EMBO Molecular Medicine
@embomolmed.org
OpenAccess journal dedicated to high quality research at the interface between clinical & basic science.
Tweets from journal editors
Tweets from journal editors
The repressor #Capicua is a barrier to #LungTumor development driven by Kras/Trp53 mutations 👉 doi.org/10.1038/s443...
By I. Ballesteros-González, @matthiasdrosten.bsky.social & colleagues @ciberisciii.bsky.social @ciccancer.bsky.social
By I. Ballesteros-González, @matthiasdrosten.bsky.social & colleagues @ciberisciii.bsky.social @ciccancer.bsky.social
November 13, 2025 at 6:55 AM
The repressor #Capicua is a barrier to #LungTumor development driven by Kras/Trp53 mutations 👉 doi.org/10.1038/s443...
By I. Ballesteros-González, @matthiasdrosten.bsky.social & colleagues @ciberisciii.bsky.social @ciccancer.bsky.social
By I. Ballesteros-González, @matthiasdrosten.bsky.social & colleagues @ciberisciii.bsky.social @ciccancer.bsky.social
Enhanced #Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in #LoweSyndrome
By Y. Sharma, P. Raghu et al @ncbsbangalore.bsky.social
🗞️ doi.org/10.1038/s443...
By Y. Sharma, P. Raghu et al @ncbsbangalore.bsky.social
🗞️ doi.org/10.1038/s443...
November 13, 2025 at 6:49 AM
Enhanced #Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in #LoweSyndrome
By Y. Sharma, P. Raghu et al @ncbsbangalore.bsky.social
🗞️ doi.org/10.1038/s443...
By Y. Sharma, P. Raghu et al @ncbsbangalore.bsky.social
🗞️ doi.org/10.1038/s443...
circ-EGFR is a predictor of response to Cetuximab and a potential target in #ColorectalCancer by S. Sui, A. Goel & al @beckman-foundation.bsky.social @cityofhope.bsky.social 👉 doi.org/10.1038/s443...
Related N&V by C. Pilati & P. Laurent-Puig @canceropolegso.bsky.social 👉 doi.org/10.1038/s443...
Related N&V by C. Pilati & P. Laurent-Puig @canceropolegso.bsky.social 👉 doi.org/10.1038/s443...
November 13, 2025 at 6:45 AM
circ-EGFR is a predictor of response to Cetuximab and a potential target in #ColorectalCancer by S. Sui, A. Goel & al @beckman-foundation.bsky.social @cityofhope.bsky.social 👉 doi.org/10.1038/s443...
Related N&V by C. Pilati & P. Laurent-Puig @canceropolegso.bsky.social 👉 doi.org/10.1038/s443...
Related N&V by C. Pilati & P. Laurent-Puig @canceropolegso.bsky.social 👉 doi.org/10.1038/s443...
📣 New issue online with a beautiful cover by B. Angi & F. Caicci! ➡️ www.embopress.org/toc/17574684...
It highlights the study by I. Szabo & colleagues at U. of Padova "Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo"
🗞️ www.embopress.org/doi/full/10....
It highlights the study by I. Szabo & colleagues at U. of Padova "Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo"
🗞️ www.embopress.org/doi/full/10....
November 12, 2025 at 6:09 AM
📣 New issue online with a beautiful cover by B. Angi & F. Caicci! ➡️ www.embopress.org/toc/17574684...
It highlights the study by I. Szabo & colleagues at U. of Padova "Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo"
🗞️ www.embopress.org/doi/full/10....
It highlights the study by I. Szabo & colleagues at U. of Padova "Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo"
🗞️ www.embopress.org/doi/full/10....
New resource online! 🐖 Benchmarking porcine #PancreaticDuctalOrganoids for #DrugScreening applications
by @ckarampelias.bsky.social, @heikolickert.bsky.social & colleagues @helmholtzmunich.bsky.social
🗞️ doi.org/10.1038/s443...
by @ckarampelias.bsky.social, @heikolickert.bsky.social & colleagues @helmholtzmunich.bsky.social
🗞️ doi.org/10.1038/s443...
November 4, 2025 at 7:47 PM
New resource online! 🐖 Benchmarking porcine #PancreaticDuctalOrganoids for #DrugScreening applications
by @ckarampelias.bsky.social, @heikolickert.bsky.social & colleagues @helmholtzmunich.bsky.social
🗞️ doi.org/10.1038/s443...
by @ckarampelias.bsky.social, @heikolickert.bsky.social & colleagues @helmholtzmunich.bsky.social
🗞️ doi.org/10.1038/s443...
