Inflammasome Lab
@inflammasomelab.bsky.social
Prof Kate Schroder's lab @ IMB-UQ studies inflammasomes in health, infection & disease. www.inflammasomelab.com UQ Ally🏳️🌈. Opinions=own.
Pinned
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...
rdcu.be
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Link: rdcu.be/d2mjm
Reposted by Inflammasome Lab
Who wants to discuss innate immunity and host defense?
Join us in Banff to share your exciting research.
www.keystonesymposia.org/conferences/...
Join us in Banff to share your exciting research.
www.keystonesymposia.org/conferences/...
Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia
Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!
www.keystonesymposia.org
November 11, 2025 at 2:55 PM
Who wants to discuss innate immunity and host defense?
Join us in Banff to share your exciting research.
www.keystonesymposia.org/conferences/...
Join us in Banff to share your exciting research.
www.keystonesymposia.org/conferences/...
Reposted by Inflammasome Lab
New story from the lab by PhD student Seb Grant. Started as a summer project and developed into an interesting story.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Evolutionary convergence of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signalling.
The coordination of efficient immune responses to infections is essential to enable pathogen clearance and host survival. Cell death modalities are a crucial component of the innate immune system and ...
www.biorxiv.org
November 3, 2025 at 3:43 PM
New story from the lab by PhD student Seb Grant. Started as a summer project and developed into an interesting story.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Inflammasome Lab
Review @cp-molcell.bsky.social @inflammasomelab.bsky.social
NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress
www.cell.com/molecular-ce...
NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress
www.cell.com/molecular-ce...
October 17, 2025 at 4:50 PM
Review @cp-molcell.bsky.social @inflammasomelab.bsky.social
NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress
www.cell.com/molecular-ce...
NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress
www.cell.com/molecular-ce...
Reposted by Inflammasome Lab
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
October 17, 2025 at 6:29 AM
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
Reposted by Inflammasome Lab
(1/2) 🎉 The 2025 ACDS Prize for Outstanding ECRs is now open!
Recognising an ECR who’s advanced the Australasian cell death community.
🏆 Winner gets a cash prize, medal & invited talk.
Apply by 7 Nov 2025 (5 pm AEDT) → australasiancelldeathsociety.com/acds-awards
Recognising an ECR who’s advanced the Australasian cell death community.
🏆 Winner gets a cash prize, medal & invited talk.
Apply by 7 Nov 2025 (5 pm AEDT) → australasiancelldeathsociety.com/acds-awards
October 16, 2025 at 3:26 AM
(1/2) 🎉 The 2025 ACDS Prize for Outstanding ECRs is now open!
Recognising an ECR who’s advanced the Australasian cell death community.
🏆 Winner gets a cash prize, medal & invited talk.
Apply by 7 Nov 2025 (5 pm AEDT) → australasiancelldeathsociety.com/acds-awards
Recognising an ECR who’s advanced the Australasian cell death community.
🏆 Winner gets a cash prize, medal & invited talk.
Apply by 7 Nov 2025 (5 pm AEDT) → australasiancelldeathsociety.com/acds-awards
Reposted by Inflammasome Lab
Dear Everyone, I've read the #NHMRC draft strategy and I have notes ...
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
October 6, 2025 at 9:27 PM
Dear Everyone, I've read the #NHMRC draft strategy and I have notes ...
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
Reposted by Inflammasome Lab
Nature research paper: Myeloperoxidase transforms chromatin into neutrophil extracellular traps
go.nature.com/4pxKgV6
go.nature.com/4pxKgV6
Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature
Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.
go.nature.com
September 20, 2025 at 11:37 AM
Nature research paper: Myeloperoxidase transforms chromatin into neutrophil extracellular traps
go.nature.com/4pxKgV6
go.nature.com/4pxKgV6
Reposted by Inflammasome Lab
Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action. New study from Kevin Wilhelmsen (BioAge Labs), Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social and colleagues: rupress.org/jem/article/...
#Inflammasome #Inflammation
#Inflammasome #Inflammation
September 9, 2025 at 3:15 PM
Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action. New study from Kevin Wilhelmsen (BioAge Labs), Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social and colleagues: rupress.org/jem/article/...
#Inflammasome #Inflammation
#Inflammasome #Inflammation
Reposted by Inflammasome Lab
🌟 I am truly honoured to be named a finalist for the Rose-Anne Kelso Commemorative Award from Life Sciences Queensland Ltd (LSQ).
A big thank you to LSQ for their tireless work in fostering innovation, collaboration, and growth across the life sciences sector in Queensland.
