Nature Reviews Bioengineering, Published online: 22 December 2025; doi:10.1038/s44222-025-00399-yClimate change and geopolitical uncertainties require proactive measures to ensure food security and human resilience, with a focus on sustainable agricultural practices and soil preservation. We explore innovative solutions to preserve, improve and restore soil health and highlight how they can address global soil degradation and ensure sustainable food production.

Nature Reviews Bioengineering, Published online: 22 December 2025; doi:10.1038/s44222-025-00399-yClimate change and geopolitical uncertainties require proactive measures to ensure food security and human resilience, with a focus on sustainable agricultural practices and soil preservation. We explore innovative solutions to preserve, improve and restore soil health and highlight how they can address global soil degradation and ensure sustainable food production.

Nature Reviews Bioengineering, Published online: 15 December 2025; doi:10.1038/s44222-025-00400-8Ageing, disease and trauma can lead to impaired muscle function, which could be restored by implantable artificial muscles. Here we outline key performance metrics required for soft artificial muscles to restore function in stress urinary incontinence and to enable sit-to-stand transfer.

Nature Reviews Bioengineering, Published online: 15 December 2025; doi:10.1038/s44222-025-00394-3Wearable biosensors can continuously monitor disease biomarkers, therapeutic drugs and health-related analytes to provide real-time diagnostic insights. The wearable biosensor Aptalyzer integrates hydrogel microneedles and an electrochemical aptamer-based biosensor to assess biomarkers in the skin interstitial fluid.

YouTube video by Nature Portfolio

Nature Reviews Bioengineering, Published online: 15 December 2025; doi:10.1038/s44222-025-00400-8Ageing, disease and trauma can lead to impaired muscle function, which could be restored by implantable artificial muscles. Here we outline key performance metrics required for soft artificial muscles to restore function in stress urinary incontinence and to enable sit-to-stand transfer.

Nature Reviews Bioengineering, Published online: 15 December 2025; doi:10.1038/s44222-025-00394-3Wearable biosensors can continuously monitor disease biomarkers, therapeutic drugs and health-related analytes to provide real-time diagnostic insights. The wearable biosensor Aptalyzer integrates hydrogel microneedles and an electrochemical aptamer-based biosensor to assess biomarkers in the skin interstitial fluid.

Nature Reviews Bioengineering, Published online: 09 December 2025; doi:10.1038/s44222-025-00395-2Biomedical engineering innovations are being reimagined to address climate and environmental challenges, from food safety and crop engineering to plastic degradation and soil remediation.

Nature Reviews Bioengineering, Published online: 09 December 2025; doi:10.1038/s44222-025-00395-2Biomedical engineering innovations are being reimagined to address climate and environmental challenges, from food safety and crop engineering to plastic degradation and soil remediation.

Nature Reviews Bioengineering, Published online: 08 December 2025; doi:10.1038/s44222-025-00376-5This Review explores the multifunctional roles of hyaluronic acid in wound healing, tissue repair and regeneration, with a focus on medical product development. By linking hyaluronic acid’s molecular interactions with regulatory classification(s), this report provides a conceptual framework for optimizing and evaluating future indications, including hyaluronic acid’s potential for treatment of traumatic skeletal muscle injuries.

Nature Reviews Bioengineering, Published online: 08 December 2025; doi:10.1038/s44222-025-00376-5This Review explores the multifunctional roles of hyaluronic acid in wound healing, tissue repair and regeneration, with a focus on medical product development. By linking hyaluronic acid’s molecular interactions with regulatory classification(s), this report provides a conceptual framework for optimizing and evaluating future indications, including hyaluronic acid’s potential for treatment of traumatic skeletal muscle injuries.

Nature Reviews Bioengineering, Published online: 03 December 2025; doi:10.1038/s44222-025-00396-1Textile waste can be transformed into functional fibres through mechanical, chemical and enzymatic recycling, followed by spinning techniques. These upcycled materials enable the sustainable development of value-added products for applications such as wound care, antibacterial textiles, energy harvesting and storage, and environmental sensing.

