Prasad Jallepalli, MD, PhD
@prasad.bsky.social
Prof & Lab Head in NYC. 100% research: cell division, genome integrity, cancer.
Curious to a fault. Also πολύτροπος. Talking here for me alone. I listen to the finest worksong. Like/repost = bookmark/news, not agreement/endorsement.
Curious to a fault. Also πολύτροπος. Talking here for me alone. I listen to the finest worksong. Like/repost = bookmark/news, not agreement/endorsement.
Reposted by Prasad Jallepalli, MD, PhD
Non-scientists truly do not know - I've been told that "the government throws money at scientists" and they still think Elon did something to help us (had to correct someone about this just today). It's exasperating
I don't think you non-science people realize what it takes to get a grant funded by NIH. Started experiments in Sept 2021 to generate 3 new mouse mutants to model human disease. Prelim dara shows they have relevant disease phenotypes worthy of study. Need a small grant first to characterize /1
January 3, 2026 at 2:20 AM
Non-scientists truly do not know - I've been told that "the government throws money at scientists" and they still think Elon did something to help us (had to correct someone about this just today). It's exasperating
it’s even more wretched in many parts of the scientific ecosystem
I lose count of the number of highly innovative scientists of all ranks who depend on winning grants like trapeze artists with no safety net to catch them
I lose count of the number of highly innovative scientists of all ranks who depend on winning grants like trapeze artists with no safety net to catch them
When I explain to people what is involved with writing a successful grant, they simply don’t believe me.
I explained it once to a famous person from Pixar, and he looked me square in the eye and said: You mean all the cancer and Alzheimer’s grants work that way? You’ve gotta be &$%#ing kidding me!
I explained it once to a famous person from Pixar, and he looked me square in the eye and said: You mean all the cancer and Alzheimer’s grants work that way? You’ve gotta be &$%#ing kidding me!
I don't think you non-science people realize what it takes to get a grant funded by NIH. Started experiments in Sept 2021 to generate 3 new mouse mutants to model human disease. Prelim dara shows they have relevant disease phenotypes worthy of study. Need a small grant first to characterize /1
January 3, 2026 at 2:04 AM
it’s even more wretched in many parts of the scientific ecosystem
I lose count of the number of highly innovative scientists of all ranks who depend on winning grants like trapeze artists with no safety net to catch them
I lose count of the number of highly innovative scientists of all ranks who depend on winning grants like trapeze artists with no safety net to catch them
Reposted by Prasad Jallepalli, MD, PhD
When I explain to people what is involved with writing a successful grant, they simply don’t believe me.
I explained it once to a famous person from Pixar, and he looked me square in the eye and said: You mean all the cancer and Alzheimer’s grants work that way? You’ve gotta be &$%#ing kidding me!
I explained it once to a famous person from Pixar, and he looked me square in the eye and said: You mean all the cancer and Alzheimer’s grants work that way? You’ve gotta be &$%#ing kidding me!
I don't think you non-science people realize what it takes to get a grant funded by NIH. Started experiments in Sept 2021 to generate 3 new mouse mutants to model human disease. Prelim dara shows they have relevant disease phenotypes worthy of study. Need a small grant first to characterize /1
January 3, 2026 at 1:14 AM
When I explain to people what is involved with writing a successful grant, they simply don’t believe me.
I explained it once to a famous person from Pixar, and he looked me square in the eye and said: You mean all the cancer and Alzheimer’s grants work that way? You’ve gotta be &$%#ing kidding me!
I explained it once to a famous person from Pixar, and he looked me square in the eye and said: You mean all the cancer and Alzheimer’s grants work that way? You’ve gotta be &$%#ing kidding me!
a sign to all that we quit the First World
Trump and Republicans have made America a pity case on the world stage
www.bbc.com/news/article...
www.bbc.com/news/article...
