41...
Reposted by Nature Reviews Immunology
Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.
NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM
#structuralimmunity #immunosky
#structuralimmunity #immunosky
Structural immunity: immune cells as architects of tissue barriers - Nature Reviews Immunology
This Perspective presents a framework of ‘structural immunity’ that positions immune cells as architects of tissue structure. Beyond their roles in antimicrobial defence, we posit that immune cells co...
www.nature.com
October 28, 2025 at 4:41 PM
Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.
A Review article by Jeremy Baldwin, @cheuserloy.bsky.social & Luca Gattinoni discusses emerging strategies to modulate #organelle functions — including the transfer or transplantation of native or synthetic organelles — that could enhance #cancer #immunotherapy.
#immunosky
#immunosky
Targeting organelle function in T cells for cancer immunotherapy - Nature Reviews Immunology
In this Review, the authors discuss the latest advances in our understanding of organelle biology in T cell-mediated antitumour immunity and how this knowledge is being used to power the next generati...
www.nature.com
October 28, 2025 at 3:23 PM
A Review article by Jeremy Baldwin, @cheuserloy.bsky.social & Luca Gattinoni discusses emerging strategies to modulate #organelle functions — including the transfer or transplantation of native or synthetic organelles — that could enhance #cancer #immunotherapy.
#immunosky
#immunosky
NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM
#structuralimmunity #immunosky
#structuralimmunity #immunosky
Structural immunity: immune cells as architects of tissue barriers - Nature Reviews Immunology
This Perspective presents a framework of ‘structural immunity’ that positions immune cells as architects of tissue structure. Beyond their roles in antimicrobial defence, we posit that immune cells co...
www.nature.com
October 28, 2025 at 3:16 PM
NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM
#structuralimmunity #immunosky
#structuralimmunity #immunosky
Reposted by Nature Reviews Immunology
A new subspecialty takes off! Astroimmunology is focused on the effects of #spaceflight on the #immunesystem and defines avenues for countermeasures. A bonus: the work will also inform research on #aging @natrevimmunol.nature.com evimmunol.nature.com www.buckinstitute.org/news/a-hitch...
A hitchhiker’s guide to the galaxy of space immunology
Buck scientists help define the scope of Astroimmunology With the advent of commercial spaceflight, an increasing number of people may be heading into space in the coming years. Some will even get ...
www.buckinstitute.org
October 16, 2025 at 4:20 PM
A new subspecialty takes off! Astroimmunology is focused on the effects of #spaceflight on the #immunesystem and defines avenues for countermeasures. A bonus: the work will also inform research on #aging @natrevimmunol.nature.com evimmunol.nature.com www.buckinstitute.org/news/a-hitch...
Reposted by Nature Reviews Immunology
Organelle fitness ➡️ cell fitness
Curious what we know about organelles in T cell function, how we learned and ways to boost therapies?
Just out @natrevimmunol.nature.com: rdcu.be/eJ90x
Curious what we know about organelles in T cell function, how we learned and ways to boost therapies?
Just out @natrevimmunol.nature.com: rdcu.be/eJ90x
Targeting organelle function in T cells for cancer immunotherapy
Nature Reviews Immunology - In this Review, the authors discuss the latest advances in our understanding of organelle biology in T cell-mediated antitumour immunity and how this knowledge is being...
rdcu.be
October 10, 2025 at 9:23 AM
Organelle fitness ➡️ cell fitness
Curious what we know about organelles in T cell function, how we learned and ways to boost therapies?
Just out @natrevimmunol.nature.com: rdcu.be/eJ90x
Curious what we know about organelles in T cell function, how we learned and ways to boost therapies?
Just out @natrevimmunol.nature.com: rdcu.be/eJ90x
Happy #treg day everyone - congratulations to Mary Brunkow, Fred Ramsdell, Shimon Sakaguchi and to all the immunologists who have contributed to this incredible field. See our collection: www.nature.com/collections/...