A big thank you to LSQ for their tireless work in fostering innovation, collaboration, and growth across the life sciences sector in Queensland.
September 7, 2025 at 9:30 AM
🌟 I am truly honoured to be named a finalist for the Rose-Anne Kelso Commemorative Award from Life Sciences Queensland Ltd (LSQ).
A big thank you to LSQ for their tireless work in fostering innovation, collaboration, and growth across the life sciences sector in Queensland.
A big thank you to LSQ for their tireless work in fostering innovation, collaboration, and growth across the life sciences sector in Queensland.
Reposted by Inflammasome Lab
🧵In collaboration with Caroline Puente-Lelievre, Ed Moody, Rosie Cater, and Tom Williams we just submitted a new paper describing the prokaryotic origins of the COMMD protein family. @cpuentelelievre.bsky.social, @rosemaryjcater.bsky.social. @kmichie.bsky.social. 1/n
The prokaryotic origins of the COMMD protein family involved in eukaryotic membrane trafficking
The ten eukaryotic COMMD proteins are core components of the Commander complex, with central roles in endosomal membrane trafficking and signalling. Each protein has an α-helical N-terminal (HN) domai...
www.biorxiv.org
September 3, 2025 at 12:24 AM
🧵In collaboration with Caroline Puente-Lelievre, Ed Moody, Rosie Cater, and Tom Williams we just submitted a new paper describing the prokaryotic origins of the COMMD protein family. @cpuentelelievre.bsky.social, @rosemaryjcater.bsky.social. @kmichie.bsky.social. 1/n
Reposted by Inflammasome Lab
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome
#Inflammasome
September 2, 2025 at 4:22 PM
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
Reposted by Inflammasome Lab
#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome
#Inflammasome
September 2, 2025 at 4:15 PM
#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome
#Inflammasome
Reposted by Inflammasome Lab
🚨It’s out @embojournal.org 🚨
Cardiolipin inhibits Caspase-4/11!
Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.
Cardiolipin inhibits Caspase-4/11!
Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.
July 23, 2025 at 11:23 AM
🚨It’s out @embojournal.org 🚨
Cardiolipin inhibits Caspase-4/11!
Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.
Cardiolipin inhibits Caspase-4/11!
Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.
Reposted by Inflammasome Lab
Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal
imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1
(CASP1), which complicates interpretation of results in functional studies and limits
their clinical potenti...
www.embopress.org
July 19, 2025 at 11:18 AM
Congrats to @malvinapiz.bsky.social and @inflammasomelab.bsky.social on their new paper on the role of cardiolipin in non canonical inflammasome activation. We’re happy to have contributed to the story 🎉🦠!!
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Inflammasome Lab
‼️ Congratulations to @malvinapiz.bsky.social on her cool work published today @embopress.org on Cardiolipin inhibiting Casp4 non-canonical inflammasome signaling outputs 👻 a lot of fun to work with Malvina and Mercedes @inflammasomelab.bsky.social on this project
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11 | The EMBO Journal
imageimageAvailable caspase-4/11 (CASP4/11) inhibitors also block the activity of caspase-1
(CASP1), which complicates interpretation of results in functional studies and limits
their clinical potenti...
www.embopress.org
July 17, 2025 at 4:41 AM
‼️ Congratulations to @malvinapiz.bsky.social on her cool work published today @embopress.org on Cardiolipin inhibiting Casp4 non-canonical inflammasome signaling outputs 👻 a lot of fun to work with Malvina and Mercedes @inflammasomelab.bsky.social on this project
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Inflammasome Lab
A joy of the job is sharing moments like this after years of working together. May I present Dr Julian Radford-Smith @jradford-smith.bsky.social, with special guests Barbara and Rosalind. Photos taken by the wonderful @lilydun.bsky.social
July 15, 2025 at 2:28 AM
A joy of the job is sharing moments like this after years of working together. May I present Dr Julian Radford-Smith @jradford-smith.bsky.social, with special guests Barbara and Rosalind. Photos taken by the wonderful @lilydun.bsky.social
Reposted by Inflammasome Lab
Thank you @inflammasomelab.bsky.social and @s-burgener.bsky.social for the invitation to visit the IMB@UQ in Brisbane! I had a fantastic time presenting my postdoc work in the Kagan lab (@jkagan1.bsky.social) and talking science!
July 7, 2025 at 10:13 PM
Thank you @inflammasomelab.bsky.social and @s-burgener.bsky.social for the invitation to visit the IMB@UQ in Brisbane! I had a fantastic time presenting my postdoc work in the Kagan lab (@jkagan1.bsky.social) and talking science!