Americans brace to start New Year without healthcare
More than 20 million Americans are preparing for steeper healthcare costs in the New Year because of expiring subsidies.
www.bbc.com
January 3, 2026 at 1:58 AM
a sign to all that we quit the First World
Reposted by Prasad Jallepalli, MD, PhD
Matt Forney is really the ideal spirit animal for the whole Tablet/Free Press crowd so the nested quote is perfect
Here is the editor of Tablet agreeably reposting someone calling nonwhite NYC immigrants "worthless biotrash." It's astonishing how quickly this stuff has escaped containment
January 2, 2026 at 3:35 PM
Matt Forney is really the ideal spirit animal for the whole Tablet/Free Press crowd so the nested quote is perfect
Reposted by Prasad Jallepalli, MD, PhD
Let's greet the new year like they did in 1601 Königsberg: with a
parade and a giant bratwurst!
1/2
parade and a giant bratwurst!
1/2
January 2, 2026 at 2:39 PM
Let's greet the new year like they did in 1601 Königsberg: with a
parade and a giant bratwurst!
1/2
parade and a giant bratwurst!
1/2
Reposted by Prasad Jallepalli, MD, PhD
Interesting "Lunch with the FT" column on Yann LeCun and his AI "superintelligence" ambitions. Not sure how much to read into this- may have been what you say after a big French meal and glasses of wine- but is this really what "we" suffer from?
giftarticle.ft.com/giftarticle/...
giftarticle.ft.com/giftarticle/...
January 2, 2026 at 2:35 PM
Interesting "Lunch with the FT" column on Yann LeCun and his AI "superintelligence" ambitions. Not sure how much to read into this- may have been what you say after a big French meal and glasses of wine- but is this really what "we" suffer from?
giftarticle.ft.com/giftarticle/...
giftarticle.ft.com/giftarticle/...
Reposted by Prasad Jallepalli, MD, PhD
"100 million deportations" necessarily implies also the expulsion of all legal migrants, plus millions of (former?) US citizens too.
In case you thought they just meant undocumented immigrants…
January 2, 2026 at 2:35 PM
"100 million deportations" necessarily implies also the expulsion of all legal migrants, plus millions of (former?) US citizens too.
Reposted by Prasad Jallepalli, MD, PhD
Bari Weiss’s CBS News directly attacking academics, subject matter experts, in the promo for her new CBS Evening News.
January 2, 2026 at 1:53 PM
Bari Weiss’s CBS News directly attacking academics, subject matter experts, in the promo for her new CBS Evening News.
Reposted by Prasad Jallepalli, MD, PhD
So CBS News will now be a real version of @theonion.com’s “American Voices.” Great.
January 2, 2026 at 1:53 PM
So CBS News will now be a real version of @theonion.com’s “American Voices.” Great.
Reposted by Prasad Jallepalli, MD, PhD
One of my greater frustrations in life is the overwhelming desire to throw my smartphone into the sea, and the grim reality that I need one to do the kind of work I do as a journalist.
But if anyone wants to design a phone *for* journalists, let me know, because this is just a…phone for your phone.
But if anyone wants to design a phone *for* journalists, let me know, because this is just a…phone for your phone.
The Clicks Communicator is a Blackberry for your phone
The Clicks Communicator is a Blackberry for your phone
Just look at that QWERTY keyboard.
buff.ly
January 2, 2026 at 1:38 PM
One of my greater frustrations in life is the overwhelming desire to throw my smartphone into the sea, and the grim reality that I need one to do the kind of work I do as a journalist.
But if anyone wants to design a phone *for* journalists, let me know, because this is just a…phone for your phone.
But if anyone wants to design a phone *for* journalists, let me know, because this is just a…phone for your phone.
Reposted by Prasad Jallepalli, MD, PhD
Seriously, every word of this @sifill.bsky.social piece is the analysis and inspiration we all need as we start 2026.
open.substack.com/pub/sherrily...
open.substack.com/pub/sherrily...
