Sharad Kumar
LightNews LightNews
molregulation.bsky.social
Sharad Kumar
@molregulation.bsky.social
68 followers 55 following 24 posts
Biomedical scientist passionate about discovery research
Posts Replies Media Videos
molregulation.bsky.social
Hidden cancer risk behind fatty liver disease targets | EurekAlert! www.eurekalert.org/news-release...
Hidden cancer risk behind fatty liver disease targets
Scientists have discovered that blocking a key cellular enzyme thought to protect against fatty liver disease may instead increase the risk of chronic liver damage and cancer as we age.
www.eurekalert.org
January 13, 2026 at 10:07 PM
molregulation.bsky.social
Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice | Science Advances www.science.org/doi/full/10....
Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice
Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.
www.science.org
January 11, 2026 at 7:45 PM
Reposted by Sharad Kumar
molregulation.bsky.social
Great to see this work, led by Loretta Dorstyn, with contributions from many colleagues and funded by NHMRC now out. Our first publication of 2026 and from the new Adelaide University.
www.science.org/doi/10.1126/...
Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice
Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.
www.science.org
January 2, 2026 at 8:44 AM
molregulation.bsky.social
Great to see this work, led by Loretta Dorstyn, with contributions from many colleagues and funded by NHMRC now out. Our first publication of 2026 and from the new Adelaide University.
www.science.org/doi/10.1126/...
Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice
Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.
www.science.org
January 2, 2026 at 8:44 AM
Reposted by Sharad Kumar
labwaggoner.bsky.social
Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer
www.science.org/doi/10.1126/...
@molregulation.bsky.social
January 2, 2026 at 12:02 AM
Reposted by Sharad Kumar
davidho.bsky.social
Of all the stupid things that this regime has done, this is right up near the top. Postdoctoral researchers come to the US on H-1B visas. This will further destroy the US science enterprise. Stupid stupid stupid.
Trump administration to add $100,000 fee for H-1B visas
The Trump administration is targeting a visa widely used by tech companies and other employers to hire foreign workers.
www.cbsnews.com
September 19, 2025 at 8:44 PM
molregulation.bsky.social
Locals in Adelaide are now in full bloom 😊
August 26, 2025 at 10:54 PM
molregulation.bsky.social
Very cool study:
LYVAC/PDZD8 is a lysosomal vacuolator | Science www.science.org/doi/10.1126/...
LYVAC/PDZD8 is a lysosomal vacuolator
Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...
www.science.org
August 22, 2025 at 1:56 AM
molregulation.bsky.social
www.nature.com/articles/s41...
New publication from our lab.
Phospholipid scramblase 1 (PLSCR1) is a novel substrate of NEDD4-2 (NEDD4L) mediated ubiquitination - Cell Death Discovery
Cell Death Discovery - Phospholipid scramblase 1 (PLSCR1) is a novel substrate of NEDD4-2 (NEDD4L) mediated ubiquitination
www.nature.com
August 22, 2025 at 12:04 AM
molregulation.bsky.social
Shades of Spring in Adelaide: frost and Sakura 😊
August 13, 2025 at 10:21 PM
Reposted by Sharad Kumar
auscelldeathsoc.bsky.social
🧬 New paper alert!
@molregulation.bsky.social’s team reveals a paradox: Nedd4-2 deficiency triggers kidney injury but protects against high blood glucose in diabetes. Fascinating twist! 🔄
Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice - Cell Death & Disease
Cell Death & Disease - Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice
www.nature.com
July 30, 2025 at 11:26 PM
Reposted by Sharad Kumar
erictopol.bsky.social
New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports.
erictopol.substack.com/p/new-anti-a...
Organ clocks for post-menopausal women taking estrogen or not taking estrogen
July 5, 2025 at 5:09 PM
Reposted by Sharad Kumar
nature.com
An analysis shows that large fractions of future generations will be exposed to extreme climate events that would occur only once every 10,000 years in the absence of global warming

https://go.nature.com/43lhNbO
Climate risk for younger generations is set to soar
An analysis shows that large fractions of future generations will be exposed to extreme climate events that would occur only once every 10,000 years in the absence of global warming.
go.nature.com
May 8, 2025 at 8:04 AM
Reposted by Sharad Kumar
nature.com
Tiger numbers in India are starting to rebound after decades of being perilously low.

