Pablo Alcón
@palconh.bsky.social
Scientist. Molecular and structural biology of DNA repair 🧬
Aarhus University 🇩🇰🇪🇺
From Extremadura, Spain 🌍
https://sites.google.com/view/alconlab/home
Aarhus University 🇩🇰🇪🇺
From Extremadura, Spain 🌍
https://sites.google.com/view/alconlab/home
Very grateful to the Danish Cancer Society and our MBG colleagues for their support!
This grant will enable us to expand our research scope and grow our team.
mbg.au.dk/en/news-and-...
This grant will enable us to expand our research scope and grow our team.
mbg.au.dk/en/news-and-...
Knæk Cancer grant to support new research in DNA repair mechanisms
Assistant Professor Pablo Alcón from the Department of Molecular Biology and Genetics has received a three-year Knæk Cancer grant of DKK 3.6 million from the Danish Cancer Society. The project aims to...
mbg.au.dk
November 12, 2025 at 10:13 AM
Very grateful to the Danish Cancer Society and our MBG colleagues for their support!
This grant will enable us to expand our research scope and grow our team.
mbg.au.dk/en/news-and-...
This grant will enable us to expand our research scope and grow our team.
mbg.au.dk/en/news-and-...
So excited to visit Salamanca this week!
Extraordinary Seminar at the IBFG!
📢 Talk by Dr. Pablo Alcón - Aarhus University (Aarhus, Denmark)
🔬Topic: Understanding DNA Repair: Visualizing Tumour Suppressors in Action
🗓 Nov 14, 2025 – 12:00 PM
📍 IBFG Auditorium, Salamanca
📢 Talk by Dr. Pablo Alcón - Aarhus University (Aarhus, Denmark)
🔬Topic: Understanding DNA Repair: Visualizing Tumour Suppressors in Action
🗓 Nov 14, 2025 – 12:00 PM
📍 IBFG Auditorium, Salamanca
November 11, 2025 at 7:06 PM
So excited to visit Salamanca this week!
Reposted by Pablo Alcón
Extraordinary Seminar at the IBFG!
📢 Talk by Dr. Pablo Alcón - Aarhus University (Aarhus, Denmark)
🔬Topic: Understanding DNA Repair: Visualizing Tumour Suppressors in Action
🗓 Nov 14, 2025 – 12:00 PM
📍 IBFG Auditorium, Salamanca
📢 Talk by Dr. Pablo Alcón - Aarhus University (Aarhus, Denmark)
🔬Topic: Understanding DNA Repair: Visualizing Tumour Suppressors in Action
🗓 Nov 14, 2025 – 12:00 PM
📍 IBFG Auditorium, Salamanca
November 11, 2025 at 12:21 PM
Extraordinary Seminar at the IBFG!
📢 Talk by Dr. Pablo Alcón - Aarhus University (Aarhus, Denmark)
🔬Topic: Understanding DNA Repair: Visualizing Tumour Suppressors in Action
🗓 Nov 14, 2025 – 12:00 PM
📍 IBFG Auditorium, Salamanca
📢 Talk by Dr. Pablo Alcón - Aarhus University (Aarhus, Denmark)
🔬Topic: Understanding DNA Repair: Visualizing Tumour Suppressors in Action
🗓 Nov 14, 2025 – 12:00 PM
📍 IBFG Auditorium, Salamanca
Reposted by Pablo Alcón
Ha muerto Antonio García-Bellido, uno de los mejores científicos de la historia de España tras descubrir las fronteras invisibles dentro de los seres vivos: elpais.com/ciencia/2025...
Muere Antonio García-Bellido, descubridor de las fronteras invisibles dentro de los seres vivos
El biólogo, fallecido a los 89 años, deja un legado científico que roza las alturas de los nobeles Santiago Ramón y Cajal y Severo Ochoa
elpais.com
November 11, 2025 at 12:36 PM
Ha muerto Antonio García-Bellido, uno de los mejores científicos de la historia de España tras descubrir las fronteras invisibles dentro de los seres vivos: elpais.com/ciencia/2025...
Reposted by Pablo Alcón
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
tinyurl.com
November 6, 2025 at 11:05 PM
𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n
Reposted by Pablo Alcón
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
November 7, 2025 at 11:43 PM
When people celebrate the individual genius of folks in science, they should also
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
Reposted by Pablo Alcón
Before her (too early) death, the amazing Sharon Begley wrote this piece on double helix co-discoverer James Watson and the racist and sexist pronouncements he seemed to revel in making in later life. Fascinating read about a troubling individual.
www.statnews.com/2025/11/07/j...
www.statnews.com/2025/11/07/j...
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 7, 2025 at 9:39 PM
Before her (too early) death, the amazing Sharon Begley wrote this piece on double helix co-discoverer James Watson and the racist and sexist pronouncements he seemed to revel in making in later life. Fascinating read about a troubling individual.
www.statnews.com/2025/11/07/j...
www.statnews.com/2025/11/07/j...
Reposted by Pablo Alcón
Reposted by Pablo Alcón
I asked him what was the most important thing he ever did. He replied “opposing the patenting of human genes”. For a full picture of Jim, his terrible flaws and his insights, we will have to wait for @nccomfort.bsky.social’s forthcoming biography.