Reposted by Inflammasome Lab
Join us at next week ACDS seminar - lineup of two fantastic speakers 🔊 all infos below 👇
June 26, 2025 at 7:21 AM
Join us at next week ACDS seminar - lineup of two fantastic speakers 🔊 all infos below 👇
Reposted by Inflammasome Lab
It was a huge pleasure to write this spotlight commentary together with @inflammasomelab.bsky.social and @JaredCoombs on the recent Cell paper of Xingbin Hu lab on spectosis in red blood cells! Congrats to all the authors for their novel and elegant study in discovery miniNLRP3 signaling in RBC 👇
June 14, 2025 at 8:44 PM
It was a huge pleasure to write this spotlight commentary together with @inflammasomelab.bsky.social and @JaredCoombs on the recent Cell paper of Xingbin Hu lab on spectosis in red blood cells! Congrats to all the authors for their novel and elegant study in discovery miniNLRP3 signaling in RBC 👇
Reposted by Inflammasome Lab
In @science.org today my essay on predicting and preventing Alzheimer's disease (open-access)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Predicting and preventing Alzheimer’s disease
With all the advances in both the science of aging and artificial intelligence (AI), we are in a propitious position to accurately and precisely determine who is at high risk of developing Alzheimer’s...
www.science.org
May 29, 2025 at 6:00 PM
In @science.org today my essay on predicting and preventing Alzheimer's disease (open-access)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Inflammasome Lab
The Hunter Meeting has made it to the blue place! 🔵 If you are joining us in the beautiful #HunterValley 2-5 June 2025 - please tag us or search #HunterMeetingOz to follow along. #STEM #CellBiology #DevBio #SpatialOmics @anzscdb.bsky.social #AustralianMeeting
May 19, 2025 at 2:18 AM
The Hunter Meeting has made it to the blue place! 🔵 If you are joining us in the beautiful #HunterValley 2-5 June 2025 - please tag us or search #HunterMeetingOz to follow along. #STEM #CellBiology #DevBio #SpatialOmics @anzscdb.bsky.social #AustralianMeeting
Reposted by Inflammasome Lab
(1/3) 🏆 Applications are now open for the 2025 ACDS Professional Development Award!
A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️
Conference? Lab visit? Data training? This one's for you.
More info below
A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️
Conference? Lab visit? Data training? This one's for you.
More info below
#celldeathresearch #careerdevelopment | Australasian Cell Death Society (ACDS)
🥇2025 ACDS Professional Development Award 🥇
Applications are now open!
Are you a PhD student or early-career researcher in the cell death field? Don’t miss your chance to apply for our $2,000 travel ...
www.linkedin.com
May 5, 2025 at 1:01 AM
(1/3) 🏆 Applications are now open for the 2025 ACDS Professional Development Award!
A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️
Conference? Lab visit? Data training? This one's for you.
More info below
A $2,000 grant for a PhD student or ECR to support national or international professional development 🌍✈️
Conference? Lab visit? Data training? This one's for you.
More info below
Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3)
shorturl.at/8lWxW
shorturl.at/8lWxW
Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases
Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is ...
shorturl.at
May 1, 2025 at 11:17 PM
Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3)
shorturl.at/8lWxW
shorturl.at/8lWxW
Congratulations @v-hornung.bsky.social! Richly deserved. Wonderful to see another inflammasome great amongst the awardees!
The full videos are available! Check them out: VEIT HORNUNG @v-hornung.bsky.social @genecenter-lmu.bsky.social
youtu.be/YBVArSDgFMA
youtu.be/YBVArSDgFMA
Veit Hornung, winner of the 2025 Collen Jeantet Prize for Translational Medicine
YouTube video by Fondation Louis-Jeantet
youtu.be
April 28, 2025 at 8:57 PM
Congratulations @v-hornung.bsky.social! Richly deserved. Wonderful to see another inflammasome great amongst the awardees!
Reposted by Inflammasome Lab
Pleased to see Kevin's paper on the Retromer complex interaction with yeast Vps5 and Vps17 proteins now online!
Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer - Nature Communications
Retromer complex cooperates with Vps5 and Vps17 in yeast to traffic transmembrane proteins. Here, the authors present structural and functional studies that reveal the mechanism of Retromer and Vps5 i...
www.nature.com
April 16, 2025 at 1:59 AM
Pleased to see Kevin's paper on the Retromer complex interaction with yeast Vps5 and Vps17 proteins now online!