Ryan Flynn
@raflynn5.bsky.social
RNA, Glycans, Space, Renewable Energy, and all technologies making lives more interesting.
PI at Boston Children’s Hospital SCP
Assistant Professor at Harvard SCRB
PI at Boston Children’s Hospital SCP
Assistant Professor at Harvard SCRB
Reposted by Ryan Flynn
What if we could “nudge” blood vessels to grow where we want them, in 3D and over time?
We show that mechanical strain can guide new vessel sprouts in 3D as they grow.
Thanks to my co-authors @shahjess.bsky.social Shah, Shashaank Venkatesh, Roger Kamm, and @rituraman.bsky.social
We show that mechanical strain can guide new vessel sprouts in 3D as they grow.
Thanks to my co-authors @shahjess.bsky.social Shah, Shashaank Venkatesh, Roger Kamm, and @rituraman.bsky.social
Preprint alert: Our latest study shows that "4D" force patterning enables spatial control of angiogenesis! Check out how we use Magnetic Matrix Actuation to precisely fabricate of 3D microvascular networks:
www.biorxiv.org/content/10.1...
Led by @sinakheiri.bsky.social @shahjess.bsky.social!
www.biorxiv.org/content/10.1...
Led by @sinakheiri.bsky.social @shahjess.bsky.social!
November 21, 2025 at 12:41 AM
What if we could “nudge” blood vessels to grow where we want them, in 3D and over time?
We show that mechanical strain can guide new vessel sprouts in 3D as they grow.
Thanks to my co-authors @shahjess.bsky.social Shah, Shashaank Venkatesh, Roger Kamm, and @rituraman.bsky.social
We show that mechanical strain can guide new vessel sprouts in 3D as they grow.
Thanks to my co-authors @shahjess.bsky.social Shah, Shashaank Venkatesh, Roger Kamm, and @rituraman.bsky.social
Reposted by Ryan Flynn
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Ryan Flynn
Preprint alert: Our latest study shows that "4D" force patterning enables spatial control of angiogenesis! Check out how we use Magnetic Matrix Actuation to precisely fabricate of 3D microvascular networks:
www.biorxiv.org/content/10.1...
Led by @sinakheiri.bsky.social @shahjess.bsky.social!
www.biorxiv.org/content/10.1...
Led by @sinakheiri.bsky.social @shahjess.bsky.social!
November 20, 2025 at 4:53 PM
Preprint alert: Our latest study shows that "4D" force patterning enables spatial control of angiogenesis! Check out how we use Magnetic Matrix Actuation to precisely fabricate of 3D microvascular networks:
www.biorxiv.org/content/10.1...
Led by @sinakheiri.bsky.social @shahjess.bsky.social!
www.biorxiv.org/content/10.1...
Led by @sinakheiri.bsky.social @shahjess.bsky.social!
Reposted by Ryan Flynn
Thrilled to see this finally announced - and glad to see good things still happening to good people!
Congratulations to Pardis, Christian, and the rest of the Sentinel team! 👏🥳
www.macfound.org/press/press-...
Congratulations to Pardis, Christian, and the rest of the Sentinel team! 👏🥳
www.macfound.org/press/press-...
Sentinel Awarded $100 Million to Prevent Pandemics
www.macfound.org
November 18, 2025 at 10:17 PM
Thrilled to see this finally announced - and glad to see good things still happening to good people!
Congratulations to Pardis, Christian, and the rest of the Sentinel team! 👏🥳
www.macfound.org/press/press-...
Congratulations to Pardis, Christian, and the rest of the Sentinel team! 👏🥳
www.macfound.org/press/press-...
Reposted by Ryan Flynn
This subject came up in the Nobel Minds broadcast (2022) during the conversation at 25:50, note economics Laureate Ben Bernanke’s “puzzlement” as to Why, and the audience’s response to the entire exchange.
youtu.be/LutI8YqJkqM?...
youtu.be/LutI8YqJkqM?...
November 17, 2025 at 6:31 AM
This subject came up in the Nobel Minds broadcast (2022) during the conversation at 25:50, note economics Laureate Ben Bernanke’s “puzzlement” as to Why, and the audience’s response to the entire exchange.
youtu.be/LutI8YqJkqM?...
youtu.be/LutI8YqJkqM?...
Reposted by Ryan Flynn
NEW: California now has nearly 17,000 megawatts of battery storage – reaching one-third of the way to our 2045 goal.
We're deploying more battery storage than any state in America, building a stronger grid, cutting pollution, and securing a safer future for our nation.
