Timothy Bredy
@twbredy.bsky.social
Professor | Director, UQ Centre for RNA in Neuroscience | Queensland Brain Institute | Noncoding RNA and memory; RNA and DNA modification in the brain.
Pinned
Director: Queensland Brain Institute - DEMENTIA RESEARCHER
The University of Queensland, Australia. Seeks a Director for the Queensland Brain Institute to lead world-class neuroscience research and global collaboration.
www.dementiaresearcher.nihr.ac.uk
Here’s the posting. Please reach out if you have any questions about the QBI or life in Brisbane.
Director: Queensland Brain Institute www.dementiaresearcher.nihr.ac.uk/job/director...
Director: Queensland Brain Institute www.dementiaresearcher.nihr.ac.uk/job/director...
Cool paper on pseudoU and memory by former postdocs Wei Wei and Xiang Li. Proud to see where they have taken their science….
molecularbrain.biomedcentral.com/articles/10....
molecularbrain.biomedcentral.com/articles/10....
PUS7-dependent Ψ reshapes specific synaptic gene exons to facilitate fear extinction memory formation - Molecular Brain
RNA modifications serve as dynamic regulators of neural plasticity through their ability to fine-tune transcript stability and splicing. Pseudouridine (Ψ), an evolutionarily conserved RNA modification...
molecularbrain.biomedcentral.com
November 11, 2025 at 11:11 AM
Cool paper on pseudoU and memory by former postdocs Wei Wei and Xiang Li. Proud to see where they have taken their science….
molecularbrain.biomedcentral.com/articles/10....
molecularbrain.biomedcentral.com/articles/10....
We have strength across a wide range of neuroscience topics, including ageing and development, brain injury and repair, cognition and behavior, mental health, RNA science, etc.
To clarify, the QBI Director need not be focused on Dementia, this just happens to be one of the sites where the recruiter has posted….
Here’s the posting. Please reach out if you have any questions about the QBI or life in Brisbane.
Director: Queensland Brain Institute www.dementiaresearcher.nihr.ac.uk/job/director...
Director: Queensland Brain Institute www.dementiaresearcher.nihr.ac.uk/job/director...
November 11, 2025 at 1:39 AM
We have strength across a wide range of neuroscience topics, including ageing and development, brain injury and repair, cognition and behavior, mental health, RNA science, etc.
To clarify, the QBI Director need not be focused on Dementia, this just happens to be one of the sites where the recruiter has posted….
Here’s the posting. Please reach out if you have any questions about the QBI or life in Brisbane.
Director: Queensland Brain Institute www.dementiaresearcher.nihr.ac.uk/job/director...
Director: Queensland Brain Institute www.dementiaresearcher.nihr.ac.uk/job/director...
Director: Queensland Brain Institute - DEMENTIA RESEARCHER
The University of Queensland, Australia. Seeks a Director for the Queensland Brain Institute to lead world-class neuroscience research and global collaboration.
www.dementiaresearcher.nihr.ac.uk
November 11, 2025 at 1:36 AM
To clarify, the QBI Director need not be focused on Dementia, this just happens to be one of the sites where the recruiter has posted….
Here’s the posting. Please reach out if you have any questions about the QBI or life in Brisbane.
Director: Queensland Brain Institute www.dementiaresearcher.nihr.ac.uk/job/director...
Director: Queensland Brain Institute www.dementiaresearcher.nihr.ac.uk/job/director...
Director: Queensland Brain Institute - DEMENTIA RESEARCHER
The University of Queensland, Australia. Seeks a Director for the Queensland Brain Institute to lead world-class neuroscience research and global collaboration.
www.dementiaresearcher.nihr.ac.uk
November 11, 2025 at 12:23 AM
Here’s the posting. Please reach out if you have any questions about the QBI or life in Brisbane.
Director: Queensland Brain Institute www.dementiaresearcher.nihr.ac.uk/job/director...
Director: Queensland Brain Institute www.dementiaresearcher.nihr.ac.uk/job/director...
The search for the next QBI Director continues. If interested, please touch base. Lots of new initiatives in play at QBI and there is substantial support for exceptional researchers with a bold vision.
