Chris Carnie
@cjcarnie.bsky.social
Group Leader at University Hospital Heidelberg. Big fan of DNA repair, metabolism and RNA biology.
Really cool work from our KiTZ colleagues!
Very proud on our stellar Alina Ritter for her frist first-author paper:
Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances #chemotherapy efficacy in #Ewing #sarcoma
tinyurl.com/3kcs3bc9
@dkfz.bsky.social
@uniheidelberg.bsky.social
@nct-heidelberg.bsky.social
Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances #chemotherapy efficacy in #Ewing #sarcoma
tinyurl.com/3kcs3bc9
@dkfz.bsky.social
@uniheidelberg.bsky.social
@nct-heidelberg.bsky.social
August 11, 2025 at 11:03 AM
Really cool work from our KiTZ colleagues!
Reposted by Chris Carnie
July 21, 2025 at 12:59 PM
Reposted by Chris Carnie
We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Postdoctoral Research Associate in the Blackford Group
A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th
candidate.hr-manager.net
May 29, 2025 at 11:26 AM
We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Reposted by Chris Carnie
🚨 Check out our latest review in #MolecularCell!
We discuss how formaldehyde, a toxic metabolic by-product, threatens genome stability and disrupts cellular homeostasis.
👏 Outstanding work by our talented PhD Std #MartaValverde @carrerasijc.bsky.social
👉📰
authors.elsevier.com/a/1lDFm3vVUP...
We discuss how formaldehyde, a toxic metabolic by-product, threatens genome stability and disrupts cellular homeostasis.
👏 Outstanding work by our talented PhD Std #MartaValverde @carrerasijc.bsky.social
👉📰
authors.elsevier.com/a/1lDFm3vVUP...
June 5, 2025 at 4:58 PM
🚨 Check out our latest review in #MolecularCell!
We discuss how formaldehyde, a toxic metabolic by-product, threatens genome stability and disrupts cellular homeostasis.
👏 Outstanding work by our talented PhD Std #MartaValverde @carrerasijc.bsky.social
👉📰
authors.elsevier.com/a/1lDFm3vVUP...
We discuss how formaldehyde, a toxic metabolic by-product, threatens genome stability and disrupts cellular homeostasis.
👏 Outstanding work by our talented PhD Std #MartaValverde @carrerasijc.bsky.social
👉📰
authors.elsevier.com/a/1lDFm3vVUP...
Reposted by Chris Carnie
Delighted to share that the results of my main postdoc project are now published in @nature.com
🔗 doi.org/10.1038/s415...
🔗 doi.org/10.1038/s415...
Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature
A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...
doi.org
May 21, 2025 at 3:27 PM
Delighted to share that the results of my main postdoc project are now published in @nature.com
🔗 doi.org/10.1038/s415...
🔗 doi.org/10.1038/s415...
A PhD position is open in my group here in Heidelberg. We'll use cool primary cell models of osteosarcoma and genetic screens to understand and overcome mechanisms of clinically acquired drug resistance. It'll be a blast!
karriere.klinikum.uni-heidelberg.de/index.php?ac...
karriere.klinikum.uni-heidelberg.de/index.php?ac...
PhD position in the biology and treatment of Osteosarcoma (m/f/d)
Pflichtfelder sind mit einem (*) markiert.
karriere.klinikum.uni-heidelberg.de
May 14, 2025 at 11:39 AM
A PhD position is open in my group here in Heidelberg. We'll use cool primary cell models of osteosarcoma and genetic screens to understand and overcome mechanisms of clinically acquired drug resistance. It'll be a blast!
karriere.klinikum.uni-heidelberg.de/index.php?ac...
karriere.klinikum.uni-heidelberg.de/index.php?ac...
Reposted by Chris Carnie
Exciting opportunity for a suitably qualified individual to join us, www.jobs.cam.ac.uk/job/50998/
Research Assistant (Jackson Group) (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant (Jackson Group) (Fixed Term) in the Cancer Research UK Cambridge Institute at the University of Cambridge.
www.jobs.cam.ac.uk
April 10, 2025 at 9:28 AM
Exciting opportunity for a suitably qualified individual to join us, www.jobs.cam.ac.uk/job/50998/
Reposted by Chris Carnie
🚀 New Paper Alert! Our latest @natrevmcb.bsky.social explores how nuclear and genome organization drive DNA double-strand break repair! 🧬
📖 Free access: rdcu.be/edViW
Please 🔄 ❤️
📖 Free access: rdcu.be/edViW
Please 🔄 ❤️
Nuclear and genome dynamics underlying DNA double-strand break repair
Nature Reviews Molecular Cell Biology - Changes in nuclear and genome organization promote the repair of DNA double-strand breaks and genome stability. Processes that are involved include the...
rdcu.be
March 18, 2025 at 1:49 PM
🚀 New Paper Alert! Our latest @natrevmcb.bsky.social explores how nuclear and genome organization drive DNA double-strand break repair! 🧬
📖 Free access: rdcu.be/edViW
Please 🔄 ❤️
📖 Free access: rdcu.be/edViW
Please 🔄 ❤️
Reposted by Chris Carnie
Happy to share our review on the cellular responses to RNA damage 🥂
Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social
www.cell.com/cell/fulltex...
Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social
www.cell.com/cell/fulltex...
Cellular responses to RNA damage
RNA plays a central role in protein biosynthesis and performs diverse regulatory and
catalytic functions, making it essential for all processes of life. Like DNA, RNA
is constantly subjected to damage...
www.cell.com
February 20, 2025 at 6:37 PM
Happy to share our review on the cellular responses to RNA damage 🥂
Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social
www.cell.com/cell/fulltex...
Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social
www.cell.com/cell/fulltex...
Reposted by Chris Carnie
Dear all,
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk
February 10, 2025 at 2:45 PM
Dear all,
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk
Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk
Reposted by Chris Carnie
Dear all, my first post! I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on k.w.caldecott@sussex.ac.uk
December 3, 2024 at 11:47 AM
Dear all, my first post! I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on k.w.caldecott@sussex.ac.uk
Happy to share a review written with the wonderful @jstingele.bsky.social on transcription-coupled DPC repair, featuring an overview of new methods, close comparison with TC-NER, comments on clinical implications and plenty of discussion of the unknowns.
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Transcription-coupled repair of DNA–protein crosslinks
DNA–protein crosslinks (DPCs) are highly toxic DNA lesions that are relevant to multiple
human diseases. They are caused by various endogenous and environmental agents, and
from the actions of enzymes...
www.cell.com
December 2, 2024 at 7:39 AM
Happy to share a review written with the wonderful @jstingele.bsky.social on transcription-coupled DPC repair, featuring an overview of new methods, close comparison with TC-NER, comments on clinical implications and plenty of discussion of the unknowns.
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Reposted by Chris Carnie
Happy to share our latest work🍾 🥳
PhD student Sophie Dürauer discovered together with many wonderful collaborators that the ubiquitylation of DNA-protein crosslinks promotes their cleavage by SPRTN more than 100-fold 🧬🔧
PhD student Sophie Dürauer discovered together with many wonderful collaborators that the ubiquitylation of DNA-protein crosslinks promotes their cleavage by SPRTN more than 100-fold 🧬🔧
Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability https://www.biorxiv.org/content/10.1101/2024.11.26.625192v1
Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability https://www.biorxiv.org/content/10.1101/2024.11.26.625192v1
The DNA-dependent protease SPRTN maintains genome stability by degrading toxic DNA-protein crosslink
www.biorxiv.org
November 28, 2024 at 6:18 PM
Happy to share our latest work🍾 🥳
PhD student Sophie Dürauer discovered together with many wonderful collaborators that the ubiquitylation of DNA-protein crosslinks promotes their cleavage by SPRTN more than 100-fold 🧬🔧
PhD student Sophie Dürauer discovered together with many wonderful collaborators that the ubiquitylation of DNA-protein crosslinks promotes their cleavage by SPRTN more than 100-fold 🧬🔧
Reposted by Chris Carnie
Your chance to join one of the best labs in the field!
Great supervisor, great project
Sadly, I'm too old
Great supervisor, great project
Sadly, I'm too old
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
November 15, 2024 at 6:10 PM
Your chance to join one of the best labs in the field!
Great supervisor, great project
Sadly, I'm too old
Great supervisor, great project
Sadly, I'm too old
Reposted by Chris Carnie
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
November 15, 2024 at 5:55 PM
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
Reposted by Chris Carnie
First post here! ✨🦋
There is still time to apply! We have a postdoc position open in our lab at Aarhus University 🇩🇰
We study DNA repair 🧬, combining biochemistry, structural biology, and single-molecule imaging 🔬
Learn more about our research, lab, and Aarhus:
sites.google.com/view/alconla...
There is still time to apply! We have a postdoc position open in our lab at Aarhus University 🇩🇰
We study DNA repair 🧬, combining biochemistry, structural biology, and single-molecule imaging 🔬
Learn more about our research, lab, and Aarhus:
sites.google.com/view/alconla...
MCR Lab
We use biochemistry, structural biology and single-molecule imaging to
understand how DNA damage is recognised, signalled and repaired.
Starting from September 2024, we are based in the
Department...
sites.google.com
November 13, 2024 at 2:26 PM
First post here! ✨🦋
There is still time to apply! We have a postdoc position open in our lab at Aarhus University 🇩🇰
We study DNA repair 🧬, combining biochemistry, structural biology, and single-molecule imaging 🔬
Learn more about our research, lab, and Aarhus:
sites.google.com/view/alconla...
There is still time to apply! We have a postdoc position open in our lab at Aarhus University 🇩🇰
We study DNA repair 🧬, combining biochemistry, structural biology, and single-molecule imaging 🔬
Learn more about our research, lab, and Aarhus:
sites.google.com/view/alconla...