Tung Le
@tunglejic.bsky.social
Dad of two, Professor, Lister Research Fellow and Wellcome Investigator at the John Innes Centre. Interested in bacterial chromosome organization & segregation, plasmids, and phages.
www.tunglelab.org
www.tunglelab.org
Pinned
Tung Le
@tunglejic.bsky.social
· Dec 4
Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation | PNAS
Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular
processes by cycling between active and inactive states thro...
www.pnas.org
Now published. Thank you very much to our collaborative team, and very supportive editors and reviewers!!!
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
In two-week time, it will be 10 years of our group. I have not regretted once joining Mol Micro Dept and more widely the John Innes Centre.
Molecular Microbiology Dept Christmas lunch at the assembly House in Norwich 12/12/25. Blessed to work with great scientists who are also great people. This photo only shows the group leaders but every person in the department is wonderful. #microsky
December 13, 2025 at 12:19 PM
In two-week time, it will be 10 years of our group. I have not regretted once joining Mol Micro Dept and more widely the John Innes Centre.
Reposted by Tung Le
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
December 12, 2025 at 2:58 PM
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
Reposted by Tung Le
Save the date! This will be an exciting meeting (+ seminar) for all bacteria lovers!!
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
December 12, 2025 at 3:14 PM
Save the date! This will be an exciting meeting (+ seminar) for all bacteria lovers!!
Reposted by Tung Le
🧵 2/7 But what about their distribution across wider bacterial diversity? And how do these systems maintain plasmids in bacteria that do not divide by binary fission, such as Streptomyces, which have a complex filamentous life cycle?
December 11, 2025 at 1:29 PM
🧵 2/7 But what about their distribution across wider bacterial diversity? And how do these systems maintain plasmids in bacteria that do not divide by binary fission, such as Streptomyces, which have a complex filamentous life cycle?
Reposted by Tung Le
📄 Delighted to share that the preprint of my main PhD work is out now!
👏 A huge thank you to everyone involved, @tommclean.bsky.social, Govind Chandra, Ngat Tran (both not on BlueSky) and especially my PhD supervisor @tunglejic.bsky.social 👏
🧵 below!
www.biorxiv.org/content/10.6...
👏 A huge thank you to everyone involved, @tommclean.bsky.social, Govind Chandra, Ngat Tran (both not on BlueSky) and especially my PhD supervisor @tunglejic.bsky.social 👏
🧵 below!
www.biorxiv.org/content/10.6...
Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems
Low-copy-number plasmids often rely on dedicated maintenance mechanisms, such as partitioning systems, to ensure stable inheritance across generations. These partition systems actively segregate siste...
www.biorxiv.org
December 11, 2025 at 1:25 PM
📄 Delighted to share that the preprint of my main PhD work is out now!
👏 A huge thank you to everyone involved, @tommclean.bsky.social, Govind Chandra, Ngat Tran (both not on BlueSky) and especially my PhD supervisor @tunglejic.bsky.social 👏
🧵 below!
www.biorxiv.org/content/10.6...
👏 A huge thank you to everyone involved, @tommclean.bsky.social, Govind Chandra, Ngat Tran (both not on BlueSky) and especially my PhD supervisor @tunglejic.bsky.social 👏
🧵 below!
www.biorxiv.org/content/10.6...
Reposted by Tung Le
Check out this work by the amazing @leahmcphillips.bsky.social from during her PhD!!
Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems https://www.biorxiv.org/content/10.64898/2025.12.10.693275v1
December 11, 2025 at 8:10 AM
Check out this work by the amazing @leahmcphillips.bsky.social from during her PhD!!
Reposted by Tung Le
Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems https://www.biorxiv.org/content/10.64898/2025.12.10.693275v1
December 11, 2025 at 5:16 AM
Stable inheritance of the Streptomyces linear plasmid SCP1 by dual ParABS partition systems https://www.biorxiv.org/content/10.64898/2025.12.10.693275v1
Reposted by Tung Le
Our study of the evolution of the ParB NTP binding domain across the Tree of Life is now published! An awesome collaboration with @tunglejic.bsky.social led by @jovanakaljevic.bsky.social at the John Ines Center. Thanks to editors and reviewers. www.pnas.org/doi/10.1073/...
www.pnas.org
December 5, 2025 at 9:05 AM
Our study of the evolution of the ParB NTP binding domain across the Tree of Life is now published! An awesome collaboration with @tunglejic.bsky.social led by @jovanakaljevic.bsky.social at the John Ines Center. Thanks to editors and reviewers. www.pnas.org/doi/10.1073/...
Reposted by Tung Le
Now published. Thank you very much to our collaborative team, and very supportive editors and reviewers!!!
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation | PNAS
Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular
processes by cycling between active and inactive states thro...
www.pnas.org
December 4, 2025 at 7:23 PM
Now published. Thank you very much to our collaborative team, and very supportive editors and reviewers!!!
