Sébastien Bontemps-Gallo, Ph.D.
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sebbontempsgallo.bsky.social
Sébastien Bontemps-Gallo, Ph.D.
@sebbontempsgallo.bsky.social
420 followers 780 following 50 posts
Associate Researcher (CNRS-HDR) | Bacteriology 🧑‍🔬

🔬Exploring bacterial stress responses and cell signaling in host-pathogen interactions and vector-borne diseases.

🏢 Based at Institut Pasteur de Lille 🇫🇷

Views are my own.
He/him
Posts Replies Media Videos
Reposted by Sébastien Bontemps-Gallo, Ph.D.
pasteurlille.bsky.social
Né il y a plus de 130 ans, l’Institut Pasteur de Lille met la science au service de la santé.

Aujourd’hui, nous faisons évoluer notre identité pour mieux refléter notre engagement collectif.

🎬 Découvrez notre nouveau film qui raconte qui nous sommes et où nous allons.

youtu.be/UyxvGUHWWtk?...
Notre identité, notre héritage, notre avenir !
YouTube video by Pasteur Lille
youtu.be
February 2, 2026 at 4:32 PM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
martinsteinegger.bsky.social
FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social.
📄 www.science.org/doi/10.1126/...
🌐 search.foldseek.com/foldmason
💾 github.com/steineggerla...
Multiple protein structure alignment at scale with FoldMason
Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...
www.science.org
January 30, 2026 at 6:11 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
ciilofficiel.bsky.social
Our new website is now live!

A redesigned interface to better showcase our research, teams, and latest news.

➡️ www.ciil.fr

@cnrs-hautsdefrance.bsky.social @inserm.fr @cnrs.fr @pasteurlille.bsky.social @rechercheulille.bsky.social
January 28, 2026 at 9:01 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
cnrs.fr
#BonneAnnée 🌟 Le #CNRS vous présente ses meilleurs vœux pour l'année 2026 !

#HappyNewYear 🌟 The French National Centre for Scientific Research (CNRS) wishes you the very best for 2026!
January 1, 2026 at 11:02 AM
sebbontempsgallo.bsky.social
A fascinating Review in Nature Reviews Microbiology shows how ancient pathogen genomics reshapes our understanding of infectious diseases. For Yersinia pestis, it synthesizes decades of work on plague evolution, while highlighting key open questions ahead.

#microsky
Insights into infectious diseases through ancient pathogen genomics - Nature Reviews Microbiology
In this Review, Kocher, Krause and Spyrou explore how ancient pathogen genomics is providing new perspectives on the history and evolution of infectious agents. They show how ancient DNA has revealed ...
www.nature.com
December 26, 2025 at 12:11 PM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
cnrs.fr
Pourquoi certaines bactéries résistent-elles aux antibiotiques ? 🦠💊 Sébastien Bontemps-Gallo, bactériologiste au CNRS, tente d'y répondre.
Brève de science : pourquoi certaines bactéries résistent-elles aux antibiotiques ?
www.cnrs.fr
December 10, 2025 at 3:55 PM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
univlille.bsky.social
🦠 "Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte", un article de @sebbontempsgallo.bsky.social (@cnrs-hautsdefrance.bsky.social / @univlille.bsky.social) pour @france.theconversation.com 👇
theconversation.com/maladie-de-l...
Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte
Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.
theconversation.com
November 25, 2025 at 8:24 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
ciilofficiel.bsky.social
📢 A new pub in Journal of Controlled Release by Dr @arnaudmachelart.bsky.social group and Dr Ruxandra Gref team

“Selective accumulation of nanoparticles in infected cells for targeted drug delivery”

@inserm.fr @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social @pasteurlille.bsky.social
Selective accumulation of nanoparticles in infected cells for targeted drug delivery
In response to the escalating threat of infectious diseases and antimicrobial resistance, novel therapeutic strategies are under active development. A…
www.sciencedirect.com
November 22, 2025 at 5:17 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
solimutmutuelle.bsky.social
#Recherche
Issus du décryptage de la méthode de camouflage très efficace de la bactérie responsable de la maladie de #Lyme, 2 projets de #vaccins permettent de l’attaquer avant qu’elle ne puisse recourir à ce stratagème.
Par @sebbontempsgallo.bsky.social de @cnrs.fr
Maladie de Lyme : comment la bactérie « Borrelia burgdorferi » nous infecte
Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.
buff.ly
November 17, 2025 at 8:30 AM
sebbontempsgallo.bsky.social
Nouvel article dans @theconversation.com FR : Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte
Comment cette bactérie déjoue notre système immunitaire et inspire de nouvelles pistes vaccinales

@cnrs-hautsdefrance.bsky.social @univlille.bsky.social
Maladie de Lyme : comment la bactérie « Borrelia burgdorferi » nous infecte
Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.
doi.org
November 11, 2025 at 10:02 AM
sebbontempsgallo.bsky.social
🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨 (2.5y)

🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a @anrs-mie.bsky.social PEPR-funded project!

🔬 Profile: PhD in microbiology

#Postdoc #Microbiology #YersiniaPestis #ResearchJobs
October 5, 2025 at 3:08 PM
sebbontempsgallo.bsky.social
🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨

🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a PEPR-funded project! (2.5y)

🔬 Profile: PhD in microbiology

#Postdoc #Microbiology #YersiniaPestis #ResearchJobs
October 5, 2025 at 3:07 PM
sebbontempsgallo.bsky.social
The Plague & Yersinia pestis team @pasteurlille.bsky.social , led by F Sebbane, shared their latest research at the Yersinia 15th Symposium in Ulaanbaatar! A Baillez presented his thesis work, A Dewitte and @sebbontempsgallo.bsky.social showcased their recent findings.
@rolandelliagus.bsky.social
September 17, 2025 at 2:01 AM
sebbontempsgallo.bsky.social
First day of the 15th International #Yersinia symposium in Ulaanbaatar, Mongolia
September 16, 2025 at 2:41 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
ciilofficiel.bsky.social
🎓 Funded PhD position available in the team of M. Pichavant & P. Gosset! Send your CV and a brief note on why you’re excited about this opportunity.

