EMBO Molecular Medicine
@embomolmed.org
OpenAccess journal dedicated to high quality research at the interface between clinical & basic science.
Tweets from journal editors
Tweets from journal editors
Pinned
📣 New issue online with a beautiful cover by B. Angi & F. Caicci! ➡️ www.embopress.org/toc/17574684...
It highlights the study by I. Szabo & colleagues at U. of Padova "Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo"
🗞️ www.embopress.org/doi/full/10....
It highlights the study by I. Szabo & colleagues at U. of Padova "Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo"
🗞️ www.embopress.org/doi/full/10....
The repressor #Capicua is a barrier to #LungTumor development driven by Kras/Trp53 mutations 👉 doi.org/10.1038/s443...
By I. Ballesteros-González, @matthiasdrosten.bsky.social & colleagues @ciberisciii.bsky.social @ciccancer.bsky.social
By I. Ballesteros-González, @matthiasdrosten.bsky.social & colleagues @ciberisciii.bsky.social @ciccancer.bsky.social
November 13, 2025 at 6:55 AM
The repressor #Capicua is a barrier to #LungTumor development driven by Kras/Trp53 mutations 👉 doi.org/10.1038/s443...
By I. Ballesteros-González, @matthiasdrosten.bsky.social & colleagues @ciberisciii.bsky.social @ciccancer.bsky.social
By I. Ballesteros-González, @matthiasdrosten.bsky.social & colleagues @ciberisciii.bsky.social @ciccancer.bsky.social
Enhanced #Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in #LoweSyndrome
By Y. Sharma, P. Raghu et al @ncbsbangalore.bsky.social
🗞️ doi.org/10.1038/s443...
By Y. Sharma, P. Raghu et al @ncbsbangalore.bsky.social
🗞️ doi.org/10.1038/s443...
November 13, 2025 at 6:49 AM
Enhanced #Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in #LoweSyndrome
By Y. Sharma, P. Raghu et al @ncbsbangalore.bsky.social
🗞️ doi.org/10.1038/s443...
By Y. Sharma, P. Raghu et al @ncbsbangalore.bsky.social
🗞️ doi.org/10.1038/s443...
circ-EGFR is a predictor of response to Cetuximab and a potential target in #ColorectalCancer by S. Sui, A. Goel & al @beckman-foundation.bsky.social @cityofhope.bsky.social 👉 doi.org/10.1038/s443...
Related N&V by C. Pilati & P. Laurent-Puig @canceropolegso.bsky.social 👉 doi.org/10.1038/s443...
Related N&V by C. Pilati & P. Laurent-Puig @canceropolegso.bsky.social 👉 doi.org/10.1038/s443...
November 13, 2025 at 6:45 AM
circ-EGFR is a predictor of response to Cetuximab and a potential target in #ColorectalCancer by S. Sui, A. Goel & al @beckman-foundation.bsky.social @cityofhope.bsky.social 👉 doi.org/10.1038/s443...
Related N&V by C. Pilati & P. Laurent-Puig @canceropolegso.bsky.social 👉 doi.org/10.1038/s443...
Related N&V by C. Pilati & P. Laurent-Puig @canceropolegso.bsky.social 👉 doi.org/10.1038/s443...
📣 New issue online with a beautiful cover by B. Angi & F. Caicci! ➡️ www.embopress.org/toc/17574684...
It highlights the study by I. Szabo & colleagues at U. of Padova "Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo"
🗞️ www.embopress.org/doi/full/10....
It highlights the study by I. Szabo & colleagues at U. of Padova "Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo"
🗞️ www.embopress.org/doi/full/10....
November 12, 2025 at 6:09 AM
📣 New issue online with a beautiful cover by B. Angi & F. Caicci! ➡️ www.embopress.org/toc/17574684...
It highlights the study by I. Szabo & colleagues at U. of Padova "Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo"
🗞️ www.embopress.org/doi/full/10....
It highlights the study by I. Szabo & colleagues at U. of Padova "Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo"
🗞️ www.embopress.org/doi/full/10....
Reposted by EMBO Molecular Medicine
New paper alert!🚨CMA is selectively impaired in the RPE of AMD patients, leading to the accumulation of undegraded substrate proteins and increased vulnerability. But it can be targeted pharmacologically!💊
@cib-csic.bsky.social @dgsomucla.bsky.social
@cib-csic.bsky.social @dgsomucla.bsky.social
Defective #ChaperoneMediatedAutophagy in the retinal pigment epithelium of #AgeRelatedMacularDegeneration patients
By JI Jiménez-Loygorri, D. Ferrington, P. Boya & colleagues at CNIO, Friburg University & UCLA
👉 doi.org/10.1038/s443...
