BaumjohannLab
@baumjohannlab.bsky.social
Research on T and B cells in immunity and autoimmunity in the lab of Dirk Baumjohann at University Hospital Bonn & Cluster of Excellence ImmunoSensation @immunosens.bsky.social #TfhCells #GCs #ImmuneOrganoids
https://BaumjohannLab.de
https://BaumjohannLab.de
Pinned
BaumjohannLab
@baumjohannlab.bsky.social
· Mar 12
Boosting human immunology: harnessing the potential of immune organoids | EMBO Molecular Medicine
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
Awesome cover art featuring my lab's recent review on human immune organoids (with @maximilianmoll.bsky.social) published in @embomolmed.org www.embopress.org/doi/full/10.... It was great working together with @teresasteffen.bsky.social and @drawimpacts.bsky.social on creating such a cool image!
Reposted by BaumjohannLab
Thrilled to share our latest work: Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy - now online in Nature Immunology. Led by Alberto Conti, Alex Evans and Teresa von Linde in the lab. www.nature.com/articles/s41...
January 16, 2026 at 12:00 PM
Thrilled to share our latest work: Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy - now online in Nature Immunology. Led by Alberto Conti, Alex Evans and Teresa von Linde in the lab. www.nature.com/articles/s41...
Reposted by BaumjohannLab
Finally, my PhD project is published! 🎉
I am thankful to all the collaborators who made this possible!
www.nature.com/articles/s41...
@natcomms.nature.com
#dendriticcells #immunesynapse #centrosome
I am thankful to all the collaborators who made this possible!
www.nature.com/articles/s41...
@natcomms.nature.com
#dendriticcells #immunesynapse #centrosome
January 15, 2026 at 7:39 AM
Finally, my PhD project is published! 🎉
I am thankful to all the collaborators who made this possible!
www.nature.com/articles/s41...
@natcomms.nature.com
#dendriticcells #immunesynapse #centrosome
I am thankful to all the collaborators who made this possible!
www.nature.com/articles/s41...
@natcomms.nature.com
#dendriticcells #immunesynapse #centrosome
Looking forward to two exciting talks by @carovinuesa.bsky.social and Dirk Elewaut in the EFIS-IL study group T-Cell Connect Europe online lecture series TODAY at 5pm CET t-cells.eu
T-Cell Connect Europe
EFIS-IL study group T CELL CONNECT EUROPE (TCC_EUROPE)
t-cells.eu
January 6, 2026 at 8:55 AM
Looking forward to two exciting talks by @carovinuesa.bsky.social and Dirk Elewaut in the EFIS-IL study group T-Cell Connect Europe online lecture series TODAY at 5pm CET t-cells.eu
Reposted by BaumjohannLab
@biorxivpreprint.bsky.social Dysregulated localization of Tfh and B cells in lymph nodes of Idiopathic multicentric Castleman disease patients
www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social
www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social
December 16, 2025 at 4:30 AM
@biorxivpreprint.bsky.social Dysregulated localization of Tfh and B cells in lymph nodes of Idiopathic multicentric Castleman disease patients
www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social
www.biorxiv.org/content/10.6... @davidfajgenbaum.bsky.social
Reposted by BaumjohannLab
🚀 New preprint!
The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab!
🔗 www.biorxiv.org/content/10.6...
The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab!
🔗 www.biorxiv.org/content/10.6...
December 15, 2025 at 10:42 PM
🚀 New preprint!
The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab!
🔗 www.biorxiv.org/content/10.6...
The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab!
🔗 www.biorxiv.org/content/10.6...
Reposted by BaumjohannLab
🎉 The new yEFIS website is now live! 🌐
We’re happy to share that our new website is officially online, check it out 👉https://www.yefis.org/
We’re happy to share that our new website is officially online, check it out 👉https://www.yefis.org/
December 10, 2025 at 3:40 PM
🎉 The new yEFIS website is now live! 🌐
We’re happy to share that our new website is officially online, check it out 👉https://www.yefis.org/
We’re happy to share that our new website is officially online, check it out 👉https://www.yefis.org/
Reposted by BaumjohannLab
@biorxivpreprint.bsky.social Access to germinal center IL-4 microniches drives tissue-divergence of IgE memory responses
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 6, 2025 at 4:26 AM
@biorxivpreprint.bsky.social Access to germinal center IL-4 microniches drives tissue-divergence of IgE memory responses
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by BaumjohannLab
@biorxivpreprint.bsky.social BCL6 is required for the development of functionally responsive IgM+ GC-independent Memory B Cells @marionpepper.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 6, 2025 at 4:28 AM
@biorxivpreprint.bsky.social BCL6 is required for the development of functionally responsive IgM+ GC-independent Memory B Cells @marionpepper.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by BaumjohannLab
The Cluster Science Days 2025 were a very joyful event bringing together our Bonn scientists to share ideas and to network.
