JelenaBezbradicaLab
@jelenalab.bsky.social
Professor of Immunology at the University of Oxford. Innate sensing and signalling in macrophages. Inflammasomes. Signalling crosstalk in inflammation. https://www.kennedy.ox.ac.uk/research/research-groups/innate-immunity-and-inflammation
Pinned
TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
www.science.org
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...
Reminder: new #InflammaZoom free Webinar is today at 2 pm BST with James Murphy @pseudokinase.bsky.social from WEHI and Jonathan Maelfait from VIB Ghent. Register via Abcam link below. See you soon!
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
October 20, 2025 at 7:36 AM
Reminder: new #InflammaZoom free Webinar is today at 2 pm BST with James Murphy @pseudokinase.bsky.social from WEHI and Jonathan Maelfait from VIB Ghent. Register via Abcam link below. See you soon!
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
October 17, 2025 at 6:29 AM
#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium)
Register now: bit.ly/4iXGqjw
Register now: bit.ly/4iXGqjw
Reposted by JelenaBezbradicaLab
Congratulations to newly minted Dr. Esther L. Jones @estherlj.bsky.social on her successful DPhil viva! A great collaborative project between the L. Dustin and Jelena Bezbradica @jelenalab.bsky.social labs. Many thanks to examiners Irina Udalova @udalovalab.bsky.social and Menna Clatworthy.
June 28, 2025 at 8:39 PM
Congratulations to newly minted Dr. Esther L. Jones @estherlj.bsky.social on her successful DPhil viva! A great collaborative project between the L. Dustin and Jelena Bezbradica @jelenalab.bsky.social labs. Many thanks to examiners Irina Udalova @udalovalab.bsky.social and Menna Clatworthy.
Reposted by JelenaBezbradicaLab
Excited to share that our paper examining how GM-CSF potentiates cytokine responses in human monocytes during bacterial infection is now online at the @asm.org journal Infection & Immunity! Congrats to @vvazquez.bsky.social, @mikelhaggadone.bsky.social, & co-authors! journals.asm.org/doi/full/10....
June 17, 2025 at 12:50 PM
Excited to share that our paper examining how GM-CSF potentiates cytokine responses in human monocytes during bacterial infection is now online at the @asm.org journal Infection & Immunity! Congrats to @vvazquez.bsky.social, @mikelhaggadone.bsky.social, & co-authors! journals.asm.org/doi/full/10....
Reposted by JelenaBezbradicaLab
Thrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧵(1/n)
elifesciences.org
April 2, 2025 at 1:02 PM
Thrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧵(1/n)
Elegant work by @jkagan1.bsky.social and team on identifying how innate immune receptor Caspase 11 recognises molecular patterns in LPS and self lipids.
What do Pablo Picasso and Charles Janeway have in common? Both were interested in patterns of life. Janeway was focused on pathogen associated molecular patterns (PAMPs) that are detected by our immune system. But what are these patterns he refers to?
March 8, 2025 at 4:34 PM
Elegant work by @jkagan1.bsky.social and team on identifying how innate immune receptor Caspase 11 recognises molecular patterns in LPS and self lipids.
Reposted by JelenaBezbradicaLab
#InterferonFriendOrFoe?! Klein @kahlenberglab.bsky.social &co show Science Immunology that UV drives mitochondrial Z-DNA to induce type I & III IFNs in keratinocytes. IFN-I upregulates ZBP1 that binds Z-DNA activating cGAS-STING to boost IFNs, photosensitivity & inflammation in #Lupus skin!
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity
ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation.
www.science.org
March 7, 2025 at 10:32 PM
#InterferonFriendOrFoe?! Klein @kahlenberglab.bsky.social &co show Science Immunology that UV drives mitochondrial Z-DNA to induce type I & III IFNs in keratinocytes. IFN-I upregulates ZBP1 that binds Z-DNA activating cGAS-STING to boost IFNs, photosensitivity & inflammation in #Lupus skin!
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...
TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways
TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.
www.science.org
March 7, 2025 at 8:49 PM
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...
Reposted by JelenaBezbradicaLab
We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland.
Registrations open March 1 - Attendance limited to 150 participants.
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Registrations open March 1 - Attendance limited to 150 participants.
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Symposium immunobiology
wp.unil.ch
January 28, 2025 at 2:33 PM
We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland.
Registrations open March 1 - Attendance limited to 150 participants.
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Registrations open March 1 - Attendance limited to 150 participants.
More info: wp.unil.ch/immunobiolog...
#ImmunoSky
Reposted by JelenaBezbradicaLab
Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to our website page iles.web.ox.ac.uk/how-apply where you can see open day videos and get full guidance.
How to Apply and Funding
iles.web.ox.ac.uk
January 16, 2025 at 2:10 PM
Two weeks to go until the application deadline for ILESLA. If you or anyone you know would benefit from full funding to carry out a PhD in Life and/or Environmental Science please visit/refer to our website page iles.web.ox.ac.uk/how-apply where you can see open day videos and get full guidance.
Reposted by JelenaBezbradicaLab
Absolutely fantastic work by Vivian Lau and @gerardlab.bsky.social on IFNy-related tumour escape! Must-read for all tumour immunologists! 💯
Tumours escape the immune system by mutating to decrease their immunogenicity. In this study, now in
@natcomms.bsky.social, we described that immune cells can adapt to IFNg-driven escape, enhancing their fitness and thereby counteracting tumour escape www.nature.com/articles/s41...
@natcomms.bsky.social, we described that immune cells can adapt to IFNg-driven escape, enhancing their fitness and thereby counteracting tumour escape www.nature.com/articles/s41...
Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models - Nature Communications
Losing sensitivity to IFNγ may contribute to tumor immune escape, but containment of IFNγ-insensitive tumors is also reported. Here the authors show, by analyzing immune landscape differences between ...
www.nature.com
January 5, 2025 at 1:22 PM
Absolutely fantastic work by Vivian Lau and @gerardlab.bsky.social on IFNy-related tumour escape! Must-read for all tumour immunologists! 💯
Ok, let's start here on @bsky.app by reposting this truly outstanding paper by @lozanzi.bsky.social and colleagues!
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.
www.cell.com
January 8, 2025 at 1:51 PM
Ok, let's start here on @bsky.app by reposting this truly outstanding paper by @lozanzi.bsky.social and colleagues!