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pilhoferlab.bsky.social
Pilhofer Lab 🦠❄️🔬
@pilhoferlab.bsky.social
1.7K followers 660 following 46 posts
Microbial cell-cell interactions | contractile injection systems | cytoskeleton | evolution | multiscale imaging | ETH Zürich
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pilhoferlab.bsky.social
Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · Mar 21
Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6
Credit: Margot Riggi (@margotriggi.bsky.social), Max-Planck Institute of Biochemistry (@mpibiochem.bsky.social)
Reposted by Pilhofer Lab 🦠❄️🔬
danielabarilla.bsky.social
📢 Interested in #chromosomes 🧬 & #archaea thriving at the edge of life? PhD project in York,UK on how archaea pass on their genome to daughter cells.Friendly supervisors: me, @steve-quinn-lab.bsky.social & @georgerheath.bsky.social

www.findaphd.com/phds/project...
📅 January 7, 2026
Please RP🙏thx!
Archaeal cells whose DNA has been stained with a blue dye. Zoomed-in images of mutant cells that display chromosome segregation defects. High-resolution images of DNA-protein complexes obtained with atomic force microscopy. Upon binding, the protein bridges distant sites, forming loops.
November 9, 2025 at 5:20 PM
Reposted by Pilhofer Lab 🦠❄️🔬
buzzbaum.bsky.social
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
Reposted by Pilhofer Lab 🦠❄️🔬
tbharat-lab.bsky.social
An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
Reposted by Pilhofer Lab 🦠❄️🔬
guo-lab.bsky.social
Great collaboration with @brunlabcaulo.bsky.social for resolving the Tad pilus machine structure by cryo-ET. Beautiful work by graduate students James Iarocci and Ryu Williston in our lab.

Preprint:https://www.biorxiv.org/content/10.1101/2025.11.05.686773v1
November 6, 2025 at 3:58 PM
Reposted by Pilhofer Lab 🦠❄️🔬
brunlabcaulo.bsky.social
Great collaboration with @guo-lab.bsky.social to determine an in situ architectural model of the Tad pilus machine. Be on the lookout soon for a preprint on the same topic by Grant Jensen and @viollierpat.bsky.social. #microsky
November 6, 2025 at 3:51 PM
Reposted by Pilhofer Lab 🦠❄️🔬
mrclmb.bsky.social
Excellent #postdoc opportunity available in @sjorsscheres.bsky.social’ group, working on new image processing algorithms for #cryoEM structure determination in their #RELION open-source software.
www.nature.com/naturecareer...
Apply by 25 NOV
#PostdocJobs #ScienceJobs
November 6, 2025 at 3:46 PM
Reposted by Pilhofer Lab 🦠❄️🔬
fridof.bsky.social
Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that!
www.uu.nl/en/news/33-m...
33 million euro investment for national electron microscope facility EMPower
A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
www.uu.nl
November 4, 2025 at 7:14 AM
Reposted by Pilhofer Lab 🦠❄️🔬
cryosagar.openemage.org
Some great years ahead for #teamtomo in the Netherlands🥳🥳
Congrats @fridof.bsky.social and the team!
November 4, 2025 at 12:33 PM
Reposted by Pilhofer Lab 🦠❄️🔬
thanbichlerlab.bsky.social
📢 Postdoc position: Cell Biology of Cyanobacteria

in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.

More information at shorturl.at/wNnDT (see Project 2)

🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025

Please repost. #Postdoc
November 2, 2025 at 7:13 PM
pilhoferlab.bsky.social
🥳 Today marks the start of the lab of former postdoc @florianwollweber.bsky.social at @embl.org Grenoble!
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!

With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇
November 1, 2025 at 12:41 PM
Reposted by Pilhofer Lab 🦠❄️🔬
floravincent.bsky.social
Exciting day for the lab: our 1rst paper is officially out in @currentbiology.bsky.social 🥳 Wonderful collaboration wt @gautamdey.bsky.social showing how Cryo-ExM achieves consistent immunostaining in diverse diatoms, from the lab and the natural environment 1/n
#ProtistsOnSky
tinyurl.com/2zxaund7
October 31, 2025 at 3:27 PM
Reposted by Pilhofer Lab 🦠❄️🔬
dudinlab.bsky.social
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky

www.cell.com/cell/fulltex...
October 31, 2025 at 2:42 PM
Reposted by Pilhofer Lab 🦠❄️🔬
maxperutzlabs.ac.at
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
Reposted by Pilhofer Lab 🦠❄️🔬
helmholtz-hiri.bsky.social
🚨 Last chance!
The Helmholtz Institute Würzburg is offering 2️⃣ JUNIOR GROUP LEADER POSITIONS in RNA BIOLOGY, RNA TECHNOLOGY or RNA MEDICINE. 🧬🧫 💻 ⚕️
The deadline is today, so apply now at www.helmholtz-hiri.de/en/e15-groups/
E15 Groups
The Helmholtz Institute for RNA-based Infection Researchopens a call for
www.helmholtz-hiri.de
October 31, 2025 at 9:58 AM
Reposted by Pilhofer Lab 🦠❄️🔬
ethz.ch
Congratulations to Nicola Aceto for receiving the Cloëtta Prize!
ETH Professor Nicola Aceto receives the 2025 Cloëtta Prize
This year’s Cloëtta Prize goes to the cancer researcher from the Department of Biology at ETH Zurich. The award is in recognition of his groundbreaking contributions to cancer metastasis research.
ethz.ch
October 31, 2025 at 10:16 AM
Reposted by Pilhofer Lab 🦠❄️🔬
biology.ox.ac.uk
We have three senior and one early-career research fellowships open! It's an exciting time to join us as we've just moved into the new Life and Mind Building

