Yoann Santin
@ysantin.bsky.social
Ph.D. in Microbiology, post-doc at @UCLouvain_be in the @LalouxLab @EMBO fellow #Bdellovibrio, former in @CascalesLab #T6SS
Reposted by Yoann Santin
📢 Postdoc position: Biochemistry & Bacterial cell biology
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
November 10, 2025 at 6:15 PM
📢 Postdoc position: Biochemistry & Bacterial cell biology
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
Reposted by Yoann Santin
An Asgard archaeon containing internal membrane compartments!! 😯
This will reshape our understanding of how the eukaryotic endomembrane system originated.
Congrats to @buzzbaum.bsky.social, @tbharat-lab.bsky.social and all ppl involved!
www.biorxiv.org/content/10.1...
This will reshape our understanding of how the eukaryotic endomembrane system originated.
Congrats to @buzzbaum.bsky.social, @tbharat-lab.bsky.social and all ppl involved!
www.biorxiv.org/content/10.1...
An Asgard archaeon with internal membrane compartments
The emergence of eukaryotes from a merger between an archaeon and a bacterial cell ~two billion years ago involved a profound change in cellular organisation. While the order in which different featur...
www.biorxiv.org
November 8, 2025 at 5:15 PM
An Asgard archaeon containing internal membrane compartments!! 😯
This will reshape our understanding of how the eukaryotic endomembrane system originated.
Congrats to @buzzbaum.bsky.social, @tbharat-lab.bsky.social and all ppl involved!
www.biorxiv.org/content/10.1...
This will reshape our understanding of how the eukaryotic endomembrane system originated.
Congrats to @buzzbaum.bsky.social, @tbharat-lab.bsky.social and all ppl involved!
www.biorxiv.org/content/10.1...
Reposted by Yoann Santin
When asked to draw a scientist, school-age kids in the United States are increasingly sketching women, according to a study from 2018.
Read more on #STEMSTEAMDay: https://scim.ag/4qFrPON
Read more on #STEMSTEAMDay: https://scim.ag/4qFrPON
November 8, 2025 at 4:11 PM
When asked to draw a scientist, school-age kids in the United States are increasingly sketching women, according to a study from 2018.
Read more on #STEMSTEAMDay: https://scim.ag/4qFrPON
Read more on #STEMSTEAMDay: https://scim.ag/4qFrPON
Reposted by Yoann Santin
As mentioned, here is the preprint by Jensen and @viollierpat.bsky.social on the in situ structure of the Tad pilus. www.biorxiv.org/content/10.1.... Nice work and great to see that we are seeing the same thing! Our preprint: www.biorxiv.org/content/10.1... #microsky
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
November 8, 2025 at 7:35 PM
As mentioned, here is the preprint by Jensen and @viollierpat.bsky.social on the in situ structure of the Tad pilus. www.biorxiv.org/content/10.1.... Nice work and great to see that we are seeing the same thing! Our preprint: www.biorxiv.org/content/10.1... #microsky
Reposted by Yoann Santin
Our latest work is out in PNAS!🎉
We show that nonequilibrium polysome dynamics help drive sister chromosomes apart. The closing division septum also contributes via steric interactions.👇
www.pnas.org/doi/10.1073/...
#MicroSky #Microbiology #Biophysics #CellBiology
We show that nonequilibrium polysome dynamics help drive sister chromosomes apart. The closing division septum also contributes via steric interactions.👇
www.pnas.org/doi/10.1073/...
#MicroSky #Microbiology #Biophysics #CellBiology
November 9, 2025 at 2:05 AM
Our latest work is out in PNAS!🎉
We show that nonequilibrium polysome dynamics help drive sister chromosomes apart. The closing division septum also contributes via steric interactions.👇
www.pnas.org/doi/10.1073/...
#MicroSky #Microbiology #Biophysics #CellBiology
We show that nonequilibrium polysome dynamics help drive sister chromosomes apart. The closing division septum also contributes via steric interactions.👇
www.pnas.org/doi/10.1073/...
#MicroSky #Microbiology #Biophysics #CellBiology
Reposted by Yoann Santin
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 8, 2025 at 1:39 PM
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Reposted by Yoann Santin
What Rosalind Franklin truly contributed to the discovery of DNA’s structure. A really informative article, perfect for a weekend coffee read. www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 8, 2025 at 9:21 AM
What Rosalind Franklin truly contributed to the discovery of DNA’s structure. A really informative article, perfect for a weekend coffee read. www.nature.com/articles/d41...
