Sharad Kumar
@molregulation.bsky.social
Biomedical scientist passionate about discovery research
Reposted by Sharad Kumar
Of all the stupid things that this regime has done, this is right up near the top. Postdoctoral researchers come to the US on H-1B visas. This will further destroy the US science enterprise. Stupid stupid stupid.
Trump administration to add $100,000 fee for H-1B visas
The Trump administration is targeting a visa widely used by tech companies and other employers to hire foreign workers.
www.cbsnews.com
September 19, 2025 at 8:44 PM
Of all the stupid things that this regime has done, this is right up near the top. Postdoctoral researchers come to the US on H-1B visas. This will further destroy the US science enterprise. Stupid stupid stupid.
Locals in Adelaide are now in full bloom 😊
August 26, 2025 at 10:54 PM
Locals in Adelaide are now in full bloom 😊
Very cool study:
LYVAC/PDZD8 is a lysosomal vacuolator | Science www.science.org/doi/10.1126/...
LYVAC/PDZD8 is a lysosomal vacuolator | Science www.science.org/doi/10.1126/...
LYVAC/PDZD8 is a lysosomal vacuolator
Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...
www.science.org
August 22, 2025 at 1:56 AM
Very cool study:
LYVAC/PDZD8 is a lysosomal vacuolator | Science www.science.org/doi/10.1126/...
LYVAC/PDZD8 is a lysosomal vacuolator | Science www.science.org/doi/10.1126/...
www.nature.com/articles/s41...
New publication from our lab.
New publication from our lab.
Phospholipid scramblase 1 (PLSCR1) is a novel substrate of NEDD4-2 (NEDD4L) mediated ubiquitination - Cell Death Discovery
Cell Death Discovery - Phospholipid scramblase 1 (PLSCR1) is a novel substrate of NEDD4-2 (NEDD4L) mediated ubiquitination
www.nature.com
August 22, 2025 at 12:04 AM
www.nature.com/articles/s41...
New publication from our lab.
New publication from our lab.
Shades of Spring in Adelaide: frost and Sakura 😊
August 13, 2025 at 10:21 PM
Shades of Spring in Adelaide: frost and Sakura 😊
Reposted by Sharad Kumar
🧬 New paper alert!
@molregulation.bsky.social’s team reveals a paradox: Nedd4-2 deficiency triggers kidney injury but protects against high blood glucose in diabetes. Fascinating twist! 🔄
@molregulation.bsky.social’s team reveals a paradox: Nedd4-2 deficiency triggers kidney injury but protects against high blood glucose in diabetes. Fascinating twist! 🔄
Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice - Cell Death & Disease
Cell Death & Disease - Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice
www.nature.com
July 30, 2025 at 11:26 PM
🧬 New paper alert!
@molregulation.bsky.social’s team reveals a paradox: Nedd4-2 deficiency triggers kidney injury but protects against high blood glucose in diabetes. Fascinating twist! 🔄
@molregulation.bsky.social’s team reveals a paradox: Nedd4-2 deficiency triggers kidney injury but protects against high blood glucose in diabetes. Fascinating twist! 🔄
Reposted by Sharad Kumar
New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports.
erictopol.substack.com/p/new-anti-a...
erictopol.substack.com/p/new-anti-a...
July 5, 2025 at 5:09 PM
New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports.
erictopol.substack.com/p/new-anti-a...
erictopol.substack.com/p/new-anti-a...
Reposted by Sharad Kumar
An analysis shows that large fractions of future generations will be exposed to extreme climate events that would occur only once every 10,000 years in the absence of global warming
https://go.nature.com/43lhNbO
https://go.nature.com/43lhNbO
Climate risk for younger generations is set to soar
An analysis shows that large fractions of future generations will be exposed to extreme climate events that would occur only once every 10,000 years in the absence of global warming.
go.nature.com
May 8, 2025 at 8:04 AM
An analysis shows that large fractions of future generations will be exposed to extreme climate events that would occur only once every 10,000 years in the absence of global warming
https://go.nature.com/43lhNbO
https://go.nature.com/43lhNbO
Reposted by Sharad Kumar
Tiger numbers in India are starting to rebound after decades of being perilously low.