We're deploying more battery storage than any state in America, building a stronger grid, cutting pollution, and securing a safer future for our nation.
November 15, 2025 at 7:07 PM
NEW: California now has nearly 17,000 megawatts of battery storage – reaching one-third of the way to our 2045 goal.
We're deploying more battery storage than any state in America, building a stronger grid, cutting pollution, and securing a safer future for our nation.
We're deploying more battery storage than any state in America, building a stronger grid, cutting pollution, and securing a safer future for our nation.
Reposted by Ryan Flynn
How much CO₂ can the world emit while limiting global temperature rise?
November 15, 2025 at 9:01 AM
How much CO₂ can the world emit while limiting global temperature rise?
Reposted by Ryan Flynn
16% of graduates students in STEM fields in the US are Chinese nationals.
If we cut funding from any professor who has been the graduate advisor of a Chinese student in the last 5 years RETROACTIVELY, research in the US will grind to a halt.
If we cut funding from any professor who has been the graduate advisor of a Chinese student in the last 5 years RETROACTIVELY, research in the US will grind to a halt.
“The prohibited activities would include joint research, co-authorship on papers, and advising a foreign graduate student or postdoctoral fellow. The language is retroactive, meaning any interactions during the previous 5 years could make a scientist ineligible for future federal funding.”
U.S. Congress considers sweeping ban on Chinese collaborations
Researchers speak out against proposal that would bar funding for U.S. scientists working with Chinese partners or training Chinese students
www.science.org
November 14, 2025 at 12:02 PM
16% of graduates students in STEM fields in the US are Chinese nationals.
If we cut funding from any professor who has been the graduate advisor of a Chinese student in the last 5 years RETROACTIVELY, research in the US will grind to a halt.
If we cut funding from any professor who has been the graduate advisor of a Chinese student in the last 5 years RETROACTIVELY, research in the US will grind to a halt.
Reposted by Ryan Flynn
And here is the story after peer review. This work highlights our current approach, which is to use Piezo channels to uncover new areas of biology that are shaped by mechanical forces: www.science.org/doi/10.1126/...
November 13, 2025 at 10:05 PM
And here is the story after peer review. This work highlights our current approach, which is to use Piezo channels to uncover new areas of biology that are shaped by mechanical forces: www.science.org/doi/10.1126/...
Reposted by Ryan Flynn
Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...
An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function
Siglec-liposomes are a multivalent and modular platform for profiling Siglec ligands and modulating immune cell function.
www.science.org
November 12, 2025 at 9:57 PM
Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...
Reposted by Ryan Flynn
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
November 11, 2025 at 1:20 AM
PSA for people with NIH grant periods starting January 1st (including most NIGMS MIRAs): your RPPR is due Saturday, but they haven’t sent out the usual automated reminders, presumably due to the shutdown
Reposted by Ryan Flynn
Meet the Raman Lab at #TERMISAM2025! Excited to share presentations from Angel Bu, Jessica Shah, Dr. Tamara Rossy, Brandon Rios, and Dr. Ferdows Afghah highlighting our latest efforts in #TissueEngineering.
@termisam.bsky.social
@termisam.bsky.social
November 10, 2025 at 2:34 PM
Meet the Raman Lab at #TERMISAM2025! Excited to share presentations from Angel Bu, Jessica Shah, Dr. Tamara Rossy, Brandon Rios, and Dr. Ferdows Afghah highlighting our latest efforts in #TissueEngineering.
@termisam.bsky.social
@termisam.bsky.social
Reposted by Ryan Flynn
Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.
Scripps Research team identifies sugar molecules that trigger placental formation
ow.ly
November 8, 2025 at 12:25 AM
Using proximity labeling and a derivatized galectin-3, scientists in the lab of Professor Mia Huang mapped glycan–protein interactions that drive placental cell fusion, published in @pnas.org, offering new insight into placental development.
Reposted by Ryan Flynn
Oh, and this also means it would be possible for multiple journals in parallel to highlight your paper. You won't be restricted to just one (similarly to how the BBC, NYT and Scientific American can all highlighted your journal-published paper today).
November 8, 2025 at 8:01 AM
Oh, and this also means it would be possible for multiple journals in parallel to highlight your paper. You won't be restricted to just one (similarly to how the BBC, NYT and Scientific American can all highlighted your journal-published paper today).