The Year America Broke Open
It would be silly to pretend that 2025 was not among the most challenging years this country has faced in modern times.
open.substack.com
January 2, 2026 at 9:06 AM
Seriously, every word of this @sifill.bsky.social piece is the analysis and inspiration we all need as we start 2026.
open.substack.com/pub/sherrily...
open.substack.com/pub/sherrily...
Reposted by Prasad Jallepalli, MD, PhD
Trump again says his health is “PERFECT” and claims he “ACED” his third straight cognitive exam, a test given by doctors to detect signs of dementia
January 2, 2026 at 12:18 PM
Trump again says his health is “PERFECT” and claims he “ACED” his third straight cognitive exam, a test given by doctors to detect signs of dementia
Reposted by Prasad Jallepalli, MD, PhD
Mamdani is showing the next Democratic president what to do in 2029
A brilliant opening maneuver. Framing his predecessor's tenure as aberrant and illegitimate is both totally reasonable and creates room for radical change.
I was wondering what Mamdani's first executive order would be, and I'm not disappointed by this.
He has wiped off the books EVERY Eric Adams executive order issued on or after September 26, 2024, the day Adams was indicted on federal bribery charges.
He has wiped off the books EVERY Eric Adams executive order issued on or after September 26, 2024, the day Adams was indicted on federal bribery charges.
January 2, 2026 at 12:00 PM
Mamdani is showing the next Democratic president what to do in 2029
Reposted by Prasad Jallepalli, MD, PhD
one of my recent preoccupations is the visceral hostility the MAGA right has for the histories and traditions of the United States. these are people who spit on the Declaration and salute third-rate European despots!
It's striking that progressives like Tim Walz and Zohran Mamdani evoke the middle American attitude that, "Yes, we can fix these social problems because we're Americans and it's the right thing to do!" While the "America first" right only emulates failed and failing nation-states elsewhere.
January 2, 2026 at 12:45 AM
one of my recent preoccupations is the visceral hostility the MAGA right has for the histories and traditions of the United States. these are people who spit on the Declaration and salute third-rate European despots!
“In the debate, Zohran brought that to my attention, my mispronunciation. I didn't do it on purpose. There's no disrespect….In the streets, we would have given Zohran a nickname, like I did for all the Guardian Angels. ‘Z Man’ would have been perfect for him. That would have been his handle.”
🤌🏽🤌🏽
🤌🏽🤌🏽
with gift link (while it lasts) www.wsj.com/opinion/free...
January 2, 2026 at 12:51 AM
“In the debate, Zohran brought that to my attention, my mispronunciation. I didn't do it on purpose. There's no disrespect….In the streets, we would have given Zohran a nickname, like I did for all the Guardian Angels. ‘Z Man’ would have been perfect for him. That would have been his handle.”
🤌🏽🤌🏽
🤌🏽🤌🏽
with gift link (while it lasts) www.wsj.com/opinion/free...
January 2, 2026 at 12:47 AM
with gift link (while it lasts) www.wsj.com/opinion/free...
Reposted by Prasad Jallepalli, MD, PhD
I was wondering what Mamdani's first executive order would be, and I'm not disappointed by this.
He has wiped off the books EVERY Eric Adams executive order issued on or after September 26, 2024, the day Adams was indicted on federal bribery charges.
He has wiped off the books EVERY Eric Adams executive order issued on or after September 26, 2024, the day Adams was indicted on federal bribery charges.
January 1, 2026 at 11:07 PM
I was wondering what Mamdani's first executive order would be, and I'm not disappointed by this.
He has wiped off the books EVERY Eric Adams executive order issued on or after September 26, 2024, the day Adams was indicted on federal bribery charges.
He has wiped off the books EVERY Eric Adams executive order issued on or after September 26, 2024, the day Adams was indicted on federal bribery charges.