This recovery offers lessons for conserving other rare animals

https://go.nature.com/3EpQfIA
Tiger turnaround as populations grow in India
Nature - Tiger numbers in India are starting to rebound after decades of being perilously low. This recovery offers lessons for conserving other rare animals.
go.nature.com
April 12, 2025 at 4:18 PM
Reposted by Sharad Kumar
labwaggoner.bsky.social
Spatial multi-omics reveals cell-type-specific nuclear compartments @nature.com
www.nature.com/articles/s41...
April 9, 2025 at 4:52 PM
Reposted by Sharad Kumar
nature.com
Nature research paper: Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia

https://go.nature.com/4j2WTDZ
Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia - Nature
Explosive growth is attributed to the BCR::ABL1 gene 3–14 years before diagnosis of chronic myeloid leukaemia, highlighting the oncogenic potency of gene fusion and the slow and sequential trajectories of most other cancers.
go.nature.com
April 9, 2025 at 7:12 PM
Reposted by Sharad Kumar
nature.com
Studies of researchers globally suggest there is a mental-health crisis in academia

https://go.nature.com/3RNAbmZ
A mental-health crisis plagues PhDs — these evidence-led initiatives offer help
Communities of researchers worldwide are taking on the toxic research cultures that drive poor psychological health among academics.
go.nature.com
April 9, 2025 at 3:27 PM
Reposted by Sharad Kumar
nature.com
“I’ve never thought that this would be accomplished in my lifetime”

Researchers have successfully sequenced the complete genomes of six ape species

https://go.nature.com/4j9jE9k
What makes us human? Milestone ape genomes promise clues
DNA sequences for the chimpanzee, orangutans and more will help scientists to determine what sets humans apart from other apes.
go.nature.com
April 9, 2025 at 4:14 PM
Reposted by Sharad Kumar
nature.com
Researchers have created the largest and most detailed wiring diagram of a mammalian brain to date, by mapping cells in a cubic millimetre of a mouse’s brain tissue

https://go.nature.com/4cu68dN
Biggest brain map ever details huge number of neurons and their activity
3D reconstruction is the first to overlay neuronal activity on a large-scale map of brain cells.
go.nature.com
April 9, 2025 at 4:36 PM
Reposted by Sharad Kumar
labwaggoner.bsky.social
Cancer vulnerabilities exposed by finding interactions among DNA repair factors @nature.com @jcornlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/d41...
April 9, 2025 at 4:38 PM
Reposted by Sharad Kumar
erictopol.bsky.social
Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome. @naturemedicine.bsky.social
March 24, 2025 at 4:03 PM
molregulation.bsky.social
Overseas universities see opportunity in U.S. ‘brain drain’ | Science | AAAS www.science.org/content/arti...
Overseas universities see opportunity in U.S. ‘brain drain’
But many U.S.-based scientists seeking to leave may struggle to find positions in countries grappling with funding issues of their own
www.science.org
March 17, 2025 at 10:34 PM
Reposted by Sharad Kumar
nature.com
Some scientists in the United States have told Nature that they are considering leaving the country in the wake of widespread disruption to research brought in by the Trump administration

Are you thinking about leaving?

https://go.nature.com/4bMGd0J
These frustrated scientists want to leave the United States – do you? Take Nature’s poll
Nature - In the wake of the Trump administration’s funding freezes and job cuts, some researchers are planning their next move.
go.nature.com
March 15, 2025 at 2:13 PM
Reposted by Sharad Kumar
erictopol.bsky.social
The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in the mouse model.
www.science.org/doi/10.1126/...
Senolytic treatment for low back pain
Senolytics drugs can reduce back pain by removing senescent cells from the intervertebral discs and spinal cord.
www.science.org
March 14, 2025 at 9:10 PM
Reposted by Sharad Kumar
drsherrypagoto.bsky.social
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.

That's not to mention the countless lives that biomedical research has saved.

Show me a better investment than that.
www.forbes.com/sites/michae...
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
www.forbes.com
March 12, 2025 at 8:47 PM