November 7, 2025 at 7:57 PM
I asked him what was the most important thing he ever did. He replied “opposing the patenting of human genes”. For a full picture of Jim, his terrible flaws and his insights, we will have to wait for @nccomfort.bsky.social’s forthcoming biography.
Reposted by Pablo Alcón
Our PLAMseq paper is out today in @ScienceAdvances . We developed a TurboID-based protein-genomic approach to map proteins and protein interactions in the genome. Validated with CTCF and RNApolII. Applied to map Histone H1 SUMOylation genomic loci.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single workflow
PLAMseq enables performance of genomics and proteomics of chromatin-associated proteins and protein interactions simultaneously.
www.science.org
November 7, 2025 at 9:25 PM
Our PLAMseq paper is out today in @ScienceAdvances . We developed a TurboID-based protein-genomic approach to map proteins and protein interactions in the genome. Validated with CTCF and RNApolII. Applied to map Histone H1 SUMOylation genomic loci.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Pablo Alcón
Excited to share our discovery of the RAD51 filament cap, built by a newly identified RAD51 paralog complex 🔬🧬
‼️ Excited to share our new paper out now in @science.org ‼️
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.
Link: www.science.org/doi/epdf/10....
Thread ⬇️ (1/8)
November 7, 2025 at 10:22 AM
Excited to share our discovery of the RAD51 filament cap, built by a newly identified RAD51 paralog complex 🔬🧬
Reposted by Pablo Alcón
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
November 6, 2025 at 4:04 PM
New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
@imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
Reposted by Pablo Alcón
🧵 Our latest preprint is available.
It describes an extraordinary case of a boy with two very rare genetic conditions: Fanconi anaemia (FANCB, with a deep intronic pathogenic variant) and embryonic triploid–diploid mosaicism.
Read more here 👉 www.medrxiv.org/content/10.1...
It describes an extraordinary case of a boy with two very rare genetic conditions: Fanconi anaemia (FANCB, with a deep intronic pathogenic variant) and embryonic triploid–diploid mosaicism.
Read more here 👉 www.medrxiv.org/content/10.1...
Multi-lineage natural gene therapy mediated by embryonic triploid mosaicism in the context of Fanconi anaemia
Fanconi anemia is a rare inherited bone marrow failure syndrome caused by inactivation of genes in the Fanconi anemia/BRCA DNA repair pathway. We report a patient with X-linked Fanconi anemia, and aty...
www.medrxiv.org
November 7, 2025 at 1:54 AM
🧵 Our latest preprint is available.
It describes an extraordinary case of a boy with two very rare genetic conditions: Fanconi anaemia (FANCB, with a deep intronic pathogenic variant) and embryonic triploid–diploid mosaicism.
Read more here 👉 www.medrxiv.org/content/10.1...
It describes an extraordinary case of a boy with two very rare genetic conditions: Fanconi anaemia (FANCB, with a deep intronic pathogenic variant) and embryonic triploid–diploid mosaicism.
Read more here 👉 www.medrxiv.org/content/10.1...
Reposted by Pablo Alcón
UK publication day for this wrist-spraining beauty! Appropriately, I’m travelling to Cambridge, where I’m doing a book launch talk at the LMB tomorrow afternoon.
November 6, 2025 at 6:26 AM
UK publication day for this wrist-spraining beauty! Appropriately, I’m travelling to Cambridge, where I’m doing a book launch talk at the LMB tomorrow afternoon.
Reposted by Pablo Alcón
Models for the architecture of the human inner kinetochore CCAN complex on centromeric α-satellite CENP-A nucleosome arrays www.biorxiv.org/content/10.1101/2025.11.04.686567v1 #cryoem
November 5, 2025 at 8:10 AM
Models for the architecture of the human inner kinetochore CCAN complex on centromeric α-satellite CENP-A nucleosome arrays www.biorxiv.org/content/10.1101/2025.11.04.686567v1 #cryoem
Reposted by Pablo Alcón
The latest from our group (@lapassmore.bsky.social)! Congrats to James and the rest of the authors!
Phosphorylation-dependent tuning of mRNA deadenylation rates
www.nature.com/articles/s41...
Phosphorylation-dependent tuning of mRNA deadenylation rates
www.nature.com/articles/s41...
Phosphorylation-dependent tuning of mRNA deadenylation rates - Nature Structural & Molecular Biology
Stowell et al. show that the intrinsically disordered region (IDR) of Puf3 binds the Ccr4–Not deadenylase complex using an extended interface. Phosphorylation of the IDR regulates the interaction to t...
www.nature.com
November 3, 2025 at 12:45 PM
The latest from our group (@lapassmore.bsky.social)! Congrats to James and the rest of the authors!
Phosphorylation-dependent tuning of mRNA deadenylation rates
www.nature.com/articles/s41...
Phosphorylation-dependent tuning of mRNA deadenylation rates
www.nature.com/articles/s41...
