Nilsson lab
@nilssonlab.bsky.social
CRISPR screening season before holiday season
October 31, 2025 at 10:46 AM
CRISPR screening season before holiday season
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
PhD student position in the Cell Signaling and Cell Cycle group at the Danish Cancer Institute.
The Cell Signaling and Cell Cycle group, headed by Prof. Jakob Nilsson, is looking for a highly motivated and enthusiastic PhD student to establish novel CRISPR
candidate.hr-manager.net
October 23, 2025 at 4:18 PM
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
Reposted by Nilsson lab
Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Polo kinase inhibits protein phosphatase 1 to promote the spindle assembly checkpoint and prevent aneuploidy
Protein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains i…
www.sciencedirect.com
October 23, 2025 at 7:14 AM
Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Nilsson lab
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
October 8, 2025 at 8:49 AM
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Arrived in Wurzburg to get the latest om phosphatases!
July 27, 2025 at 4:31 PM
Arrived in Wurzburg to get the latest om phosphatases!
Returning from two great days at ICR in London to visit Norman Davey and many others. Need 20 days next time!
July 4, 2025 at 8:20 PM
Returning from two great days at ICR in London to visit Norman Davey and many others. Need 20 days next time!
Reposted by Nilsson lab
The @embo.org #chromoploidy2025 is over. It was an amazing workshop organized by a perfect match of scientists and friends @mcclellandlab.bsky.social @bendavidlab.bsky.social @stesantaguida.bsky.social @foijer-lab.bsky.social, Elsa Logarinho, Caroline Audouin and myself
May 4, 2025 at 3:34 PM
The @embo.org #chromoploidy2025 is over. It was an amazing workshop organized by a perfect match of scientists and friends @mcclellandlab.bsky.social @bendavidlab.bsky.social @stesantaguida.bsky.social @foijer-lab.bsky.social, Elsa Logarinho, Caroline Audouin and myself
Here we go - 4 days of excellent science in Italy
April 27, 2025 at 12:15 PM
Here we go - 4 days of excellent science in Italy
Reposted by Nilsson lab
Back again TOMORROW (Thursday April 3rd) for another IDPSeminars!
Noon central time - sign up for the webinar here
forms.gle/3yCHeYvuuqLh...
Noon central time - sign up for the webinar here
forms.gle/3yCHeYvuuqLh...
April 2, 2025 at 9:50 PM
Back again TOMORROW (Thursday April 3rd) for another IDPSeminars!
Noon central time - sign up for the webinar here
forms.gle/3yCHeYvuuqLh...
Noon central time - sign up for the webinar here
forms.gle/3yCHeYvuuqLh...
Come join us for the phosphatase meeting this summer! Deadline approaching for signing up for this great meeting.
meetings.embo.org/event/25-pho...
meetings.embo.org/event/25-pho...
Phosphatases: from basic research to translation
Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…
meetings.embo.org
March 26, 2025 at 4:59 AM
Come join us for the phosphatase meeting this summer! Deadline approaching for signing up for this great meeting.
meetings.embo.org/event/25-pho...
meetings.embo.org/event/25-pho...
Happy to share our latest work on phosphoprotein phosphatase (PPP) regulation. We integrate CRISPR knockout and focused base editor screens to uncover the regulatory landscape of PPPs (more below). Great collaboration with the Zhu, Davey, Kettenbach and Ogris labs.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions
Serine/Threonine phosphoprotein phosphatases (PPPs, PP1-PP7) are conserved metalloenzymes and central to intracellular signaling in eukaryotes, but the details of their regulation is poorly understood...
www.biorxiv.org
February 16, 2025 at 1:45 PM
Happy to share our latest work on phosphoprotein phosphatase (PPP) regulation. We integrate CRISPR knockout and focused base editor screens to uncover the regulatory landscape of PPPs (more below). Great collaboration with the Zhu, Davey, Kettenbach and Ogris labs.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Nilsson lab
www.nytimes.com/2025/02/14/o...
An eloquent defense of American science by Harold Varmus, a Nobel Prize winning scientist during his days at UCSF, former director of the NIH and NCI, and former President of Memorial Sloan Kettering Cancer Center (full disclosure — it’s where I work)
An eloquent defense of American science by Harold Varmus, a Nobel Prize winning scientist during his days at UCSF, former director of the NIH and NCI, and former President of Memorial Sloan Kettering Cancer Center (full disclosure — it’s where I work)
Opinion | American Science is Under Attack (Gift Article)
The Trump administration hobbles research and endangers the public health.
www.nytimes.com
February 14, 2025 at 1:42 PM
www.nytimes.com/2025/02/14/o...