Reposted by Yoann Santin
🚨 A fantastic opportunity to join HIRI to start your research group on RNA Biology 👇 www.nature.com/naturecareer...
Junior Group Leader for RNA-Biology, RNA-Technology or RNA-Medicine (f/m/d) - Würzburg (Stadt), Bayern (DE) job with Helmholtz-Institut für RNA-basierte Infektionsforschung (HIRI) | 12844907
#RNAexcellence Junior Group Leader Positions (f/m/d) Job advertisement no.: 089/2025 Starting date: As soon as possible. The con...
www.nature.com
October 27, 2025 at 9:55 PM
🚨 A fantastic opportunity to join HIRI to start your research group on RNA Biology 👇 www.nature.com/naturecareer...
Reposted by Yoann Santin
If Linux (for OS) is any model, OpenFold3 wants to become the standard for structural biology in academia & industry alike. Ambitious—but necessary. #OpenSource https://www.maffulli.net/2025/10/30/openfold3-open-source-replacement-alphafold/ #ai
OpenFold3 is an Open Source foundation model competing with the proprietary AlphaFold - ][ Stefano Maffulli
Reposted OpenFold Consortium Releases Preview of OpenFold3: An Open-Source Foundation Model for Structure Prediction of Proteins, Nucleic Acids, and Drugs (businesswire.com) It was bound to …
www.maffulli.net
November 3, 2025 at 8:47 PM
If Linux (for OS) is any model, OpenFold3 wants to become the standard for structural biology in academia & industry alike. Ambitious—but necessary. #OpenSource https://www.maffulli.net/2025/10/30/openfold3-open-source-replacement-alphafold/ #ai
Reposted by Yoann Santin
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
openrxiv.org
November 6, 2025 at 2:32 PM
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Reposted by Yoann Santin
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
November 6, 2025 at 3:51 PM
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
Reposted by Yoann Santin
🚨New preprint out!
We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research. (1/8)
www.biorxiv.org/content/10.1...
We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research. (1/8)
www.biorxiv.org/content/10.1...
November 6, 2025 at 5:26 PM
🚨New preprint out!
We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research. (1/8)
www.biorxiv.org/content/10.1...
We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research. (1/8)
www.biorxiv.org/content/10.1...
Reposted by Yoann Santin
Generative AI antibody design takes a big turn
1️⃣ Atomically accurate de novo design of antibodies with RFdiffusion www.nature.com/articles/s41...
2️⃣Generation of antigen-specific paired-chain antibodies using large language models
www.cell.com/cell/fulltex...
1️⃣ Atomically accurate de novo design of antibodies with RFdiffusion www.nature.com/articles/s41...
2️⃣Generation of antigen-specific paired-chain antibodies using large language models
www.cell.com/cell/fulltex...
Generation of antigen-specific paired-chain antibodies using large language models
MAGE is a sequence-based protein language model designed to generate diverse human
antibody sequences targeting various pathogens, including SARS-CoV-2, H5N1, and RSV-A.
This AI-driven approach addres...
www.cell.com
November 6, 2025 at 9:01 AM
Generative AI antibody design takes a big turn
1️⃣ Atomically accurate de novo design of antibodies with RFdiffusion www.nature.com/articles/s41...
2️⃣Generation of antigen-specific paired-chain antibodies using large language models
www.cell.com/cell/fulltex...
1️⃣ Atomically accurate de novo design of antibodies with RFdiffusion www.nature.com/articles/s41...
2️⃣Generation of antigen-specific paired-chain antibodies using large language models
www.cell.com/cell/fulltex...
Reposted by Yoann Santin
Reposted by Yoann Santin
In situ Architecture of the Tad Pilus Machine in Caulobacter crescentus https://www.biorxiv.org/content/10.1101/2025.11.05.686773v1
November 6, 2025 at 4:16 AM
In situ Architecture of the Tad Pilus Machine in Caulobacter crescentus https://www.biorxiv.org/content/10.1101/2025.11.05.686773v1
Reposted by Yoann Santin
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
November 4, 2025 at 5:20 PM
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
Reposted by Yoann Santin
📢 Postdoc position: Cell Biology of Cyanobacteria
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
November 2, 2025 at 7:13 PM
📢 Postdoc position: Cell Biology of Cyanobacteria
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
Reposted by Yoann Santin
Exciting #postdoc opportunity in T. Gensollen's group!