Fellowships in fungal disease, mycology, conservation science + nature finance, & plant sciences in thread 👇
www.youtube.com/watch?v=_amV...
Oxford's new Life and Mind Building
YouTube video by University of Oxford
www.youtube.com
October 31, 2025 at 10:20 AM
Reposted by Pilhofer Lab 🦠❄️🔬
dodonova-sveta.bsky.social
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Reposted by Pilhofer Lab 🦠❄️🔬
sjorsscheres.bsky.social
We are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated.

mrc.tal.net/vx/appcentre...
Quick Check Needed
mrc.tal.net
October 29, 2025 at 9:17 AM
Reposted by Pilhofer Lab 🦠❄️🔬
lifeonthewedge.bsky.social
Our colleagues Vinith Kishore and Valentin Debarnot from the @ivandokmanic.bsky.social lab have come up with an amazing deep learning tool for denoising and filling the missing wedge in #cryoET data. I'm pleased to introduce Icecream🍧
Icecream: High-Fidelity Equivariant Cryo-Electron Tomography
Cryo-electron tomography (cryo-ET) visualizes 3D cellular architecture in near-native states. Recent deep-learning methods (CryoCARE, IsoNet, DeepDeWedge, CryoLithe) improve denoising and artifact cor...
www.biorxiv.org
October 23, 2025 at 11:13 AM
Reposted by Pilhofer Lab 🦠❄️🔬
jerryknowsnothing.bsky.social
First time posting on Bluesky! 🥳 We discovered a new pilus family in cyanobacteria. The pilin has a novel protein fold that forms a super-tight double-layer tube. Similar gene clusters exist in a few cyanobacterial orders. A great collaboration with John and others! www.nature.com/articles/s41...
A family of tubular pili from harmful algal bloom forming cyanobacterium Microcystis aeruginosa - Nature Communications
Ricca et al discover a new family of tubular pili in Microcystis aeruginosa, a harmful algal bloom-forming cyanobacterium. These pili are crucial for buoyancy by forming cell micro-colonies, which inc...
www.nature.com
October 24, 2025 at 4:08 AM
Reposted by Pilhofer Lab 🦠❄️🔬
cm-schroeder.bsky.social
After a long break from social media, I’m finally on Bluesky and have a preprint alert from my lab!

doi.org/10.1101/2025...
A microexon in Arp2 alters tissue-specific Arp2/3-generated actin structures
The Arp2/3 complex nucleates essential branched actin networks in most eukaryotes. Interestingly, the subunit Arp2 encodes two splice variants that differ merely by five amino acids in the D-loop, whi...
doi.org
October 24, 2025 at 7:25 PM
Reposted by Pilhofer Lab 🦠❄️🔬
tanjastadler.bsky.social
Open position at the Swiss Institute of Bioinformatics:
We are looking for a Director of the Center of Pathogen Bioinformatics
apply.refline.ch/499599/0346/...
I am in the Center's steering board together with fantastic colleagues (Emma Hodcroft @firefoxx66.bsky.social, Richard Neher @neher.io, and
Director, Center for Pathogen Bioinformatics
The Centre for Pathogen Bioinformatics (CPB) is a unit of SIB which offers expertise and services in pathogen bioinformatics, computational molecular epidemiology and related multi-site project manage...
apply.refline.ch
October 25, 2025 at 1:03 PM
Reposted by Pilhofer Lab 🦠❄️🔬
chlandalab.bsky.social
Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET!
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
October 24, 2025 at 8:11 AM
Reposted by Pilhofer Lab 🦠❄️🔬
ardemp.bskyverified.social
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!

apply.interfolio.com/174756
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 14, 2025 at 5:35 PM
Reposted by Pilhofer Lab 🦠❄️🔬
camiloperezc6h6.bsky.social
UGA is seeking a tenure-track Assistant Professor to develop an innovative research program focused on disease mechanisms. The ideal candidate will use cryo-EM and other structural techniques, with potential applications to future therapies.
Apply here: www.ugajobsearch.com/postings/456...
Assistant Professor of Structural Biology
The Franklin College of Arts and Sciences at the University of Georgia (UGA) invites applications for multiple open faculty positions, beginning August 1, 2026. We are broadly interested in scientists...
www.ugajobsearch.com
October 22, 2025 at 3:35 PM