@cnrs-hautsdefrance.bsky.social @pasteurlille.bsky.social @univlille.bsky.social @inserm.fr @chulille.bsky.social
September 2, 2025 at 9:10 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
ciilofficiel.bsky.social
⚠️ Cas de peste détecté aux USA : peut-on encore mourir de cette maladie ? Le 19 août 2025 un cas a été confirmé en Californie

Dans un article @ouest-france.fr Dr Sebbane, Chef d'équipe @inserm.fr fait le point.

@pasteurlille.bsky.social @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social
Cas de peste détecté aux États-Unis : peut-on encore mourir de cette maladie ? | Ouest-France
[Ouest-France] Un cas de peste a été détecté en Californie, aux États-Unis, mardi 19 août. Pourrait-on voir réapparaître la bactérie responsable de la maladie en France, où la dernière infection connu...
sante.ouest-france.fr
August 22, 2025 at 3:22 PM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
cp-starprotocols.bsky.social
Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel #protocol #starprotocols #cellpress
Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel
Quantifying the phosphorylation levels of proteins involved in bacterial signaling pathways is essential for understanding their role in stress adaptation and infection processes. Here, we present a protocol for the semi-quantitative assessment of the phosphorylation level of the transcriptional regulator CpxR during the infection process using Phos-tag gel. We describe steps for Dickeya dadantii infection of chicory leaves, followed by bacterial extraction, rapid acidic cell lysis, and subseque...
dlvr.it
August 5, 2025 at 9:09 PM
sebbontempsgallo.bsky.social
Just out in Nature Genetics @natureportfolio.nature.com !

Wu et al. analyzed 242 Yersinia pestis genomes, uncovering IS-driven rearrangements, which enhanced #phylogenetic resolution and resolved the third #pandemic’s polytomy, revealing adaptive changes in #virulence and #stress response.
Insights into Yersinia pestis evolution through rearrangement analysis of 242 complete genomes - Nature Genetics
Analysis of synteny blocks and genomic rearrangement patterns of 178 newly sequenced and 64 publicly available complete genomes of Yersinia pestis highlights the impact of key variations on genes invo...
www.nature.com
August 5, 2025 at 12:24 PM
sebbontempsgallo.bsky.social
New pub in STAR Protocols @cp-starprotocols.bsky.social to detect the phosphorylation level of response regulators of two-component systems during host infection using a Phos-tag approach.

By @ugsf-lille.bsky.social @ciilofficiel.bsky.social
@univlille.bsky.social @cnrs-hautsdefrance.bsky.social
Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel
Quantifying the phosphorylation levels of proteins involved in bacterial signaling pathways is essential for understanding their role in stress adapta…
www.sciencedirect.com
August 2, 2025 at 12:59 PM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
alexis-verger.cpesr.fr
[Resources]

#AlphaFold protein and PPI prediction databases

1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org

2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr...

3️⃣ Human interactome prodata.swmed.edu/humanPPI

4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev

1/2
July 30, 2025 at 11:25 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
lalouxlab.bsky.social
Bacterial cell wall & periplasm paradigm shift - important read #MicroSky

www.nature.com/articles/s41...
July 29, 2025 at 4:01 PM
sebbontempsgallo.bsky.social
#Climate extremes may reduce #Lymedisease risk?

Broughton et al. show Borrelia burgdorferi prevalence in Ixodes pacificus ticks declines under climate stress—challenging long-held assumptions about vector-borne disease and global warming.

#VectorBiology
Climate differentially impacts ticks infected and uninfected with Borrelia burgdorferi
Climate parameters show negative correlations with B. burgdorferi infection prevalence but low impact on uninfected tick density.
www.science.org
July 21, 2025 at 6:37 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
gissotlab.bsky.social
We will soon hire a postdoctoral fellow. Please contact me for more details.
ciilofficiel.bsky.social Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · Jul 16
A project coordinated by Mathieu Gissot @gissotlab.bsky.social in collaboration with David Dauvillée @chlamyd0.bsky.social - @ugsf-lille.bsky.social , PSBToxo, has been selected by the #ANR
More info below👇

@cnrs-hautsdefrance.bsky.social @univlille.bsky.social @pasteurlille.bsky.social @inserm.fr
July 16, 2025 at 11:40 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
audreylinkenheld.bsky.social
#VSS
Merci @thiebaultceline.bsky.social de faire vivre la coalition féministe entre associations et parlementaires pour une loi cadre intégrale.

Les travaux avancent !
Pour les concrétiser il faudra évidemment aussi des moyens #PLF2026

@socialistesan.bsky.social @socialistes-senat.bsky.social
July 9, 2025 at 12:28 PM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
ysantin.bsky.social
You thought all OMPs were trimeric? 🧐 Not in our predator B. bacteriovorus! 🦠
Excited to have contributed to this great collab with the Lovering lab on this intriguing protein. @lalouxlab.bsky.social
👉 Paper here!
www.nature.com/articles/s41...

#BacterialPredation #Bdellovibrio #StructuralBiology
A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily - Nature Communications
This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfa...
www.nature.com
July 7, 2025 at 6:58 AM