During the event the Cluster participants could enjoy talks, interactive poster sessions and a fun evening program in a comfortable atmosphere fostering scientific exchange.
During the event the Cluster participants could enjoy talks, interactive poster sessions and a fun evening program in a comfortable atmosphere fostering scientific exchange.
November 20, 2025 at 10:54 AM
The Cluster Science Days 2025 were a very joyful event bringing together our Bonn scientists to share ideas and to network.
During the event the Cluster participants could enjoy talks, interactive poster sessions and a fun evening program in a comfortable atmosphere fostering scientific exchange.
During the event the Cluster participants could enjoy talks, interactive poster sessions and a fun evening program in a comfortable atmosphere fostering scientific exchange.
Reposted by BaumjohannLab
November 18, 2025 at 4:00 PM
Reposted by BaumjohannLab
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
November 11, 2025 at 12:52 PM
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
Reposted by BaumjohannLab
Registration is open for the Spring School on Immunology, hosted by DGfI
March 15–20, 2026 | Ettal, Bavaria
🎓 An intensive training course for PhDs, postdocs & clinician scientists
Apply by 15 Nov 2025 → https://loom.ly/LxBXUfI
@dgfi-org.bsky.social
March 15–20, 2026 | Ettal, Bavaria
🎓 An intensive training course for PhDs, postdocs & clinician scientists
Apply by 15 Nov 2025 → https://loom.ly/LxBXUfI
@dgfi-org.bsky.social
November 11, 2025 at 5:48 PM
Registration is open for the Spring School on Immunology, hosted by DGfI
March 15–20, 2026 | Ettal, Bavaria
🎓 An intensive training course for PhDs, postdocs & clinician scientists
Apply by 15 Nov 2025 → https://loom.ly/LxBXUfI
@dgfi-org.bsky.social
March 15–20, 2026 | Ettal, Bavaria
🎓 An intensive training course for PhDs, postdocs & clinician scientists
Apply by 15 Nov 2025 → https://loom.ly/LxBXUfI
@dgfi-org.bsky.social
Reposted by BaumjohannLab
ICYMI: Engineering and biofabrication of early cancer models
Engineering and biofabrication of early cancer models
Nature Reviews Bioengineering, Published online: 03 November 2025; doi:10.1038/s44222-025-00371-wEarly cancer biology and detection research is limited owing to a lack of clinical samples from pre-malignant and early-stage tumours. This Review discusses engineered in vitro systems that mimic early disease stages to investigate tumour progression and identify biomarkers for early cancer detection.
www.nature.com
November 4, 2025 at 4:43 PM
ICYMI: Engineering and biofabrication of early cancer models
Reposted by BaumjohannLab
@biorxivpreprint.bsky.social Lymphatic constraint of germinal centers optimizes protective antibody responses
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social
November 6, 2025 at 2:48 AM
@biorxivpreprint.bsky.social Lymphatic constraint of germinal centers optimizes protective antibody responses
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social
www.biorxiv.org/content/10.1... @thelundlab.bsky.social
@nyulangone.bsky.social @carlanowosad.bsky.social
Reposted by BaumjohannLab
What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)?
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
November 5, 2025 at 6:24 PM
What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)?
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
Reposted by BaumjohannLab
🚨 A fantastic opportunity to join HIRI to start your research group on RNA Biology 👇 www.nature.com/naturecareer...
Junior Group Leader for RNA-Biology, RNA-Technology or RNA-Medicine (f/m/d) - Würzburg (Stadt), Bayern (DE) job with Helmholtz-Institut für RNA-basierte Infektionsforschung (HIRI) | 12844907
#RNAexcellence Junior Group Leader Positions (f/m/d) Job advertisement no.: 089/2025 Starting date: As soon as possible. The con...
www.nature.com
October 27, 2025 at 9:55 PM
🚨 A fantastic opportunity to join HIRI to start your research group on RNA Biology 👇 www.nature.com/naturecareer...
Reposted by BaumjohannLab
Arai, Kawakami, Sakaguchi (2025 #Nobel laureate) and colleagues show that oral antigen exposure combined with CD28 costimulation blockade generates functionally stable antigen-specific CD101⁺ pTreg cells even in previously antigen-sensitized hosts. rupress.org/jem/article/...
October 21, 2025 at 5:01 PM
Arai, Kawakami, Sakaguchi (2025 #Nobel laureate) and colleagues show that oral antigen exposure combined with CD28 costimulation blockade generates functionally stable antigen-specific CD101⁺ pTreg cells even in previously antigen-sensitized hosts. rupress.org/jem/article/...