Reposted by Ryan Flynn
You’ll be proud that your reviewed preprint was highlighted by Nature, just like you’re proud when your paper is highlighted by the New York Times. You'll add that to your C.V. You'll still read them because they'll have good content (2/2).
November 8, 2025 at 6:02 AM
You’ll be proud that your reviewed preprint was highlighted by Nature, just like you’re proud when your paper is highlighted by the New York Times. You'll add that to your C.V. You'll still read them because they'll have good content (2/2).
Reposted by Ryan Flynn
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
November 8, 2025 at 6:02 AM
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
Reposted by Ryan Flynn
This is what every single person with any experience in China has been warning about from the start.
Very good WaPo story by Katrina Northrop and Rudy Lu. www.washingtonpost.com/world/2025/1... And good, clear headline!
Very good WaPo story by Katrina Northrop and Rudy Lu. www.washingtonpost.com/world/2025/1... And good, clear headline!
November 7, 2025 at 4:20 AM
This is what every single person with any experience in China has been warning about from the start.
Very good WaPo story by Katrina Northrop and Rudy Lu. www.washingtonpost.com/world/2025/1... And good, clear headline!
Very good WaPo story by Katrina Northrop and Rudy Lu. www.washingtonpost.com/world/2025/1... And good, clear headline!
Reposted by Ryan Flynn
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
openrxiv.org
November 6, 2025 at 2:32 PM
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Reposted by Ryan Flynn
Please read the thoughtful Blog that @richardsever.bsky.social and the @openrxiv.bsky.social team wrote on integrating pre-prints with AI review openrxiv.org/enabling-rev...
November 6, 2025 at 3:11 PM
Please read the thoughtful Blog that @richardsever.bsky.social and the @openrxiv.bsky.social team wrote on integrating pre-prints with AI review openrxiv.org/enabling-rev...
Reposted by Ryan Flynn
And you can of course also go through to the q.e.d website: www.qedscience.com
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
www.qedscience.com
November 6, 2025 at 3:05 PM
And you can of course also go through to the q.e.d website: www.qedscience.com
Reposted by Ryan Flynn
Here's how you can go to @qedscience.bsky.social from the @openrxiv.bsky.social @biorxivpreprint.bsky.social website, when you submit a manuscript:
November 6, 2025 at 2:49 PM
Here's how you can go to @qedscience.bsky.social from the @openrxiv.bsky.social @biorxivpreprint.bsky.social website, when you submit a manuscript:
Reposted by Ryan Flynn
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 2:49 PM
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
Reposted by Ryan Flynn
If you're looking for a faculty position at the intersection of ecology and computing (both broadly defined), please apply to this joint search between the CEE Department and the College of Computing at MIT: cee.mit.edu/people/share...
Faculty Position in the Department of Civil and Environmental Engineering and the Schwarzman College of Computing - cee.mit.edu
The Department of Civil and Environmental Engineering (CEE), together with the Schwarzman College of Computing (SCC) at the Massachusetts Institute of Technology (MIT) in Cambridge MA, seeks candidate...
cee.mit.edu
November 5, 2025 at 7:27 PM
If you're looking for a faculty position at the intersection of ecology and computing (both broadly defined), please apply to this joint search between the CEE Department and the College of Computing at MIT: cee.mit.edu/people/share...
Reposted by Ryan Flynn
Visionary talk from Jennifer Lewis yesterday at the MIT.nano Dresselhaus Lecture, highlighting opportunities for 3D printing in soft robotics & tissue engineering! You can watch the full lecture and the q&a session (moderated by me!) here: mitnano.mit.edu/events/dress...
@wyssinstitute.bsky.social
@wyssinstitute.bsky.social
November 4, 2025 at 4:01 PM
Visionary talk from Jennifer Lewis yesterday at the MIT.nano Dresselhaus Lecture, highlighting opportunities for 3D printing in soft robotics & tissue engineering! You can watch the full lecture and the q&a session (moderated by me!) here: mitnano.mit.edu/events/dress...
@wyssinstitute.bsky.social
@wyssinstitute.bsky.social
Reposted by Ryan Flynn
When ChatGPT was asked to rate 40,000 résumés, it ranked the older male candidates as better quality than the younger female applicants.
Age and gender distortion in online media and large language models - Nature
Stereotypes of age-related gender bias are socially distorted, as evidenced by the age gap in the representations of women and men across various media and algorithms, despite no systematic age differ...
www.nature.com
November 2, 2025 at 9:47 PM
When ChatGPT was asked to rate 40,000 résumés, it ranked the older male candidates as better quality than the younger female applicants.