By JI Jiménez-Loygorri, D. Ferrington, P. Boya & colleagues at CNIO, Friburg University & UCLA
👉 doi.org/10.1038/s443...
November 11, 2025 at 3:55 PM
New paper alert!🚨CMA is selectively impaired in the RPE of AMD patients, leading to the accumulation of undegraded substrate proteins and increased vulnerability. But it can be targeted pharmacologically!💊
@cib-csic.bsky.social @dgsomucla.bsky.social
@cib-csic.bsky.social @dgsomucla.bsky.social
Reposted by EMBO Molecular Medicine
Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....
Benchmarking porcine pancreatic ductal organoids for drug screening applications | EMBO Molecular Medicine
imageimageState-of-the-art single-cell RNA sequencing and proteomics approaches were employed
to benchmark porcine and human pancreatic ductal organoid systems for use as a drug
screening and testing ...
www.embopress.org
November 5, 2025 at 7:50 PM
Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....
New resource online! 🐖 Benchmarking porcine #PancreaticDuctalOrganoids for #DrugScreening applications
by @ckarampelias.bsky.social, @heikolickert.bsky.social & colleagues @helmholtzmunich.bsky.social
🗞️ doi.org/10.1038/s443...
by @ckarampelias.bsky.social, @heikolickert.bsky.social & colleagues @helmholtzmunich.bsky.social
🗞️ doi.org/10.1038/s443...
November 4, 2025 at 7:47 PM
New resource online! 🐖 Benchmarking porcine #PancreaticDuctalOrganoids for #DrugScreening applications
by @ckarampelias.bsky.social, @heikolickert.bsky.social & colleagues @helmholtzmunich.bsky.social
🗞️ doi.org/10.1038/s443...
by @ckarampelias.bsky.social, @heikolickert.bsky.social & colleagues @helmholtzmunich.bsky.social
🗞️ doi.org/10.1038/s443...
#MitochondrialDamage drives #Tcell immunometabolic paralysis after major surgery
By S. Hirschberger, S. Kreth, M. Hübner and colleagues at Ludwig-Maximilian-University
🗞️ doi.org/10.1038/s443...
By S. Hirschberger, S. Kreth, M. Hübner and colleagues at Ludwig-Maximilian-University
🗞️ doi.org/10.1038/s443...
November 3, 2025 at 9:26 PM
#MitochondrialDamage drives #Tcell immunometabolic paralysis after major surgery
By S. Hirschberger, S. Kreth, M. Hübner and colleagues at Ludwig-Maximilian-University
🗞️ doi.org/10.1038/s443...
By S. Hirschberger, S. Kreth, M. Hübner and colleagues at Ludwig-Maximilian-University
🗞️ doi.org/10.1038/s443...
ENOblock synergizes with colistin to treat #AcinetobacterBaumannii infections
By I. Molina Panadero, Y. Smani and colleagues @pablodeolavide.upo.es
🗞️ doi.org/10.1038/s443...
By I. Molina Panadero, Y. Smani and colleagues @pablodeolavide.upo.es
🗞️ doi.org/10.1038/s443...
October 31, 2025 at 9:06 PM
ENOblock synergizes with colistin to treat #AcinetobacterBaumannii infections
By I. Molina Panadero, Y. Smani and colleagues @pablodeolavide.upo.es
🗞️ doi.org/10.1038/s443...
By I. Molina Panadero, Y. Smani and colleagues @pablodeolavide.upo.es
🗞️ doi.org/10.1038/s443...
A heterozygous post-zygotic ZNF334 truncation mutation in #monocytes was identified as a cause of late-onset cold-induced #AutoinflammatoryDisease ➡️ doi.org/10.1038/s443...
By JL Lan, CA Yang and colleagues at China Medical University Taichung
By JL Lan, CA Yang and colleagues at China Medical University Taichung
October 30, 2025 at 7:22 PM
A heterozygous post-zygotic ZNF334 truncation mutation in #monocytes was identified as a cause of late-onset cold-induced #AutoinflammatoryDisease ➡️ doi.org/10.1038/s443...
By JL Lan, CA Yang and colleagues at China Medical University Taichung
By JL Lan, CA Yang and colleagues at China Medical University Taichung
Defective #ChaperoneMediatedAutophagy in the retinal pigment epithelium of #AgeRelatedMacularDegeneration patients
By JI Jiménez-Loygorri, D. Ferrington, P. Boya & colleagues at CNIO, Friburg University & UCLA
👉 doi.org/10.1038/s443...