#MitochondrialDamage drives #Tcell immunometabolic paralysis after major surgery
By S. Hirschberger, S. Kreth, M. Hübner and colleagues at Ludwig-Maximilian-University
🗞️ doi.org/10.1038/s443...
By S. Hirschberger, S. Kreth, M. Hübner and colleagues at Ludwig-Maximilian-University
🗞️ doi.org/10.1038/s443...
November 3, 2025 at 9:26 PM
#MitochondrialDamage drives #Tcell immunometabolic paralysis after major surgery
By S. Hirschberger, S. Kreth, M. Hübner and colleagues at Ludwig-Maximilian-University
🗞️ doi.org/10.1038/s443...
By S. Hirschberger, S. Kreth, M. Hübner and colleagues at Ludwig-Maximilian-University
🗞️ doi.org/10.1038/s443...
ENOblock synergizes with colistin to treat #AcinetobacterBaumannii infections
By I. Molina Panadero, Y. Smani and colleagues @pablodeolavide.upo.es
🗞️ doi.org/10.1038/s443...
By I. Molina Panadero, Y. Smani and colleagues @pablodeolavide.upo.es
🗞️ doi.org/10.1038/s443...
October 31, 2025 at 9:06 PM
ENOblock synergizes with colistin to treat #AcinetobacterBaumannii infections
By I. Molina Panadero, Y. Smani and colleagues @pablodeolavide.upo.es
🗞️ doi.org/10.1038/s443...
By I. Molina Panadero, Y. Smani and colleagues @pablodeolavide.upo.es
🗞️ doi.org/10.1038/s443...
A heterozygous post-zygotic ZNF334 truncation mutation in #monocytes was identified as a cause of late-onset cold-induced #AutoinflammatoryDisease ➡️ doi.org/10.1038/s443...
By JL Lan, CA Yang and colleagues at China Medical University Taichung
By JL Lan, CA Yang and colleagues at China Medical University Taichung
October 30, 2025 at 7:22 PM
A heterozygous post-zygotic ZNF334 truncation mutation in #monocytes was identified as a cause of late-onset cold-induced #AutoinflammatoryDisease ➡️ doi.org/10.1038/s443...
By JL Lan, CA Yang and colleagues at China Medical University Taichung
By JL Lan, CA Yang and colleagues at China Medical University Taichung
Defective #ChaperoneMediatedAutophagy in the retinal pigment epithelium of #AgeRelatedMacularDegeneration patients
By JI Jiménez-Loygorri, D. Ferrington, P. Boya & colleagues at CNIO, Friburg University & UCLA
👉 doi.org/10.1038/s443...
By JI Jiménez-Loygorri, D. Ferrington, P. Boya & colleagues at CNIO, Friburg University & UCLA
👉 doi.org/10.1038/s443...
October 30, 2025 at 4:33 PM
Defective #ChaperoneMediatedAutophagy in the retinal pigment epithelium of #AgeRelatedMacularDegeneration patients
By JI Jiménez-Loygorri, D. Ferrington, P. Boya & colleagues at CNIO, Friburg University & UCLA
👉 doi.org/10.1038/s443...
By JI Jiménez-Loygorri, D. Ferrington, P. Boya & colleagues at CNIO, Friburg University & UCLA
👉 doi.org/10.1038/s443...
A 6-metabolite plasma panel was developed & validated for #GastricCancer diagnosis, revealing diagnostic potential and a mechanistic role for isovalerylcarnitine 👉 doi.org/10.1038/s443...
By Yongjie Xu, Lingbin Du, Xiangdong Cheng & colleagues at Hangzhou Institute of Medicine
By Yongjie Xu, Lingbin Du, Xiangdong Cheng & colleagues at Hangzhou Institute of Medicine
October 28, 2025 at 3:40 PM
A 6-metabolite plasma panel was developed & validated for #GastricCancer diagnosis, revealing diagnostic potential and a mechanistic role for isovalerylcarnitine 👉 doi.org/10.1038/s443...
By Yongjie Xu, Lingbin Du, Xiangdong Cheng & colleagues at Hangzhou Institute of Medicine
By Yongjie Xu, Lingbin Du, Xiangdong Cheng & colleagues at Hangzhou Institute of Medicine
Don’t miss ➡️ #InSilicoModeling guides identification of novel #JAK1 variants associated with #ImmuneDysregulation
By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social
🗞️ doi.org/10.1038/s443...
By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social
🗞️ doi.org/10.1038/s443...
