Pilhofer Lab 🦠❄️🔬
@pilhoferlab.bsky.social
Microbial cell-cell interactions | contractile injection systems | cytoskeleton | evolution | multiscale imaging | ETH Zürich
- run by lab members -
- run by lab members -
Pinned
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
Reposted by Pilhofer Lab 🦠❄️🔬
The cryo cyclical multiplexing expansion microscopy (Cy-ExM) preprint from
@seweryn-galecki.bsky.social , @kevin-dean.bsky.social et al is online.
20 targets across an entire cell. Mr. Snouty also joined the fun.
www.biorxiv.org/content/10.6...
@seweryn-galecki.bsky.social , @kevin-dean.bsky.social et al is online.
20 targets across an entire cell. Mr. Snouty also joined the fun.
www.biorxiv.org/content/10.6...
January 2, 2026 at 7:39 PM
The cryo cyclical multiplexing expansion microscopy (Cy-ExM) preprint from
@seweryn-galecki.bsky.social , @kevin-dean.bsky.social et al is online.
20 targets across an entire cell. Mr. Snouty also joined the fun.
www.biorxiv.org/content/10.6...
@seweryn-galecki.bsky.social , @kevin-dean.bsky.social et al is online.
20 targets across an entire cell. Mr. Snouty also joined the fun.
www.biorxiv.org/content/10.6...
Reposted by Pilhofer Lab 🦠❄️🔬
A balance of infection and harmony called endosymbiosis helps shape evolution. For the first time, biologists have reproduced this arrangement between microbes in a lab.
Scientists Re-Create the Microbial Dance That Sparked Complex Life | Quanta Magazine
Evolution was fueled by endosymbiosis, cellular alliances in which one microbe makes a permanent home inside another. For the first time, biologists made it happen in the lab.
www.quantamagazine.org
December 31, 2025 at 4:46 PM
A balance of infection and harmony called endosymbiosis helps shape evolution. For the first time, biologists have reproduced this arrangement between microbes in a lab.
Reposted by Pilhofer Lab 🦠❄️🔬
Available Postdoc position in my lab to advance ASO technology for biotechnology, food production, infectious diseases, environmental microbiology & more. Looking for specialists in these areas with an interest in RNA applications. Involves numerous national & international collaborations.
December 30, 2025 at 11:48 AM
Available Postdoc position in my lab to advance ASO technology for biotechnology, food production, infectious diseases, environmental microbiology & more. Looking for specialists in these areas with an interest in RNA applications. Involves numerous national & international collaborations.
Reposted by Pilhofer Lab 🦠❄️🔬
A super detailed protocol + video on Cryo-ExM - Cryo-Expansion Microscopy, led by the labs of our former postdocs @marinelap.bsky.social & @ebertiaux.bsky.social.
Clear, practical, and very useful for anyone doing nanoscale imaging 🚀 app.jove.com/t/68595/expa...
Clear, practical, and very useful for anyone doing nanoscale imaging 🚀 app.jove.com/t/68595/expa...
December 25, 2025 at 1:41 PM
A super detailed protocol + video on Cryo-ExM - Cryo-Expansion Microscopy, led by the labs of our former postdocs @marinelap.bsky.social & @ebertiaux.bsky.social.
Clear, practical, and very useful for anyone doing nanoscale imaging 🚀 app.jove.com/t/68595/expa...
Clear, practical, and very useful for anyone doing nanoscale imaging 🚀 app.jove.com/t/68595/expa...
Reposted by Pilhofer Lab 🦠❄️🔬
We are looking for a team leader to join the cryo-EM facility work at the new Ernst Ruska-Centre 2.0 at the Forschungszentrum Jülich. We have a series of microscopes used by (@irene-vercellino.bsky.social, Schröder, @sachsegroup.bsky.social) and external users.
www.fz-juelich.de/de/karriere/...
www.fz-juelich.de/de/karriere/...
Team Leader – Life Science Cryo-Electron Microscopy (Cryo-EM) Facility
Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons (ER-C) at Forschungszentrum Jülich houses some of the world`s most advanced electron microscopes and tools for nanocharacterisation. U...
www.fz-juelich.de
December 23, 2025 at 9:42 AM
We are looking for a team leader to join the cryo-EM facility work at the new Ernst Ruska-Centre 2.0 at the Forschungszentrum Jülich. We have a series of microscopes used by (@irene-vercellino.bsky.social, Schröder, @sachsegroup.bsky.social) and external users.
www.fz-juelich.de/de/karriere/...
www.fz-juelich.de/de/karriere/...
