Eugene Valkov
@eugenevalkov.bsky.social
mRNA regulation & decay | biochemistry | structural biology | molecular biology | cancer
All views are personal.
Google Scholar: tinyurl.com/EuValScholar
ORCID: 0000-0002-3721-1739
All views are personal.
Google Scholar: tinyurl.com/EuValScholar
ORCID: 0000-0002-3721-1739
Gold is for the mistress – silver for the maid" –
Copper for the craftsman cunning at his trade!"
"Good!" said the Baron, sitting in his hall,
But Iron – Cold Iron – is master of them all." Kipling, 1910.
Copper for the craftsman cunning at his trade!"
"Good!" said the Baron, sitting in his hall,
But Iron – Cold Iron – is master of them all." Kipling, 1910.
January 3, 2026 at 5:20 PM
Gold is for the mistress – silver for the maid" –
Copper for the craftsman cunning at his trade!"
"Good!" said the Baron, sitting in his hall,
But Iron – Cold Iron – is master of them all." Kipling, 1910.
Copper for the craftsman cunning at his trade!"
"Good!" said the Baron, sitting in his hall,
But Iron – Cold Iron – is master of them all." Kipling, 1910.
Reposted by Eugene Valkov
Check out the latest paper from the Gonatopoulos-Pournatzis lab using CRASP-seq, an RNA-coupled #CRISPR screening platform, to uncover novel #splicing regulators.
Online Now: RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria Online now:
RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria
This study introduces CRASP-seq, an RNA-coupled CRISPR screening platform designed to systematically identify regulatory factors and domains of alternative pre-mRNA splicing. Using this technology, ZNF207 is identified as a bona fide splicing regulator through its interaction with U1 snRNP components. ZNF207 modulates aberrant LMNA splicing, a critical event linked to progeria.
dlvr.it
December 31, 2025 at 7:12 PM
Reposted by Eugene Valkov
AI based framework for RNA modif detection using nanopore #RNAbiology
SWARM: A Single-Molecule Workflow for High-Precision Profiling of RNA Modifications
Nanopore direct RNA sequencing promises to decode the epitranscriptome by detecting multiple modifications on individual RNA molecules, but its potential for biological discovery is hampered by high f...
www.biorxiv.org
December 21, 2025 at 1:22 PM
AI based framework for RNA modif detection using nanopore #RNAbiology
Reposted by Eugene Valkov
🔥 THIS IS HUGE!
Horizon is the world’s science programme, hosted by the EU. It just got bigger.
Other non-European countries associated to the programme (ie paying in) include Korea, New Zealand, Canada.
Horizon is the world’s science programme, hosted by the EU. It just got bigger.
Other non-European countries associated to the programme (ie paying in) include Korea, New Zealand, Canada.
December 22, 2025 at 4:26 PM
🔥 THIS IS HUGE!
Horizon is the world’s science programme, hosted by the EU. It just got bigger.
Other non-European countries associated to the programme (ie paying in) include Korea, New Zealand, Canada.
Horizon is the world’s science programme, hosted by the EU. It just got bigger.
Other non-European countries associated to the programme (ie paying in) include Korea, New Zealand, Canada.
#1 movie when you were ten is how your 2026 going to go
December 20, 2025 at 2:40 PM
#1 movie when you were ten is how your 2026 going to go
Reposted by Eugene Valkov
very unusual - a tRNA regulated anion channel
December 18, 2025 at 5:26 PM
very unusual - a tRNA regulated anion channel
Reposted by Eugene Valkov
My "News & views" was published today @natmethods.nature.com
Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left...
www.nature.com/articles/s41...
Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left...
www.nature.com/articles/s41...
Targeted RNA-binding protein degradation to improve mRNA live imaging in animal cells - Nature Methods
The gold standard system for mRNA imaging in live cells just got upgraded by being degraded. This development improves signal-to-noise ratios and may lead to a better understanding of mRNA transport a...
www.nature.com
December 17, 2025 at 11:13 AM
My "News & views" was published today @natmethods.nature.com
Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left...
www.nature.com/articles/s41...
Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left...
www.nature.com/articles/s41...
