Christoph Heuser-Loy
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cheuserloy.bsky.social
Christoph Heuser-Loy
@cheuserloy.bsky.social
600 followers 230 following 11 posts
Immunologist || T cells | Synthetic Biology | ACT at lit.eu (Luca Gattinoni's lab) #immunosky
Hiker | Cyclist
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cheuserloy.bsky.social
Great meeting, great science! Thank you for bringing everyone together @kischober.bsky.social
December 2, 2024 at 6:39 PM
cheuserloy.bsky.social
Boosting the therapeutic potential of anti-Tumor T cells by ectopic expression of the small, regulatory protein Lmo4 doi.org/10.1038/s413...
Figure 1 from LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling
November 19, 2024 at 4:34 PM
cheuserloy.bsky.social
Mitochondrial loading of anti-tumor T cells boosts cell fitness, expansion, infiltration, and anti-tumor efficacy: authors.elsevier.com/sd/article/S... @cellpressnews.bsky.social @kischober.bsky.social @dfgpublic.bsky.social
Fluorescence image of human BMSC-T cell co-culture. Blue: nuclei, red: Mito-dsRed, green: Phalloidin green
November 19, 2024 at 4:34 PM
cheuserloy.bsky.social
Hi! 👋 Wondering what's in this blackbox? In the Gattinoni lab at lit.eu, we're investigating physiological CD8 T cell differentiation to design strategies increasing cell fitness and in vivo efficacy up to clinical testing #adoptivecelltherapy #syntheticbiology #immunosky
Some recent examples:
Schematic T cell differentiation trajectories under chronic antigen stimulation towards exhaustion and approaches (immune checkpoint blockade, IL-10, and functional diversion) to promote potent T cell responses under exhaustion-inducing conditions, e.g., in tumor patients.
November 19, 2024 at 4:34 PM