Thomas Henry
@cinflammasome.bsky.social
Researcher at CIRI, Lyon, France.
Working on innate immune signalling pathways in autoinflammatory diseases and bacterial infections.
Francisella and the type 6 secretion system
Inflammasomes & ALPK1/TIFA pathway
FMF, PAAND & ROSAH
Working on innate immune signalling pathways in autoinflammatory diseases and bacterial infections.
Francisella and the type 6 secretion system
Inflammasomes & ALPK1/TIFA pathway
FMF, PAAND & ROSAH
IRF2 regulates both GSDMD expression and NK cells antibacterial functions. Check the latest paper from the lab @ciri-lyon.bsky.social published in @emboreports.org. IRF2 as a key immune regulator against our favorite bug, #Francisella tularensis! #inflammasome link.springer.com/article/10.1...
IRF2 deficiency disrupts pyroptosis, NK cell interferon-γ production and resistance to Francisella - EMBO Reports
IRF2 plays an indirect role in inflammasome activation by regulating Caspase-4 and Gasdermin D (GSDMD) levels. However, the in vivo relevance of this regulatory circuit is unknown. We generate IRF2KO ...
link.springer.com
February 2, 2026 at 7:25 AM
IRF2 regulates both GSDMD expression and NK cells antibacterial functions. Check the latest paper from the lab @ciri-lyon.bsky.social published in @emboreports.org. IRF2 as a key immune regulator against our favorite bug, #Francisella tularensis! #inflammasome link.springer.com/article/10.1...
Reposted by Thomas Henry
Rhinoviruses cause common cold & asthma attacks but are also often benign. Using nasal organoids, we learned how the community of cells in the lining the nasal passages coordinates to respond to rhinovirus and which responses lead to excess mucus & inflammation. www.cell.com/cell-press-b...
Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling
Rhinoviruses are the most frequent cause of common colds and also a major cause of
respiratory distress in high-risk groups. Using single-cell sequencing of rhinovirus-infected
nasal epithelial organo...
www.cell.com
January 20, 2026 at 9:23 PM
Rhinoviruses cause common cold & asthma attacks but are also often benign. Using nasal organoids, we learned how the community of cells in the lining the nasal passages coordinates to respond to rhinovirus and which responses lead to excess mucus & inflammation. www.cell.com/cell-press-b...
Reposted by Thomas Henry
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
January 20, 2026 at 10:01 AM
LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.
🔗 doi.org/10.64898/202...
#CryoET
Proficiency in French required.
Contact thomas.henry@inserm.fr for research
Jean-Pierre Moussus for teaching.
And coming soon: two additional Associate Professor (MCU) positions at CIRI: 1 in clinical bacteriology (IUT Génie Biologique) & 1 in immunology (Université Claude Bernard Lyon 1).
Contact thomas.henry@inserm.fr for research
Jean-Pierre Moussus for teaching.
And coming soon: two additional Associate Professor (MCU) positions at CIRI: 1 in clinical bacteriology (IUT Génie Biologique) & 1 in immunology (Université Claude Bernard Lyon 1).
January 13, 2026 at 8:47 AM
Proficiency in French required.
Contact thomas.henry@inserm.fr for research
Jean-Pierre Moussus for teaching.
And coming soon: two additional Associate Professor (MCU) positions at CIRI: 1 in clinical bacteriology (IUT Génie Biologique) & 1 in immunology (Université Claude Bernard Lyon 1).
Contact thomas.henry@inserm.fr for research
Jean-Pierre Moussus for teaching.
And coming soon: two additional Associate Professor (MCU) positions at CIRI: 1 in clinical bacteriology (IUT Génie Biologique) & 1 in immunology (Université Claude Bernard Lyon 1).
📢 Recruitment of an Associate Professor (Maître de conférences) in Bacteriology at CIRI and ENS de Lyon.
Research at @ciri-lyon.bsky.social @francoisrousset.bsky.social
@labxc.bsky.social
Anti-phage Immunity, Horizontal gene/ MGE transfer
📚 Teaching at ENS de Lyon within the Department of Biology.