By JI Jiménez-Loygorri, D. Ferrington, P. Boya & colleagues at CNIO, Friburg University & UCLA
👉 doi.org/10.1038/s443...
October 30, 2025 at 4:33 PM
Defective #ChaperoneMediatedAutophagy in the retinal pigment epithelium of #AgeRelatedMacularDegeneration patients
By JI Jiménez-Loygorri, D. Ferrington, P. Boya & colleagues at CNIO, Friburg University & UCLA
👉 doi.org/10.1038/s443...
By JI Jiménez-Loygorri, D. Ferrington, P. Boya & colleagues at CNIO, Friburg University & UCLA
👉 doi.org/10.1038/s443...
A 6-metabolite plasma panel was developed & validated for #GastricCancer diagnosis, revealing diagnostic potential and a mechanistic role for isovalerylcarnitine 👉 doi.org/10.1038/s443...
By Yongjie Xu, Lingbin Du, Xiangdong Cheng & colleagues at Hangzhou Institute of Medicine
By Yongjie Xu, Lingbin Du, Xiangdong Cheng & colleagues at Hangzhou Institute of Medicine
October 28, 2025 at 3:40 PM
A 6-metabolite plasma panel was developed & validated for #GastricCancer diagnosis, revealing diagnostic potential and a mechanistic role for isovalerylcarnitine 👉 doi.org/10.1038/s443...
By Yongjie Xu, Lingbin Du, Xiangdong Cheng & colleagues at Hangzhou Institute of Medicine
By Yongjie Xu, Lingbin Du, Xiangdong Cheng & colleagues at Hangzhou Institute of Medicine
Don’t miss ➡️ #InSilicoModeling guides identification of novel #JAK1 variants associated with #ImmuneDysregulation
By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social
🗞️ doi.org/10.1038/s443...
By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social
🗞️ doi.org/10.1038/s443...
October 28, 2025 at 3:35 PM
Don’t miss ➡️ #InSilicoModeling guides identification of novel #JAK1 variants associated with #ImmuneDysregulation
By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social
🗞️ doi.org/10.1038/s443...
By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social
🗞️ doi.org/10.1038/s443...
Reposted by EMBO Molecular Medicine
3D human microvessel model shows how malaria parasite Plasmodium falciparum disrupts the brain's tiny blood vessels & affects pericytes
📷 Rory K M Long et al, @embl.org Barcelona in
@embomolmed.org
➡️ bpod.org.uk/archive/2025...
📷 Rory K M Long et al, @embl.org Barcelona in
@embomolmed.org
➡️ bpod.org.uk/archive/2025...
October 26, 2025 at 9:25 AM
3D human microvessel model shows how malaria parasite Plasmodium falciparum disrupts the brain's tiny blood vessels & affects pericytes
📷 Rory K M Long et al, @embl.org Barcelona in
@embomolmed.org
➡️ bpod.org.uk/archive/2025...
📷 Rory K M Long et al, @embl.org Barcelona in
@embomolmed.org
➡️ bpod.org.uk/archive/2025...
Online today! #CARD14 signaling in intestinal epithelial cells induces #IntestinalInflammation and intestinal transit delay
By A. Aidarova, R. Beyaert, I. Afonina & colleagues @viblifesciences.bsky.social UGent
➡️ doi.org/10.1038/s443...
By A. Aidarova, R. Beyaert, I. Afonina & colleagues @viblifesciences.bsky.social UGent
➡️ doi.org/10.1038/s443...
October 23, 2025 at 8:31 PM
Online today! #CARD14 signaling in intestinal epithelial cells induces #IntestinalInflammation and intestinal transit delay
By A. Aidarova, R. Beyaert, I. Afonina & colleagues @viblifesciences.bsky.social UGent
➡️ doi.org/10.1038/s443...
By A. Aidarova, R. Beyaert, I. Afonina & colleagues @viblifesciences.bsky.social UGent
➡️ doi.org/10.1038/s443...
Reposted by EMBO Molecular Medicine
Proud to share our contribution with Prof. Gabbiani and Prof. De Meyer on #SMAD7 regulation in cardiac and skeletal tissue resolution, featured in @embomolmed.org (Vol. 17, No. 9 (Sep/ 2025) #CardioSky #fibrosis #muscle #vascular #inflammation
Read this Perspective by L Martin, G Gabbiani & GRY De Meyer at University of Antwerp on the role of #SMAD7 in cardiac, skeletal muscle, and vascular tissues.