This recovery offers lessons for conserving other rare animals
https://go.nature.com/3EpQfIA
This recovery offers lessons for conserving other rare animals
https://go.nature.com/3EpQfIA
Tiger turnaround as populations grow in India
Nature - Tiger numbers in India are starting to rebound after decades of being perilously low. This recovery offers lessons for conserving other rare animals.
go.nature.com
April 12, 2025 at 4:18 PM
Tiger numbers in India are starting to rebound after decades of being perilously low.
This recovery offers lessons for conserving other rare animals
https://go.nature.com/3EpQfIA
This recovery offers lessons for conserving other rare animals
https://go.nature.com/3EpQfIA
Reposted by Sharad Kumar
Spatial multi-omics reveals cell-type-specific nuclear compartments @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 9, 2025 at 4:52 PM
Spatial multi-omics reveals cell-type-specific nuclear compartments @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sharad Kumar
Nature research paper: Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia
https://go.nature.com/4j2WTDZ
https://go.nature.com/4j2WTDZ
Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia - Nature
Explosive growth is attributed to the BCR::ABL1 gene 3–14 years before diagnosis of chronic myeloid leukaemia, highlighting the oncogenic potency of gene fusion and the slow and sequential trajectories of most other cancers.
go.nature.com
April 9, 2025 at 7:12 PM
Nature research paper: Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia
https://go.nature.com/4j2WTDZ
https://go.nature.com/4j2WTDZ
Reposted by Sharad Kumar
Studies of researchers globally suggest there is a mental-health crisis in academia
https://go.nature.com/3RNAbmZ
https://go.nature.com/3RNAbmZ
A mental-health crisis plagues PhDs — these evidence-led initiatives offer help
Communities of researchers worldwide are taking on the toxic research cultures that drive poor psychological health among academics.
go.nature.com
April 9, 2025 at 3:27 PM
Studies of researchers globally suggest there is a mental-health crisis in academia
https://go.nature.com/3RNAbmZ
https://go.nature.com/3RNAbmZ
Reposted by Sharad Kumar
“I’ve never thought that this would be accomplished in my lifetime”
Researchers have successfully sequenced the complete genomes of six ape species
https://go.nature.com/4j9jE9k
Researchers have successfully sequenced the complete genomes of six ape species
https://go.nature.com/4j9jE9k
What makes us human? Milestone ape genomes promise clues
DNA sequences for the chimpanzee, orangutans and more will help scientists to determine what sets humans apart from other apes.
go.nature.com
April 9, 2025 at 4:14 PM
“I’ve never thought that this would be accomplished in my lifetime”
Researchers have successfully sequenced the complete genomes of six ape species
https://go.nature.com/4j9jE9k
Researchers have successfully sequenced the complete genomes of six ape species
https://go.nature.com/4j9jE9k
Reposted by Sharad Kumar
Researchers have created the largest and most detailed wiring diagram of a mammalian brain to date, by mapping cells in a cubic millimetre of a mouse’s brain tissue
https://go.nature.com/4cu68dN
https://go.nature.com/4cu68dN
Biggest brain map ever details huge number of neurons and their activity
3D reconstruction is the first to overlay neuronal activity on a large-scale map of brain cells.
go.nature.com
April 9, 2025 at 4:36 PM
Researchers have created the largest and most detailed wiring diagram of a mammalian brain to date, by mapping cells in a cubic millimetre of a mouse’s brain tissue
https://go.nature.com/4cu68dN
https://go.nature.com/4cu68dN
Reposted by Sharad Kumar
Cancer vulnerabilities exposed by finding interactions among DNA repair factors @nature.com @jcornlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
April 9, 2025 at 4:38 PM
Cancer vulnerabilities exposed by finding interactions among DNA repair factors @nature.com @jcornlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Reposted by Sharad Kumar
Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome. @naturemedicine.bsky.social
March 24, 2025 at 4:03 PM
Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome. @naturemedicine.bsky.social
Overseas universities see opportunity in U.S. ‘brain drain’ | Science | AAAS www.science.org/content/arti...
Overseas universities see opportunity in U.S. ‘brain drain’
But many U.S.-based scientists seeking to leave may struggle to find positions in countries grappling with funding issues of their own
www.science.org
March 17, 2025 at 10:34 PM
Overseas universities see opportunity in U.S. ‘brain drain’ | Science | AAAS www.science.org/content/arti...
