Inflammasome Lab
@inflammasomelab.bsky.social
Prof Kate Schroder's lab @ IMB-UQ studies inflammasomes in health, infection & disease. www.inflammasomelab.com UQ Ally🏳️🌈. Opinions=own.
Pinned
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...
rdcu.be
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Link: rdcu.be/d2mjm
It's shaping up to be an amazing line up at the Gordon Cell Death meeting! Register now! www.grc.org/cell-death-c...
2026 Cell Death Conference GRC
The 2026 Gordon Research Conference on Cell Death will be held in Les Diablerets, Vaud (fr) Switzerland. Apply today to reserve your spot.
www.grc.org
February 17, 2026 at 5:00 AM
It's shaping up to be an amazing line up at the Gordon Cell Death meeting! Register now! www.grc.org/cell-death-c...
Reposted by Inflammasome Lab
#MysterySolved! Fantastic @cp-immunity.bsky.social by @brozlab.bsky.social, Began &co showing that GBP1 is essential for non-canonical #inflammasome activation during infections & acts as a mechanoenzime that fragments LPS micelles allowing Caspase-4 activity! www.sciencedirect.com/science/arti...
Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation
The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…
www.sciencedirect.com
February 16, 2026 at 6:29 PM
#MysterySolved! Fantastic @cp-immunity.bsky.social by @brozlab.bsky.social, Began &co showing that GBP1 is essential for non-canonical #inflammasome activation during infections & acts as a mechanoenzime that fragments LPS micelles allowing Caspase-4 activity! www.sciencedirect.com/science/arti...
Reposted by Inflammasome Lab
💫 You’re invited - our first event of 2026 is just around the corner! 💫
(1/6)
💡Join us for an exciting morning of insightful talks from leading experts and invaluable conversations with members of the cell death community
(1/6)
💡Join us for an exciting morning of insightful talks from leading experts and invaluable conversations with members of the cell death community
February 13, 2026 at 4:00 AM
💫 You’re invited - our first event of 2026 is just around the corner! 💫
(1/6)
💡Join us for an exciting morning of insightful talks from leading experts and invaluable conversations with members of the cell death community
(1/6)
💡Join us for an exciting morning of insightful talks from leading experts and invaluable conversations with members of the cell death community
Reposted by Inflammasome Lab
I am delighted to share our characterisation of natural antagonism of TLR7/8 in Nature Immunology. We propose a model where 2’O-Methyl RNA fragments keep TLR7/8 in check, preventing autoimmunity. > www.nature.com/articles/s41...
2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity | Nature Immunology
www.nature.com
February 10, 2026 at 10:05 AM
I am delighted to share our characterisation of natural antagonism of TLR7/8 in Nature Immunology. We propose a model where 2’O-Methyl RNA fragments keep TLR7/8 in check, preventing autoimmunity. > www.nature.com/articles/s41...
Reposted by Inflammasome Lab
A fantastic innate immunity conference coming soon. Join us!
youtu.be/xmQv36uYm7s?...
youtu.be/xmQv36uYm7s?...
Innate Immunity Meeting Promo
YouTube video by KeystoneSymposia
youtu.be
February 5, 2026 at 4:29 AM
A fantastic innate immunity conference coming soon. Join us!
youtu.be/xmQv36uYm7s?...
youtu.be/xmQv36uYm7s?...
Deadlines are approaching for @keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March in Banff! See key dates: keysym.us/KSInnateImmune26 #KSInnateImmune26
Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia
Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!
keysym.us
February 5, 2026 at 3:29 AM
Deadlines are approaching for @keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March in Banff! See key dates: keysym.us/KSInnateImmune26 #KSInnateImmune26
Is there a gasdermin-shaped hole in your life that needs filling? Join us for the SMART Symposium on #Pyroptosis & #Gasdermin Biology in September! Amazing biology & speakers, organised by the wonderful Vishva Dixit, @v-hornung.bsky.social, Feng Shao & Hao Wu!
symposia.smart.org.cn/sym/event/Fu...
symposia.smart.org.cn/sym/event/Fu...
Symposia
symposia.smart.org.cn
February 5, 2026 at 2:56 AM
Is there a gasdermin-shaped hole in your life that needs filling? Join us for the SMART Symposium on #Pyroptosis & #Gasdermin Biology in September! Amazing biology & speakers, organised by the wonderful Vishva Dixit, @v-hornung.bsky.social, Feng Shao & Hao Wu!
symposia.smart.org.cn/sym/event/Fu...
symposia.smart.org.cn/sym/event/Fu...