Nobel Prize in Physiology or Medicine 2025
The 2025 Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries ...
www.nature.com
October 6, 2025 at 5:02 PM
Happy #treg day everyone - congratulations to Mary Brunkow, Fred Ramsdell, Shimon Sakaguchi and to all the immunologists who have contributed to this incredible field. See our collection: www.nature.com/collections/...
Reposted by Nature Reviews Immunology
Happy to have our work highlighted on a day when we are celebrating #treg cells! These cells do it all, even modulate how we sense the environment!
Highlight of Science Immunology paper by @thepenkpanther.bsky.social, Alexander Rudensky and colleagues @mskcancercenter.bsky.social @scripps.edu @wcm-imp.bsky.social
#immunology #immunosky #neurosky
#immunology #immunosky #neurosky
Skin Treg cells set the tone for neuronal activation - Nature Reviews Immunology
A study in Science Immunology reports that regulatory T cells in the skin modulate neuronal tone directly through their production of the opioid enkephalin.
www.nature.com
October 6, 2025 at 3:39 PM
Happy to have our work highlighted on a day when we are celebrating #treg cells! These cells do it all, even modulate how we sense the environment!
Highlight of Science Immunology paper by @thepenkpanther.bsky.social, Alexander Rudensky and colleagues @mskcancercenter.bsky.social @scripps.edu @wcm-imp.bsky.social
#immunology #immunosky #neurosky
#immunology #immunosky #neurosky
Skin Treg cells set the tone for neuronal activation - Nature Reviews Immunology
A study in Science Immunology reports that regulatory T cells in the skin modulate neuronal tone directly through their production of the opioid enkephalin.
www.nature.com
October 6, 2025 at 8:04 AM
Highlight of Science Immunology paper by @thepenkpanther.bsky.social, Alexander Rudensky and colleagues @mskcancercenter.bsky.social @scripps.edu @wcm-imp.bsky.social
#immunology #immunosky #neurosky
#immunology #immunosky #neurosky
NEW Review of neoadjuvant #immunotherapy in melanoma by Francesca Fallarino & Christian Blank @nkinl.bsky.social discusses where the field is heading next in terms of understanding immune education in therapy resistance and biomarker-driven personalization
#immunology #oncology #cancer #melanoma
#immunology #oncology #cancer #melanoma
Lessons from neoadjuvant immunotherapy in melanoma: understanding antitumour immunity and tumour escape - Nature Reviews Immunology
Neoadjuvant (chemo)immunotherapy has become a new standard-of-care option for patients with cancer. This Perspective discusses the lessons learnt for neoadjuvant immunotherapy in the context of melano...
www.nature.com
September 22, 2025 at 4:08 PM
NEW Review of neoadjuvant #immunotherapy in melanoma by Francesca Fallarino & Christian Blank @nkinl.bsky.social discusses where the field is heading next in terms of understanding immune education in therapy resistance and biomarker-driven personalization
#immunology #oncology #cancer #melanoma
#immunology #oncology #cancer #melanoma
Reposted by Nature Reviews Immunology
Just in time for #Cd1Mr12025
Our Review on Innate-like T cell Metabolism is out!
Access free here: rdcu.be/eEV67
Please share with your Immunometabolism friends!
@cd1mr1.bsky.social
@lji.org @uniklinikkoeln.bsky.social
@natureportfolio.nature.com @natrevimmunol.nature.com
Our Review on Innate-like T cell Metabolism is out!
Access free here: rdcu.be/eEV67
Please share with your Immunometabolism friends!
@cd1mr1.bsky.social
@lji.org @uniklinikkoeln.bsky.social
@natureportfolio.nature.com @natrevimmunol.nature.com
Metabolic control of innate-like T cells - Nature Reviews Immunology
Functional and metabolic properties of innate-like T cells — namely, iNKT cells, MAIT cells and some γδ T cells — differ from those of conventional T cells. This Review describes how metabolic pathway...
www.nature.com
September 8, 2025 at 6:45 PM
Just in time for #Cd1Mr12025
Our Review on Innate-like T cell Metabolism is out!