🗞️ doi.org/10.1038/s443...
🗞️ doi.org/10.1038/s443...
October 21, 2025 at 6:00 PM
Proud to share our contribution with Prof. Gabbiani and Prof. De Meyer on #SMAD7 regulation in cardiac and skeletal tissue resolution, featured in @embomolmed.org (Vol. 17, No. 9 (Sep/ 2025) #CardioSky #fibrosis #muscle #vascular #inflammation
Reposted by EMBO Molecular Medicine
Interesting knockout phenotype on intestinal stem cell regeneration.
@embomolmed.org
www.embopress.org/doi/full/10....
@embomolmed.org
www.embopress.org/doi/full/10....
Injury-induced intestinal stem cell renewal requires capillary morphogenesis gene 2 | EMBO Molecular Medicine
imageimageHyaline Fibromatosis Syndrome (HFS) is caused by mutations in the CMG2 gene. Full
loss of function mutations lead to death around 18 months due to recurrent diarrhea
of unknown origin. We us...
www.embopress.org
October 12, 2025 at 6:44 AM
Interesting knockout phenotype on intestinal stem cell regeneration.
@embomolmed.org
www.embopress.org/doi/full/10....
@embomolmed.org
www.embopress.org/doi/full/10....
📣 Our October issue is online! www.embopress.org/toc/17574684...
This month's cover highlights the article by C. Zhu, M. Kong et al (www.embopress.org/doi/full/10....) that uncovers a new mechanism underlying #MyocardialFibrosis with druggable targets.
Scientific illustration by the authors
This month's cover highlights the article by C. Zhu, M. Kong et al (www.embopress.org/doi/full/10....) that uncovers a new mechanism underlying #MyocardialFibrosis with druggable targets.
Scientific illustration by the authors
October 10, 2025 at 2:10 PM
📣 Our October issue is online! www.embopress.org/toc/17574684...
This month's cover highlights the article by C. Zhu, M. Kong et al (www.embopress.org/doi/full/10....) that uncovers a new mechanism underlying #MyocardialFibrosis with druggable targets.
Scientific illustration by the authors
This month's cover highlights the article by C. Zhu, M. Kong et al (www.embopress.org/doi/full/10....) that uncovers a new mechanism underlying #MyocardialFibrosis with druggable targets.
Scientific illustration by the authors
Brown remodeling of #WhiteAdiposeTissue protects against #AbdominalAorticAneurysm via batokine FSTL1
By C. Huang, Y. Huang, B. Huang, L. Yao, J. Wang, Y. Chen, Z. Liu and colleagues at Sun Yat-Sen University
➡️ doi.org/10.1038/s443...
By C. Huang, Y. Huang, B. Huang, L. Yao, J. Wang, Y. Chen, Z. Liu and colleagues at Sun Yat-Sen University
➡️ doi.org/10.1038/s443...
October 9, 2025 at 7:59 PM
Brown remodeling of #WhiteAdiposeTissue protects against #AbdominalAorticAneurysm via batokine FSTL1
By C. Huang, Y. Huang, B. Huang, L. Yao, J. Wang, Y. Chen, Z. Liu and colleagues at Sun Yat-Sen University
➡️ doi.org/10.1038/s443...
By C. Huang, Y. Huang, B. Huang, L. Yao, J. Wang, Y. Chen, Z. Liu and colleagues at Sun Yat-Sen University
➡️ doi.org/10.1038/s443...
#AI -identified #CD133 -targeting natural compounds demonstrate differential anti-tumor effects and mechanisms in pan-cancer models
By Y. Hou, Z. Wang, W. Wang, Y. Zhang, X. Dai, S. Ma & colleagues
🗞️ doi.org/10.1038/s443...
By Y. Hou, Z. Wang, W. Wang, Y. Zhang, X. Dai, S. Ma & colleagues
🗞️ doi.org/10.1038/s443...
October 6, 2025 at 11:25 AM
#AI -identified #CD133 -targeting natural compounds demonstrate differential anti-tumor effects and mechanisms in pan-cancer models
By Y. Hou, Z. Wang, W. Wang, Y. Zhang, X. Dai, S. Ma & colleagues
🗞️ doi.org/10.1038/s443...
By Y. Hou, Z. Wang, W. Wang, Y. Zhang, X. Dai, S. Ma & colleagues
🗞️ doi.org/10.1038/s443...
A neuroprotective tetrapeptide for treatment of #AcuteTraumaticBrainInjury
By A. Mann, S. Hussain, E. Ruoslahti & colleagues @sbpdiscovery.bsky.social
➡️ doi.org/10.1038/s443...