Reposted by BaumjohannLab
Looking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
E15 Groups
The Helmholtz Institute for RNA-based Infection Researchopens a call for
www.helmholtz-hiri.de
October 13, 2025 at 1:30 PM
Looking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Reposted by BaumjohannLab
Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Tertiary lymphoid structures support the development of allergen-specific progenitor CD4+ T cells
Tissue-resident memory CD4+ T cells (TRM) are key sentinels of the adaptive immune response that provide a rapid, robust inflammatory response upon reactivation in non-lymphoid tissues. While CD4+ TRM...
www.biorxiv.org
October 10, 2025 at 7:22 PM
Asthma is a chronic disease characterized by acute, intermittent, recurrent episodes of airway inflammation. A decade of work developing the tools, techniques and collaborations needed to figure out how CD4+ T cells in the lungs propagate disease can be found here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by BaumjohannLab
🚀 WE ARE HIRING 3️⃣ Independent Group Leaders for #mdcBerlin's new cutting-edge Bioengineering Cluster within our Biomedical Engineering Program.
Lead cutting-edge research at the interface of biology, engineering, and medicine in Berlin.
👉 Apply now: www.mdc-berlin.de/career/jobs/...
Lead cutting-edge research at the interface of biology, engineering, and medicine in Berlin.
👉 Apply now: www.mdc-berlin.de/career/jobs/...
October 9, 2025 at 11:00 AM
🚀 WE ARE HIRING 3️⃣ Independent Group Leaders for #mdcBerlin's new cutting-edge Bioengineering Cluster within our Biomedical Engineering Program.
Lead cutting-edge research at the interface of biology, engineering, and medicine in Berlin.
👉 Apply now: www.mdc-berlin.de/career/jobs/...
Lead cutting-edge research at the interface of biology, engineering, and medicine in Berlin.
👉 Apply now: www.mdc-berlin.de/career/jobs/...
Reposted by BaumjohannLab
Thanks @10xgenomics.bsky.social for the shout out and for making your data publicly available
Why waste precious resources ($$) to reinvent data that already exists? Cool human datasets ready to go
(Although now we have scratched the spatial itch, we may need to do more @chinweetan.bsky.social 🤔)
Why waste precious resources ($$) to reinvent data that already exists? Cool human datasets ready to go
(Although now we have scratched the spatial itch, we may need to do more @chinweetan.bsky.social 🤔)
How do cytokines tune immune helpers?
Nature Immunology study from @groomlab.bsky.social ’s lab at @wehi-research.bsky.social used @10xgenomics.bsky.social single-cell & spatial tech to map T follicular helper (TFH) cells diversity.
🔗 www.nature.com/articles/s41...
#Immunology #SpatialBiology
Nature Immunology study from @groomlab.bsky.social ’s lab at @wehi-research.bsky.social used @10xgenomics.bsky.social single-cell & spatial tech to map T follicular helper (TFH) cells diversity.
🔗 www.nature.com/articles/s41...
#Immunology #SpatialBiology
October 9, 2025 at 9:54 AM
Thanks @10xgenomics.bsky.social for the shout out and for making your data publicly available
Why waste precious resources ($$) to reinvent data that already exists? Cool human datasets ready to go
(Although now we have scratched the spatial itch, we may need to do more @chinweetan.bsky.social 🤔)
Why waste precious resources ($$) to reinvent data that already exists? Cool human datasets ready to go
(Although now we have scratched the spatial itch, we may need to do more @chinweetan.bsky.social 🤔)
Reposted by BaumjohannLab
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...
October 8, 2025 at 5:17 PM
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells @natimmunol.nature.com @yuripritykin.bsky.social Rudensky @princetonupress.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...
Reposted by BaumjohannLab
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
October 6, 2025 at 11:21 AM
A small primer on the #NobelPrize awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi today. This prize was for combining two separate fields of immunology research - genetic research on IPEX and immunology research of regulatory T cells (#Tregs), with enormous impact on biology/medicine
Reposted by BaumjohannLab
The Nobel Assembly at Karolinska Institutet has decided to award the 2025 Nobel Prize in Physiology or Medicine to:
Mary E. Brunkow, Fred Ramsdell, Shimon Sakaguchi
“for their discoveries concerning peripheral immune tolerance”
Mary E. Brunkow, Fred Ramsdell, Shimon Sakaguchi
“for their discoveries concerning peripheral immune tolerance”
The official website of the Nobel Prize - NobelPrize.org
The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for the purpose of engaging, inspiring and spreading knowledge about the Nobel Prize as well as the discoveries and achievements of the laureates.
www.nobelprize.org
October 6, 2025 at 9:48 AM
The Nobel Assembly at Karolinska Institutet has decided to award the 2025 Nobel Prize in Physiology or Medicine to:
Mary E. Brunkow, Fred Ramsdell, Shimon Sakaguchi
“for their discoveries concerning peripheral immune tolerance”
Mary E. Brunkow, Fred Ramsdell, Shimon Sakaguchi
“for their discoveries concerning peripheral immune tolerance”
Reposted by BaumjohannLab
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
October 6, 2025 at 9:34 AM
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize