Christoph Heuser-Loy
@cheuserloy.bsky.social
Immunologist || T cells | Synthetic Biology | ACT at lit.eu (Luca Gattinoni's lab) #immunosky
Hiker | Cyclist
Hiker | Cyclist
Pinned
Targeting organelle function in T cells for cancer immunotherapy
Nature Reviews Immunology - In this Review, the authors discuss the latest advances in our understanding of organelle biology in T cell-mediated antitumour immunity and how this knowledge is being...
rdcu.be
Organelle fitness ➡️ cell fitness
Curious what we know about organelles in T cell function, how we learned and ways to boost therapies?
Just out @natrevimmunol.nature.com: rdcu.be/eJ90x
Curious what we know about organelles in T cell function, how we learned and ways to boost therapies?
Just out @natrevimmunol.nature.com: rdcu.be/eJ90x
Reposted by Christoph Heuser-Loy
Jo in our team - we are looking for a PhD student, postdoc or lab manager!
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
Postdoc or PhD student position in molecular dissection of cellular crosstalk in the intestinal mucosa
lnkd.in
November 11, 2025 at 6:20 AM
Jo in our team - we are looking for a PhD student, postdoc or lab manager!
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
More information and links to job portal for application submission:
lnkd.in/dcU2Vg7W
lnkd.in/dgVKTARV
Please share widely 🙏🏼
@yefis-immunology.bsky.social @syis-ecr.bsky.social
Reposted by Christoph Heuser-Loy
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
November 11, 2025 at 12:52 PM
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
Reposted by Christoph Heuser-Loy
This is interesting for a number of reasons. www.nature.com/articles/s41...
Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity - Nature Biotechnology
T cell immunity declines with thymic atrophy, but thymic cell grafts rescue T cell function.
www.nature.com
November 3, 2025 at 4:05 PM
This is interesting for a number of reasons. www.nature.com/articles/s41...
Reposted by Christoph Heuser-Loy
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
October 28, 2025 at 8:06 AM
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
Reposted by Christoph Heuser-Loy
A Review article by Jeremy Baldwin, @cheuserloy.bsky.social & Luca Gattinoni discusses emerging strategies to modulate #organelle functions — including the transfer or transplantation of native or synthetic organelles — that could enhance #cancer #immunotherapy.
#immunosky
#immunosky
Targeting organelle function in T cells for cancer immunotherapy - Nature Reviews Immunology
In this Review, the authors discuss the latest advances in our understanding of organelle biology in T cell-mediated antitumour immunity and how this knowledge is being used to power the next generati...
www.nature.com
October 28, 2025 at 3:23 PM
A Review article by Jeremy Baldwin, @cheuserloy.bsky.social & Luca Gattinoni discusses emerging strategies to modulate #organelle functions — including the transfer or transplantation of native or synthetic organelles — that could enhance #cancer #immunotherapy.
#immunosky
#immunosky
Reposted by Christoph Heuser-Loy
Open position! The group of Kaan Boztug at the Clinic for Pediatric Immunology and Rheumatology in Bonn is looking for a
Postdoc in Bioinformatics/Computational Biology (m/f/d) (full-time position 100 %) for inatially 7 years.
More information on our website: www.immunosensation.de/opportunitie...
Postdoc in Bioinformatics/Computational Biology (m/f/d) (full-time position 100 %) for inatially 7 years.
More information on our website: www.immunosensation.de/opportunitie...
October 23, 2025 at 7:12 AM
Open position! The group of Kaan Boztug at the Clinic for Pediatric Immunology and Rheumatology in Bonn is looking for a
Postdoc in Bioinformatics/Computational Biology (m/f/d) (full-time position 100 %) for inatially 7 years.
More information on our website: www.immunosensation.de/opportunitie...
Postdoc in Bioinformatics/Computational Biology (m/f/d) (full-time position 100 %) for inatially 7 years.
More information on our website: www.immunosensation.de/opportunitie...
Organelle fitness ➡️ cell fitness
Curious what we know about organelles in T cell function, how we learned and ways to boost therapies?
Just out @natrevimmunol.nature.com: rdcu.be/eJ90x
Curious what we know about organelles in T cell function, how we learned and ways to boost therapies?
Just out @natrevimmunol.nature.com: rdcu.be/eJ90x
Targeting organelle function in T cells for cancer immunotherapy
Nature Reviews Immunology - In this Review, the authors discuss the latest advances in our understanding of organelle biology in T cell-mediated antitumour immunity and how this knowledge is being...
rdcu.be
October 10, 2025 at 9:23 AM
Organelle fitness ➡️ cell fitness
Curious what we know about organelles in T cell function, how we learned and ways to boost therapies?
Just out @natrevimmunol.nature.com: rdcu.be/eJ90x
Curious what we know about organelles in T cell function, how we learned and ways to boost therapies?
Just out @natrevimmunol.nature.com: rdcu.be/eJ90x
Reposted by Christoph Heuser-Loy
New #flowcytometery protocol drop from Oliver Burton.
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Optimization of the Blocking and Signal Preservation Protocol in High‐Parameter Flow Cytometry
High quality input data is the key to successful interpretation of any scientific assay. In flow cytometry, fluorescently-conjugated antibodies allow us to simultaneously measure an incredible range ...
currentprotocols.onlinelibrary.wiley.com
September 25, 2025 at 5:06 PM
New #flowcytometery protocol drop from Oliver Burton.
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
This one is on optimising blocking while preserving signal, in particular how to overcome Fc interactions and dye-dye interactions, and preventing tandem break-down.
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Christoph Heuser-Loy
You like engineering T cells, but you are missing the right flavor?
Check out 'one-pot' PASTA recipe 🔥🍝: www.biorxiv.org/content/10.1101/2025.09.10.675267v1
We combined a unique mix of CRISPR knock-in with serine integrases for easy-to-adopt
𝐏rogrammable
𝐀nd
𝐒ite-specific
𝐓ransgene
𝐀ddition
🧪
Check out 'one-pot' PASTA recipe 🔥🍝: www.biorxiv.org/content/10.1101/2025.09.10.675267v1
We combined a unique mix of CRISPR knock-in with serine integrases for easy-to-adopt
𝐏rogrammable
𝐀nd
𝐒ite-specific
𝐓ransgene
𝐀ddition
🧪
Versatile and efficient non-viral integration of large transgenes in human T cells via CRISPR knock-in and engineered integrases
Current gene transfer methods often lack the precision, versatility, or efficiency when integrating large transgenes, limiting the ability to engineer therapeutic T-cells with more complex payloads. H...
www.biorxiv.org
September 19, 2025 at 5:30 AM
You like engineering T cells, but you are missing the right flavor?
Check out 'one-pot' PASTA recipe 🔥🍝: www.biorxiv.org/content/10.1101/2025.09.10.675267v1
We combined a unique mix of CRISPR knock-in with serine integrases for easy-to-adopt
𝐏rogrammable
𝐀nd
𝐒ite-specific
𝐓ransgene
𝐀ddition
🧪
Check out 'one-pot' PASTA recipe 🔥🍝: www.biorxiv.org/content/10.1101/2025.09.10.675267v1
We combined a unique mix of CRISPR knock-in with serine integrases for easy-to-adopt
𝐏rogrammable
𝐀nd
𝐒ite-specific
𝐓ransgene
𝐀ddition
🧪
Reposted by Christoph Heuser-Loy
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
currentprotocols.onlinelibrary.wiley.com
September 19, 2025 at 2:39 PM
For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Applications for postdocs (MD/PhD) to the Mildred Scheel School of Oncology are open: msso-cologne-bonn.de/application
👩🔬 Check out the opportunities in the Cologne-Bonn cancer research hub in the heart of Europe! 🌍
👩🔬 Check out the opportunities in the Cologne-Bonn cancer research hub in the heart of Europe! 🌍
Application
msso-cologne-bonn.de
September 19, 2025 at 2:01 PM
Applications for postdocs (MD/PhD) to the Mildred Scheel School of Oncology are open: msso-cologne-bonn.de/application
👩🔬 Check out the opportunities in the Cologne-Bonn cancer research hub in the heart of Europe! 🌍
👩🔬 Check out the opportunities in the Cologne-Bonn cancer research hub in the heart of Europe! 🌍
Reposted by Christoph Heuser-Loy
🚨 Open #position! The group of Zeinab Abdullah is looking for two PhD students for
a) Characterisation of hepatic NK-like T cells
b) Dissecting the role of STING signalling in anti-viral T cell responses
Application deadline: October 30
More information: www.immunosensation.de/opportunitie...
a) Characterisation of hepatic NK-like T cells
b) Dissecting the role of STING signalling in anti-viral T cell responses
Application deadline: October 30
More information: www.immunosensation.de/opportunitie...
September 17, 2025 at 7:35 AM
🚨 Open #position! The group of Zeinab Abdullah is looking for two PhD students for
a) Characterisation of hepatic NK-like T cells
b) Dissecting the role of STING signalling in anti-viral T cell responses
Application deadline: October 30
More information: www.immunosensation.de/opportunitie...
a) Characterisation of hepatic NK-like T cells
b) Dissecting the role of STING signalling in anti-viral T cell responses
Application deadline: October 30
More information: www.immunosensation.de/opportunitie...