Nature Reviews Bioengineering, Published online: 02 December 2025; doi:10.1038/s44222-025-00390-7Illness during pregnancy presents a therapeutic dilemma: treatment must protect the mother without compromising fetal health. Yet, most drugs remain insufficiently studied in pregnancy. Understanding pregnancy stage-specific drug pharmacokinetics and placental drug transport can guide the design of nanomedicine to optimize treatments during pregnancy.

Nature Reviews Bioengineering, Published online: 03 December 2025; doi:10.1038/s44222-025-00396-1Textile waste can be transformed into functional fibres through mechanical, chemical and enzymatic recycling, followed by spinning techniques. These upcycled materials enable the sustainable development of value-added products for applications such as wound care, antibacterial textiles, energy harvesting and storage, and environmental sensing.

Nature Reviews Bioengineering, Published online: 02 December 2025; doi:10.1038/s44222-025-00390-7Illness during pregnancy presents a therapeutic dilemma: treatment must protect the mother without compromising fetal health. Yet, most drugs remain insufficiently studied in pregnancy. Understanding pregnancy stage-specific drug pharmacokinetics and placental drug transport can guide the design of nanomedicine to optimize treatments during pregnancy.

Rehabilitation after ischaemic stroke can promote only limited recovery for many patients with stroke. This Review discusses how the distinctly reparative environment of the subacute time window after stroke can inform the design of biology-driven biomaterial-based stroke therapies.

Nature Reviews Bioengineering, Published online: 21 November 2025; doi:10.1038/s44222-025-00392-5Dynamic precision medicine enables preemptive cancer therapy switching in response to emerging resistance. Owing to their modular architecture and tumour-targeting capabilities, nanomedicines are theoretically well-suited to support such adaptive strategies. However, the questions remain whether modular design can consistently yield durable therapeutic responses, and whether the temporal constraints imposed by tumour evolution allow the practical implementation of dynamic nanomedicine.

Nature Reviews Bioengineering, Published online: 21 November 2025; doi:10.1038/s44222-025-00392-5Dynamic precision medicine enables preemptive cancer therapy switching in response to emerging resistance. Owing to their modular architecture and tumour-targeting capabilities, nanomedicines are theoretically well-suited to support such adaptive strategies. However, the questions remain whether modular design can consistently yield durable therapeutic responses, and whether the temporal constraints imposed by tumour evolution allow the practical implementation of dynamic nanomedicine.

Nature Reviews Bioengineering, Published online: 17 November 2025; doi:10.1038/s44222-025-00388-1If large language models can replicate academic writing, perhaps it was never as creative as once believed. We propose rethinking the scientific article as a multimodal endeavour. Exploring how words, visuals and other modes can work together helps us imagine new ways of creating and communicating scientific knowledge.

Nature Reviews Bioengineering, Published online: 17 November 2025; doi:10.1038/s44222-025-00386-3Artificial intelligence might reshape the approach to science, from generating concepts and hypotheses to designing experiments, analysing data and publishing findings. However, it might also introduce risks around data integrity, reproducibility, accountability and bias. Here we provide practical guidance on how to responsibly integrate artificial intelligence into the research pipeline.

Nature Reviews Bioengineering, Published online: 17 November 2025; doi:10.1038/s44222-025-00393-4An article in Nature Biotechnology reports a microphysiological tumour-on-achip model that supports vascularization of human tumour explants and controlled perfusion with CAR T cells, enabling the in vitro study of CAR T cell activity within the human tumour microenvironment.

Nature Reviews Bioengineering, Published online: 17 November 2025; doi:10.1038/s44222-025-00388-1If large language models can replicate academic writing, perhaps it was never as creative as once believed. We propose rethinking the scientific article as a multimodal endeavour. Exploring how words, visuals and other modes can work together helps us imagine new ways of creating and communicating scientific knowledge.

Nature Reviews Bioengineering, Published online: 17 November 2025; doi:10.1038/s44222-025-00386-3Artificial intelligence might reshape the approach to science, from generating concepts and hypotheses to designing experiments, analysing data and publishing findings. However, it might also introduce risks around data integrity, reproducibility, accountability and bias. Here we provide practical guidance on how to responsibly integrate artificial intelligence into the research pipeline.