Reposted by Inflammasome Lab
The IMB at the University of Queensland is looking for a new Mass Spectrometry Facility Manager. See details below.
Closing date 13th of February.
uq.wd3.myworkdayjobs.com/en-GB/uqcare...
Closing date 13th of February.
uq.wd3.myworkdayjobs.com/en-GB/uqcare...
Mass Spectrometry Platform Manager
Institute for Molecular Bioscience Full-time (100%), permanent position Base salary will be in the range $117,958.12 - $132,247.57+ 17% Superannuation (HEW Level 8) Based at our St Lucia Campus About ...
uq.wd3.myworkdayjobs.com
February 5, 2026 at 12:20 AM
The IMB at the University of Queensland is looking for a new Mass Spectrometry Facility Manager. See details below.
Closing date 13th of February.
uq.wd3.myworkdayjobs.com/en-GB/uqcare...
Closing date 13th of February.
uq.wd3.myworkdayjobs.com/en-GB/uqcare...
Reposted by Inflammasome Lab
We’re delighted to see this out today! Latest work from the lab reveals insights into the evolution of brain immunity and the developmental and evolutionary plasticity of lymphatic endothelial cells.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Convergent evolution of scavenger cell development at brain borders - Nature
Transcription factor osr2 is identified as a specific marker and regulator of mural lymphatic endothelial cell (muLEC) differentiation and maintenance, and muLECs and border-associated macrophages sha...
www.nature.com
January 21, 2026 at 8:42 PM
We’re delighted to see this out today! Latest work from the lab reveals insights into the evolution of brain immunity and the developmental and evolutionary plasticity of lymphatic endothelial cells.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Inflammasome Lab
#ARCschedule Jan26 update
ARC announced huge delays & 3-month announcement windows (used to be 2 weeks).
Delay in months per scheme:
🔹LP25: 1–4
🔹IC/IH26: 1–4
🔹FT26: 1–3
🔹LP26: 2.5–5.5
🔹LE27: 2–5
🔹DE27: 1.5–4.5
🔹DP27: 3–6
Just … appalling. Unworkable.
Data ▶️ docs.google.com/spreadsheets...
ARC announced huge delays & 3-month announcement windows (used to be 2 weeks).
Delay in months per scheme:
🔹LP25: 1–4
🔹IC/IH26: 1–4
🔹FT26: 1–3
🔹LP26: 2.5–5.5
🔹LE27: 2–5
🔹DE27: 1.5–4.5
🔹DP27: 3–6
Just … appalling. Unworkable.
Data ▶️ docs.google.com/spreadsheets...
January 12, 2026 at 5:19 AM
#ARCschedule Jan26 update
ARC announced huge delays & 3-month announcement windows (used to be 2 weeks).
Delay in months per scheme:
🔹LP25: 1–4
🔹IC/IH26: 1–4
🔹FT26: 1–3
🔹LP26: 2.5–5.5
🔹LE27: 2–5
🔹DE27: 1.5–4.5
🔹DP27: 3–6
Just … appalling. Unworkable.
Data ▶️ docs.google.com/spreadsheets...
ARC announced huge delays & 3-month announcement windows (used to be 2 weeks).
Delay in months per scheme:
🔹LP25: 1–4
🔹IC/IH26: 1–4
🔹FT26: 1–3
🔹LP26: 2.5–5.5
🔹LE27: 2–5
🔹DE27: 1.5–4.5
🔹DP27: 3–6
Just … appalling. Unworkable.
Data ▶️ docs.google.com/spreadsheets...
Reposted by Inflammasome Lab
Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice | Science Advances www.science.org/doi/full/10....
Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice
Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.
www.science.org
January 11, 2026 at 7:45 PM
Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice | Science Advances www.science.org/doi/full/10....