An eloquent defense of American science by Harold Varmus, a Nobel Prize winning scientist during his days at UCSF, former director of the NIH and NCI, and former President of Memorial Sloan Kettering Cancer Center (full disclosure — it’s where I work)
An eloquent defense of American science by Harold Varmus, a Nobel Prize winning scientist during his days at UCSF, former director of the NIH and NCI, and former President of Memorial Sloan Kettering Cancer Center (full disclosure — it’s where I work)
Reposted by Nilsson lab
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 12, 2025 at 6:28 AM
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Nilsson lab
🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)
The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.
tinyurl.com
February 12, 2025 at 2:53 PM
🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
Goodbye to my office for the last 14 years. Time to pack down and head for new adventures
February 9, 2025 at 5:06 PM
Goodbye to my office for the last 14 years. Time to pack down and head for new adventures
Reposted by Nilsson lab
Congratulations to @andibrunner.bsky.social
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
@andibrunner.bsky.social et al. @ellenberglab.bsky.social show that interphase organization into Cohesin-driven loops occurs in a sequential and hierarchical manner - just like the mitotic organization by Condensins. https://buff.ly/426gIEu
@wanluzhang.bsky.social
@wanluzhang.bsky.social
January 9, 2025 at 9:57 PM
Congratulations to @andibrunner.bsky.social
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
and the team, and many thanks to the lab of Jan-Michael Peters for support!
We found that the interphase and mitotic chromatin loop organization have more in common than previously thought:
In both stages big loops are built first, small ones second
Interesting read - large scale base editor screen to probe S,T and Y function in RPE1 cells.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Functional profiling of serine, threonine and tyrosine sites - Nature Chemical Biology
The use of an adenine base editor enables identification of functional serine, threonine and tyrosine residues that impact cell fitness on a genome-wide scale with possible involvement in phosphorylat...
www.nature.com
January 10, 2025 at 5:42 AM
Interesting read - large scale base editor screen to probe S,T and Y function in RPE1 cells.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nilsson lab
Want to come work with me? Short postdoc opportunity. Deadline tomorrow ⚡️ jobportal.ku.dk/videnskabeli...
Postdoc of molecular data science
jobportal.ku.dk
January 5, 2025 at 6:30 PM
Want to come work with me? Short postdoc opportunity. Deadline tomorrow ⚡️ jobportal.ku.dk/videnskabeli...
Reposted by Nilsson lab
Just in time for Christmas. Latest from the lab www.biorxiv.org/content/10.1... great collaborative effort with @nilssonlab.bsky.social @andrea-musacchio.bsky.social and Mathieu Bollen.
POLO kinase inhibits Protein Phosphatase 1 to promote the Spindle Assembly Checkpoint and prevent aneuploidy
Protein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains ill-defined. Here, we demonstrate in vitro and in D...
www.biorxiv.org
December 24, 2024 at 4:17 PM
Just in time for Christmas. Latest from the lab www.biorxiv.org/content/10.1... great collaborative effort with @nilssonlab.bsky.social @andrea-musacchio.bsky.social and Mathieu Bollen.
In case you still haven't found the perfect Xmas present:
meetings.embo.org/event/25-pho...
meetings.embo.org/event/25-pho...
Phosphatases: from basic research to translation
Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…
meetings.embo.org
December 24, 2024 at 3:29 PM
In case you still haven't found the perfect Xmas present:
meetings.embo.org/event/25-pho...
meetings.embo.org/event/25-pho...
Lad xmas party - merry xmas to everyone!
December 17, 2024 at 4:23 PM
Lad xmas party - merry xmas to everyone!
Goodbye to Mads and good luck with the PhD. Thanks for the PP2A-B55 in lego - awesome!
December 17, 2024 at 4:22 PM
Goodbye to Mads and good luck with the PhD. Thanks for the PP2A-B55 in lego - awesome!
Thanks to all the organisers for a great meeting. Many discussions and ideas.
December 12, 2024 at 2:38 PM
Thanks to all the organisers for a great meeting. Many discussions and ideas.
On our way to the FASEB phosphatase meeting with a short stop in LA. Look forward to some excellent days of science and sun.
December 8, 2024 at 2:53 PM
On our way to the FASEB phosphatase meeting with a short stop in LA. Look forward to some excellent days of science and sun.
Reposted by Nilsson lab
Do you need a starting pack of researcher working on intrinsically disordered proteins?
Well, you might head over to @idpseminars.bsky.social and hit followers.
Tw***** was important for the birth of IDPseminars and for spreading the word. It would be cool to re-kindle that community here.
Well, you might head over to @idpseminars.bsky.social and hit followers.
Tw***** was important for the birth of IDPseminars and for spreading the word. It would be cool to re-kindle that community here.
November 25, 2024 at 11:44 AM
Do you need a starting pack of researcher working on intrinsically disordered proteins?
Well, you might head over to @idpseminars.bsky.social and hit followers.
Tw***** was important for the birth of IDPseminars and for spreading the word. It would be cool to re-kindle that community here.
Well, you might head over to @idpseminars.bsky.social and hit followers.
Tw***** was important for the birth of IDPseminars and for spreading the word. It would be cool to re-kindle that community here.