Research at @ciri-lyon.bsky.social @francoisrousset.bsky.social
@labxc.bsky.social
Anti-phage Immunity, Horizontal gene/ MGE transfer
📚 Teaching at ENS de Lyon within the Department of Biology.
January 13, 2026 at 8:47 AM
📢 Recruitment of an Associate Professor (Maître de conférences) in Bacteriology at CIRI and ENS de Lyon.
Research at @ciri-lyon.bsky.social @francoisrousset.bsky.social
@labxc.bsky.social
Anti-phage Immunity, Horizontal gene/ MGE transfer
📚 Teaching at ENS de Lyon within the Department of Biology.
Research at @ciri-lyon.bsky.social @francoisrousset.bsky.social
@labxc.bsky.social
Anti-phage Immunity, Horizontal gene/ MGE transfer
📚 Teaching at ENS de Lyon within the Department of Biology.
Reposted by Thomas Henry
I'm humbled to receive the Paoletti Prize awarded by @cnrsbiologie.bsky.social 😌 and very grateful to present and past mentors !
@francoisrousset.bsky.social, chercheur en microbiologie au @ciri-lyon.bsky.social est lauréat du Prix Paoletti 2025.
👋 @cnrs-rhoneauvergne.bsky.social
buff.ly/o9MCTni
👋 @cnrs-rhoneauvergne.bsky.social
buff.ly/o9MCTni
Francois Rousset, chercheur en microbiologie | Prix Paoletti 2025
Après une thèse en microbiologie à l’Institut Pasteur sous la direction de David Bikard (2017-2020), François Rousset rejoint en 2021 l’équipe de Rotem Sorek au Weizmann Institute of Science pour son…
www.youtube.com
January 8, 2026 at 9:12 PM
I'm humbled to receive the Paoletti Prize awarded by @cnrsbiologie.bsky.social 😌 and very grateful to present and past mentors !
"Don’t mourn his loss—be grateful that you knew him". Bacteriologist at Pasteur then at INEM, Alain Charbit spent most of his career working on Intracellular bacteria and notably Francisella tularensis to decipher the role of its metabolism in virulence. He was a colleague and a friend.
December 16, 2025 at 8:12 AM
"Don’t mourn his loss—be grateful that you knew him". Bacteriologist at Pasteur then at INEM, Alain Charbit spent most of his career working on Intracellular bacteria and notably Francisella tularensis to decipher the role of its metabolism in virulence. He was a colleague and a friend.
Reposted by Thomas Henry
🌟 New preprint alert! 🌟 We’re excited to share the latest work from @francoisleulier.bsky.social lab, now on bioRxiv!
Symbiosis through lysis: prophage activation underlies Lactiplantibacillus plantarum probiotic function https://www.biorxiv.org/content/10.64898/2025.12.15.694388v1
December 16, 2025 at 7:03 AM
🌟 New preprint alert! 🌟 We’re excited to share the latest work from @francoisleulier.bsky.social lab, now on bioRxiv!
Reposted by Thomas Henry
An ERC Consolidator Grant for Lucie ETIENNE @lucievirevolte.bsky.social, Researcher PI at the CIRI (@cnrs-rhoneauvergne.bsky.social, @ensdelyon.bsky.social, @insermaura.bsky.social, UCBL, @hospicescivilslyon.bsky.social , UJM-Saint Etienne)!
CONGRATULATIONS!!🎉👏
www.insb.cnrs.fr/fr/personne/...
CONGRATULATIONS!!🎉👏
www.insb.cnrs.fr/fr/personne/...
December 12, 2025 at 10:56 AM
An ERC Consolidator Grant for Lucie ETIENNE @lucievirevolte.bsky.social, Researcher PI at the CIRI (@cnrs-rhoneauvergne.bsky.social, @ensdelyon.bsky.social, @insermaura.bsky.social, UCBL, @hospicescivilslyon.bsky.social , UJM-Saint Etienne)!
CONGRATULATIONS!!🎉👏
www.insb.cnrs.fr/fr/personne/...
CONGRATULATIONS!!🎉👏
www.insb.cnrs.fr/fr/personne/...