November 6, 2025 at 2:40 AM
The search for the next QBI Director continues. If interested, please touch base. Lots of new initiatives in play at QBI and there is substantial support for exceptional researchers with a bold vision.
I'll admit it! The suspense is killing me.
November 3, 2025 at 7:55 AM
I'll admit it! The suspense is killing me.
Understatement!
Interesting!
#RNASky
#RNASky
And another interesting paper from Bonasio lab @upenn.edu www.biorxiv.org/content/10.1... "Pseudouridine selects RNAs for extracellular transport" noting among other things "..that MYL6 is a pU-binding protein required for secretion of RNAs." notable MYL6 is found in the Kossiakoff work as a csRBP!
November 2, 2025 at 8:37 PM
Understatement!
picosecond times scales for rna modifications….. imagine structure states are not far of this speed so riboswitchs must be wicked fast.
x.com/j_a_c_s/stat...
x.com/j_a_c_s/stat...
J. Am. Chem. Soc. on X: "UV Excitation of Uracil Results in the Formation of a Ground-State Intermediate in Less Than One Picosecond and Its Decay is Quenched by Nucleophilic Water Addition | Journal of the American Chemical Society @cwru https://t.co/XguIlmKJ7r" / X
UV Excitation of Uracil Results in the Formation of a Ground-State Intermediate in Less Than One Picosecond and Its Decay is Quenched by Nucleophilic Water Addition | Journal of the American Chemical Society @cwru https://t.co/XguIlmKJ7r
x.com
November 1, 2025 at 4:55 AM
picosecond times scales for rna modifications….. imagine structure states are not far of this speed so riboswitchs must be wicked fast.
x.com/j_a_c_s/stat...
x.com/j_a_c_s/stat...
🧬 New review on nanopore basecalling models is out! ✨
Congrats to @soniacruciani.bsky.social (former Novoa Lab PhD, now postdoc at the Deplancke Lab, EPFL) and @evamarianovoa.bsky.social👏
📖 www.nature.com/articles/s41...
Congrats to @soniacruciani.bsky.social (former Novoa Lab PhD, now postdoc at the Deplancke Lab, EPFL) and @evamarianovoa.bsky.social👏
📖 www.nature.com/articles/s41...
Client Challenge
www.nature.com
October 29, 2025 at 7:23 AM
RNome? Sad that politics won’t allow us to call it what it is.
Exciting news for the RNA research community!
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
Unlocking the regulatory code of RNA: launching the Human RNome Project - Genome Biology
The human RNome, the complete set of RNA molecules in human cells, arises through complex processing and includes diverse molecular species. While research traditionally focuses on four canonical nucl...
genomebiology.biomedcentral.com
October 26, 2025 at 10:02 AM
RNome? Sad that politics won’t allow us to call it what it is.
Looks like the right conditions for RNA structure function control inside neurons.
Temperature-Dependent Ion Migration Underlies Sequence-Specific RNA Collapse https://www.biorxiv.org/content/10.1101/2025.10.20.683600v1
October 22, 2025 at 1:05 AM
Looks like the right conditions for RNA structure function control inside neurons.
Future thinking.
For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
October 21, 2025 at 2:06 AM
Future thinking.
It’s that time a year again…
October 19, 2025 at 6:11 AM
It’s that time a year again…
The QBI is crowdfunding its Brain Research Endowment Fund and we've almost reach our 2025 target. Please share with your network, we would appreciate any and all gifts to support Discovery Research.
givingday.uq.edu.au/campaigns/qb...
givingday.uq.edu.au/campaigns/qb...
QBI Brain Research Endowment Fund - The University of Queensland
At QBI, we’re accelerating science to change lives.
Our researchers are working at speed to transform how we understand, prevent and treat brain disorders like Alzheimer’s, Parkinson’s, stroke, motor ...
givingday.uq.edu.au
October 15, 2025 at 5:43 AM
The QBI is crowdfunding its Brain Research Endowment Fund and we've almost reach our 2025 target. Please share with your network, we would appreciate any and all gifts to support Discovery Research.
givingday.uq.edu.au/campaigns/qb...
givingday.uq.edu.au/campaigns/qb...