Reposted by Pablo Alcón
📢 Excited to share that our study has just been published in Nature Communications! We uncover how CRL4-DCAF12 regulates the cellular levels of MCMBP, a chaperone essential for assembling nascent MCM2-7 complexes, to ensure accurate and error-free genome duplication.
October 28, 2025 at 3:04 PM
📢 Excited to share that our study has just been published in Nature Communications! We uncover how CRL4-DCAF12 regulates the cellular levels of MCMBP, a chaperone essential for assembling nascent MCM2-7 complexes, to ensure accurate and error-free genome duplication.
Reposted by Pablo Alcón
I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.
October 24, 2025 at 5:44 PM
I love AlphaFold—but please include PAE (Predicted Aligned Error) plots for every “interaction.” Pretty PDBs ≠ proof. If the PAE doesn’t show an interface, it ain’t one. Show the plots. Structural biology's reputation is on the line.
Reposted by Pablo Alcón
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
PhD student position in the Cell Signaling and Cell Cycle group at the Danish Cancer Institute.
The Cell Signaling and Cell Cycle group, headed by Prof. Jakob Nilsson, is looking for a highly motivated and enthusiastic PhD student to establish novel CRISPR
candidate.hr-manager.net
October 23, 2025 at 4:18 PM
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
Reposted by Pablo Alcón
Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
October 22, 2025 at 4:41 PM
Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Read more: www2.mrc-lmb.cam.ac.uk/a-new-method...
#LMBResearch
Reposted by Pablo Alcón
Thrilled to see Leyre’s PhD work finally out!
We reported the #cryoEM structures of an extracellular contractile injection system from P. luminescens in extended and contracted states, providing structural insight into its architecture and contraction mechanism 🔬
www.nature.com/articles/s41...
We reported the #cryoEM structures of an extracellular contractile injection system from P. luminescens in extended and contracted states, providing structural insight into its architecture and contraction mechanism 🔬
www.nature.com/articles/s41...
Structural characterization of an extracellular contractile injection system from Photorhabdus luminescens in extended and contracted states - Nature Communications
Marín-Arraiza and colleagues report the cryo-EM structures of an extracellular contractile injection system from Photorhabdus luminescens in extended and contracted states, providing structural insigh...
www.nature.com
October 22, 2025 at 1:25 PM
Thrilled to see Leyre’s PhD work finally out!
We reported the #cryoEM structures of an extracellular contractile injection system from P. luminescens in extended and contracted states, providing structural insight into its architecture and contraction mechanism 🔬
www.nature.com/articles/s41...
We reported the #cryoEM structures of an extracellular contractile injection system from P. luminescens in extended and contracted states, providing structural insight into its architecture and contraction mechanism 🔬
www.nature.com/articles/s41...
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...
www.science.org
October 13, 2025 at 2:05 PM
A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging | Science www.science.org/doi/10.1126/...
Reposted by Pablo Alcón
#womeninSTEM #womeninscience #Nobelprize
Trading cards to share, print and collect
cc @francesarnold.bsky.social @carolynbertozzi.bskyverified.social @jenniferdoudna.bsky.social @e-charpentier.bsky.social
link (aninfinityofhypotheses.wordpress.com/wp-content/u...)
Trading cards to share, print and collect
cc @francesarnold.bsky.social @carolynbertozzi.bskyverified.social @jenniferdoudna.bsky.social @e-charpentier.bsky.social
link (aninfinityofhypotheses.wordpress.com/wp-content/u...)
October 10, 2025 at 1:07 PM
#womeninSTEM #womeninscience #Nobelprize
Trading cards to share, print and collect
cc @francesarnold.bsky.social @carolynbertozzi.bskyverified.social @jenniferdoudna.bsky.social @e-charpentier.bsky.social
link (aninfinityofhypotheses.wordpress.com/wp-content/u...)
Trading cards to share, print and collect
cc @francesarnold.bsky.social @carolynbertozzi.bskyverified.social @jenniferdoudna.bsky.social @e-charpentier.bsky.social
link (aninfinityofhypotheses.wordpress.com/wp-content/u...)
We still can’t predict much of anything in biology
blog.genesmindsmachines.com/p/we-still-c...
blog.genesmindsmachines.com/p/we-still-c...
We still can’t predict much of anything in biology
Biology is hard. Yes, even for AI.
blog.genesmindsmachines.com
October 9, 2025 at 2:01 PM
We still can’t predict much of anything in biology
blog.genesmindsmachines.com/p/we-still-c...
blog.genesmindsmachines.com/p/we-still-c...
Reposted by Pablo Alcón
🧬 Preprint alert!
"Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity."
Read the manuscript here 👉 www.biorxiv.org/content/10.1...
"Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity."
Read the manuscript here 👉 www.biorxiv.org/content/10.1...
Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity
Mutations in the ATRX chromatin remodeller predispose to a developmental genetic disorder and cancer, but how it safeguards genome and telomere stability remains unresolved. Here, we uncover critical ...
www.biorxiv.org
October 7, 2025 at 9:49 PM
🧬 Preprint alert!
"Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity."
Read the manuscript here 👉 www.biorxiv.org/content/10.1...
"Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity."
Read the manuscript here 👉 www.biorxiv.org/content/10.1...