Reposted by Eugene Valkov
A mechanism for controlling mRNA localization to neuronal projections:
Daniel Dominguez, Matthew Taliaferro @jmtali.bsky.social and collaborators implicated ALS-linked TDP-43 as inhibitor of mRNA accumulation in neurites, possibly by promoting their decay
link.springer.com/article/10.1...
Daniel Dominguez, Matthew Taliaferro @jmtali.bsky.social and collaborators implicated ALS-linked TDP-43 as inhibitor of mRNA accumulation in neurites, possibly by promoting their decay
link.springer.com/article/10.1...
TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stability - The EMBO Journal
The subcellular localization of many mRNAs to neuronal projections allows neurons to efficiently and rapidly react to spatially restricted external cues. However, for most of these RNAs, the mechanism...
link.springer.com
December 15, 2025 at 1:00 PM
A mechanism for controlling mRNA localization to neuronal projections:
Daniel Dominguez, Matthew Taliaferro @jmtali.bsky.social and collaborators implicated ALS-linked TDP-43 as inhibitor of mRNA accumulation in neurites, possibly by promoting their decay
link.springer.com/article/10.1...
Daniel Dominguez, Matthew Taliaferro @jmtali.bsky.social and collaborators implicated ALS-linked TDP-43 as inhibitor of mRNA accumulation in neurites, possibly by promoting their decay
link.springer.com/article/10.1...
Reposted by Eugene Valkov
Download our large database of funding opportunities for early-career faculty and researchers
Download it here: research.jhu.edu/rdt/funding-...
433 funding opportunities.
Download it here: research.jhu.edu/rdt/funding-...
433 funding opportunities.
December 14, 2025 at 4:22 PM
Download our large database of funding opportunities for early-career faculty and researchers
Download it here: research.jhu.edu/rdt/funding-...
433 funding opportunities.
Download it here: research.jhu.edu/rdt/funding-...
433 funding opportunities.
Reposted by Eugene Valkov
Download our large database of postdoc fellowships in all fields of research.
Database freely available to all; 281 fellowships.
Download here: research.jhu.edu/rdt/funding-...
Database freely available to all; 281 fellowships.
Download here: research.jhu.edu/rdt/funding-...
December 13, 2025 at 1:38 PM
Download our large database of postdoc fellowships in all fields of research.
Database freely available to all; 281 fellowships.
Download here: research.jhu.edu/rdt/funding-...
Database freely available to all; 281 fellowships.
Download here: research.jhu.edu/rdt/funding-...
Reposted by Eugene Valkov
When your PI presents your work
December 15, 2025 at 12:00 PM
When your PI presents your work
One has to assume that 2025 was also also a tough year for this raccoon
Look, you break into a liquor store, knock shit all over the place, go on a bender, and pass out on the bathroom floor ... it's probably not your first time.
Drunk raccoon found in liquor store is a repeat offender, officials say
Virginia animal protection officials say the furry bandit is suspected in break-ins at a martial arts studio and Department of Motor Vehicles office.
www.washingtonpost.com
December 14, 2025 at 11:33 PM
One has to assume that 2025 was also also a tough year for this raccoon
My talk from the latest RNA Collaborative Seminar Series is now available on YouTube. The second talk in the session was given by Rachel Braun (Sara Cherry’s lab) on TTP and its role in regulating antiviral immunity. youtu.be/2Aj-xbi3dPI #RNAsky #RNAbiology
December 10: NCI RNA Biology Initiative & Penn Institute for RNA Innovation
YouTube video by RNA Collaborative Seminar Series
youtu.be
December 12, 2025 at 5:59 PM
My talk from the latest RNA Collaborative Seminar Series is now available on YouTube. The second talk in the session was given by Rachel Braun (Sara Cherry’s lab) on TTP and its role in regulating antiviral immunity. youtu.be/2Aj-xbi3dPI #RNAsky #RNAbiology
Reposted by Eugene Valkov
Why Grandma, what big emdashes you have
IN DEPTH | If you could speak to your dead grandmother forever, would you?