Access free here: rdcu.be/eEV67
Please share with your Immunometabolism friends!
@cd1mr1.bsky.social
@lji.org @uniklinikkoeln.bsky.social
@natureportfolio.nature.com @natrevimmunol.nature.com
Our Review on Innate-like T cell Metabolism is out!
Access free here: rdcu.be/eEV67
Please share with your Immunometabolism friends!
@cd1mr1.bsky.social
@lji.org @uniklinikkoeln.bsky.social
@natureportfolio.nature.com @natrevimmunol.nature.com
NEW Review online now
#immunosky
#immunosky
Targeting MHC-E as a new strategy for vaccines and immunotherapeutics - Nature Reviews Immunology
The dual nature of non-polymorphic MHC-E as a ligand for innate receptors and as an antigen-presenting protein raises the possibility of new, universally effective vaccines and immunotherapies for inf...
www.nature.com
September 5, 2025 at 8:07 AM
NEW Review online now
#immunosky
#immunosky
Reposted by Nature Reviews Immunology
📌In #September @natrevimmunol.nature.com issue, read our #comprehensive #Review: "The #Diversity of #CD8+ T #cell #dysfunction in #cancer and #viral #infection"
⏩Read: www.nature.com/articles/s41...
🤝Result of fruitful #Collaboration w/ @deadoc80.bsky.social @labliston.bsky.social & Kellie Smith!
⏩Read: www.nature.com/articles/s41...
🤝Result of fruitful #Collaboration w/ @deadoc80.bsky.social @labliston.bsky.social & Kellie Smith!
August 31, 2025 at 11:49 AM
📌In #September @natrevimmunol.nature.com issue, read our #comprehensive #Review: "The #Diversity of #CD8+ T #cell #dysfunction in #cancer and #viral #infection"
⏩Read: www.nature.com/articles/s41...
🤝Result of fruitful #Collaboration w/ @deadoc80.bsky.social @labliston.bsky.social & Kellie Smith!
⏩Read: www.nature.com/articles/s41...
🤝Result of fruitful #Collaboration w/ @deadoc80.bsky.social @labliston.bsky.social & Kellie Smith!
Reposted by Nature Reviews Immunology
#ThrowbackThursday: In 1980 the 🌍🌎🌏 was declared #smallpox free, thanks to mass vaccination efforts.
Smallpox was an acute contagious disease caused by the variola virus. It was one of the most devastating diseases known to humanity. #VaccinesWork
Smallpox was an acute contagious disease caused by the variola virus. It was one of the most devastating diseases known to humanity. #VaccinesWork
August 28, 2025 at 9:17 AM
#ThrowbackThursday: In 1980 the 🌍🌎🌏 was declared #smallpox free, thanks to mass vaccination efforts.
Smallpox was an acute contagious disease caused by the variola virus. It was one of the most devastating diseases known to humanity. #VaccinesWork
Smallpox was an acute contagious disease caused by the variola virus. It was one of the most devastating diseases known to humanity. #VaccinesWork
Reposted by Nature Reviews Immunology
The aryl hydrocarbon receptor has become a promising target for therapeutic immune modulation in inflammatory diseases, cancer and infections. Read about the field in this review in the August issue
www.nature.com/articles/s41...
rdcu.be/eBJKu
www.nature.com/articles/s41...
rdcu.be/eBJKu
The aryl hydrocarbon receptor: a rehabilitated target for therapeutic immune modulation - Nature Reviews Drug Discovery
The aryl hydrocarbon receptor (AHR) mediates the toxic effects of environmental pollutants and regulates innate and adaptive immune responses. This Review discusses how, in the past, AHR activation wa...
www.nature.com
August 21, 2025 at 2:21 PM
The aryl hydrocarbon receptor has become a promising target for therapeutic immune modulation in inflammatory diseases, cancer and infections. Read about the field in this review in the August issue
www.nature.com/articles/s41...
rdcu.be/eBJKu
www.nature.com/articles/s41...
rdcu.be/eBJKu