Tung Le
@tunglejic.bsky.social
Dad of two, Professor, Lister Research Fellow and Wellcome Investigator at the John Innes Centre. Interested in bacterial chromosome organization & segregation, plasmids, and phages.
www.tunglelab.org
www.tunglelab.org
Pinned
Tung Le
@tunglejic.bsky.social
· Oct 11
Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation
Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular processes by cycling between active and inactive states through nucleotide binding and hydrolysis. These mechanis...
www.biorxiv.org
new preprint from our group & Antoine Hocher: www.biorxiv.org/content/10.1...
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
October 21, 2025 at 9:16 PM
“Keep knives sharp and cut gently to spray less” I cried so much when I worked in a restaurant back then, wish I knew this!!!
Very important findings!!!
Droplet outbursts from onion cutting | PNAS www.pnas.org/doi/10.1073/...
October 21, 2025 at 7:19 PM
“Keep knives sharp and cut gently to spray less” I cried so much when I worked in a restaurant back then, wish I knew this!!!
Reposted by Tung Le
Chromosome replication and cell division cycles are not synchronized in Staphylococcus aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle
#bacteria #microbiology
#bacteria #microbiology
Chromosome segregation dynamics during the cell cycle of Staphylococcus aureus - Nature Communications
Our understanding of chromosome organization and dynamics in spherical bacteria, such as Staphylococcus aureus, remains limited. Here, the authors show that chromosome replication and cell division cycles are not synchronized in S. aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle.
bit.ly
October 21, 2025 at 2:51 PM
Chromosome replication and cell division cycles are not synchronized in Staphylococcus aureus, with cells exhibiting two segregated origins of replication at the start of the cell cycle
#bacteria #microbiology
#bacteria #microbiology
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
October 15, 2025 at 6:32 PM
Reposted by Tung Le
We have a PhD opportunity available in our group @johninnescentre.bsky.social through the NRP Doctoral Training Partnership. Help us uncover the Hidden Diversity of Bacterial NLRs.
Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...
Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...
Beyond Immunity: Uncovering the Hidden Diversity of Bacterial NLRs (SCHLIMPERT_J26DTP) | Doctoral Training Partnership
Join us in exploring the hidden functions of ancient immune proteins in bacteria. Bacteria, like plants and animals, have evolved sophisticated systems to detect and respond to threats.
biodtp.norwichresearchpark.ac.uk
October 13, 2025 at 6:46 AM
We have a PhD opportunity available in our group @johninnescentre.bsky.social through the NRP Doctoral Training Partnership. Help us uncover the Hidden Diversity of Bacterial NLRs.
Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...
Start date: October 2026. For more information and how to apply👉 biodtp.norwichresearchpark.ac.uk/projects/bey...
new preprint from our group & Antoine Hocher: www.biorxiv.org/content/10.1...
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.
Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation
Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular processes by cycling between active and inactive states through nucleotide binding and hydrolysis. These mechanis...
www.biorxiv.org
October 11, 2025 at 11:36 AM
new preprint from our group & Antoine Hocher: www.biorxiv.org/content/10.1...
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
October 8, 2025 at 6:05 PM
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
October 7, 2025 at 6:20 AM
Reposted by Tung Le
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre
The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…
www.jic.ac.uk
October 3, 2025 at 4:06 PM
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Reposted by Tung Le
Start independent research at the JIC with us 👇.
Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes.
Please do get in touch by email if you'd like to know more 👍
Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes.
Please do get in touch by email if you'd like to know more 👍
VACANCY - Independent research fellowships leading to tenured positions
We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships.
APPLICATION DEADLINE: 10 November 2025
Click here to apply: jic.link/Fellows
We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships.
APPLICATION DEADLINE: 10 November 2025
Click here to apply: jic.link/Fellows
October 3, 2025 at 6:36 PM
Start independent research at the JIC with us 👇.
Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes.
Please do get in touch by email if you'd like to know more 👍
Really interested in finding those with an interest in structural biology and biochemistry of plants and microbes.