How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk
Learn more: shorturl.at/F8hqE
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Immunology #Microbiology #Microbiota #Omics
How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk
Learn more: shorturl.at/F8hqE
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Immunology #Microbiology #Microbiota #Omics
Early-life Immune Imprinting and Inflammatory Diseases - IPBS-Toulouse
Our team studies neonatal immunity. We are particularly interested in mapping the mucosal cell subsets[…]
shorturl.at
November 4, 2025 at 5:32 AM
Exciting #postdoc opportunity in T. Gensollen's group!
How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk
Learn more: shorturl.at/F8hqE
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Immunology #Microbiology #Microbiota #Omics
How early-life interactions between the immune system and microbiota shape lifelong immune imprinting and disease risk
Learn more: shorturl.at/F8hqE
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Immunology #Microbiology #Microbiota #Omics
Reposted by Yoann Santin
Exciting #postdoc opportunity in KL Ung's group!
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
November 4, 2025 at 5:34 AM
Exciting #postdoc opportunity in KL Ung's group!
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Understanding the molecular mechanisms of cell wall remodeling in pathogens
Learn more: shorturl.at/gPuFV
Deadline: January 15, 2026
Contact: recruit@ipbs.fr
#Protein #Biochemistry #StructuralBiology #Biophysics #CryoEM
Reposted by Yoann Santin
Excited to share our new preprint on Myxococcus xanthus!
We show that two distinct motility motors can propel the same bacterial cell simultaneously, and that this dual propulsion is tunable by environmental calcium. 🧵 1/6
📄 Read it here →https://www.biorxiv.org/content/10.1101/2025.10.29.685086v1
We show that two distinct motility motors can propel the same bacterial cell simultaneously, and that this dual propulsion is tunable by environmental calcium. 🧵 1/6
📄 Read it here →https://www.biorxiv.org/content/10.1101/2025.10.29.685086v1
October 31, 2025 at 1:24 PM
Excited to share our new preprint on Myxococcus xanthus!
We show that two distinct motility motors can propel the same bacterial cell simultaneously, and that this dual propulsion is tunable by environmental calcium. 🧵 1/6
📄 Read it here →https://www.biorxiv.org/content/10.1101/2025.10.29.685086v1
We show that two distinct motility motors can propel the same bacterial cell simultaneously, and that this dual propulsion is tunable by environmental calcium. 🧵 1/6
📄 Read it here →https://www.biorxiv.org/content/10.1101/2025.10.29.685086v1
Reposted by Yoann Santin
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
October 29, 2025 at 5:11 PM
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
Reposted by Yoann Santin
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
DNA from Napoleon’s 1812 army identifies the pathogens likely responsible for the army’s demise during their Russian retreat. www.cell.com/current-biol...
Nicolás Rascovan & colleagues
@currentbiology.bsky.social
Nicolás Rascovan & colleagues
@currentbiology.bsky.social
October 27, 2025 at 7:24 AM
Reposted by Yoann Santin
2025 Lasker~Koshland Special Achievement Award in Medical Science winner Dr Lucy Shapiro discusses her discovery of how bacteria coordinate their genetic logic to generate distinct daughter cells.
ja.ma/47ajuLj
ja.ma/47ajuLj
October 26, 2025 at 10:00 AM
2025 Lasker~Koshland Special Achievement Award in Medical Science winner Dr Lucy Shapiro discusses her discovery of how bacteria coordinate their genetic logic to generate distinct daughter cells.
ja.ma/47ajuLj
ja.ma/47ajuLj
Reposted by Yoann Santin
First time posting on Bluesky! 🥳 We discovered a new pilus family in cyanobacteria. The pilin has a novel protein fold that forms a super-tight double-layer tube. Similar gene clusters exist in a few cyanobacterial orders. A great collaboration with John and others! www.nature.com/articles/s41...
A family of tubular pili from harmful algal bloom forming cyanobacterium Microcystis aeruginosa - Nature Communications
Ricca et al discover a new family of tubular pili in Microcystis aeruginosa, a harmful algal bloom-forming cyanobacterium. These pili are crucial for buoyancy by forming cell micro-colonies, which inc...
www.nature.com
October 24, 2025 at 4:08 AM
First time posting on Bluesky! 🥳 We discovered a new pilus family in cyanobacteria. The pilin has a novel protein fold that forms a super-tight double-layer tube. Similar gene clusters exist in a few cyanobacterial orders. A great collaboration with John and others! www.nature.com/articles/s41...