October 28, 2025 at 3:35 PM
Don’t miss ➡️ #InSilicoModeling guides identification of novel #JAK1 variants associated with #ImmuneDysregulation
By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social
🗞️ doi.org/10.1038/s443...
By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social
🗞️ doi.org/10.1038/s443...
Online today! #CARD14 signaling in intestinal epithelial cells induces #IntestinalInflammation and intestinal transit delay
By A. Aidarova, R. Beyaert, I. Afonina & colleagues @viblifesciences.bsky.social UGent
➡️ doi.org/10.1038/s443...
By A. Aidarova, R. Beyaert, I. Afonina & colleagues @viblifesciences.bsky.social UGent
➡️ doi.org/10.1038/s443...
October 23, 2025 at 8:31 PM
Online today! #CARD14 signaling in intestinal epithelial cells induces #IntestinalInflammation and intestinal transit delay
By A. Aidarova, R. Beyaert, I. Afonina & colleagues @viblifesciences.bsky.social UGent
➡️ doi.org/10.1038/s443...
By A. Aidarova, R. Beyaert, I. Afonina & colleagues @viblifesciences.bsky.social UGent
➡️ doi.org/10.1038/s443...
📣 Our October issue is online! www.embopress.org/toc/17574684...
This month's cover highlights the article by C. Zhu, M. Kong et al (www.embopress.org/doi/full/10....) that uncovers a new mechanism underlying #MyocardialFibrosis with druggable targets.
Scientific illustration by the authors
This month's cover highlights the article by C. Zhu, M. Kong et al (www.embopress.org/doi/full/10....) that uncovers a new mechanism underlying #MyocardialFibrosis with druggable targets.
Scientific illustration by the authors
October 10, 2025 at 2:10 PM
📣 Our October issue is online! www.embopress.org/toc/17574684...
This month's cover highlights the article by C. Zhu, M. Kong et al (www.embopress.org/doi/full/10....) that uncovers a new mechanism underlying #MyocardialFibrosis with druggable targets.
Scientific illustration by the authors
This month's cover highlights the article by C. Zhu, M. Kong et al (www.embopress.org/doi/full/10....) that uncovers a new mechanism underlying #MyocardialFibrosis with druggable targets.
Scientific illustration by the authors
Brown remodeling of #WhiteAdiposeTissue protects against #AbdominalAorticAneurysm via batokine FSTL1
By C. Huang, Y. Huang, B. Huang, L. Yao, J. Wang, Y. Chen, Z. Liu and colleagues at Sun Yat-Sen University
➡️ doi.org/10.1038/s443...
By C. Huang, Y. Huang, B. Huang, L. Yao, J. Wang, Y. Chen, Z. Liu and colleagues at Sun Yat-Sen University
➡️ doi.org/10.1038/s443...
October 9, 2025 at 7:59 PM
Brown remodeling of #WhiteAdiposeTissue protects against #AbdominalAorticAneurysm via batokine FSTL1
By C. Huang, Y. Huang, B. Huang, L. Yao, J. Wang, Y. Chen, Z. Liu and colleagues at Sun Yat-Sen University
➡️ doi.org/10.1038/s443...
By C. Huang, Y. Huang, B. Huang, L. Yao, J. Wang, Y. Chen, Z. Liu and colleagues at Sun Yat-Sen University
➡️ doi.org/10.1038/s443...
#AI -identified #CD133 -targeting natural compounds demonstrate differential anti-tumor effects and mechanisms in pan-cancer models
By Y. Hou, Z. Wang, W. Wang, Y. Zhang, X. Dai, S. Ma & colleagues
🗞️ doi.org/10.1038/s443...
By Y. Hou, Z. Wang, W. Wang, Y. Zhang, X. Dai, S. Ma & colleagues
🗞️ doi.org/10.1038/s443...
October 6, 2025 at 11:25 AM
#AI -identified #CD133 -targeting natural compounds demonstrate differential anti-tumor effects and mechanisms in pan-cancer models
By Y. Hou, Z. Wang, W. Wang, Y. Zhang, X. Dai, S. Ma & colleagues
🗞️ doi.org/10.1038/s443...
By Y. Hou, Z. Wang, W. Wang, Y. Zhang, X. Dai, S. Ma & colleagues
🗞️ doi.org/10.1038/s443...
A neuroprotective tetrapeptide for treatment of #AcuteTraumaticBrainInjury
By A. Mann, S. Hussain, E. Ruoslahti & colleagues @sbpdiscovery.bsky.social
➡️ doi.org/10.1038/s443...
By A. Mann, S. Hussain, E. Ruoslahti & colleagues @sbpdiscovery.bsky.social
➡️ doi.org/10.1038/s443...