Reposted by Pilhofer Lab 🦠❄️🔬
The paper by Pia Lavriha, Carina Fluri, Jorge Hernández González and Volodymyr Korkhov, published in @natcomms.nature.com provides molecular insights into lipid-mediated conformational changes in Cx32 gap junction channels. More: biol.ethz.ch/en/news-and-...
December 23, 2025 at 12:52 PM
The paper by Pia Lavriha, Carina Fluri, Jorge Hernández González and Volodymyr Korkhov, published in @natcomms.nature.com provides molecular insights into lipid-mediated conformational changes in Cx32 gap junction channels. More: biol.ethz.ch/en/news-and-...
Reposted by Pilhofer Lab 🦠❄️🔬
📢 20 postdoctoral positions (full-time, 4 years) for outstanding female scientists 👩🔬 🔬 @univie.ac.at
The E-STEEM programme call opens January 7th, 2026 and closes March 3rd, 2026.
careers.univie.ac.at/en/postdoc/e...
I participate as a host...
The E-STEEM programme call opens January 7th, 2026 and closes March 3rd, 2026.
careers.univie.ac.at/en/postdoc/e...
I participate as a host...
careers.univie.ac.at
December 16, 2025 at 12:56 PM
📢 20 postdoctoral positions (full-time, 4 years) for outstanding female scientists 👩🔬 🔬 @univie.ac.at
The E-STEEM programme call opens January 7th, 2026 and closes March 3rd, 2026.
careers.univie.ac.at/en/postdoc/e...
I participate as a host...
The E-STEEM programme call opens January 7th, 2026 and closes March 3rd, 2026.
careers.univie.ac.at/en/postdoc/e...
I participate as a host...
Reposted by Pilhofer Lab 🦠❄️🔬
We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)!
GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.
Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.
👉 www.unige.ch/genexm/
GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.
Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.
👉 www.unige.ch/genexm/
December 10, 2025 at 8:43 PM
We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)!
GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.
Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.
👉 www.unige.ch/genexm/
GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.
Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.
👉 www.unige.ch/genexm/
Reposted by Pilhofer Lab 🦠❄️🔬
JOB ALERT: Operations Director (DCI–Lausanne).
The DCI, a joint initiative of EPFL, UNIL, UNIGE and UNIBE, is recruiting an Operations Director to lead the cryo-EM facility in Lausanne.
📩 Questions: CEO of the DCI: @chgenoud.bsky.social
🔗 Apply here: careers.epfl.ch/job/Lausanne...
The DCI, a joint initiative of EPFL, UNIL, UNIGE and UNIBE, is recruiting an Operations Director to lead the cryo-EM facility in Lausanne.
📩 Questions: CEO of the DCI: @chgenoud.bsky.social
🔗 Apply here: careers.epfl.ch/job/Lausanne...
December 17, 2025 at 12:00 PM
JOB ALERT: Operations Director (DCI–Lausanne).
The DCI, a joint initiative of EPFL, UNIL, UNIGE and UNIBE, is recruiting an Operations Director to lead the cryo-EM facility in Lausanne.
📩 Questions: CEO of the DCI: @chgenoud.bsky.social
🔗 Apply here: careers.epfl.ch/job/Lausanne...
The DCI, a joint initiative of EPFL, UNIL, UNIGE and UNIBE, is recruiting an Operations Director to lead the cryo-EM facility in Lausanne.
📩 Questions: CEO of the DCI: @chgenoud.bsky.social
🔗 Apply here: careers.epfl.ch/job/Lausanne...
Reposted by Pilhofer Lab 🦠❄️🔬
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
December 19, 2025 at 4:45 PM
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.
Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
Reposted by Pilhofer Lab 🦠❄️🔬
We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...
December 19, 2025 at 8:14 AM
We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...
Reposted by Pilhofer Lab 🦠❄️🔬
Sign up now for the EMBO Workshop "#MolecularBiology of #Archaea: Life Through the Prism of Archaea" in Cambridge, UK, 6–10 July 2026.