Reposted by Prasad Jallepalli, MD, PhD
Reposted by Prasad Jallepalli, MD, PhD
“In most heart transplants, surgeons hook the donor’s two major veins directly to the recipient’s. But with a heart this small, that felt especially risky. So, Dr. Goldstone offered an alternative technique, stitching the tops of the heart’s two upper chambers to the remnants of Luna’s”
90 Minutes to Give Baby Luna a New Heart
www.nytimes.com
January 2, 2026 at 12:01 AM
“In most heart transplants, surgeons hook the donor’s two major veins directly to the recipient’s. But with a heart this small, that felt especially risky. So, Dr. Goldstone offered an alternative technique, stitching the tops of the heart’s two upper chambers to the remnants of Luna’s”
Reposted by Prasad Jallepalli, MD, PhD
Kim is a phenomenal historian, equally well versed in political history and NYC’s history. Listen to her.
In @nytopinion.nytimes.com
Zohran Mamdani “is part of a long tradition in New York City that has framed itself as seeking to reclaim the democratic community of the city from wealth, power and greed,” Kim Phillips-Fein writes.
Zohran Mamdani “is part of a long tradition in New York City that has framed itself as seeking to reclaim the democratic community of the city from wealth, power and greed,” Kim Phillips-Fein writes.
Opinion | Why New York City Needs Someone Like Mamdani
The new mayor is an entirely familiar type of New York politician.
nyti.ms
January 1, 2026 at 8:34 PM
Kim is a phenomenal historian, equally well versed in political history and NYC’s history. Listen to her.
Reposted by Prasad Jallepalli, MD, PhD
Magic Johnson was the grand marshal of the Rose Parade today, and as someone who remembers his November 1991 HIV announcement: if you had told anybody that day that he would be alive and healthy 34+ years later, I don't think they would have believed you. Medicine and research—they work.
January 1, 2026 at 6:17 PM
Magic Johnson was the grand marshal of the Rose Parade today, and as someone who remembers his November 1991 HIV announcement: if you had told anybody that day that he would be alive and healthy 34+ years later, I don't think they would have believed you. Medicine and research—they work.
Reposted by Prasad Jallepalli, MD, PhD
We're bigger by population than like 38 of the 50 states and *just* missed 300 homicides. Really impressive stuff.
A remarkable trend that will come as a shock to you if your only info about NYC is from this Fox News.
Homicides in NYC...
1990: 2,262
1993: 1,927
1998: 629
2001: 649
2013: 335
2019: 320
2021: 488
2024: 382
2025 (as of 12/28): 302
Homicides in NYC...
1990: 2,262
1993: 1,927
1998: 629
2001: 649
2013: 335
2019: 320
2021: 488
2024: 382
2025 (as of 12/28): 302
January 1, 2026 at 8:12 PM
We're bigger by population than like 38 of the 50 states and *just* missed 300 homicides. Really impressive stuff.
Reposted by Prasad Jallepalli, MD, PhD
Philip Rivers says he's done with NFL, heading 'back to the sideline' reut.rs/44QlB5g
Philip Rivers says he's done with NFL, heading 'back to the sideline'
Philip Rivers confirmed that his NFL career will be over once the Indianapolis Colts' season ends this weekend.
reut.rs
January 1, 2026 at 7:40 PM
Philip Rivers says he's done with NFL, heading 'back to the sideline' reut.rs/44QlB5g
Reposted by Prasad Jallepalli, MD, PhD
They can play word games all they like but "Integralists" in this context explicitly reject the U S. Constitution and hold up as models Franco's Spain or Pinochet's Chile. They are enemies of American democracy.
William Branson Donahue—president of College Republicans of America—says that he is promoting “integralism, not theocracy,” but his post misleadingly omits that “integralism” is shorthand for “Catholic integralism” & that the doctrine seeks to “integrate” Church & state. 1/
x.com/realwilldona...
x.com/realwilldona...
January 1, 2026 at 6:53 PM
They can play word games all they like but "Integralists" in this context explicitly reject the U S. Constitution and hold up as models Franco's Spain or Pinochet's Chile. They are enemies of American democracy.