Reposted by Thomas Henry
Join our online BoltzGen presentation and Q&A on Wed. Dec. 17th at noon ET!
A few new results, many new insights, and lots of good discussion, I am sure!
Paper: www.biorxiv.org/content/10.1...
Presentation sign up + Zoom: luma.com/b24bd37m
A few new results, many new insights, and lots of good discussion, I am sure!
Paper: www.biorxiv.org/content/10.1...
Presentation sign up + Zoom: luma.com/b24bd37m
BoltzGen Zoom presentation + Q&A · Zoom · Luma
Join us on Zoom on Wednesday, Dec. 17th for details on our new model BoltzGen and discussions on the future of biomolecular design 🧬
There will be a 35 minute…
luma.com
December 11, 2025 at 7:42 PM
Join our online BoltzGen presentation and Q&A on Wed. Dec. 17th at noon ET!
A few new results, many new insights, and lots of good discussion, I am sure!
Paper: www.biorxiv.org/content/10.1...
Presentation sign up + Zoom: luma.com/b24bd37m
A few new results, many new insights, and lots of good discussion, I am sure!
Paper: www.biorxiv.org/content/10.1...
Presentation sign up + Zoom: luma.com/b24bd37m
Kudos to Pauline, Flora, Yvan and the #Pyrin team, and many thanks to all the collaborators notably @sophiegeorgin.bsky.social @fhu-inflamme.bsky.social, Alessandra Carbone & Marco Gattorno's teams.
December 5, 2025 at 4:13 PM
Kudos to Pauline, Flora, Yvan and the #Pyrin team, and many thanks to all the collaborators notably @sophiegeorgin.bsky.social @fhu-inflamme.bsky.social, Alessandra Carbone & Marco Gattorno's teams.
Finally, thanks to Guilaine Boursier, Martin Broly and Florian Milhavet, we used SpeckSeq and the international variant classification guidelines to update the Infevers website and disseminate the revised classification. infevers.umai-montpellier.fr/web/search.p...
December 5, 2025 at 4:13 PM
Finally, thanks to Guilaine Boursier, Martin Broly and Florian Milhavet, we used SpeckSeq and the international variant classification guidelines to update the Infevers website and disseminate the revised classification. infevers.umai-montpellier.fr/web/search.p...
SpeckSeq was validated in primary cells from patients with specific MEFV genotypes and led to new diagnoses. Particularly, we describe two patients homozygous for a rare pathogenic MEFV variant and presenting with an atypical phenotype: generalized pustular psoriasis with systemic inflammation.
December 5, 2025 at 4:13 PM
SpeckSeq was validated in primary cells from patients with specific MEFV genotypes and led to new diagnoses. Particularly, we describe two patients homozygous for a rare pathogenic MEFV variant and presenting with an atypical phenotype: generalized pustular psoriasis with systemic inflammation.
SpeckSeq is a mutation scanning experiment guided by human genetics. It highlights key residues along the pyrin protein including around the phosphorylated serine residues, in the B-box domain and in the B30.2 domain, a protein pocket where pregnanolone, a progesterone catabolite docks.
December 5, 2025 at 4:13 PM
SpeckSeq is a mutation scanning experiment guided by human genetics. It highlights key residues along the pyrin protein including around the phosphorylated serine residues, in the B-box domain and in the B30.2 domain, a protein pocket where pregnanolone, a progesterone catabolite docks.
SpeckSeq separates the MEFV variants depending on their hyper-responsiveness to distinct stimuli classifying them as either FMF-like variants or PAAND-like variants.
December 5, 2025 at 4:13 PM
SpeckSeq separates the MEFV variants depending on their hyper-responsiveness to distinct stimuli classifying them as either FMF-like variants or PAAND-like variants.
Discover SpeckSeq, a method combining DNA barcoding of gene variants, single cell sorting based on ASC speck formation and NGS. 228 MEFV variants classified in a single experiment. Novel pathogenic variants identified in addition to the well known FMF and PAAND variants.
December 5, 2025 at 4:13 PM
Discover SpeckSeq, a method combining DNA barcoding of gene variants, single cell sorting based on ASC speck formation and NGS. 228 MEFV variants classified in a single experiment. Novel pathogenic variants identified in addition to the well known FMF and PAAND variants.