Working with a great team to organize @keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March! Join us to explore emerging research in Banff! keysym.us/KSInnateImmune26 #KSInnateImmune26
Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia
Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!
keysym.us
January 1, 2026 at 11:22 PM
Working with a great team to organize @keystoneSymposia.bsky.social #InnateImmunity : Diversity in #HostDefense & Disease, this March! Join us to explore emerging research in Banff! keysym.us/KSInnateImmune26 #KSInnateImmune26
Join us for an all-star line up for the 2026 #KeystoneSymposia on #InnateImmunity, co-organised by @jkagan1.bsky.social & @brozlab.bsky.social A joint meeting with joint meeting with the Keystone Aging Symposium in beautiful Banff, Canada. Register now! #inflammasomes, #TLRs, #myeloid, #epithelia
November 24, 2025 at 5:35 AM
Join us for an all-star line up for the 2026 #KeystoneSymposia on #InnateImmunity, co-organised by @jkagan1.bsky.social & @brozlab.bsky.social A joint meeting with joint meeting with the Keystone Aging Symposium in beautiful Banff, Canada. Register now! #inflammasomes, #TLRs, #myeloid, #epithelia
What do David Bowie, Queen & #inflammasomes have in common? Read our new review to find out! Deep dive into #NLRP1, #Inflammasomes, and innate immunity — covering activation, regulation & disease links. Great work from lab members Jeremy Yap & Kinga Duszyc!
authors.elsevier.com/a/1ly0C3vVUP...
authors.elsevier.com/a/1ly0C3vVUP...
authors.elsevier.com
November 24, 2025 at 3:59 AM
What do David Bowie, Queen & #inflammasomes have in common? Read our new review to find out! Deep dive into #NLRP1, #Inflammasomes, and innate immunity — covering activation, regulation & disease links. Great work from lab members Jeremy Yap & Kinga Duszyc!
authors.elsevier.com/a/1ly0C3vVUP...
authors.elsevier.com/a/1ly0C3vVUP...
Cracking the #CellDeath code! What has the field recently discovered, and what is on the horizon? Delighted to contribute to this article in #NatureStructuralMolecularBiology!
#Immunology #NatureSMB #Inflammasomes
rdcu.be/eG1Nm
#Immunology #NatureSMB #Inflammasomes
rdcu.be/eG1Nm
Towards a molecular and structural definition of cell death
Nature Structural & Molecular Biology - Cell death contributes to tissue homeostasis and plays critical roles in inflammation and host defense. Our increasing understanding of the physiological...
rdcu.be
November 24, 2025 at 3:24 AM
Cracking the #CellDeath code! What has the field recently discovered, and what is on the horizon? Delighted to contribute to this article in #NatureStructuralMolecularBiology!
#Immunology #NatureSMB #Inflammasomes
rdcu.be/eG1Nm
#Immunology #NatureSMB #Inflammasomes
rdcu.be/eG1Nm
Reposted by Inflammasome Lab
Happy to announce that our paper is finally out! Thanks to @brozlab.bsky.social and co-authors @elliottbernard.bsky.social @ehartenian.bsky.social 🥳 the NLRP6 inflammasome is activated by sterile- or pathogen-induced endolysosomal damage @embojournal.org
November 20, 2025 at 4:08 PM
Happy to announce that our paper is finally out! Thanks to @brozlab.bsky.social and co-authors @elliottbernard.bsky.social @ehartenian.bsky.social 🥳 the NLRP6 inflammasome is activated by sterile- or pathogen-induced endolysosomal damage @embojournal.org
Reposted by Inflammasome Lab
Who wants to discuss innate immunity and host defense?
Join us in Banff to share your exciting research.
www.keystonesymposia.org/conferences/...
Join us in Banff to share your exciting research.
www.keystonesymposia.org/conferences/...
Innate Immunity: Diversity in Host Defense and Disease | Keystone Symposia
Join us at the Keystone Symposia on Innate Immunity: Diversity in Host Defense and Disease, March 2026, in Banff, with field leaders!
www.keystonesymposia.org
November 11, 2025 at 2:55 PM
Who wants to discuss innate immunity and host defense?
Join us in Banff to share your exciting research.
www.keystonesymposia.org/conferences/...
Join us in Banff to share your exciting research.
www.keystonesymposia.org/conferences/...
Reposted by Inflammasome Lab
New story from the lab by PhD student Seb Grant. Started as a summer project and developed into an interesting story.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Evolutionary convergence of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signalling.
