Sébastien Bontemps-Gallo, Ph.D.
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sebbontempsgallo.bsky.social
Sébastien Bontemps-Gallo, Ph.D.
@sebbontempsgallo.bsky.social
Associate Researcher (CNRS-HDR) | Bacteriology 🧑‍🔬

🔬Exploring bacterial stress responses and cell signaling in host-pathogen interactions and vector-borne diseases.

🏢 Based at Institut Pasteur de Lille 🇫🇷

Views are my own.
He/him
Nouvel article dans @theconversation.com FR : Maladie de Lyme : comment la bactérie Borrelia burgdorferi nous infecte
Comment cette bactérie déjoue notre système immunitaire et inspire de nouvelles pistes vaccinales

@cnrs-hautsdefrance.bsky.social @univlille.bsky.social
Maladie de Lyme : comment la bactérie « Borrelia burgdorferi » nous infecte
Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.
doi.org
November 11, 2025 at 10:02 AM
🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨 (2.5y)

🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a @anrs-mie.bsky.social PEPR-funded project!

🔬 Profile: PhD in microbiology

#Postdoc #Microbiology #YersiniaPestis #ResearchJobs
October 5, 2025 at 3:08 PM
🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨

🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a PEPR-funded project! (2.5y)

🔬 Profile: PhD in microbiology

#Postdoc #Microbiology #YersiniaPestis #ResearchJobs
October 5, 2025 at 3:07 PM
The Plague & Yersinia pestis team @pasteurlille.bsky.social , led by F Sebbane, shared their latest research at the Yersinia 15th Symposium in Ulaanbaatar! A Baillez presented his thesis work, A Dewitte and @sebbontempsgallo.bsky.social showcased their recent findings.
@rolandelliagus.bsky.social
September 17, 2025 at 2:01 AM
First day of the 15th International #Yersinia symposium in Ulaanbaatar, Mongolia
September 16, 2025 at 2:41 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
🎓 Funded PhD position available in the team of M. Pichavant & P. Gosset! Send your CV and a brief note on why you’re excited about this opportunity.

@cnrs-hautsdefrance.bsky.social @pasteurlille.bsky.social @univlille.bsky.social @inserm.fr @chulille.bsky.social
September 2, 2025 at 9:10 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
⚠️ Cas de peste détecté aux USA : peut-on encore mourir de cette maladie ? Le 19 août 2025 un cas a été confirmé en Californie

Dans un article @ouest-france.fr Dr Sebbane, Chef d'équipe @inserm.fr fait le point.

@pasteurlille.bsky.social @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social
Cas de peste détecté aux États-Unis : peut-on encore mourir de cette maladie ? | Ouest-France
[Ouest-France] Un cas de peste a été détecté en Californie, aux États-Unis, mardi 19 août. Pourrait-on voir réapparaître la bactérie responsable de la maladie en France, où la dernière infection connu...
sante.ouest-france.fr
August 22, 2025 at 3:22 PM
Just out in Nature Genetics @natureportfolio.nature.com !

Wu et al. analyzed 242 Yersinia pestis genomes, uncovering IS-driven rearrangements, which enhanced #phylogenetic resolution and resolved the third #pandemic’s polytomy, revealing adaptive changes in #virulence and #stress response.
Insights into Yersinia pestis evolution through rearrangement analysis of 242 complete genomes - Nature Genetics
Analysis of synteny blocks and genomic rearrangement patterns of 178 newly sequenced and 64 publicly available complete genomes of Yersinia pestis highlights the impact of key variations on genes invo...
www.nature.com
August 5, 2025 at 12:24 PM
New pub in STAR Protocols @cp-starprotocols.bsky.social to detect the phosphorylation level of response regulators of two-component systems during host infection using a Phos-tag approach.

By @ugsf-lille.bsky.social @ciilofficiel.bsky.social
@univlille.bsky.social @cnrs-hautsdefrance.bsky.social
Protocol to monitor activation of a two-component system in Dickeya dadantii during chicory leaf infection using Phos-tag gel
Quantifying the phosphorylation levels of proteins involved in bacterial signaling pathways is essential for understanding their role in stress adapta…
www.sciencedirect.com
August 2, 2025 at 12:59 PM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
[Resources]

#AlphaFold protein and PPI prediction databases

1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org

2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr...

3️⃣ Human interactome prodata.swmed.edu/humanPPI

4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev

1/2
July 30, 2025 at 11:25 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
Bacterial cell wall & periplasm paradigm shift - important read #MicroSky

www.nature.com/articles/s41...
July 29, 2025 at 4:01 PM
#Climate extremes may reduce #Lymedisease risk?

Broughton et al. show Borrelia burgdorferi prevalence in Ixodes pacificus ticks declines under climate stress—challenging long-held assumptions about vector-borne disease and global warming.

