Nilsson lab
@nilssonlab.bsky.social
congrats Carlos and team - pleasure to work with you as always
October 23, 2025 at 4:16 PM
congrats Carlos and team - pleasure to work with you as always
Nice. Intriguing with UBE2C - would think the protein is unstable so you would slow down APC/C and prolong arrest.
July 27, 2025 at 2:50 PM
Nice. Intriguing with UBE2C - would think the protein is unstable so you would slow down APC/C and prolong arrest.
MSK also under DOGE investigations? I thought you would be safe. Hope to see you in Italy
February 18, 2025 at 12:47 PM
MSK also under DOGE investigations? I thought you would be safe. Hope to see you in Italy
In addition to uncovering CYB5R4 our functional map hints at many additional regulatory pathways and mechanisms that can now be explored by the community. Thanks to Norman Davey this will be facilitated through a website allowing exploration of the base editor screens slim.icr.ac.uk/base_editing...
SLiM team resources @ ICR
slim.icr.ac.uk
February 16, 2025 at 1:45 PM
In addition to uncovering CYB5R4 our functional map hints at many additional regulatory pathways and mechanisms that can now be explored by the community. Thanks to Norman Davey this will be facilitated through a website allowing exploration of the base editor screens slim.icr.ac.uk/base_editing...
We find that CYB5R4 mediated activation of PP4 is critical for controlling the response to the DNA damaging agents cisplatin and Illudin S that cause elevated levels of ROS. This extends earlier important observations from the @durocher1.bsky.social lab on CYB5R4 (Olivieri et al 2020).
February 16, 2025 at 1:45 PM
We find that CYB5R4 mediated activation of PP4 is critical for controlling the response to the DNA damaging agents cisplatin and Illudin S that cause elevated levels of ROS. This extends earlier important observations from the @durocher1.bsky.social lab on CYB5R4 (Olivieri et al 2020).
We uncover CYB5R4 as an activator of PP4 and PP6 but not the closely related PP2A. CYB5R4 is a dedicated reductase for the catalytic metal ions and we show that this pathway is conserved from yeast to man. Thus PP4 and PP6 activity is regulated by oxidation and reduction of the metal ions.
February 16, 2025 at 1:45 PM
We uncover CYB5R4 as an activator of PP4 and PP6 but not the closely related PP2A. CYB5R4 is a dedicated reductase for the catalytic metal ions and we show that this pathway is conserved from yeast to man. Thus PP4 and PP6 activity is regulated by oxidation and reduction of the metal ions.