Deadline: 15 April
https://meetings.embo.org/event/26-archaea
#EMBOArchaeaBiology #EMBOevents #CellBiology #StructuralBiology #ecology #evolution #biophysics 🧪
Deadline: 15 April
https://meetings.embo.org/event/26-archaea
#EMBOArchaeaBiology #EMBOevents #CellBiology #StructuralBiology #ecology #evolution #biophysics 🧪
December 17, 2025 at 7:10 AM
Sign up now for the EMBO Workshop "#MolecularBiology of #Archaea: Life Through the Prism of Archaea" in Cambridge, UK, 6–10 July 2026.
Deadline: 15 April
https://meetings.embo.org/event/26-archaea
#EMBOArchaeaBiology #EMBOevents #CellBiology #StructuralBiology #ecology #evolution #biophysics 🧪
Deadline: 15 April
https://meetings.embo.org/event/26-archaea
#EMBOArchaeaBiology #EMBOevents #CellBiology #StructuralBiology #ecology #evolution #biophysics 🧪
Reposted by Pilhofer Lab 🦠❄️🔬
Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious?
Either way, we have good news.
We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July.
Sign up: meetings.embo.org/event/26-arc...
We look forward to seeing you in Cambridge, UK
Please repost!!
Either way, we have good news.
We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July.
Sign up: meetings.embo.org/event/26-arc...
We look forward to seeing you in Cambridge, UK
Please repost!!
meetings.embo.org
December 16, 2025 at 12:58 PM
Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious?
Either way, we have good news.
We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July.
Sign up: meetings.embo.org/event/26-arc...
We look forward to seeing you in Cambridge, UK
Please repost!!
Either way, we have good news.
We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July.
Sign up: meetings.embo.org/event/26-arc...
We look forward to seeing you in Cambridge, UK
Please repost!!
Reposted by Pilhofer Lab 🦠❄️🔬
Happy to share the last work of @jmartinkus.bsky.social, led by @dukasju.bsky.social
Immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @currentbiology.bsky.social
Kudos !!
www.cell.com/current-biol...
Immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @currentbiology.bsky.social
Kudos !!
www.cell.com/current-biol...
Poly-immunity arrays associated with Rhs toxins confer wide protection against competitors
Martinkus et al. show that Photorhabdus and Xenorhabdus species encode arrays of immunity
genes whose protein products neutralize toxins secreted by competitors. These arrays,
often linked to Xer pass...
www.cell.com
December 15, 2025 at 5:02 PM
Happy to share the last work of @jmartinkus.bsky.social, led by @dukasju.bsky.social
Immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @currentbiology.bsky.social
Kudos !!
www.cell.com/current-biol...
Immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @currentbiology.bsky.social
Kudos !!
www.cell.com/current-biol...
Reposted by Pilhofer Lab 🦠❄️🔬
Apply by Feb. 3 to join HHMI's Janelia Research Campus as a Group Leader!
Group Leaders drive breakthroughs & experimental approaches in imaging, molecular engineering, protein chemistry, mass spectrometry, & methods that don't yet exist. Learn more: janelia.org/groupleader 🧪
Group Leaders drive breakthroughs & experimental approaches in imaging, molecular engineering, protein chemistry, mass spectrometry, & methods that don't yet exist. Learn more: janelia.org/groupleader 🧪
December 15, 2025 at 6:15 PM
Apply by Feb. 3 to join HHMI's Janelia Research Campus as a Group Leader!
Group Leaders drive breakthroughs & experimental approaches in imaging, molecular engineering, protein chemistry, mass spectrometry, & methods that don't yet exist. Learn more: janelia.org/groupleader 🧪
Group Leaders drive breakthroughs & experimental approaches in imaging, molecular engineering, protein chemistry, mass spectrometry, & methods that don't yet exist. Learn more: janelia.org/groupleader 🧪
Reposted by Pilhofer Lab 🦠❄️🔬
Franziska Faber and I are recruiting shared postdocs, PhD students to work on Fusobacterium & new BGCs. www.helmholtz-hiri.de/fileadmin/HI...
December 12, 2025 at 3:43 PM
Franziska Faber and I are recruiting shared postdocs, PhD students to work on Fusobacterium & new BGCs. www.helmholtz-hiri.de/fileadmin/HI...