The coordination of efficient immune responses to infections is essential to enable pathogen clearance and host survival. Cell death modalities are a crucial component of the innate immune system and ...
www.biorxiv.org
November 3, 2025 at 3:43 PM
New story from the lab by PhD student Seb Grant. Started as a summer project and developed into an interesting story.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Inflammasome Lab
Review @cp-molcell.bsky.social @inflammasomelab.bsky.social
NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress
www.cell.com/molecular-ce...
NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress
www.cell.com/molecular-ce...
October 17, 2025 at 4:50 PM
Review @cp-molcell.bsky.social @inflammasomelab.bsky.social
NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress
www.cell.com/molecular-ce...
NLRP1 under pressure: An overview of the NLRP1 inflammasome as a sensor of cellular stress
www.cell.com/molecular-ce...
Reposted by Inflammasome Lab
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
October 17, 2025 at 6:29 AM
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
Reposted by Inflammasome Lab
(1/2) 🎉 The 2025 ACDS Prize for Outstanding ECRs is now open!
Recognising an ECR who’s advanced the Australasian cell death community.
🏆 Winner gets a cash prize, medal & invited talk.
Apply by 7 Nov 2025 (5 pm AEDT) → australasiancelldeathsociety.com/acds-awards
Recognising an ECR who’s advanced the Australasian cell death community.
🏆 Winner gets a cash prize, medal & invited talk.
Apply by 7 Nov 2025 (5 pm AEDT) → australasiancelldeathsociety.com/acds-awards
October 16, 2025 at 3:26 AM
(1/2) 🎉 The 2025 ACDS Prize for Outstanding ECRs is now open!
Recognising an ECR who’s advanced the Australasian cell death community.
🏆 Winner gets a cash prize, medal & invited talk.
Apply by 7 Nov 2025 (5 pm AEDT) → australasiancelldeathsociety.com/acds-awards
Recognising an ECR who’s advanced the Australasian cell death community.
🏆 Winner gets a cash prize, medal & invited talk.
Apply by 7 Nov 2025 (5 pm AEDT) → australasiancelldeathsociety.com/acds-awards
Reposted by Inflammasome Lab
Dear Everyone, I've read the #NHMRC draft strategy and I have notes ...
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
October 6, 2025 at 9:27 PM
Dear Everyone, I've read the #NHMRC draft strategy and I have notes ...
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
So I'm going to...🧵🤔🧵😱🧵😵💫🧵🙏🧵🧵🧵
This is a repost from X because you all need to know!
#NHMRCdraftStratergy #Ihavenotes #ValueFundamentalScience
@nhmrc.bsky.social
Reposted by Inflammasome Lab
Nature research paper: Myeloperoxidase transforms chromatin into neutrophil extracellular traps
go.nature.com/4pxKgV6
go.nature.com/4pxKgV6
Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature
Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.
go.nature.com
September 20, 2025 at 11:37 AM
Nature research paper: Myeloperoxidase transforms chromatin into neutrophil extracellular traps
go.nature.com/4pxKgV6
go.nature.com/4pxKgV6
Reposted by Inflammasome Lab
Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action. New study from Kevin Wilhelmsen (BioAge Labs), Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social and colleagues: rupress.org/jem/article/...
#Inflammasome #Inflammation
#Inflammasome #Inflammation
September 9, 2025 at 3:15 PM
Discovery of potent and selective inhibitors of human #NLRP3 with a novel mechanism of action. New study from Kevin Wilhelmsen (BioAge Labs), Rebecca Coll @colllab.bsky.social @wwiem-qub.bsky.social and colleagues: rupress.org/jem/article/...
#Inflammasome #Inflammation
#Inflammasome #Inflammation
Reposted by Inflammasome Lab
🌟 I am truly honoured to be named a finalist for the Rose-Anne Kelso Commemorative Award from Life Sciences Queensland Ltd (LSQ).
A big thank you to LSQ for their tireless work in fostering innovation, collaboration, and growth across the life sciences sector in Queensland.
A big thank you to LSQ for their tireless work in fostering innovation, collaboration, and growth across the life sciences sector in Queensland.
September 7, 2025 at 9:30 AM
🌟 I am truly honoured to be named a finalist for the Rose-Anne Kelso Commemorative Award from Life Sciences Queensland Ltd (LSQ).
A big thank you to LSQ for their tireless work in fostering innovation, collaboration, and growth across the life sciences sector in Queensland.
A big thank you to LSQ for their tireless work in fostering innovation, collaboration, and growth across the life sciences sector in Queensland.