Please do get in touch by email if you'd like to know more 👍
VACANCY - Independent research fellowships leading to tenured positions
We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships.
APPLICATION DEADLINE: 10 November 2025
Click here to apply: jic.link/Fellows
We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships.
APPLICATION DEADLINE: 10 November 2025
Click here to apply: jic.link/Fellows
October 3, 2025 at 5:09 PM
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.
Find out more: www.jic.ac.uk/training-car...
Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre
The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…
www.jic.ac.uk
October 3, 2025 at 4:06 PM
Independent research fellowships leading to tenured positions at the John Innes Centre.
Repost = nice. Thank you very much!!!
Repost = nice. Thank you very much!!!
Reposted by Tung Le
🚨PhD Opportunity Alert🚨 Join me, @suzieh.bsky.social and @walllabuoglasgow.bsky.social to investigate how environment shapes anti-phage defences & prophage–prophage conflict in Pseudomonas aeruginosa.
Apply here:
www.gla.ac.uk/postgraduate...
Apply here:
www.gla.ac.uk/postgraduate...
October 1, 2025 at 7:58 PM
🚨PhD Opportunity Alert🚨 Join me, @suzieh.bsky.social and @walllabuoglasgow.bsky.social to investigate how environment shapes anti-phage defences & prophage–prophage conflict in Pseudomonas aeruginosa.
Apply here:
www.gla.ac.uk/postgraduate...
Apply here:
www.gla.ac.uk/postgraduate...
Major advance here for our field!!!
September 26, 2025 at 7:29 PM
Major advance here for our field!!!
Reposted by Tung Le
Reposted by Tung Le
Jovana Kaljevic (now postdoc @tunglejic.bsky.social ) saw how extremely compact Bdello chromosomes are packed during the non-proliferative attack phase (see pmc.ncbi.nlm.nih.gov/articles/PMC... ). GFP is excluded from the nucleoid area! 2/n
Chromosome choreography during the non-binary cell cycle of a predatory bacterium
In bacteria, the dynamics of chromosome replication and segregation are tightly coordinated with cell-cycle progression and largely rely on specific spatiotemporal arrangement of the chromosome. Where...
pmc.ncbi.nlm.nih.gov
September 26, 2025 at 9:09 AM
Jovana Kaljevic (now postdoc @tunglejic.bsky.social ) saw how extremely compact Bdello chromosomes are packed during the non-proliferative attack phase (see pmc.ncbi.nlm.nih.gov/articles/PMC... ). GFP is excluded from the nucleoid area! 2/n
Reposted by Tung Le
Happy to finally show our story of the connection between nucleoid conformation, transcription & predation in our favorite predator Bdellovibrio bacteriovorus. 🧵 1/n
📝New preprint! #MicroSky
🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.
🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.
www.biorxiv.org/content/10.1...
🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.
🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.
www.biorxiv.org/content/10.1...
Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle
The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...
www.biorxiv.org
September 26, 2025 at 9:09 AM
Happy to finally show our story of the connection between nucleoid conformation, transcription & predation in our favorite predator Bdellovibrio bacteriovorus. 🧵 1/n
Reposted by Tung Le
Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle https://www.biorxiv.org/content/10.1101/2025.09.24.678257v1
September 24, 2025 at 7:17 PM
Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle https://www.biorxiv.org/content/10.1101/2025.09.24.678257v1
Very creative and clever!!!
Dosa: A method to covalently barcode proteinsfor high throughput biochemistry https://www.biorxiv.org/content/10.1101/2025.09.21.677650v1
September 24, 2025 at 5:29 PM
Very creative and clever!!!
Reposted by Tung Le
Dosa: A method to covalently barcode proteinsfor high throughput biochemistry https://www.biorxiv.org/content/10.1101/2025.09.21.677650v1
September 23, 2025 at 12:35 PM
Dosa: A method to covalently barcode proteinsfor high throughput biochemistry https://www.biorxiv.org/content/10.1101/2025.09.21.677650v1
Reposted by Tung Le
New PrePrint from the Vecchiarelli and Mosalaganti (@shyamalm.bsky.social) labs! 🧵
Collaboration with the Giessen and Pi labs
Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav!
www.biorxiv.org/content/10.1...