October 6, 2025 at 11:21 AM
A neuroprotective tetrapeptide for treatment of #AcuteTraumaticBrainInjury
By A. Mann, S. Hussain, E. Ruoslahti & colleagues @sbpdiscovery.bsky.social
➡️ doi.org/10.1038/s443...
By A. Mann, S. Hussain, E. Ruoslahti & colleagues @sbpdiscovery.bsky.social
➡️ doi.org/10.1038/s443...
Complete attenuation of #PlasmodiumFalciparum sporozoites by atovaquone–proguanil 👉 doi.org/10.1038/s443...
By S Borrmann, Z Sulyok, K Müller, R Fendel, S Hoffman, P Kremsner, K Matuschewski, B Mordmüller & colleagues
Read also related N&V by G Rochfort Peters & J Baum 👉 doi.org/10.1038/s443...
By S Borrmann, Z Sulyok, K Müller, R Fendel, S Hoffman, P Kremsner, K Matuschewski, B Mordmüller & colleagues
Read also related N&V by G Rochfort Peters & J Baum 👉 doi.org/10.1038/s443...
September 29, 2025 at 7:02 PM
Complete attenuation of #PlasmodiumFalciparum sporozoites by atovaquone–proguanil 👉 doi.org/10.1038/s443...
By S Borrmann, Z Sulyok, K Müller, R Fendel, S Hoffman, P Kremsner, K Matuschewski, B Mordmüller & colleagues
Read also related N&V by G Rochfort Peters & J Baum 👉 doi.org/10.1038/s443...
By S Borrmann, Z Sulyok, K Müller, R Fendel, S Hoffman, P Kremsner, K Matuschewski, B Mordmüller & colleagues
Read also related N&V by G Rochfort Peters & J Baum 👉 doi.org/10.1038/s443...
New method ➡️ Domain-substituted IGF2 tag modulates targeting of lentiviral #GeneTherapy for #HunterSyndrome
By F. Catalano, WWMP Pijnappel & colleagues @erasmusmc.bsky.social
🗞️ doi.org/10.1038/s443...
By F. Catalano, WWMP Pijnappel & colleagues @erasmusmc.bsky.social
🗞️ doi.org/10.1038/s443...
September 29, 2025 at 6:55 PM
New method ➡️ Domain-substituted IGF2 tag modulates targeting of lentiviral #GeneTherapy for #HunterSyndrome
By F. Catalano, WWMP Pijnappel & colleagues @erasmusmc.bsky.social
🗞️ doi.org/10.1038/s443...
By F. Catalano, WWMP Pijnappel & colleagues @erasmusmc.bsky.social
🗞️ doi.org/10.1038/s443...
📣 Metabolic #cardiomyopathies: untangling clinical heterogeneity with human #StemCell derived models
By A. Passadouro, @rhhoutkooper.bsky.social, S. Mosegaard & colleagues at University of Amsterdam
➡️ doi.org/10.1038/s443...
By A. Passadouro, @rhhoutkooper.bsky.social, S. Mosegaard & colleagues at University of Amsterdam
➡️ doi.org/10.1038/s443...
September 23, 2025 at 6:45 PM
📣 Metabolic #cardiomyopathies: untangling clinical heterogeneity with human #StemCell derived models
By A. Passadouro, @rhhoutkooper.bsky.social, S. Mosegaard & colleagues at University of Amsterdam
➡️ doi.org/10.1038/s443...
By A. Passadouro, @rhhoutkooper.bsky.social, S. Mosegaard & colleagues at University of Amsterdam
➡️ doi.org/10.1038/s443...
Impaired migration and #LungInvasion of human #melanoma by a novel small molecule targeting the transmembrane domain of death receptor #p75NTR
by V. Lopes-Rodrigues, C. Ibanez & colleagues
doi.org/10.1038/s443...
by V. Lopes-Rodrigues, C. Ibanez & colleagues
doi.org/10.1038/s443...
September 19, 2025 at 2:13 PM
Impaired migration and #LungInvasion of human #melanoma by a novel small molecule targeting the transmembrane domain of death receptor #p75NTR
by V. Lopes-Rodrigues, C. Ibanez & colleagues
doi.org/10.1038/s443...
by V. Lopes-Rodrigues, C. Ibanez & colleagues
doi.org/10.1038/s443...
Glycans on non-structural protein 1 prevent premature #Tcell mediated #DengueVirus clearance
By F. Idris, S. Alonso & colleagues at National Centre for Infectious Diseases Singapore
🗞️ doi.org/10.1038/s443...