Reposted by Christoph Heuser-Loy
🧵How to write and manage your first research budgets
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
September 3, 2025 at 4:03 PM
🧵How to write and manage your first research budgets
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
Reposted by Christoph Heuser-Loy
I could not get myself to watch it but hopefully this inspires others to pursue immunology! Follow your curiosity folks and don't let the current leadership discourage you, tides ebb and flow - we are ultimately on the right boat. cheers
LJI Assistant Professor Miguel Reina-Campos, Ph.D. (@reinacampos.bsky.social) leads fascinating #ImmuneCell research in his lab. Now he's being recognized by @aai.org on a national stage!
Congrats, Dr. Reina-Campos!
www.youtube.com/watch?v=ib7O...
#SanDiego #Science #STEM #health #medicine
Congrats, Dr. Reina-Campos!
www.youtube.com/watch?v=ib7O...
#SanDiego #Science #STEM #health #medicine
Miguel Reina Campos, Ph.D., on receiving a 2025 ASPIRE Award
YouTube video by The American Association of Immunologists (AAI)
www.youtube.com
August 14, 2025 at 7:51 PM
I could not get myself to watch it but hopefully this inspires others to pursue immunology! Follow your curiosity folks and don't let the current leadership discourage you, tides ebb and flow - we are ultimately on the right boat. cheers
Gradually for sure, kicking in (long) before reaching PI status if you ask me...
Somewhere along the way, things shift in terms of how PIs are seen by their students
go.nature.com/4kZYQRx
go.nature.com/4kZYQRx
From bench to big boss: mitigating the widening gap between PI and lab
Laboratory dynamics can change as the age and experience of the principal investigator increase. But there are ways to combat this.
go.nature.com
August 4, 2025 at 9:33 PM
Gradually for sure, kicking in (long) before reaching PI status if you ask me...
Reposted by Christoph Heuser-Loy
🚨 There is a new W2 Professorship for Tumor Immunology (permanent position) available in our department. 🎓 🧫 🧪 🔬
ℹ️ Check out the details here: www.uni-bonn.de/en/universit...
⏰ Apply now! Application deadline is August 26, 2025.
📢 Please share!
@unibonn.bsky.social @immunosens.bsky.social
ℹ️ Check out the details here: www.uni-bonn.de/en/universit...
⏰ Apply now! Application deadline is August 26, 2025.
📢 Please share!
@unibonn.bsky.social @immunosens.bsky.social
W2 Professorship for Tumor Immunology
W2 Professorship
www.uni-bonn.de
July 22, 2025 at 9:22 AM
🚨 There is a new W2 Professorship for Tumor Immunology (permanent position) available in our department. 🎓 🧫 🧪 🔬
ℹ️ Check out the details here: www.uni-bonn.de/en/universit...
⏰ Apply now! Application deadline is August 26, 2025.
📢 Please share!
@unibonn.bsky.social @immunosens.bsky.social
ℹ️ Check out the details here: www.uni-bonn.de/en/universit...
⏰ Apply now! Application deadline is August 26, 2025.
📢 Please share!
@unibonn.bsky.social @immunosens.bsky.social
Reposted by Christoph Heuser-Loy
Naive T cell vs Killer T cell
January 20, 2025 at 7:51 AM
Naive T cell vs Killer T cell
Reposted by Christoph Heuser-Loy
Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library
Positive research cultures provide the environment for scientists to explore ideas, grow as individuals, develop team science and create a positive impact on those around them. Here we focus on key a...
onlinelibrary.wiley.com
January 17, 2025 at 11:53 AM
Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Christoph Heuser-Loy
🚨 Open #position! The group of Christoph Wilhelm at the University Hospital Bonn is looking for a
Postdoctoral fellow (m/f/d) – metabolic and nutritional regulation of immunity
Application deadline is February 10!
Visit our website for more information.
#job #postdoc #science #immunology
Postdoctoral fellow (m/f/d) – metabolic and nutritional regulation of immunity
Application deadline is February 10!
Visit our website for more information.
#job #postdoc #science #immunology
January 15, 2025 at 6:54 AM
🚨 Open #position! The group of Christoph Wilhelm at the University Hospital Bonn is looking for a
Postdoctoral fellow (m/f/d) – metabolic and nutritional regulation of immunity
Application deadline is February 10!
Visit our website for more information.
#job #postdoc #science #immunology
Postdoctoral fellow (m/f/d) – metabolic and nutritional regulation of immunity
Application deadline is February 10!
Visit our website for more information.
#job #postdoc #science #immunology
Reposted by Christoph Heuser-Loy
An excellent review on spike-in normalization in ChIP-seq. When done correctly, spike-in is a vast improvement in quantitation. However best practices are non-obvious. Suboptimal design & analysis are shown to lead to erroneous conclusions in the literature. www.nature.com/articles/s41...