Reposted by Timothy Bredy
… plants and infecting fungi can use packets of havoc-wreaking RNA as a form of coevolutionary information warfare: An enemy cell reads the RNA and builds self-harming proteins with its own molecular machinery.
Cells Across the Tree of Life Exchange ‘Text Messages’ Using RNA | Quanta Magazine
Long known as a messenger within cells, RNA is increasingly seen as life’s molecular communication system — even between organisms widely separated by evolution.
www.quantamagazine.org
October 13, 2025 at 8:26 PM
… plants and infecting fungi can use packets of havoc-wreaking RNA as a form of coevolutionary information warfare: An enemy cell reads the RNA and builds self-harming proteins with its own molecular machinery.
Say what? 👍
We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...
DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells
The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...
www.biorxiv.org
October 8, 2025 at 3:19 AM
Say what? 👍
Like!
A good day to remember John Gurdon’s school report from his biology master at Eton
October 8, 2025 at 1:20 AM
Like!
Solid thread.
Dear Everyone, I've read the #NHMRC draft strategy and I have notes ...
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
October 7, 2025 at 8:31 AM
Solid thread.
RNA in neuroscience people, save the date, this course is going to be epic. All are welcome!
www.neurosas.org/advanced-cou...
www.neurosas.org/advanced-cou...
RNA Technologies and Therapeutics for Neuroscience - Neuroscience School of Advanced Studies
RNA Technologies and Therapeutics for Neuroscience May 30-June 7, 2026 Director: Timothy Bredy University of Queensland, Australia Faculty: Gene Yeo, University of California, San Diego, USA Eri...
www.neurosas.org
October 6, 2025 at 1:11 AM
RNA in neuroscience people, save the date, this course is going to be epic. All are welcome!
www.neurosas.org/advanced-cou...
www.neurosas.org/advanced-cou...
Nowadays, too many institutions thinking ‘if we build it they will come’ combined with a shortsighted research funding model, a saturated Phd training sector, bloated admin load, and a general decline in creativity. Tough times indeed!
Sometimes I think about how from 1935-1975ish, Bell Labs produced an insane amount of revolutionary science and technology, including 11 Nobel Prizes, the transistor, UNIX, C, the laser, the solar cell, information theory, etc. The secret? Provide scientists with ample, steady, no-strings funding.
sites.stat.columbia.edu
October 6, 2025 at 12:50 AM
Nowadays, too many institutions thinking ‘if we build it they will come’ combined with a shortsighted research funding model, a saturated Phd training sector, bloated admin load, and a general decline in creativity. Tough times indeed!
Occasional PSA:
Intracellular molecular processing, especially in neurons, is not about differential RNA expression or even protein abundance for that matter. Not about quantity.
It’s about qualitative, functional states.
The sooner we get there as a community the faster the science advances
Intracellular molecular processing, especially in neurons, is not about differential RNA expression or even protein abundance for that matter. Not about quantity.
It’s about qualitative, functional states.
The sooner we get there as a community the faster the science advances
September 30, 2025 at 1:35 AM
Occasional PSA:
Intracellular molecular processing, especially in neurons, is not about differential RNA expression or even protein abundance for that matter. Not about quantity.
It’s about qualitative, functional states.
The sooner we get there as a community the faster the science advances
Intracellular molecular processing, especially in neurons, is not about differential RNA expression or even protein abundance for that matter. Not about quantity.
It’s about qualitative, functional states.
The sooner we get there as a community the faster the science advances
RNA and Proteins: Who Bosses Whom? | Science | AAAS www.science.org/content/blog...
September 30, 2025 at 1:22 AM
RNA and Proteins: Who Bosses Whom? | Science | AAAS www.science.org/content/blog...
We've been busy in the lab, and I'm super proud of the team right now. These three papers are great examples of "Night Science", creative, curiosity driven work at its best! All are works in progress.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Dynamic regulation of neuronal Vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5
Vaults are large ribonucleoprotein complexes of unknown function in neurons. Here, we report that the Vault-associated noncoding RNA, Vaultrc5, is highly enriched at the synapse and is required for ac...
www.biorxiv.org
September 21, 2025 at 10:50 PM
We've been busy in the lab, and I'm super proud of the team right now. These three papers are great examples of "Night Science", creative, curiosity driven work at its best! All are works in progress.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...