Reposted by Sharad Kumar
Some scientists in the United States have told Nature that they are considering leaving the country in the wake of widespread disruption to research brought in by the Trump administration
Are you thinking about leaving?
https://go.nature.com/4bMGd0J
Are you thinking about leaving?
https://go.nature.com/4bMGd0J
These frustrated scientists want to leave the United States – do you? Take Nature’s poll
Nature - In the wake of the Trump administration’s funding freezes and job cuts, some researchers are planning their next move.
go.nature.com
March 15, 2025 at 2:13 PM
Some scientists in the United States have told Nature that they are considering leaving the country in the wake of widespread disruption to research brought in by the Trump administration
Are you thinking about leaving?
https://go.nature.com/4bMGd0J
Are you thinking about leaving?
https://go.nature.com/4bMGd0J
Reposted by Sharad Kumar
The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in the mouse model.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Senolytic treatment for low back pain
Senolytics drugs can reduce back pain by removing senescent cells from the intervertebral discs and spinal cord.
www.science.org
March 14, 2025 at 9:10 PM
The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in the mouse model.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Sharad Kumar
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 12, 2025 at 8:47 PM
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
That's not to mention the countless lives that biomedical research has saved.
Show me a better investment than that.
www.forbes.com/sites/michae...
Reposted by Sharad Kumar
How does SARS-CoV-2 lead to the multisystem inflammatory syndrome in children, a rare, potentially fatal condition?
www.nature.com/articles/s41...
High levels of TGFβ interfere with the child's response to control Epstein Barr virus, leading to its reactivation and severe inflammation @nature.com
www.nature.com/articles/s41...
High levels of TGFβ interfere with the child's response to control Epstein Barr virus, leading to its reactivation and severe inflammation @nature.com
TGFβ links EBV to multisystem inflammatory syndrome in children - Nature
Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.
www.nature.com
March 12, 2025 at 4:39 PM
How does SARS-CoV-2 lead to the multisystem inflammatory syndrome in children, a rare, potentially fatal condition?
www.nature.com/articles/s41...
High levels of TGFβ interfere with the child's response to control Epstein Barr virus, leading to its reactivation and severe inflammation @nature.com
www.nature.com/articles/s41...
High levels of TGFβ interfere with the child's response to control Epstein Barr virus, leading to its reactivation and severe inflammation @nature.com
Reposted by Sharad Kumar
next Canadian government should think of boosting research funding up here and trying to grab as many American postdocs and researchers as possible
March 12, 2025 at 1:08 PM
next Canadian government should think of boosting research funding up here and trying to grab as many American postdocs and researchers as possible
Reposted by Sharad Kumar
Nature research paper: MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC
https://go.nature.com/41IPJwX
https://go.nature.com/41IPJwX
MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC - Nature
In a model of pancreatic ductal adenocarcinoma, extrachromosomal DNAs are shown to be a source of high-level focal amplification driving MYC heterogeneity and phenotypic adaptation.
go.nature.com
March 12, 2025 at 7:34 PM
Nature research paper: MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC
https://go.nature.com/41IPJwX
https://go.nature.com/41IPJwX
Reposted by Sharad Kumar
Australia: Shergold says ARC funding scheme redesign should set the course for decades ahead (free to read): www.researchprofessionalnews.com/rr-news-aust...
ARC redesign ‘will set funding direction for next two decades’ - Research Professional News
Chair explains why Australian Research Council is rejecting defined splits between basic and applied funding
www.researchprofessionalnews.com
March 10, 2025 at 10:46 PM
Australia: Shergold says ARC funding scheme redesign should set the course for decades ahead (free to read): www.researchprofessionalnews.com/rr-news-aust...
“NIH-funded research contributed to 354 of 356 drugs approved by the US Food and Drug Administration in 2010–19.”
Abrupt cuts by the Trump administration to the US National Institutes of Health threaten progress in medical research globally
https://go.nature.com/3FbZP1N
https://go.nature.com/3FbZP1N
How the NIH dominates the world’s health research — in charts
Abrupt cuts by the Trump administration to the US National Institutes of Health threaten progress in medical research globally.
go.nature.com
March 10, 2025 at 6:45 PM
“NIH-funded research contributed to 354 of 356 drugs approved by the US Food and Drug Administration in 2010–19.”