The Wild West of spike-in normalization - Nature Biotechnology
The proper use of spike-in normalization in ChIP-seq improves sensitivity for detecting genome-wide changes between conditions, but improper use is common, calling some biological conclusions into que...
www.nature.com
December 20, 2024 at 3:14 AM
An excellent review on spike-in normalization in ChIP-seq. When done correctly, spike-in is a vast improvement in quantitation. However best practices are non-obvious. Suboptimal design & analysis are shown to lead to erroneous conclusions in the literature. www.nature.com/articles/s41...
Reposted by Christoph Heuser-Loy
Hidden among our immune system's seeds, scientists found special ones that could revolutionize cancer treatments and vaccines.
@deekshadeep @danapeer.bsky.social @jexpmed.bsky.social
t.co/k5lwZHxzxi
#ImmunoSky 🧪
@deekshadeep @danapeer.bsky.social @jexpmed.bsky.social
t.co/k5lwZHxzxi
#ImmunoSky 🧪
December 31, 2024 at 4:11 PM
Hidden among our immune system's seeds, scientists found special ones that could revolutionize cancer treatments and vaccines.
@deekshadeep @danapeer.bsky.social @jexpmed.bsky.social
t.co/k5lwZHxzxi
#ImmunoSky 🧪
@deekshadeep @danapeer.bsky.social @jexpmed.bsky.social
t.co/k5lwZHxzxi
#ImmunoSky 🧪
Reposted by Christoph Heuser-Loy
🔭 What’s in store next for cell therapy for solid tumours?
2024 has been seismic with the @fda.gov approval of Lifileucel (melanoma) & Afami-cel (sarcoma).
Check out this outlook piece out today in Nat Cancer by Kishton & Restifo 👇
@natureportfolio.bsky.social
www.nature.com/articles/s43...
2024 has been seismic with the @fda.gov approval of Lifileucel (melanoma) & Afami-cel (sarcoma).
Check out this outlook piece out today in Nat Cancer by Kishton & Restifo 👇
@natureportfolio.bsky.social
www.nature.com/articles/s43...
T cells lead the charge against solid tumors - Nature Cancer
In 2024, two groundbreaking approvals from the US Food and Drug Administration for T cell-based therapies that target solid tumors were achieved. Lifileucel, a polyclonal tumor-infiltrating lymphocyte...
www.nature.com
December 17, 2024 at 9:50 PM
🔭 What’s in store next for cell therapy for solid tumours?
2024 has been seismic with the @fda.gov approval of Lifileucel (melanoma) & Afami-cel (sarcoma).
Check out this outlook piece out today in Nat Cancer by Kishton & Restifo 👇
@natureportfolio.bsky.social
www.nature.com/articles/s43...
2024 has been seismic with the @fda.gov approval of Lifileucel (melanoma) & Afami-cel (sarcoma).
Check out this outlook piece out today in Nat Cancer by Kishton & Restifo 👇
@natureportfolio.bsky.social
www.nature.com/articles/s43...
Reposted by Christoph Heuser-Loy
1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇
biorxiv.org/content/10.1101/2024.12.11.627935v1
biorxiv.org/content/10.1101/2024.12.11.627935v1
December 12, 2024 at 2:48 PM
1/🚀 Excited to share RegVelo, our new cell model combining RNA velocity with gene regulatory network (GRN) dynamics to model cellular changes and predict in silico perturbations. Here's how it works and why it matters! 🧵👇
biorxiv.org/content/10.1101/2024.12.11.627935v1
biorxiv.org/content/10.1101/2024.12.11.627935v1
Reposted by Christoph Heuser-Loy
VERY excited to welcome this paper out in @natBME where we introduce the GEMINI platform for engineering multifunctional extracellular vesicles as versatile, programmable, biological delivery vehicles
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery ...
Biologics can be specifically delivered to T cells by genetically engineering cells to secrete extracellular vesicles that actively load protein cargo and that display high-affinity T-cell-targeting d...
www.nature.com
November 27, 2023 at 5:22 PM
VERY excited to welcome this paper out in @natBME where we introduce the GEMINI platform for engineering multifunctional extracellular vesicles as versatile, programmable, biological delivery vehicles
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Christoph Heuser-Loy
Der Betrieb in Berlin kreist seit dem Ampel-Aus um die Parteien der alten Bundesrepublik – argumentiert und berichtet an einem Drittel der Wähler vorbei. Das könnte sich rächen. Eine Kolumne.
Tauchsieder: Die Bonner Bubble-Republik
Der Betrieb in Berlin kreist seit dem Ampel-Aus um die Parteien der alten Bundesrepublik – argumentiert und berichtet an einem Drittel der Wähler vorbei. Das könnte sich rächen. Eine Kolumne.
www.wiwo.de
December 8, 2024 at 7:40 AM
Der Betrieb in Berlin kreist seit dem Ampel-Aus um die Parteien der alten Bundesrepublik – argumentiert und berichtet an einem Drittel der Wähler vorbei. Das könnte sich rächen. Eine Kolumne.