Carsten Sachse
@sachsegroup.bsky.social
The Sachse group @fz_juelich: #cryoEM #cryoET #CLEM #FIBSEM #autophagy.
We are looking for a team leader to join the cryo-EM facility work at the new Ernst Ruska-Centre 2.0 at the Forschungszentrum Jülich. We have a series of microscopes used by (@irene-vercellino.bsky.social, Schröder, @sachsegroup.bsky.social) and external users.
www.fz-juelich.de/de/karriere/...
www.fz-juelich.de/de/karriere/...
Team Leader – Life Science Cryo-Electron Microscopy (Cryo-EM) Facility
Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons (ER-C) at Forschungszentrum Jülich houses some of the world`s most advanced electron microscopes and tools for nanocharacterisation. U...
www.fz-juelich.de
December 23, 2025 at 9:42 AM
We are looking for a team leader to join the cryo-EM facility work at the new Ernst Ruska-Centre 2.0 at the Forschungszentrum Jülich. We have a series of microscopes used by (@irene-vercellino.bsky.social, Schröder, @sachsegroup.bsky.social) and external users.
www.fz-juelich.de/de/karriere/...
www.fz-juelich.de/de/karriere/...
Really happy to see the work (doi.org/10.1038/s414...) published. Here, we show the full-length helical cryo-EM structure of p62/SQSTM1 and first cryo-ET visual of p62 positive structures inside the cell.
Structural organization of p62 filaments and the cellular ultrastructure of calcium-rich p62-enwrapped lipid droplet cargo - Nature Communications
The selective autophagy receptor p62/SQSTM1 is organized in a structured double helical filament in vitro, the cryo-electron tomographic images in ATG5 knockdown conditions reveal Ca-rich layers of p6...
doi.org
December 4, 2025 at 2:01 PM
Really happy to see the work (doi.org/10.1038/s414...) published. Here, we show the full-length helical cryo-EM structure of p62/SQSTM1 and first cryo-ET visual of p62 positive structures inside the cell.
Reposted by Carsten Sachse
Grateful to have received the Wilhelm und Else Heraeus-Stiftung Research Fellowship, to support my group’s work at the Ernst Ruska-Centre (ER-C) of Forschungszentrum Jülich #cryoem
November 9, 2025 at 9:26 AM
Grateful to have received the Wilhelm und Else Heraeus-Stiftung Research Fellowship, to support my group’s work at the Ernst Ruska-Centre (ER-C) of Forschungszentrum Jülich #cryoem
Reposted by Carsten Sachse
Finally in peer-reviewed form: Mapping the ultrastructural topology of the corynebacterial cell surface. @bupbuse.bsky.social @vikramalva.bsky.social
Please also see concurrent beautiful work from @adriasogues.bsky.social and Han Remaut.
Please also see concurrent beautiful work from @adriasogues.bsky.social and Han Remaut.
The unique #CellEnvelope of #corynebacteria: @tbharat-lab.bsky.social &co map the C. glutamicum cell surface, revealing a patchy S-layer & specific assembly of the PS2 protein, thereby informing our understanding of cell envelopes that contain #MycolicAcids @plosbiology.org 🧪 plos.io/3Y6JNgw
April 23, 2025 at 2:07 PM
Finally in peer-reviewed form: Mapping the ultrastructural topology of the corynebacterial cell surface. @bupbuse.bsky.social @vikramalva.bsky.social
Please also see concurrent beautiful work from @adriasogues.bsky.social and Han Remaut.
Please also see concurrent beautiful work from @adriasogues.bsky.social and Han Remaut.
Reposted by Carsten Sachse
After years parked at a Polara, I’m excited to share that my PhD work is finally out! We figured out why imaging at liquid helium temperatures wasn’t working—and how to fix it.
🔗 www.pnas.org/doi/10.1073/...
🔗 www.pnas.org/doi/10.1073/...
Reducing the effects of radiation damage in cryo-EM using liquid helium temperatures | PNAS
The physical limit in determining the atomic structure of biological molecules is
radiation damage. In electron cryomicroscopy, there have been num...
www.pnas.org
April 23, 2025 at 4:23 AM
After years parked at a Polara, I’m excited to share that my PhD work is finally out! We figured out why imaging at liquid helium temperatures wasn’t working—and how to fix it.
🔗 www.pnas.org/doi/10.1073/...
🔗 www.pnas.org/doi/10.1073/...
Philipp's manuscript on our CryoVIA toolkit www.sciencedirect.com/science/arti... is out! For those interested in studying protein lipid interactions and high-throughput analysis of membrane structures (sizes, shapes, curvature etc.) - this could be your tool (github.com/philipp-scho...).
CryoVIA: An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs
Imaging of lipid structures and associated protein complexes using cryoelectron microscopy (cryo-EM) is a common visualization and structure determina…
www.sciencedirect.com
February 10, 2025 at 9:55 AM
Philipp's manuscript on our CryoVIA toolkit www.sciencedirect.com/science/arti... is out! For those interested in studying protein lipid interactions and high-throughput analysis of membrane structures (sizes, shapes, curvature etc.) - this could be your tool (github.com/philipp-scho...).
Our first post on blue: grad student Philipp's software: for those interested in looking at membrane reconstitution by cryo-EM. Automated analysis of lipid fine structure and membrane shape classifications: biorxiv.org/cgi/content/...
CryoVIA - An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs
Imaging of lipid structures and associated protein complexes using electron cryo-microscopy (cryo-EM) is a common visualization and structure determination technique. The quantitative analysis of the ...
biorxiv.org
January 14, 2025 at 4:55 PM
Our first post on blue: grad student Philipp's software: for those interested in looking at membrane reconstitution by cryo-EM. Automated analysis of lipid fine structure and membrane shape classifications: biorxiv.org/cgi/content/...
Reposted by Carsten Sachse
Excited to share that I have been elected as member of the "Junge Kolleg" of the Nordrhein-Westfalian Academy of Sciences and Arts. I am honoured to have this opportunity to serve the community! Here's the link to the announcement, unfortunately only in German www.awk.nrw/news/nachwuc...
Nachwuchsförderung: Nordrhein-Westfälische Akademie nimmt neun neue Stipendiatinnen und Stipendiaten in ihr Junges Kolleg auf
Zum 1. Januar 2025 begrüßt die Nordrhein-Westfälische Akademie der Wissenschaften und der Künste neun weitere herausragende Talente in ihrem Jungen Kolleg. Sie haben die Jury in einem mehrstufigen Aus...
www.awk.nrw
December 18, 2024 at 10:48 AM
Excited to share that I have been elected as member of the "Junge Kolleg" of the Nordrhein-Westfalian Academy of Sciences and Arts. I am honoured to have this opportunity to serve the community! Here's the link to the announcement, unfortunately only in German www.awk.nrw/news/nachwuc...