J Magarian Blander
magarianblander.bsky.social
J Magarian Blander
@magarianblander.bsky.social
Armenian American Scientist studies immune responses to #microbes, #tissueinjury, & earliest stages of #cancer.
Professor, Head of Biomedical Research Lab
https://www.theblanderlab.org
#macrophage #Dendriticcell #inflammasome #celldeath #Tcell
To those of you interested in #inflammation #resolution and #tumormicroenvironment. I recorded this-braving cold windy conditions- to catch your interest. Join us!
youtu.be/jxcpEc8I9Eo.
Hope it musters your interest!

@keystonesymposia.bsky.social
Conference Alert ⏰ 🔔:
vimeo.com/1136180246/1...
symposia.bsky.social
symposia.bsky.social
January 13, 2026 at 11:16 PM
Reposted by J Magarian Blander
⏳ Deadline Jan. 14 (11:59 PM MST)! Submit abstracts/apply for scholarships for Tumor Microenvironment / Inflammation Resolution.

🔗 keysym.us/KSTumorMicro26
| keysym.us/KSInflammati...

@coussenslab.bsky.social @sandramcallister.bsky.social @laurakiessling.bsky.social @magarianblander.bsky.social
January 12, 2026 at 6:14 PM
@drjonlim.bsky.social & @reisesousalab.bsky.social show cDC1s & DNGR1 favor "tethered" neoantigens from F-actin proteins, trapping them in necrotic debris for better cross-presentation! Calls for prioritizing these neoantigens for cancer vaccine design #Immunotherapy www.nature.com/articles/s41...
Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology
Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...
www.nature.com
January 2, 2026 at 7:19 PM
Reposted by J Magarian Blander
Very grateful to Prof. Blander & Dr. Jha for a thoughtful @natimmunol.nature.com 𝘕𝘦𝘸𝘴 & 𝘝𝘪𝘦𝘸𝘴 piece on our work 🙏

📄 A clear & critical perspective that places our findings in the broader context of dendritic cell biology, cross-presentation, and tumour immunoediting.

@reisesousalab.bsky.social
Tethered neoantigens from the dead sculpt tumor fate - Nature Immunology
New data show that DNGR-1 enables type 1 conventional dendritic cells to sculpt cancer immunoediting through selective cross-presentation of F-actin-tethered neoantigens, enriching tumors for immune-e...
www.nature.com
January 2, 2026 at 5:22 PM
Secret Santa with our incredible lab family; thoughtful gifts, fresh popcorn, homemade cookies, laughter, and holiday cheer. Wishing everyone a joyful season full of rest, peace, and time with loved ones. Happy Holidays!
#LabLife #SecretSanta #HappyHolidays
December 24, 2025 at 12:56 AM
Thrilled to announce that my postdoc, Chongbo (Bob) Yang, is a Crohn's & Colitis Foundation Research Fellows Awardee! Meticulous to the core, Bob turns "impossible" into "inevitable" breakthroughs. Bob investigates DC response to RIPK3-driven inflammatory cell death. @crohnscolitisfdn.bsky.social
November 1, 2025 at 3:52 AM
Good news shouldn’t wait, but it’s been a hectic work-heavy summer. I am delighted and honored to be among the Kenneth Rainin Foundation 2025 Innovator Award Grantees. Thank you to @krfoundation.org for supporting our work.

krfoundation.org/news/health/...

krfoundation.org/our-work/hea...
Over $4 Million Awarded In IBD Research Grants - Kenneth Rainin Foundation
The 2025 Innovator Awards grantee projects explore new ways to reduce inflammation and restore gut health, targeted treatment options with fewer side effects and the chance for lasting healing, and th...
krfoundation.org
September 19, 2025 at 7:22 PM
Thrilled to see two of my former postdocs, @gaetanbarbet.bsky.social ‬⁩ and Johan Garaude, shining on the speaker list at the @frenchdcsociety.bsky.social Biennial Meeting, @pasteur.fr ! Proud of their amazing work and contributions to the field! #Dendriticcell #ProudMentor
May 28, 2025 at 6:57 PM
Working with a great team to organize @keystonesymposia.bsky.social “Inflammation Resolution: Emerging Concepts, Mechanisms, and Disease Insights” in Whistler, May 17-20 2026. SAVE THE DATE. Join us! keysym.us/KSInflammati... #KSInflammation26 #inflammation #inflammationresolution #cancer
Inflammation Resolution: Emerging Concepts, Mechanisms and Disease Insights | Keystone Symposia
Join us at the Keystone Symposia on Inflammation Resolution: Emerging Concepts, Mechanisms and Disease Insights, May 2026, in Whistler, with field leaders!
keysym.us
May 21, 2025 at 11:13 PM
Also: Loving the collaboration between Johan Garaude @immunoconcept @inserm.fr and Leif Sander @sanderlab.bsky.social on this work. Johan and Leif met in my lab and have been friends and collaborators since (I’ll just say a while ago). Brings a smile to my face!
www.nature.com/articles/s41...
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...
www.nature.com
March 7, 2025 at 11:07 PM
Thrilled for Johan Garaude’s @inserm.fr new work in Nature! I’m proud to see this Blander lab alumnus shine. His group shows bacterial cAMP accumulation signals death, fueling macrophage recycling—a fresh live-vs-dead immune twist. Stellar work with huge impact! www.nature.com/articles/s41...
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...
www.nature.com
March 7, 2025 at 10:34 PM
Vita-PAMP bacterial mRNA+LPS in sterile tissue = potentially dangerous live bacteria, & like virulence factors, activate the noncanonical NLRP3 inflammasome. Find out the common & distinct features of activating this pathway by a vita-PAMP vs virulence factor:
www.sciencedirect.com/science/arti...
January 25, 2025 at 9:36 PM
Grateful to have our newly published work in Nature Immunology highlighted by @weillcornell.bsky.social. Honored to contribute to the amazing research happening here.
news.weill.cornell.edu/news/2025/01...
#Medicalresearch #cancer #immunology #inflammasome
Immune Complex Shaves Stem Cells to Protect against Cancer
A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, accord...
news.weill.cornell.edu
January 20, 2025 at 12:36 AM
Macrophages help tumors grow, but what about early on when transformed cells first arise in tissue? Macrophages may collaborate with the cell-intrinsic barriers to transformation in a form of ‘oncogenic monitoring’. Curious? My hypothesis full text here till 2/15
authors.elsevier.com/a/1kKoc3OeyG...
January 13, 2025 at 1:29 AM
Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis.

Happy to share here: www.nature.com/articles/s41...
A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis - Nature Immunology
Blander and colleagues report a homeostatic regulatory effect played by inflammasomes in the bone marrow stromal compartment that suppresses premalignant stages of lymphomagenesis.
www.nature.com
January 6, 2025 at 12:29 AM