By A. Mann, S. Hussain, E. Ruoslahti & colleagues @sbpdiscovery.bsky.social
➡️ doi.org/10.1038/s443...
October 6, 2025 at 11:21 AM
A neuroprotective tetrapeptide for treatment of #AcuteTraumaticBrainInjury
By A. Mann, S. Hussain, E. Ruoslahti & colleagues @sbpdiscovery.bsky.social
➡️ doi.org/10.1038/s443...
By A. Mann, S. Hussain, E. Ruoslahti & colleagues @sbpdiscovery.bsky.social
➡️ doi.org/10.1038/s443...
Complete attenuation of #PlasmodiumFalciparum sporozoites by atovaquone–proguanil 👉 doi.org/10.1038/s443...
By S Borrmann, Z Sulyok, K Müller, R Fendel, S Hoffman, P Kremsner, K Matuschewski, B Mordmüller & colleagues
Read also related N&V by G Rochfort Peters & J Baum 👉 doi.org/10.1038/s443...
By S Borrmann, Z Sulyok, K Müller, R Fendel, S Hoffman, P Kremsner, K Matuschewski, B Mordmüller & colleagues
Read also related N&V by G Rochfort Peters & J Baum 👉 doi.org/10.1038/s443...
September 29, 2025 at 7:02 PM
Complete attenuation of #PlasmodiumFalciparum sporozoites by atovaquone–proguanil 👉 doi.org/10.1038/s443...
By S Borrmann, Z Sulyok, K Müller, R Fendel, S Hoffman, P Kremsner, K Matuschewski, B Mordmüller & colleagues
Read also related N&V by G Rochfort Peters & J Baum 👉 doi.org/10.1038/s443...
By S Borrmann, Z Sulyok, K Müller, R Fendel, S Hoffman, P Kremsner, K Matuschewski, B Mordmüller & colleagues
Read also related N&V by G Rochfort Peters & J Baum 👉 doi.org/10.1038/s443...
New method ➡️ Domain-substituted IGF2 tag modulates targeting of lentiviral #GeneTherapy for #HunterSyndrome
By F. Catalano, WWMP Pijnappel & colleagues @erasmusmc.bsky.social
🗞️ doi.org/10.1038/s443...
By F. Catalano, WWMP Pijnappel & colleagues @erasmusmc.bsky.social
🗞️ doi.org/10.1038/s443...
September 29, 2025 at 6:55 PM
New method ➡️ Domain-substituted IGF2 tag modulates targeting of lentiviral #GeneTherapy for #HunterSyndrome
By F. Catalano, WWMP Pijnappel & colleagues @erasmusmc.bsky.social
🗞️ doi.org/10.1038/s443...
By F. Catalano, WWMP Pijnappel & colleagues @erasmusmc.bsky.social
🗞️ doi.org/10.1038/s443...
📣 Metabolic #cardiomyopathies: untangling clinical heterogeneity with human #StemCell derived models
By A. Passadouro, @rhhoutkooper.bsky.social, S. Mosegaard & colleagues at University of Amsterdam
➡️ doi.org/10.1038/s443...
By A. Passadouro, @rhhoutkooper.bsky.social, S. Mosegaard & colleagues at University of Amsterdam
➡️ doi.org/10.1038/s443...
September 23, 2025 at 6:45 PM
📣 Metabolic #cardiomyopathies: untangling clinical heterogeneity with human #StemCell derived models
By A. Passadouro, @rhhoutkooper.bsky.social, S. Mosegaard & colleagues at University of Amsterdam
➡️ doi.org/10.1038/s443...
By A. Passadouro, @rhhoutkooper.bsky.social, S. Mosegaard & colleagues at University of Amsterdam
➡️ doi.org/10.1038/s443...
Impaired migration and #LungInvasion of human #melanoma by a novel small molecule targeting the transmembrane domain of death receptor #p75NTR
by V. Lopes-Rodrigues, C. Ibanez & colleagues
doi.org/10.1038/s443...
by V. Lopes-Rodrigues, C. Ibanez & colleagues
doi.org/10.1038/s443...
September 19, 2025 at 2:13 PM
Impaired migration and #LungInvasion of human #melanoma by a novel small molecule targeting the transmembrane domain of death receptor #p75NTR
by V. Lopes-Rodrigues, C. Ibanez & colleagues
doi.org/10.1038/s443...
by V. Lopes-Rodrigues, C. Ibanez & colleagues
doi.org/10.1038/s443...