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Tung Le
Our preprint is now published in PNAS! This came together thanks to a great collaboration with Antoine Hocher and a strong team effort from the Le Lab. Thank you to the reviewers and to everyone who helped improve it. I hope ParB aficionados will enjoy it.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation | PNAS
Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular
processes by cycling between active and inactive states thro...
www.pnas.org
December 4, 2025 at 8:10 PM
Our preprint is now published in PNAS! This came together thanks to a great collaboration with Antoine Hocher and a strong team effort from the Le Lab. Thank you to the reviewers and to everyone who helped improve it. I hope ParB aficionados will enjoy it.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Tung Le
Marjory Stephenson Prize 2026: Professor Mark Buttner — @johninnescentre.bsky.social
Outreach and Engagement Prize 2026: @lindsaybroadbent.bsky.social — @uniofsurrey.bsky.social
Translational Microbiology Prize 2026: @alanlparker.bsky.social — @cancerwales.bsky.social
Outreach and Engagement Prize 2026: @lindsaybroadbent.bsky.social — @uniofsurrey.bsky.social
Translational Microbiology Prize 2026: @alanlparker.bsky.social — @cancerwales.bsky.social
November 19, 2025 at 2:58 PM
Marjory Stephenson Prize 2026: Professor Mark Buttner — @johninnescentre.bsky.social
Outreach and Engagement Prize 2026: @lindsaybroadbent.bsky.social — @uniofsurrey.bsky.social
Translational Microbiology Prize 2026: @alanlparker.bsky.social — @cancerwales.bsky.social
Outreach and Engagement Prize 2026: @lindsaybroadbent.bsky.social — @uniofsurrey.bsky.social
Translational Microbiology Prize 2026: @alanlparker.bsky.social — @cancerwales.bsky.social
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
October 21, 2025 at 9:16 PM
“Keep knives sharp and cut gently to spray less” I cried so much when I worked in a restaurant back then, wish I knew this!!!
Very important findings!!!
Droplet outbursts from onion cutting | PNAS www.pnas.org/doi/10.1073/...
October 21, 2025 at 7:19 PM
“Keep knives sharp and cut gently to spray less” I cried so much when I worked in a restaurant back then, wish I knew this!!!
Reposted by Tung Le
Chromosome replication and cell division cycles are not synchronized in Staphylococcus aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle
#bacteria #microbiology
#bacteria #microbiology
Chromosome segregation dynamics during the cell cycle of Staphylococcus aureus - Nature Communications
Our understanding of chromosome organization and dynamics in spherical bacteria, such as Staphylococcus aureus, remains limited. Here, the authors show that chromosome replication and cell division cycles are not synchronized in S. aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle.
bit.ly
October 21, 2025 at 2:51 PM
Chromosome replication and cell division cycles are not synchronized in Staphylococcus aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle
#bacteria #microbiology
#bacteria #microbiology
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
October 15, 2025 at 6:32 PM
Reposted by Tung Le
We have a PhD opportunity available in our group @johninnescentre.bsky.social through the NRP Doctoral Training Partnership. Help us uncover the Hidden Diversity of Bacterial NLRs.
Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...
Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...
Beyond Immunity: Uncovering the Hidden Diversity of Bacterial NLRs (SCHLIMPERT_J26DTP) | Doctoral Training Partnership
Join us in exploring the hidden functions of ancient immune proteins in bacteria. Bacteria, like plants and animals, have evolved sophisticated systems to detect and respond to threats.
biodtp.norwichresearchpark.ac.uk
October 13, 2025 at 6:46 AM
We have a PhD opportunity available in our group @johninnescentre.bsky.social through the NRP Doctoral Training Partnership. Help us uncover the Hidden Diversity of Bacterial NLRs.
Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...
Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...
new preprint from our group & Antoine Hocher: www.biorxiv.org/content/10.1...
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.
Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation
Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular processes by cycling between active and inactive states through nucleotide binding and hydrolysis. These mechanis...
www.biorxiv.org
October 11, 2025 at 11:36 AM
new preprint from our group & Antoine Hocher: www.biorxiv.org/content/10.1...
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
October 8, 2025 at 6:05 PM
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
October 7, 2025 at 6:20 AM
Reposted by Tung Le
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre
The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…
www.jic.ac.uk
October 3, 2025 at 4:06 PM
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Reposted by Tung Le
Start independent research at the JIC with us 👇.
Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes.
Please do get in touch by email if you'd like to know more 👍
Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes.
Please do get in touch by email if you'd like to know more 👍
VACANCY - Independent research fellowships leading to tenured positions
We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships.
APPLICATION DEADLINE: 10 November 2025
Click here to apply: jic.link/Fellows
We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships.
APPLICATION DEADLINE: 10 November 2025
Click here to apply: jic.link/Fellows
October 3, 2025 at 6:36 PM
Start independent research at the JIC with us 👇.
Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes.
Please do get in touch by email if you'd like to know more 👍
Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes.
Please do get in touch by email if you'd like to know more 👍
VACANCY - Independent research fellowships leading to tenured positions
We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships.
APPLICATION DEADLINE: 10 November 2025
Click here to apply: jic.link/Fellows
We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships.
APPLICATION DEADLINE: 10 November 2025
Click here to apply: jic.link/Fellows
October 3, 2025 at 5:09 PM
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre
The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…
www.jic.ac.uk
October 3, 2025 at 4:06 PM
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Reposted by Tung Le
🚨PhD Opportunity Alert🚨 Join me, @suzieh.bsky.social and @walllabuoglasgow.bsky.social to investigate how environment shapes anti-phage defences & prophage–prophage conflict in Pseudomonas aeruginosa.
Apply here:
www.gla.ac.uk/postgraduate...
Apply here:
www.gla.ac.uk/postgraduate...
October 1, 2025 at 7:58 PM
🚨PhD Opportunity Alert🚨 Join me, @suzieh.bsky.social and @walllabuoglasgow.bsky.social to investigate how environment shapes anti-phage defences & prophage–prophage conflict in Pseudomonas aeruginosa.
Apply here:
www.gla.ac.uk/postgraduate...
Apply here:
www.gla.ac.uk/postgraduate...
Major advance here for our field!!!
September 26, 2025 at 7:29 PM
Major advance here for our field!!!