If you could speak to your dead grandmother forever, would you?
www.independent.co.uk
December 11, 2025 at 12:07 AM
Why Grandma, what big emdashes you have
Reposted by Eugene Valkov
Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752 - Medical Research Council
Location: Cambridge. Vacancy: Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752. Closing Date: 04/01/2026, 23:55
mrc.tal.net
December 10, 2025 at 2:28 PM
Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Reposted by Eugene Valkov
Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
December 8, 2025 at 4:40 PM
Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
Reposted by Eugene Valkov
Stunning footage from earlier today, when the new Kilauea eruption covered the USGS Webcam 3, which is situated in the Halemaʻumaʻu crater near the southern rim of the much larger Kilauea caldera.
This *isn't* what the people of Pompeii saw.
But it's not very far off.
This *isn't* what the people of Pompeii saw.
But it's not very far off.
December 7, 2025 at 1:37 AM
Stunning footage from earlier today, when the new Kilauea eruption covered the USGS Webcam 3, which is situated in the Halemaʻumaʻu crater near the southern rim of the much larger Kilauea caldera.
This *isn't* what the people of Pompeii saw.
But it's not very far off.
This *isn't* what the people of Pompeii saw.
But it's not very far off.
“So long as men can breathe or eyes can see,
So long lives this, and this gives life to thee.”
So long lives this, and this gives life to thee.”
Which lines of poetry live rent-free in your head?
December 7, 2025 at 4:37 AM
“So long as men can breathe or eyes can see,
So long lives this, and this gives life to thee.”
So long lives this, and this gives life to thee.”
Movie you've watched more than six time with a gif. Hard mode: no Stars (either War or Trek), LOTR, or Marvel.
December 7, 2025 at 3:12 AM
Movie you've watched more than six time with a gif. Hard mode: no Stars (either War or Trek), LOTR, or Marvel.
Reposted by Eugene Valkov
GTPBP1 is a GTPase implicated in neurodevelopment. Our cryo-EM maps show GTPBP1 delivering tRNA to ribosome.
Due to delayed GTPase dissociation, mRNA decoding is more stringent than with bona fide delivery factor eEF1A.
Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
Due to delayed GTPase dissociation, mRNA decoding is more stringent than with bona fide delivery factor eEF1A.
Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
December 5, 2025 at 6:30 PM
GTPBP1 is a GTPase implicated in neurodevelopment. Our cryo-EM maps show GTPBP1 delivering tRNA to ribosome.
Due to delayed GTPase dissociation, mRNA decoding is more stringent than with bona fide delivery factor eEF1A.
Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
Due to delayed GTPase dissociation, mRNA decoding is more stringent than with bona fide delivery factor eEF1A.
Congrats to Denis Susorov and collab with Pestova lab! tinyurl.com/3smdvt3v
Reposted by Eugene Valkov
We mapped the whole human fallopian tube in 3D and at single-cell resolution via our CODA workflow.
More about this work here: biorxiv.org/content/10.1...
More about this work here: biorxiv.org/content/10.1...
December 3, 2025 at 2:24 AM
We mapped the whole human fallopian tube in 3D and at single-cell resolution via our CODA workflow.
More about this work here: biorxiv.org/content/10.1...
More about this work here: biorxiv.org/content/10.1...
Is it too much to ask that Outlook should stop autocorrecting “oligos” to “olives”?
December 2, 2025 at 12:35 AM
Is it too much to ask that Outlook should stop autocorrecting “oligos” to “olives”?
Reposted by Eugene Valkov
Teaching people how mRNA vaccines actually work protects against misconceptions about mRNA vaccination changing the recipient's DNA, without the need to repeat the false claims, according to experiments with over 3,500 participants. In PNAS: https://ow.ly/sVwH50Xzutc
November 29, 2025 at 8:00 PM
Teaching people how mRNA vaccines actually work protects against misconceptions about mRNA vaccination changing the recipient's DNA, without the need to repeat the false claims, according to experiments with over 3,500 participants. In PNAS: https://ow.ly/sVwH50Xzutc
Who would have thought? 🤨
November 30, 2025 at 12:44 AM
Who would have thought? 🤨
We as a family must have visited every state park in the 200-mile radius
What's a charming memory you have from the worst period of the pandemic?
November 30, 2025 at 12:40 AM
We as a family must have visited every state park in the 200-mile radius