#VectorBiology
Climate differentially impacts ticks infected and uninfected with Borrelia burgdorferi
Climate parameters show negative correlations with B. burgdorferi infection prevalence but low impact on uninfected tick density.
www.science.org
July 21, 2025 at 6:37 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
We will soon hire a postdoctoral fellow. Please contact me for more details.
A project coordinated by Mathieu Gissot @gissotlab.bsky.social in collaboration with David Dauvillée @chlamyd0.bsky.social - @ugsf-lille.bsky.social , PSBToxo, has been selected by the #ANR
More info below👇

@cnrs-hautsdefrance.bsky.social @univlille.bsky.social @pasteurlille.bsky.social @inserm.fr
July 16, 2025 at 11:40 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
#VSS
Merci @thiebaultceline.bsky.social de faire vivre la coalition féministe entre associations et parlementaires pour une loi cadre intégrale.

Les travaux avancent !
Pour les concrétiser il faudra évidemment aussi des moyens #PLF2026

@socialistesan.bsky.social @socialistes-senat.bsky.social
July 9, 2025 at 12:28 PM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
You thought all OMPs were trimeric? 🧐 Not in our predator B. bacteriovorus! 🦠
Excited to have contributed to this great collab with the Lovering lab on this intriguing protein. @lalouxlab.bsky.social
👉 Paper here!
www.nature.com/articles/s41...

#BacterialPredation #Bdellovibrio #StructuralBiology
A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily - Nature Communications
This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfa...
www.nature.com
July 7, 2025 at 6:58 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
A new study delivers the most comprehensive phylogenomic analysis of Spirochaetes to date, revealing their deep evolutionary roots and shedding light on the loss of spiral morphology and host adaptation.
✍️ @microbiomol.bsky.social and coll. @pasteur.fr
📖 shorturl.at/UxAWu
#MicroSky
July 7, 2025 at 5:20 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
Recently interviewed by Mark Martin for his “Matters Microbial” podcast!

m.youtube.com/watch?si=O6w...
Matters Microbial #31: Spirochetes do things...differently
Today, Dr. Brian Stevenson of the University of Kentucky College of Medicine joins the #QualityQuorum to discuss a twisty twirling form of life, spirochetes,...
m.youtube.com
March 14, 2024 at 8:18 PM
At long last, the genome of Xenopsylla cheopis — the infamous Oriental rat flea and historic vector of plague — has been sequenced and published!

A genomic treasure trove for vector biologists, evolutionary entomologists, and plague researchers alike.

#Genomics #Entomology #VectorBiology #NIH
An insight into the draft genome of the Oriental rat flea, Xenopsylla cheopis, together with its Wolbachia endosymbiont - BMC Genomics
Background The Oriental rat flea, Xenopsylla cheopis, is a main vector of plague caused by the bacterium Yersinia pestis. Transcriptomic analysis of this insect and the interaction between Yersinia an...
bmcgenomics.biomedcentral.com
July 3, 2025 at 4:58 AM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
🚨 New review from our group!
PhD student Amine Pochet dives into the use of cyclodextrins beyond drug delivery — as active agents against infectious diseases.
@ciilofficiel.bsky.social @pasteurlille.bsky.social @inserm.fr @univlille.bsky.social

www.sciencedirect.com/science/arti...
Beta-cyclodextrins in infectious disease therapy: A review of their function beyond simple drug carriers
Cyclodextrins (CDs) are cyclic oligosaccharides derived from starch through enzymatic conversion. Over the past decades, CDs and their derivatives (dC…
www.sciencedirect.com
July 2, 2025 at 8:15 PM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
1/8 - New in @natcomms.nature.com !
☣️ Meet Yersinia enterocolitica (Ye) — a lesser-known but still dangerous cousin of Yersinia pestis.
We uncover how this invasive pathogen can survive and adapt for 14 years inside a human host under constant antibiotic pressure 👇
www.nature.com/articles/s41...
In-host evolution of Yersinia enterocolitica during a chronic human infection - Nature Communications
This study documents the evolution of antibiotic resistance and major growth defects in Yersinia enterocolitica in a patient over 14 years, revealing genetic changes that shed light on bacterial adapt...
www.nature.com
July 1, 2025 at 6:05 PM
📢 Our latest article is out!
We present a cost-effective in-house #RNASeq workflow using @nanoporetech.com direct cDNA, perfect for high-risk pathogens.
Applied to #Yersinia pestis, transcriptomic profiling (21 °C/flea vs 37 °C/host) reveals novel operons & sulfur metabolism upregulation.
Exploring temperature-dependent transcriptomic adaptations in Yersinia pestis using direct cDNA sequencing by Oxford Nanopore Technologies - Scientific Reports
Scientific Reports - Exploring temperature-dependent transcriptomic adaptations in Yersinia pestis using direct cDNA sequencing by Oxford Nanopore Technologies
doi.org
July 1, 2025 at 7:35 PM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
🔬 Maladie de #Lyme : à l'Institut Pasteur de Lille (@ciilofficiel.bsky.social) le Dr Bontemps-Gallo décrypte Borrelia burgdorferi, rôle des tiques, défis du diagnostic et impact de l’environnement. 🔎 Un regard captivant sur une zoonose discrète mais complexe ➡️ bit.ly/4kNtQF9
June 12, 2025 at 2:01 PM
Reposted by Sébastien Bontemps-Gallo, Ph.D.
Excited to share our latest review! Check it out to see what we know so far about how Staphylococcus aureus coordinates key processes during its cell cycle
June 9, 2025 at 11:57 AM