Here is the latest paper of the lab @ciri-lyon.bsky.social on the pyrin #inflammasome, the MEFV gene variants and the associated autoinflammatory diseases, Familial Mediteranean fever (FMF) and PAAND.
In @jem.org, Bronnec, @cinflammasome.bsky.social et al. developed SpeckSeq to evaluate the pathogenicity of 228 MEFV variants. SpeckSeq leads to a revised classification of MEFV variants, new diagnoses, & novel insights on pyrin structure–function relationship. rupress.org/jem/article/...
December 5, 2025 at 4:13 PM
Here is the latest paper of the lab @ciri-lyon.bsky.social on the pyrin #inflammasome, the MEFV gene variants and the associated autoinflammatory diseases, Familial Mediteranean fever (FMF) and PAAND.
Reposted by Thomas Henry
International Call: recruitment of an Early-Career Team Leader in Virology at CIRI!
For further information: ciri.ens-lyon.fr/nous-rejoind...
For further information: ciri.ens-lyon.fr/nous-rejoind...
December 1, 2025 at 3:11 PM
International Call: recruitment of an Early-Career Team Leader in Virology at CIRI!
For further information: ciri.ens-lyon.fr/nous-rejoind...
For further information: ciri.ens-lyon.fr/nous-rejoind...
Reposted by Thomas Henry
Our latest work from @brozlab.bsky.social and led by @alexandraboegli.bsky.social is out now in @embojournal.org. Check out our findings on how the intestinal #inflammasome NLRP6 senses lysosomal damage to trigger pyroptotic cell death.
The NLRP6 inflammasome is activated by sterile or pathogen-induced endolysosomal damage | The EMBO Journal
imageimageThe innate immune sensor NLRP6 is known to control host defense against bacteria and
viruses in the gastrointestinal tract by a poorly-understood mechanism. This study
shows that NLRP6 forms...
www.embopress.org
November 21, 2025 at 2:18 PM
Our latest work from @brozlab.bsky.social and led by @alexandraboegli.bsky.social is out now in @embojournal.org. Check out our findings on how the intestinal #inflammasome NLRP6 senses lysosomal damage to trigger pyroptotic cell death.
Reposted by Thomas Henry
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome
#Inflammasome
September 2, 2025 at 4:22 PM
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
Reposted by Thomas Henry
Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters
May 19, 2025 at 10:46 AM
Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters
Reposted by Thomas Henry
We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network.
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens
Shivcharan et al. report that endosomal damage sensing by the danger receptor galectin-8
licenses noncanonical inflammasome activation and pyroptosis during intracellular
bacterial infections in human...
www.cell.com
July 17, 2025 at 12:12 PM
We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network.
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
Reposted by Thomas Henry
#LocationLocationLocation! #NewVirusSensingModality! Lahaye, @manellab.bsky.social &co show @cp-cell.bsky.social that nuclear cGAS senses viruses by recognizing centromeric DNA amplification caused by viral effectors that degrade centromere proteins! www.cell.com/cell/abstrac...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification
and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune
surveillance mechanism in the nu...
www.cell.com
June 3, 2025 at 11:26 AM
#LocationLocationLocation! #NewVirusSensingModality! Lahaye, @manellab.bsky.social &co show @cp-cell.bsky.social that nuclear cGAS senses viruses by recognizing centromeric DNA amplification caused by viral effectors that degrade centromere proteins! www.cell.com/cell/abstrac...
Reposted by Thomas Henry
Review: Spaan, Boisson, and @sethlucianmasters.bsky.social review the known primary disorders of the polyubiquitination pathways in humans that lead to #autoinflammation and/or #immunodeficiency rupress.org/jem/article/...
April 15, 2025 at 6:18 PM
Review: Spaan, Boisson, and @sethlucianmasters.bsky.social review the known primary disorders of the polyubiquitination pathways in humans that lead to #autoinflammation and/or #immunodeficiency rupress.org/jem/article/...
Reposted by Thomas Henry
🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
April 13, 2025 at 3:58 PM
🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!