Thomas Henry
@cinflammasome.bsky.social
Researcher at CIRI, Lyon, France.
Working on innate immune signalling pathways in autoinflammatory diseases and bacterial infections.
Francisella and the type 6 secretion system
Inflammasomes & ALPK1/TIFA pathway
FMF, PAAND & ROSAH
Working on innate immune signalling pathways in autoinflammatory diseases and bacterial infections.
Francisella and the type 6 secretion system
Inflammasomes & ALPK1/TIFA pathway
FMF, PAAND & ROSAH
Reposted by Thomas Henry
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome
#Inflammasome
September 2, 2025 at 4:22 PM
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
Reposted by Thomas Henry
Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters
May 19, 2025 at 10:46 AM
Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters
Reposted by Thomas Henry
We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network.
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens
Shivcharan et al. report that endosomal damage sensing by the danger receptor galectin-8
licenses noncanonical inflammasome activation and pyroptosis during intracellular
bacterial infections in human...
www.cell.com
July 17, 2025 at 12:12 PM
We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network.
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2
Reposted by Thomas Henry
#LocationLocationLocation! #NewVirusSensingModality! Lahaye, @manellab.bsky.social &co show @cp-cell.bsky.social that nuclear cGAS senses viruses by recognizing centromeric DNA amplification caused by viral effectors that degrade centromere proteins! www.cell.com/cell/abstrac...
Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification
and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune
surveillance mechanism in the nu...
www.cell.com
June 3, 2025 at 11:26 AM
#LocationLocationLocation! #NewVirusSensingModality! Lahaye, @manellab.bsky.social &co show @cp-cell.bsky.social that nuclear cGAS senses viruses by recognizing centromeric DNA amplification caused by viral effectors that degrade centromere proteins! www.cell.com/cell/abstrac...
Reposted by Thomas Henry
Review: Spaan, Boisson, and @sethlucianmasters.bsky.social review the known primary disorders of the polyubiquitination pathways in humans that lead to #autoinflammation and/or #immunodeficiency rupress.org/jem/article/...
April 15, 2025 at 6:18 PM
Review: Spaan, Boisson, and @sethlucianmasters.bsky.social review the known primary disorders of the polyubiquitination pathways in humans that lead to #autoinflammation and/or #immunodeficiency rupress.org/jem/article/...
Reposted by Thomas Henry
🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
April 13, 2025 at 3:58 PM
🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)
Please share!
Another link between RHO GTPases and inflammasomes. RAC2 GoF variants activate the NLRP3 inflammasome, Congrats to the Boyer group @lauboye.bsky.social!
bsky.app/profile/jem....
bsky.app/profile/jem....
The Boyer group @lauboye.bsky.social show NLRP3 #inflammasome activation in circulating myeloid cells by human RAC2 gain-of-function variants that are linked to rare immune disorders. rupress.org/jem/article/...
📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
April 11, 2025 at 7:17 AM
Another link between RHO GTPases and inflammasomes. RAC2 GoF variants activate the NLRP3 inflammasome, Congrats to the Boyer group @lauboye.bsky.social!
bsky.app/profile/jem....
bsky.app/profile/jem....
Reposted by Thomas Henry
Many phages encode "sponge" proteins that catch immune signaling molecules to block bacterial immunity. Two preprints report a defense system plugged the other way around: the signaling molecule constitutively inhibits the effector, so that sponges trigger effector activity 🤯 what a wild mechanism!
Excited to share that my work from the @aaronwhiteley.bsky.social lab is now on bioRxiv! With @benmorehouse.bsky.social, we discovered that the Panoptes defense system—named after the all-seeing watchman of Hera—uses decoy nucleotides to detect phage anti-defense proteins.
A minimal CRISPR polymerase produces decoy cyclic nucleotides to detect phage anti-defense proteins
Bacteria use antiphage systems to combat phages, their ubiquitous competitors, and evolve new defenses through repeated reshuffling of basic functional units into novel reformulations. A common theme ...
www.biorxiv.org
April 1, 2025 at 6:54 AM
Many phages encode "sponge" proteins that catch immune signaling molecules to block bacterial immunity. Two preprints report a defense system plugged the other way around: the signaling molecule constitutively inhibits the effector, so that sponges trigger effector activity 🤯 what a wild mechanism!
Reposted by Thomas Henry
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
March 21, 2025 at 3:16 PM
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
Reposted by Thomas Henry
Portimine A #toxin causes #SkinInflammation through ZAKα-dependent #NLRP1 inflammasome activation
By P. Brehmer, F. Roca, F. Zhong, J. Common, @etienne-meunier.bsky.social, P. Hess & colleagues
🗞️https://doi.org/10.1038/s44321-025-00197-4
By P. Brehmer, F. Roca, F. Zhong, J. Common, @etienne-meunier.bsky.social, P. Hess & colleagues
🗞️https://doi.org/10.1038/s44321-025-00197-4
February 14, 2025 at 8:24 PM
Portimine A #toxin causes #SkinInflammation through ZAKα-dependent #NLRP1 inflammasome activation
By P. Brehmer, F. Roca, F. Zhong, J. Common, @etienne-meunier.bsky.social, P. Hess & colleagues
🗞️https://doi.org/10.1038/s44321-025-00197-4
By P. Brehmer, F. Roca, F. Zhong, J. Common, @etienne-meunier.bsky.social, P. Hess & colleagues
🗞️https://doi.org/10.1038/s44321-025-00197-4
Reposted by Thomas Henry
A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis.
rdcu.be/d9iRG
rdcu.be/d9iRG
Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants
Nature Immunology - Gain-of-function variants in the gene encoding NLRP3 lead to constitutive inflammasome activation and excessive IL-1β production. In this resource, authors perform...
rdcu.be
February 11, 2025 at 9:57 AM
A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis.
rdcu.be/d9iRG
rdcu.be/d9iRG