By F. Idris, S. Alonso & colleagues at National Centre for Infectious Diseases Singapore
🗞️ doi.org/10.1038/s443...
September 19, 2025 at 2:10 PM
Glycans on non-structural protein 1 prevent premature #Tcell mediated #DengueVirus clearance
By F. Idris, S. Alonso & colleagues at National Centre for Infectious Diseases Singapore
🗞️ doi.org/10.1038/s443...
By F. Idris, S. Alonso & colleagues at National Centre for Infectious Diseases Singapore
🗞️ doi.org/10.1038/s443...
Dietary supplementation of #ArachidonicAcid promotes #HumoralImmunity
By. S. Feng, E. Ma, X. Na, Z. Wang, L. Zhao, A. Zhao, G. Cheng & colleagues at Tsinghua University
➡️ doi.org/10.1038/s443...
By. S. Feng, E. Ma, X. Na, Z. Wang, L. Zhao, A. Zhao, G. Cheng & colleagues at Tsinghua University
➡️ doi.org/10.1038/s443...
September 16, 2025 at 8:59 AM
Dietary supplementation of #ArachidonicAcid promotes #HumoralImmunity
By. S. Feng, E. Ma, X. Na, Z. Wang, L. Zhao, A. Zhao, G. Cheng & colleagues at Tsinghua University
➡️ doi.org/10.1038/s443...
By. S. Feng, E. Ma, X. Na, Z. Wang, L. Zhao, A. Zhao, G. Cheng & colleagues at Tsinghua University
➡️ doi.org/10.1038/s443...
Bead-based plasma #proteomics workflows boost proteome coverage but are vulnerable to cellular contamination, highlighting the need for contamination-aware quality control in #biomarker discovery.
K. Korff, M. Mann, P. Geyer & colleagues @mpibiochem.bsky.social
🗞️ doi.org/10.1038/s443...
K. Korff, M. Mann, P. Geyer & colleagues @mpibiochem.bsky.social
🗞️ doi.org/10.1038/s443...
September 16, 2025 at 8:54 AM
Bead-based plasma #proteomics workflows boost proteome coverage but are vulnerable to cellular contamination, highlighting the need for contamination-aware quality control in #biomarker discovery.
K. Korff, M. Mann, P. Geyer & colleagues @mpibiochem.bsky.social
🗞️ doi.org/10.1038/s443...
K. Korff, M. Mann, P. Geyer & colleagues @mpibiochem.bsky.social
🗞️ doi.org/10.1038/s443...
Anti-M1R/B6R antibody characterization & bispecific design for enhanced #orthopoxvirus protection.
🗞 doi.org/10.1038/s443...
by R. Zhao, L. Wu, Y. Zhang, J. Ma, J. Xue, Q. Wang & colleagues at Chinese Academy of Medical Sciences
🗞 doi.org/10.1038/s443...
by R. Zhao, L. Wu, Y. Zhang, J. Ma, J. Xue, Q. Wang & colleagues at Chinese Academy of Medical Sciences
September 11, 2025 at 8:48 AM
Anti-M1R/B6R antibody characterization & bispecific design for enhanced #orthopoxvirus protection.
🗞 doi.org/10.1038/s443...
by R. Zhao, L. Wu, Y. Zhang, J. Ma, J. Xue, Q. Wang & colleagues at Chinese Academy of Medical Sciences
🗞 doi.org/10.1038/s443...
by R. Zhao, L. Wu, Y. Zhang, J. Ma, J. Xue, Q. Wang & colleagues at Chinese Academy of Medical Sciences
CETN3 deficiency induces #microcephaly by disrupting neural stem/progenitor cell fate through impaired #CentrosomeAssembly and #RNAsplicing 👉 doi.org/10.1038/s443...
by J. Xu, X. Mao, Z. Liu, H. Wang, Z. Guo, S. Bian & colleagues at Tongji University & Changsha University
by J. Xu, X. Mao, Z. Liu, H. Wang, Z. Guo, S. Bian & colleagues at Tongji University & Changsha University
September 11, 2025 at 8:42 AM
CETN3 deficiency induces #microcephaly by disrupting neural stem/progenitor cell fate through impaired #CentrosomeAssembly and #RNAsplicing 👉 doi.org/10.1038/s443...
by J. Xu, X. Mao, Z. Liu, H. Wang, Z. Guo, S. Bian & colleagues at Tongji University & Changsha University
by J. Xu, X. Mao, Z. Liu, H. Wang, Z. Guo, S. Bian & colleagues at Tongji University & Changsha University