Reposted by Pilhofer Lab 🦠❄️🔬
“Cultivation of Methanonezhaarchaeia, the third class of methanogens within the phylum Thermoproteota” by @kohtzarchaeota.bsky.social, Sylvia Nupp, and myself is out in Science Advances. 90% enriched culture of a methyl-dismutating thermoproteotal methanogen. #Microsky 🧪 tinyurl.com/bdcc3uzs
Cultivation of Methanonezhaarchaeia, the third class of methanogens within the phylum Thermoproteota
The cultivation of a group of methanogens illuminates their metabolic diversity and the evolution of archaea.
www.science.org
December 12, 2025 at 7:22 PM
“Cultivation of Methanonezhaarchaeia, the third class of methanogens within the phylum Thermoproteota” by @kohtzarchaeota.bsky.social, Sylvia Nupp, and myself is out in Science Advances. 90% enriched culture of a methyl-dismutating thermoproteotal methanogen. #Microsky 🧪 tinyurl.com/bdcc3uzs
Reposted by Pilhofer Lab 🦠❄️🔬
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
December 12, 2025 at 2:58 PM
Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
Reposted by Pilhofer Lab 🦠❄️🔬
Reposted by Pilhofer Lab 🦠❄️🔬
Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752 - Medical Research Council
Location: Cambridge. Vacancy: Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752. Closing Date: 04/01/2026, 23:55
mrc.tal.net
December 10, 2025 at 2:28 PM
Postdoc opportunity with Michel Goedert and myself to work on #cryoEM/#cryoET structures of #amyloids. Feel free to email me with any questions you might have.
mrc.tal.net/vx/mobile-0/...
mrc.tal.net/vx/mobile-0/...
Reposted by Pilhofer Lab 🦠❄️🔬
We are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!
Tenure Track Professorship (W1 with Tenure Track to W3) in “Molecular Biology" (f/m/d) - Heidelberg job with Universität Heidelberg | 12850668
The Center for Molecular Biology of Heidelberg University (ZMBH) and the Faculty of Biosciences invite applications for a Tenure Track Professors...
www.nature.com
December 9, 2025 at 6:11 PM
We are recruiting a tenure track professor in the broader area of molecular biology @zmbh.uni-heidelberg.de at Heidelberg University! www.nature.com/naturecareer... Please share and apply!
Reposted by Pilhofer Lab 🦠❄️🔬
🥳 Our new paper on C2CD3 is out in @plosbiology.org
With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET.
Big congrats to @ebertiaux.bsky.social and all involved.
With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET.
Big congrats to @ebertiaux.bsky.social and all involved.
How does C2CD3 contribute to distal appendage formation in centrioles? @centriolelab.bsky.social show that C2CD3 acts as a central architectural organizer of the distal #centriole, bridging the luminal distal ring complex & peripheral appendage sites @plosbiology.org 🧪 plos.io/496XZuH
December 10, 2025 at 12:36 PM
🥳 Our new paper on C2CD3 is out in @plosbiology.org
With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET.
Big congrats to @ebertiaux.bsky.social and all involved.
With the labs of @cellarchlab.com , @chgenoud.bsky.social , and @stearnslab.bsky.social , we revealed the mammalian centriole Distal Ring architecture by combining #UExM and in situ #CryoET.
Big congrats to @ebertiaux.bsky.social and all involved.
Reposted by Pilhofer Lab 🦠❄️🔬
🔬 Call to create junior research groups at the Institut Pasteur
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research
The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
research.pasteur.fr
December 8, 2025 at 8:53 AM
🔬 Call to create junior research groups at the Institut Pasteur
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies
📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD
Apply now 📝 research.pasteur.fr/en/call/crea...
#JobOpportunity #Research
Reposted by Pilhofer Lab 🦠❄️🔬
Please RT. Post-doc opportunity alert! 💥 closing soon 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
December 5, 2025 at 5:06 PM
Please RT. Post-doc opportunity alert! 💥 closing soon 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
Reposted by Pilhofer Lab 🦠❄️🔬
An Asgard Archaeon (Lokiarchaeum ossiferum) growing and retracting its arms
December 3, 2025 at 8:32 PM
An Asgard Archaeon (Lokiarchaeum ossiferum) growing and retracting its arms