Collaboration with the Giessen and Pi labs
Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav!
www.biorxiv.org/content/10.1...
Engineering Spatial Control of Bacterial Organelles
Bacteria were once thought to lack organelles, but it is now clear they confine cellular reactions using an array of membrane- and protein-based compartments. A central question, however, is how bacte...
www.biorxiv.org
September 23, 2025 at 5:38 PM
New PrePrint from the Vecchiarelli and Mosalaganti (@shyamalm.bsky.social) labs! 🧵
Collaboration with the Giessen and Pi labs
Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav!
www.biorxiv.org/content/10.1...
Collaboration with the Giessen and Pi labs
Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav!
www.biorxiv.org/content/10.1...
Reposted by Tung Le
Ever wondered how to position organelles in bacteria? Wonder no more!
Happy to have contributed to this fantastic story from @cellforganized.bsky.social' lab.
The avenues this opens in the synthetic biology space are enormous!
Movie: Carboxysomes positioned in E. coli!
Preprint: shorturl.at/D6xVg
Happy to have contributed to this fantastic story from @cellforganized.bsky.social' lab.
The avenues this opens in the synthetic biology space are enormous!
Movie: Carboxysomes positioned in E. coli!
Preprint: shorturl.at/D6xVg
September 23, 2025 at 3:31 PM
Ever wondered how to position organelles in bacteria? Wonder no more!
Happy to have contributed to this fantastic story from @cellforganized.bsky.social' lab.
The avenues this opens in the synthetic biology space are enormous!
Movie: Carboxysomes positioned in E. coli!
Preprint: shorturl.at/D6xVg
Happy to have contributed to this fantastic story from @cellforganized.bsky.social' lab.
The avenues this opens in the synthetic biology space are enormous!
Movie: Carboxysomes positioned in E. coli!
Preprint: shorturl.at/D6xVg
Reposted by Tung Le
🚨🚨🚨Calling all Caulophiles and Alpha aficionados - stayed tuned for a virtual CauloCon in early 2026. And HOPEFULLY an in person alpha meeting in 2027!! DM me or @chienlab.bsky.social w questions or to stay in the know.
two men are standing next to each other and one of them is saying `` you wanna hang out shoot the breeze ''
ALT: two men are standing next to each other and one of them is saying `` you wanna hang out shoot the breeze ''
media.tenor.com
September 19, 2025 at 11:01 PM
🚨🚨🚨Calling all Caulophiles and Alpha aficionados - stayed tuned for a virtual CauloCon in early 2026. And HOPEFULLY an in person alpha meeting in 2027!! DM me or @chienlab.bsky.social w questions or to stay in the know.
@unibirmingham.bsky.social A nice surprise! Two Vietnamese, Two Perry prize winners from their Birmingham undergrad days, just 18 years apart, met acccidently at the Lister meeting!!!
September 11, 2025 at 5:54 PM
@unibirmingham.bsky.social A nice surprise! Two Vietnamese, Two Perry prize winners from their Birmingham undergrad days, just 18 years apart, met acccidently at the Lister meeting!!!
Reposted by Tung Le
New opportunity in the lab for a research assistant (technician), to support our BBSRC and @erc.europa.eu funded project @microclockerc.bsky.social on the Bacillus subtilis circadian clock. For this, we're looking for microbiology research experience #chronobiology www.jic.ac.uk/vacancies/re...
Research Assistant (Dodd Group) | John Innes Centre
An exciting opportunity has arisen for a Research Assistant to join the Dodd Group, conducting cutting-edge research into circadian rhythms in bacteria and plants.
www.jic.ac.uk
August 27, 2025 at 1:08 PM
New opportunity in the lab for a research assistant (technician), to support our BBSRC and @erc.europa.eu funded project @microclockerc.bsky.social on the Bacillus subtilis circadian clock. For this, we're looking for microbiology research experience #chronobiology www.jic.ac.uk/vacancies/re...